+ All Categories
Home > Documents > A Bio-Implantable Platform for Inductive Data and Power ... · batt 4.1V: CV phase- to be...

A Bio-Implantable Platform for Inductive Data and Power ... · batt 4.1V: CV phase- to be...

Date post: 03-Aug-2020
Category:
Upload: others
View: 4 times
Download: 0 times
Share this document with a friend
4
A Bio-Implantable Platform for Inductive Data and Power Transfer with Integrated Battery Charging Michael Sole * , Ayodele Sanni *† , Antonio Vilches , Christofer Toumazou *† and Timothy G. Constandinou *† * Department of Electrical and Electronic Engineering, Imperial College London, SW7 2BT, UK Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, UK Email: {michael.sole08,a.sanni08,a.vilches,c.toumazou,t.constandinou}@imperial.ac.uk Abstract—This paper describes a mixed signal subsystem for the inductive transfer of power and data to a fully-implantable medical device. The design includes circuits for the inductive power recovery and energy storage (charging), in addition to data recovery and demodulation. The data link is used to upload (at a data rate of up to 180Kbps) calibration and configuration data to the implanted device and integrates both error detection and cor- rection on the recovered bitstream. The system incorporates an implanted Li-Ion micro-battery with supporting charging hard- ware to provide an uninterrupted power supply for autonomous deployment. This is to provide continuous operation without the requirement for an externally worn unit and additionally ensures registry (i.e. patient calibration) settings are maintained. The circuit has been implemented in a commercially available 0.35μm CMOS technology without requiring high-voltage device options. Index Terms—neural prosthesis, inductive telemetry, implanted device, data recovery, power recovery, battery charging I. I NTRODUCTION Medical devices that interface with neural pathways for sen- sory or motor rehabilitation have recently enjoyed significant interest [1]. This is partially due to the huge successes of cochlea implants but also the semiconductor industries relent- less progress on integration density. This enabling technology has provided medical devices the opportunity to implement advanced systems at miniature scale suitable for implantation. Furthermore, modern submicron CMOS technologies make it possible for such systems to be implemented using highly energy efficient circuits and systems. Coupled with advances in rechargeable battery technology makes the notion of totally implantable prosthetic devices technically feasible. Conventional neuroprosthetic technology, for example, commercially-available cochlear implants are generally based on a two module device comprising of the implanted unit and a body-worn unit (housing the battery and processing electron- ics). Power and data are typically transferred through the skin using a transcutaneous inductive link [2], [3]. An emerging breed of new autonomous and fully-implantable devices will aim to combine these in one implanted unit and use a body- worn device simply for charging and calibration. However, such devices would introduce new design challenges [4], for example, including an implanted battery and optimising the prosthesis electronics to operate on a limited power budget. In this paper, we present a data and power management system for such a transcutaneous link, combining traditional circuits for data and power recovery together with new require- ments for voltage regulation and recharging. All circuits have been implemented using a standard (i.e. non-high voltage) CMOS technology. II. SYSTEM OVERVIEW The overall system consists of three main blocks: the power recovery/management circuit, the data recovery circuit and the charger circuit. The system architecture is shown in Fig. 1. The transcutaneous link allows to transmit both power and data to the implant by using ON/OFF keying with Pulse Width Modulation (PWM) [3]. This is achieved using a pair of coupled inductors (one implanted and one external) that form part of an LC tank tuned to a carrier frequency of 2MHz (for minimum absorption in water). The primary LC tank (i.e. external unit) is based on the discrete circuit reported in [2]. The secondary LC tank (i.e. implanted unit) connects to the circuit described herein feeding both the power and data recovery blocks. The power recovery block (see Fig. 1(a)) rectifies and limits the AC signal to provide the DC supply for the voltage reference and regulation circuits. The data recovery block (see Fig. 1(d)) limits, envelope detects, integrates and thresholds the signal to demodulate the data. The charging circuit implements a two phase charge cycle (constant current and constant voltage) to efficiently load the implanted battery. III. I MPLEMENTATION The circuit has been implemented in a commercially- available 0.35μm CMOS technology without requiring high- voltage device options. This has been achieved by using parasitic pn junction diodes (n-well/p-diffusion) for the rec- tification and voltage limiting circuits thus to ensure all MOS devices are shielded from possible overvoltage fluctuations. A. Inductive Coupling The planar coils have been fabricated using a standard FR4 laminate (i.e. 35μm copper on a 0.8mm epoxy-resin substrate). The design specifications are given in Table I and the fabricated prototypes are shown in Fig. 2. B. Power Recovery Circuit The block diagram of the power recovery circuit is shown in Fig. 1(a). The input (i.e. connection to LC tank) feeds a high- voltage tolerant full-wave rectifier that has been implemented
Transcript
Page 1: A Bio-Implantable Platform for Inductive Data and Power ... · batt 4.1V: CV phase- to be maintained at 4.1V until the charge current reaches 5% the initial [7]. 3) Charging Circuit:

