A. Maillet, POIWG#25, Feb 3-5, 2009 1

Inc 19-20 Experiments supported by

CADMOS and using the EPM

Alain MAILLETCADMOS

Alain.Maillet@medes.cnes.fr+33-561283357

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CADMOS INC19-20 Experiments

DOSIS SOLO CARD Integrated Cardiovascular Neurospat

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Sodium retention in microgravity (SOLO) PI: Martina Heer, PhDCoI: DLR: L. Beck, P. Frings, N. Baecker, Panum Inst., Copenhagen: P. Norsk, MD NASA JSC, Houston: S.M. Smith

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• Stimulus: - 2 different levels of salt intake (low, average normal) for 5 days each

- randomized regarding the sequence of salt intake

• Schedule: - prefered: later in the mission - study phases close together

• Blood samples: day 5• 24 h Urine sample: day 6 (final void: day 6 morning void)

• Body mass: day 4 and 6

SOLO STUDY DESIGN

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In-flight measurements SOLO

6 days 6 days> 4

weeks>1month

Session 1

Crew Member Launche

s

1< days <7

Session 2

Crew Member Lands

Day 2 Day 5Day 4Day 3Day 1

Session Breakdown (1 or 2)

Body Mass Measurements with SLAMMD – POIC Planning

Blood Sampling with RC: blood draw and blood stow - ESA Planning; RC processing and MELFI insertion – POIC Planning

Day 6

Controlled Diet Monitoring (random low or normal salt intake) – ESA PlanningDiet and Exercise Log – ESA Planning

Blood Sampling with PCBA: blood stick and PCBA measurement - ESA PlanningUrine Sampling: 24-hr urine collection - ESA Planning; MELFI insertion – POIC Planning

MELFI PCBA Retrieval – POIC Planning

PCBA Software Update – ESA Planning

This new activity requires to have the EPM ON, It is planned to link this with other experiments which require also EPM (for example DOSIS)

NEW ACTIVITY vs. INCR-17:

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SOLO HARDWARE

Already on-board EPM CDL PCBA Kit (EPM Cardiolab Portable Clinical Blood Analyzer)

Required for each increment: Need for PCBA SW update

File uplink via EPM Use of EPM and Cardiolab GCP

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SOLO HARDWARE

• Upload on 34P PCBA Consumables‘ Kit including the PCBA Cartridges Bag (cold stowage @ 4°C) Solo Blood Sample Kit Solo Urine Collection Kit

• Already on-board EPM CDL PCBA Kit (EPM Cardiolab Portable Clinical Blood Analyzer)

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Long-term microgravity: A model for investigating mechanisms of heart disease and sympatho adrenal activity during long

duration space flight

CARDCARD

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Major changes from last CARD session:

- 24 hrs Urine Collection using ESA Urine Collection Kit.

- Only one 24 hrs session pr. subject.

- Holter BP recording session will have battery change and data storage after 1/3 part of session (i.e. end of day one)

- Refrigerated centrifugation is not mandatory, but nice to have.

Major changesMajor changes

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CARD TimelineCARD Timeline

Holter BP:Data StorageBattery Exch

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CARD – HOLTER BP Activities

As for SOLO, use of EPM and its Cardiolab Science Module Before CARD recording session starts:

Holter AA battery insertionSetup of CARD Holter

End of day 1: Holter data transfer and storageHolter AA battery exchangeSetup of CARD Holter

On Day 2: Holter data transfer and storageHolter AA battery removal End of session

using CDL GCP

using CDL GCP

using CDL GCP

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Integrated Carfdiovascular (ICV)

OPERATIONS SUMMARYInflight, resting echocardiograms (using the HRF

Ultrasound) with ECG recording will be performed on flight days 14, 30, 135, and R-15 using real-time remote guidance. On FD75, an exercise echo session will be performed with echo measurements taken before and after exercise. Both the Resting and Exercise Echo sessions will be preceded or followed by 24 hours of ambulatory BP/Holter/Activity monitoring. For these sessions, subjects will apply electrodes and then don the HRF Holter Monitor 2, ESA Cardiopres, and two Actiwatches (one at the waist and one at the ankle). These devices will be worn for 24 hours after which the devices will be doffed and the data from all experiment hardware will be downloaded to the HRF PC and downlinked to the ground. In-flight exercise and medication logs will be obtained through data sharing.

PRINCIPAL INVESTIGATORSMichael Bungo Benjamin LevineUniversity of Texas Medical School Institute for Exercise & Environmental MedicineHouston, TX, USA Dallas, TX, USA

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Cardiopres Description

CDL-CBPD

CARDIOPRES

Beat by beat continuous recording: heart rate and blood pressure (SBP, DBP, MAP), 12 derivations ECG with R spike time marker, RR-interval

Breathing: frequency, inspiration/expiration 2 analog inputs

7 output signals batteries Data storage on PCMCIA card

startstop

PRES

RESP/...

ECG

DISK

ESC

12 C2:14/30PHY:27

PRES

RESP/...

ECG

DISK

C2

C1

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ICV CADMOS Implication

1St ICV session is planned beginning of June CADMOS EPM related Part (until Stage 17A):

CBPD data transfer to CDL DMCUby crewCBPD data downlink from CDL DMCU to ground (ground activity)

CADMOS CBPD support (12 subjects/5 sessions in flight)PD Support to NASAConsumables (cuffs)

using CDL GCP