Zurich Open Repository andArchiveUniversity of ZurichMain LibraryStrickhofstrasse 39CH-8057 Zurichwww.zora.uzh.ch
Year: 2017
A systematic review of the survival and complication rates of resin-bondedfixed dental prostheses after a mean observation period of at least 5 years
Thoma, Daniel S ; Sailer, Irena ; Ioannidis, Alexis ; Zwahlen, Marcel ; Makarov, Nikolay ; Pjetursson,Bjarni E
Abstract: OBJECTIVES The objective of this systematic review was to assess the 5-year and 10-yearsurvival of resin-bonded fixed dental prostheses (RBBs) and to describe the incidence of technical andbiological complications. MATERIALS AND METHODS An electronic MEDLINE search complementedby manual searching was conducted to identify prospective and retrospective cohort studies and case serieson RBBs with a mean follow-up time of at least 5 years. Patients had to have been examined clinically atthe follow-up visit. Assessment of the identified studies and data extraction were performed independentlyby two reviewers. Failure and complication rates were analyzed using robust Poisson regression modelsto obtain summary estimates of 5- and 10-year proportions. RESULTS The search provided 367 titlesand 87 abstracts. Full-text analysis was performed for 22 articles resulting in seven studies that met theinclusion criteria. Five articles were found through manual search, and 17 studies were provided from(Pjetursson et al. 2008, Clinical Oral Implants Research, 19, 131), resulting in an overall number ofincluded studies of 29. Meta-analysis of these studies reporting on 2300 RBBs indicated an estimatedsurvival of resin-bonded bridges of 91.4% (95 percent confidence interval [95% CI]: 86.7-94.4%) after 5years and 82.9% (95% CI: 73.2-89.3%) after 10 years. A significantly higher survival rate was reportedfor RBBs with zirconia framework compared with RBBs from other materials. RBBs with one retainerhad a significantly higher survival rate (P < 0.0001) and a lower de-bonding rate (P = 0.001) comparedwith RBBs retained by two or more retainers. Moreover, the survival rate was higher for RBBs insertedin the anterior area of the oral cavity compared with posterior RBBs. The most frequent complicationswere de-bonding (loss of retention), which occurred in 15% (95% CI: 10.9-20.6%) and chipping of theveneering material that was reported for 4.1% (95% CI: 1.8-9.5%) of the RBBs over an observationperiod of 5 years. CONCLUSION Despite the high survival rate of RBBs after 5 and 10 years, technicalcomplications like de-bonding and minor chipping were frequent. RBBs with zirconia framework andRBBs with one retainer tooth showed the highest survival rate.
DOI: https://doi.org/10.1111/clr.13007
Posted at the Zurich Open Repository and Archive, University of ZurichZORA URL: https://doi.org/10.5167/uzh-136864Journal ArticleAccepted Version
Originally published at:Thoma, Daniel S; Sailer, Irena; Ioannidis, Alexis; Zwahlen, Marcel; Makarov, Nikolay; Pjetursson, BjarniE (2017). A systematic review of the survival and complication rates of resin-bonded fixed dental prosthe-ses after a mean observation period of at least 5 years. Clinical Oral Implants Research, 28(11):1421-1432.
1
A systematic review of the survival and complication
rates of resin bonded fixed dental prostheses after an
observation period of at least 5 years
Daniel S. Thoma1, Irena Sailer2, Ioannidis Alexis1, Marcel Zwahlen3, Nikolay
Makarov2, 4, Bjarni E. Pjetursson4, 2.
1) Clinic of Fixed and Removable Prosthodontics and Dental Material Science, University of
Zurich, Zurich, Switzerland
2) Division of Fixed Prosthodontics and Biomaterials, University Clinics for Dental Medicine,
University of Geneva
3) Institute of Social and Preventive Medicine, University of Bern, Berne, Switzerland
4) Private Practice, Moscow, Russia
5) Division of Reconstructive Dentistry, Faculty of Odontology, University of Iceland, Reykjavik,
Iceland
Key words: Resin-bonded bridges, fixed dental prostheses, fiber reinforced composite, systematic
review, survival, success, longitudinal, failures, complication rates, technical complications, biological
complications, de-bonding
Running title: Systematic review of resin-bonded bridges
Number of figures: 2
Number of tables: 5
Address for correspondence:
Prof. Dr. med. dent. Bjarni E. Pjetursson, DDS, MAS Perio, PhD.
Department of Reconstructive Dentistry
Faculty of Odontology
University of Iceland
Vatnsmyrarvegi 16
101 Reykjavik, Iceland
Phone: +354 525 4871
2
Abstract Objectives: The objective of this systematic review was to assess the 5-year and 10-year survival of
resin bonded fixed dental prostheses (RBBs) and to describe the incidence of technical and biological
complications.