A Bio-Implantable Platform for Inductive Data andPower Transfer with Integrated Battery Charging

Michael Sole∗, Ayodele Sanni∗†, Antonio Vilches†, Christofer Toumazou∗† and Timothy G. Constandinou∗†∗Department of Electrical and Electronic Engineering, Imperial College London, SW7 2BT, UK

†Centre for Bio-Inspired Technology, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, UKEmail: michael.sole08,a.sanni08,a.vilches,c.toumazou,[email protected]

Abstract—This paper describes a mixed signal subsystem forthe inductive transfer of power and data to a fully-implantablemedical device. The design includes circuits for the inductivepower recovery and energy storage (charging), in addition to datarecovery and demodulation. The data link is used to upload (at adata rate of up to 180Kbps) calibration and configuration data tothe implanted device and integrates both error detection and cor-rection on the recovered bitstream. The system incorporates animplanted Li-Ion micro-battery with supporting charging hard-ware to provide an uninterrupted power supply for autonomousdeployment. This is to provide continuous operation without therequirement for an externally worn unit and additionally ensuresregistry (i.e. patient calibration) settings are maintained. Thecircuit has been implemented in a commercially available 0.35µmCMOS technology without requiring high-voltage device options.

Index Terms—neural prosthesis, inductive telemetry, implanteddevice, data recovery, power recovery, battery charging

I. INTRODUCTION

Medical devices that interface with neural pathways for sen-sory or motor rehabilitation have recently enjoyed significantinterest [1]. This is partially due to the huge successes ofcochlea implants but also the semiconductor industries relent-less progress on integration density. This enabling technologyhas provided medical devices the opportunity to implementadvanced systems at miniature scale suitable for implantation.Furthermore, modern submicron CMOS technologies make itpossible for such systems to be implemented using highlyenergy efficient circuits and systems. Coupled with advancesin rechargeable battery technology makes the notion of totallyimplantable prosthetic devices technically feasible.

Conventional neuroprosthetic technology, for example,commercially-available cochlear implants are generally basedon a two module device comprising of the implanted unit anda body-worn unit (housing the battery and processing electron-ics). Power and data are typically transferred through the skinusing a transcutaneous inductive link [2], [3]. An emergingbreed of new autonomous and fully-implantable devices willaim to combine these in one implanted unit and use a body-worn device simply for charging and calibration. However,such devices would introduce new design challenges [4], forexample, including an implanted battery and optimising theprosthesis electronics to operate on a limited power budget.

In this paper, we present a data and power managementsystem for such a transcutaneous link, combining traditional

circuits for data and power recovery together with new require-ments for voltage regulation and recharging. All circuits havebeen implemented using a standard (i.e. non-high voltage)CMOS technology.

II. SYSTEM OVERVIEW

The overall system consists of three main blocks: the powerrecovery/management circuit, the data recovery circuit and thecharger circuit. The system architecture is shown in Fig. 1.

The transcutaneous link allows to transmit both power anddata to the implant by using ON/OFF keying with Pulse WidthModulation (PWM) [3]. This is achieved using a pair ofcoupled inductors (one implanted and one external) that formpart of an LC tank tuned to a carrier frequency of 2MHz(for minimum absorption in water). The primary LC tank(i.e. external unit) is based on the discrete circuit reportedin [2]. The secondary LC tank (i.e. implanted unit) connectsto the circuit described herein feeding both the power anddata recovery blocks. The power recovery block (see Fig. 1(a))rectifies and limits the AC signal to provide the DC supply forthe voltage reference and regulation circuits. The data recoveryblock (see Fig. 1(d)) limits, envelope detects, integrates andthresholds the signal to demodulate the data. The chargingcircuit implements a two phase charge cycle (constant currentand constant voltage) to efficiently load the implanted battery.

III. IMPLEMENTATION

The circuit has been implemented in a commercially-available 0.35µm CMOS technology without requiring high-voltage device options. This has been achieved by usingparasitic pn junction diodes (n-well/p-diffusion) for the rec-tification and voltage limiting circuits thus to ensure all MOSdevices are shielded from possible overvoltage fluctuations.

A. Inductive Coupling

The planar coils have been fabricated using a standardFR4 laminate (i.e. 35µm copper on a 0.8mm epoxy-resinsubstrate). The design specifications are given in Table I andthe fabricated prototypes are shown in Fig. 2.

B. Power Recovery Circuit

The block diagram of the power recovery circuit is shown inFig. 1(a). The input (i.e. connection to LC tank) feeds a high-voltage tolerant full-wave rectifier that has been implemented

Page 2: A Bio-Implantable Platform for Inductive Data and Power ... · batt 4.1V: CV phase- to be maintained at 4.1V until the charge current reaches 5% the initial [7]. 3) Charging Circuit:

RectifierInd1

Ind2

Data_in (from the implant)

Vdd 5V

Vdd 3.3V

GND

VoltageRegulator

3.3 V

BandgapReference

1.2V

VoltageRegulator

5 V

Voltagelimiter

Inductive linkData recovery

block

Charger circuit

Data_out

Clk

Vdd 3.3V

GND

Batt LowInd1

Ind2

skin

Emitter circuit

Implanted Chip

(Vdd 5V)

Battery

Power recovery block

Clock

PWMDemodulator

SERIAL-//SHIFT

REGISTER

ControlRegister

load

HAMMING DECODER(Combinator

ial)

8-to-1DEMULTIPLEXOR

ControlBlock

selection

enable

Voltagelimiter

Ind1

Ind2

EnvelopeDetector Integrator Comparator

Integrator Comparator

0

1

Demodulatedbits

Modulatedsignal

to the Hamming decoderFrom the inductive link

Phase Generator

Clock

(c) Top Level (d) Data Recovery Block

(b) PWM Demodulator(a) Power Recovery Block

Data

Fig. 1. System architecture of the bio-implantable platform. Shown is: (a) the power recovery block, (b) the PWM demodulator, (c) top-level organisationand (d) the data recover block.

TABLE ICOIL SPECIFICATIONS

Parameter Quantity Unit

Outer, inner diameter 20, 6 mmTrack width, separation 150, 150 µmTrack length 1.27 mRDC/Rs 3.9/5.6 ΩTrack capacitance 3.47 pFQ for no load, 500Ω, maximum load 21.9, 3.4, 122.4 -Impedance (Parallel capacitance) 22.935 KΩCoil self-resonance 27.3 MHzCapacitance (LC resonance of 2MHz) 647 pF

(a) Test platform (coupling) (b) Single coil of 300µm pitch

Fig. 2. Prototype planar coils fabricated on standard FR4 substrate.

using p-diffusion/n-well diodes (in 0.35µm CMOS these tendto have a reverse breakdown voltage of over 30V whilst havinga low junction potential of about 0.5V). This is followed byDC voltage clamp to ensure proceeding stages are protectedfrom over-voltage conditions that may arise due to varyingcoupling efficiency. This may be caused by changing the coil-to-coil spacing (implanted and external) in addition to patient-