Materials and Methods: An electronic Medline search complemented by manual searching was
conducted to identify prospective and retrospective cohort studies and case series on RBBs with a
mean follow-up time of at least 5 years. Patients had to have been examined clinically at the follow-up
visit. Assessment of the identified studies and data extraction were performed independently by two
reviewers. Failure and complication rates were analyzed using robust Poisson regression models to
obtain summary estimates of 5-year and 10-year proportions.
Results: The search provided 367 titles and 87 abstracts. Full-text analysis was performed for 22
articles resulting in 7 studies that met the inclusion criteria. Five articles were found through manual
search and 17 studies were provided from (Pjetursson et al. 2008) resulting in an overall number of
included studies of 29. Meta-analysis of these studies reporting on 2300 RBBs indicated an estimated
survival of resin-bonded bridges of 91.4% (95 percent confidence interval (95% CI): 86.7% -94.4%)
after 5 years and 82.9% (95% CI: 73.2% - 89.3%) after 10 years. A significantly higher survival rate
was reported for RBBs with zirconia framework compared with RBBs from other materials. RBBs with
one retainer had a significantly higher survival rate (p<0.0001) and a lower debonding rate (p=0.001)
compared with RBBs retained by two or more retainers. Moreover, the survival rate was higher for
RBBs inserted in the anterior area of the oral cavity compared with posterior RBBs. The most frequent
complications were de-bonding (loss of retention), which occurred in 15% (95% CI: 10.9 – 20.6%) and
chipping of the veneering material that was reported for 4.1% (95% CI: 1.8 – 9.5%) of the RBBs over
an observation period of 5 years.
Conclusion: Despite the high survival rate of RBBs after 5 and 10 years, technical complications like
de-bonding and minor chipping were frequent. RBBs with zirconia framework and one retainer tooth
showed the highest survival rate.
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Introduction
The recognized replacement of single missing teeth presents one of the greatest challenges in
reconstructive dentistry, predominantly in the esthetic zone. Various therapeutic options exist to
replace single missing teeth using fixed tooth- or implant-borne reconstructions. This includes the use
of traditional fixed dental prostheses (FDPs), implant-supported single crowns (SCI) and resin-bonded
fixed dental prostheses (RBB). In order to provide a basis for prosthetic treatment planning, systematic
reviews were performed summarizing the existing dental literature on clinical studies with a medium-
and long-term follow-up (Jung et al. 2012; Pjetursson et al. 2015; Pjetursson et al. 2008). Obtained
data for metal-ceramic FDPs demonstrated 5-year survival rates of 94.4% (95% confidence interval
(CI): 91.2-96.5%), for SCIs of 96.3% (95% CI: 94.2-97.6%) and for RBB of 87.7% (95% CI: 81.6-
91.9%). Apart from survival rates, patients and clinicians need to be aware of the frequency and type
of complications occurring during the maintenance phase following the insertion of a reconstruction.
Technical, biological and esthetic complication rates for FDPs, SCIs and RBBs range between 1.5 and
12.9 during a 5-year observation period (Jung et al. 2012; Pjetursson et al. 2015; Pjetursson et al.
2008). These outcomes, however, do not take into account the entire extent of the treatment, which
further includes the overall status of the dentition, occlusion, age, treatment time, invasiveness and the
cost-effectiveness (Antonarakis et al. 2014). Disadvantages associated with SCI predominantly
include a relatively long treatment time and at least one surgical procedure and relatively high initial
costs. In contrast, FDPs do usually not require any surgical procedure, shorter treatment time and
lower initial costs, but require neighboring teeth to be prepared for full crowns. Neither one, SCI nor
FDP, have a reported superior cost-effectiveness over time (Beikler & Flemmig 2015). From a
patient’s perspective, alternative treatment options, mainly in a caries-free dentition are requested.
This should include a minimal-invasive therapeutic approach with lower costs and a shorter treatment
time. RBBs have long been considered as mid-term provisional reconstructions with approximately 2
years of service (Howe & Denehy 1977; Rochette 1973). Moreover, RBBs were predominantly used in
the anterior area and only later expanded to posterior regions (Livaditis 1980). Clinical data, however,
indicated that this type of reconstruction does indeed offer high long-term survival rates (Sailer et al.
2013; Saker et al. 2014; Sasse & Kern 2013). Apart from these, minimal-invasiveness, lower costs
and treatment time offer further advantages over traditional FDPs and SCIs. Moreover, newer
development in terms of materials (ceramics) and the use of single-retainer RBB offer further benefits
4
and demonstrate promising clinical long-term results (Sasse & Kern 2013). Data from available studies
have, however, not been combined in the past years using a systematic approach. In order to provide
the dental community with the most recent evidence-based clinical data, the present systematic review
was performed as an update of a previously published systematic review (Pjetursson et al. 2008).
The objectives of the present systematic review were to obtain the long-term survival rate of RBBs and
to evaluate the incidence of technical, biological and esthetic complications over an observation period
of at least 5 years.
5
Materials and methods
Focused questions
“What are the survival and complication rates of RBBs after a mean observation period of 5 years?”
“What is the influence of the framework material, the location (maxilla, mandible, anterior, posterior)
and the number of retainers on the survival and complications rates of RBBs after a mean
observation period of 5 years?”
Search strategy and study selection
This systematic review was designed as an update to a previous publication with the same objectives
(Pjetursson et al. 2008). A Medline (PubMed) search was performed for clinical studies, including
articles published from February 1, 2007 up to October 28, 2015 in the Dental literature. The search
was limited to the English and German languages. In addition, full text articles of reviews on the same
topic published between February 2007 and October 2015 were obtained and screened for relevant
articles (reference list “list of reviews”). This was complimented by a hand search of the reference list
of all included publications.
The following search was applied:
((Denture, Partial, Fixed, Resin-Bonded[Mesh]) OR (RBB[all fields] OR fixed partial denture*[all fields]
OR FPD[all fields] OR FPDs[all fields] OR fixed dental prosthesis[all fields] OR fixed dental
prostheses[all fields] OR FDP[all fields] OR FDPs[all fields] OR bridge*[all fields] OR adhesive
bridge*[all fields] OR maryland bridge*[all fields])) AND (Survival[Mesh] OR survival rate[Mesh] OR
survival analysis[Mesh] OR dental restoration failure[Mesh] OR prosthesis failure[Mesh] OR treatment
failure[Mesh]).
Inclusion criteria
This systematic review was based on specific inclusion criteria:
• Human trials
• Mean follow-up of 5 years or more
• Prospective and retrospective cohort studies and case series
• Published in dental journals
• Patient needed to be examined clinically at the follow-up visit
6
• Reported details of suprastructure
• Included at least 10 patients
• Language: English; German
Exclusion criteria
Studies not meeting all inclusion criteria were excluded from the review. Moreover, publications were
excluded if the were based on patient records (i.e. questionnaires, interviews). Studies were also
excluded if extensive tooth preparations were performed (e.g. inlay-retained FDPs).
Selection of studies
Two authors (DTH, AIO) independently screened the titles and abstracts derived from this broad
search for possible inclusion in the review. Disagreements were resolved by discussion. If no abstract
was available in the database, the abstract of the printed article was used. Based on the selection of
abstracts, articles were then obtained in full text. If title and abstract did not provide sufficient
information regarding the inclusion criteria, the full report was obtained as well. Again, disagreements
were resolved by discussion and Cohen’s Kappa-coefficient was calculated as a measure of
agreement between the 2 readers. The final selection based on inclusion/exclusion criteria was made
for the full text articles. For that purpose, Materials and Methods, Results and Discussion of these
studies were screened. This step was carried out again by 2 readers (DTH, AIO) and double-
checked. Any questions that came up during the screening were discussed within the group to aim for
consensus. In addition, all 17 studies from the previous systematic review (Pjetursson et al. 2008)
were included in the analyses.
Data extraction and method of analysis
Four reviewers (DTH, AIO, ISA, BEP) independently screened the full-text articles. Any
disagreements were discussed to aim for consensus and to standardize the subsequent analyses.
The four reviewers then independently extracted the data of all included studies using data extraction
tables. In addition, data of the included publications of the previously published review (Pjetursson et
al. 2008) were extracted as well. All extracted data were double-checked, and any questions that
came up during the screening and the data extraction were discussed within the group to aim for
consensus.
Of the 29 studies included, information on the survival of the reconstructions and on biological and
7
technical complications was retrieved. RBB survival was defined as the RBB remaining in-situ with or
without modification for the entire observation period. Failure was defined as the RBBs that were lost
and required re-fabrication, or multiple re-cementations. Biological complications included caries on
abutment teeth, and periodontal disease progression. Technical complications analyzed included loss
of retention, with or without loss of the reconstruction, and fractures of the veneering ceramic, with or
without loss of the reconstruction. From the studies included, the number of events for all these
categories was extracted and the corresponding total exposure time of the reconstruction was
calculated.