100/6

Q4

C1

5pF

36/6

Q1

C2

1pF

R126KΩ

R34KΩ

R226KΩ

C3

1pF

36/6

Q3

186/6

Q8

36/6

Q9

VERTICAL

Q7

VERTICAL

Q6

100/6

Q5 36/6

Q2

IBIAS

X1

Fig. 3. Circuit schematic for the master bandgap reference powered fromthe +5.5V unregulated supply to generate the +1.20V reference for voltageregulation (all devices shown are thick oxide).

to-patient variation depending on surgical implantation.The unregulated DC supply is smoothed using an off-

chip miniature SMT capacitor (0402, 10µF, 6.3V) to providea supply of around 5.5V. This powers the master voltagereference (see Fig. 3) which provides a bandgap referenceof approximately 1.20V. Particular attention has been givento power supply rejection and process variation whereas tem-perature variation is not an issue (implanted devices benefitfrom the bodies regulation of core body temperature). In turnthis bandgap reference is used to provide regulated suppliesof +5V (to power the battery charging circuit) and +3.3V (topower the underlying medical device) using standard voltageregulator topologies.

C. Implantable Battery and Charging Circuit

1) Rechargeable Battery: Modern Lithium-Ion technologyprovides good characteristics for implantable rechargeable

Page 3: A Bio-Implantable Platform for Inductive Data and Power ... · batt 4.1V: CV phase- to be maintained at 4.1V until the charge current reaches 5% the initial [7]. 3) Charging Circuit:

batteries including high energy density and voltage, low self-discharge rate and no memory effects compared to othertechnologies [5]. Drawbacks however are that the capacitydecreases with increasing charge cycles and overcharges [6].We have chosen to base our design on the Contego Series ofLi-Ion batteries by EaglePicher Technologies. These typicallyhave an operating voltage of 3.7V with maximum chargepotential of 4.1V and minimum discharge to 3V. This series isavailable in capacities from 500µAh to 350mAh and are ratedfor 1000 charge cycles whilst operating at 37oC.

2) Charging Strategy: A common charging strategy toensure a fast charge time, efficient energy delivery andmaintain battery health is the constant-current(CC)/constant-voltage(CV) method. This allows the battery to reach closeto 100% its capacity at the end of the charge, deliveringapproximately 65% during the first phase (CC) and 35%during the second phase (CV). For the selected series of Li-Ionbatteries, these phases are defined as follows:

• For Vbatt <4.1V: CC phase- to be maintained at a ratebetween 0.1C to 1C (C=capacity).

• For Vbatt ≥4.1V: CV phase- to be maintained at 4.1Vuntil the charge current reaches 5% the initial [7].

3) Charging Circuit: The circuit implementation to thecharger is shown in Figure 4. The voltage Vphase is the controlsignal for the CC/CV phases and the voltage Veoc flags theend of charge signal. For the CC phase, a charge rate ofC/3 has been chosen to strike a good trade-off between highcharge current, shorter charge time and minimising batteryheat dissipation. For a battery of capacity 115mAh, thisequates to a 38mA CC level. This is derived from a PTATreference with current scaled up using a high current drivemirror. It is essential that the output impedance of the driverstage is as high as possible so as to maintain a constant currentwith varying battery voltage, i.e. increasing from 3.3 V to 4.1V. To achieve a high output impedance a regulated cascodeoutput stage [8] has been implemented. For the CV phase, itis crucial (to avoid damage to the Li-Ion cell) that the biasdoes not exceed the maximum charge rating of the battery(4.1V). Thus the voltage bias that provides the 4.1V referencehas been designed to achieve a 3σ variation of under 50mV.

D. Data Recovery Circuit

To recover the data from the inductively coupled signaldata recovery hardware is required within the implanted unit.The external unit (before modulating within the 2MHz carrier)first applies Hamming(12,8) encoding and then modulates thedata as a 33% (data “0”) or 66% (data “1”) duty cycle. AHamming(12,8) scheme is used to allow for the correction ofall 12 possible single errors and simultaneously detect eightof the nine double adjacent errors.

The data recovery circuit is shown in Fig. 1(d). This takesthe LC tank signal, recovers the envelope, demodulates thedata and then applies a Hamming decoder to detect/recovererrors. The LC tank voltage is first scaled down through apotential divider to provide a safety margin to voltage surges.This feeds the PWM demodulator (Fig. 1(b)) that is based

1mA

100/0.5

Q1

3800/0.5

Q2

5000/0.5

Q3

4.20V+_ 4.10V+_

VBATT

VEOC

VPHASE

Li-Ion

SW1

SW2

COMP

R115Ω

+_4.15V

SW3

(a) Constant Current (CC) charger (b) Constant Voltage (CV) charger

(c) Mode (CC/CV) Select

X1

X2

X3

X4

COMP

Low ROUT

Fig. 4. The charger circuit configured for a 115mAh Li-Ion Battery. Shownis: (a) the CC charger, (b) the CV charger and (c) the charge mode select.

on the design reported in [3]. Within the PWM demodulator,the envelope detector first recovers the modulating signal byusing a charge pump that charges/discharges a NMOS gatecapacitance. A phase generator [9] then uses the envelope tocontrol two integrators that feed comparators to determine adata “0” or “1” and the clock signal is recovered by extractingthe PWM period. The raw bitstream is then loaded serially intoa 12-bit parallel register which feeds the Hamming decoderthat can detect and recover a single-bit error. This is achievedby using a Hamming encoder to recalculate the check bitsusing the demodulated data bits and then comparing this tothe raw bitstream to determine the position of the error. The8-bit (error corrected) word is then resynchronised using agray-counter based control register and streamed out seriallyto the underlying medical device.

IV. SIMULATION RESULTS

The circuit was simulated using the Cadence Spectre(5.1.41isr1) simulator with foundry supplied BSIM3 models.

Transient simulation results illustrating the power recovery,data recovery and charging are shown in Figs. 5, 6 and 7respectively:

• Power recovery (Fig. 5), illustrating the power supplystart-up on application of the carrier stimulus on theprimary coil (external unit) with a 1KΩ load. The start-uptime to reach within 0.1% the final unregulated voltageoutput is approximately 20ms, mainly due to the off-chipsmoothing capacitor charge time. However, the bandgapreference (+1.2V) and regulated +3.3V/+5V supplies arestable within 5ms.

• Battery Charging (Fig. 6), illustrating the CC (Fig. 6(a))and CV (Fig. 6(b)) phases. This has been configuredfor a 115mAh battery which has been simulated by avoltage source increasing from 3.0V to 4.1V (CC phase)and a current source decreasing from 38mA to 0mA (CVphase). During the CC phase, at t=1s, Vphase signals 5Vindicating that the CC phase is finished. The CV phase is

Page 4: A Bio-Implantable Platform for Inductive Data and Power ... · batt 4.1V: CV phase- to be maintained at 4.1V until the charge current reaches 5% the initial [7]. 3) Charging Circuit:

Fig. 5. Transient response of the power recovery/regulation on start-up.

/V_batt

/I_batt

/V_phase

/V_eoc

V(V

)V(

V)

V(V

)I(m

A)

4.25

3.75

3.25

2.7550

30

10

-10

0

5

0

5

Transient Response

Time (s)0 0.5 1.0 1.5 2.0

Constant Current (CC) Phase

Constant Voltage (CV) Phase

3.3mA

Fig. 6. Transient response of the charging profile showing CC and CV phasesusing a behavioral Li-Ion battery model.

terminated when Vphase reaches 4.15V that representinga 3.3mA charge current and Veoc signals 5V indicatingthat the charge is finished.

• Data recovery (Fig. 7), illustrating the complete datarecovery chain at the maximum bit rate of 180Kbps.

/Vdata2

/data_recovered

/data_int

/load

/enable

/Data_out

0 50 100 150 200time (μs)

Transient Response

-0.5

3.5

-0.5

3.5

-0.5

3.5

-0.5

3.5

-0.5

3.5

-1.5

1.5

0

Fig. 7. Transient response of the data transmission and demodulation at180Kbps (maximum bit-rate).

V. DISCUSSION AND CONCLUSION

This paper has described an integrated platform for trans-mitting power and data to a fully-implantable device includingcircuitry for efficient battery charging.

This system provides the underlying medical device with a+3.3V power source in addition to the recovered clock anddata (bitstream) input for uploading of calibration or patientdata. In order to reliably load control data to the end-deviceit is preferable to implement an input serial-shift register thattriggers a parallel data load to the core registers when theinput bitstream is perfectly aligned. This can be implementedusing a bitstream preceded by flush bits and a start sequenceas reported in [10].

On removal of the external supply (i.e. the body worn unit),the implanted battery is connected to the +3.3V supply usinga forward-biased diode (at nominal current consumption) todrop the battery supply from +4.1V to +3.3V. For a staticload, this would provide a stable level, however for varyingloads and/or circuits sensitive to supply variation additionalregulation would be required. Also, for applications requiringa higher voltage supply (eg. neural stimulators), a voltageboosting circuit can be driven from the +3.3V supply.

The system has been developed to work with low cost FR4-based planar coils and can achieve a maximum data rate of180Kbps using a 2MHz carrier, additionally including a Ham-ming(12,8) decoder to enhance data integrity. The integratedbattery charger can be easily configured to operate with aseries of implantable Li-Ion batteries from 500µAh to 350mAhcapacities. Finally, the integrated circuit has been implementedin a commercially-available 0.35µm CMOS technology with-out the requirement for high-voltage devices (>5V).

ACKNOWLEDGMENT

The authors would like to acknowledge EPSRC grantsEP/F04612X/1 and EP/I000569/1 for supporting this work.

REFERENCES

[1] K. W. Horch and G. S. Dhillon, Neuroprosthetics Theory and Practice.World Scientific, 2004.

[2] A. Vilches, A. Sanni and C. Toumazou, “Single coil pair transcutaneousenergy and data transceiver for low power bio-implant use,” IET Elec-tronics Letters, vol. 45, no. 14, 2009.

[3] O. Omeni and C. Toumazou, “A cmos micro-power widebanddata/power transfer system for biomedical implants,” Proc. IEEE ISCAS,vol. 5, pp. 61–64, 2003.

[4] A. Eftekhar, S. Paraskevopoulou and T. G. Constandinou, “Towards NextGeneration Neural Interfaces: Optimizing Power, Bandwidth and DataQuality,” Proc. IEEE BioCAS, pp. 122–125, 2010.

[5] J. Lopez, et al., “Fast-charge in li-ion batteries for portable applications,”Proc. IEEE INTELEC, pp. 19–24, 2004.

[6] D. M. Spillman and E. S. Takeuchi, “Lithium ion batteries for medicaldevices,” Proc. IEEE Batt. Conf. Apps. and Adv., pp. 203–208, 1999.

[7] S. Dearborn, “Charging li-ion batteries for maximum run times,” PowerElectronics Technology, pp. 40–49, 2005.

[8] E. Sackinger and W. Guggenbuhl, “A high-swing, high-impedance moscascode circuit,” IEEE JSSC, vol. 25, no. 1, pp. 289–298, 1990.

[9] J. A. De Lima, et al., “A low-power soi pwm discriminator for biomed-ical applications,” Proc. IEEE ISCAS, vol. 5, pp. 277–280, 2000.

[10] T. G. Constandinou, J. Georgiou and C. Toumazou, “A partial-current-steering biphasic stimulation driver for vestibular prostheses,” Trans.IEEE TBCAS, vol. 2, no. 2, pp. 106–113, 2008.


Recommended