Statistical analysis
Failure and complication rates were calculated by dividing the number of events (failures or
complications) in the numerator by the total exposure time (RBB-time or abutment-time) in the
denominator. The numerator could usually be extracted directly from the publication. The total
exposure time was calculated by taking the sum of:
(1) Exposure time of RBBs/abutments that could be followed for the whole observation time.
(2) Exposure time up to a failure of the RBBs/abutments that were lost due to failure during the
observation time.
(3) Exposure time up to the end of observation time for RBBs/abutments that did not complete
the observation period due to reasons such as death of the patient, change of address,
refusal to participate, non-response, chronic illnesses, missed appointments and work
commitments.
For each study, event rates for RBBs and/ or abutments were calculated by dividing the total number
of events by the total RBBs or abutments’ exposure time in
years. For further analysis, the total number of events was considered to be Poisson distributed for a
given sum of RBBs exposure years, and Poisson regression with a logarithmic link-function and total
exposure time per study as an offset variable were used (Kirkwood & Sterne 2003a).
Robust standard errors were calculated to obtain 95% confidence intervals (CIs) of the summary
estimates of the event rates. In order to assess the heterogeneity of the study-specific event rates,
the Spearman goodness-of-fit statistics and associated P-value were calculated. Five- and 10-year
survival proportions were calculated via the relationship between event rate and survival function S,
S(T) = exp(-T x event rate), by assuming constant event rates (Kirkwood & Sterne 2003b). The 95%
8
CIs for the survival proportions were calculated using the 95% confidence limits of the event rates.
Multivariable Poisson regression was used to investigate formally whether event rates varied by
material utilized, number of retainers (one vs. multiple) andposition of the reconstruction (maxilla vs.
mandible or anterior vs. posterior).
All analyses were performed using Stata, version 12.1 (Stata Corp., College Station, TX, USA).
9
Results
Included studies
A total of 29 studies on RBBs were included in the analysis (Figure 1). Seventeen of the included
studies originated from the previous systematic review (Pjetursson et al. 2008) with the same clinical
question. The remaining 12 studies were identified by the present literature search. The
characteristics of the selected studies are shown in Table 1. These studies reported on 27 different
patient cohorts. The oldest study was published in 1990, and the median year of publication was
2003. Fifteen of the studies were prospective, 13 were retrospective studies and one multi-center
study was described as a mixture of a pro- and retrospective design (van Heumen et al. 2009). The
studies included more than 2366 patients ageing between 13 and 87 years. The proportion of patients
with RBBs who could not be followed for the complete study period was available for 22 of the 29
studies and ranged from 0 to 63%, with an average drop-out rate of 16%. The studies were conducted
under different environmental settings: 22 University setting, 2 private practices and 4 specialists’
clinics. Twenty-six studies reported on anterior and 21 on posterior RBBs. Four of the studies
(Creugers & Kayser 1992; Creugers et al. 1990; Kern 2005; Kern & Sasse 2011) were classified as
multiple-publications on the same patient cohort. The older studies (Creugers et al. 1990; Kern 2005)
were included because they gave additional information on technical complications, but were not used
for survival analysis.
The preparation designs ranged from very conservative preparations or no preparation to extensive
preparations with grooves, guide planes and wrap-around design to improve the prostheses’
mechanical retention. The materials used for the fabrication of the RBBs consisted of veneered
(ceramic or resin) and non-veneered metal frameworks, all-ceramic materials (veneered densely
sintered zirconia or glass reinforced ceramic frameworks) or composite frameworks veneered with
composite. Different surface treatments to the bonding area of the RBBs were performed prior to
cementation with various resin cements. All descriptive data are presented in Table 1.
Survival
Twenty-three out of the 29 included studies reported on the survival of the reconstructions (Table 2).
Meta-analysis revealed that of the originally 2300 RBBs placed, 251 RBBs were known to be totally
lost or had de-bonded more than once. In the meta-analysis, the annual failure rate was estimated at
10
1.8 (95% CI: 1.30 - 2.56) (Figure 2), translating into a 5-year overall survival rate for RBBs of 91.3%
(95% CI: 88% - 93.7%) (Table 2). The included studies were also divided according to the mean
observation time. A group of 18 studies reported on 1755 RBBs with a mean follow-up time of 5.1
years and a group of five studies reported on 545 RBBs with a mean follow-up time of 8.9 years. An
annual failure rate of 1.80 and 1.88 was estimated for the former and the latter group, respectively.
The difference did not reach statistical significance (p=0.905). Hence, the failure rate of RBBs seems
to be relatively linear over the first 10 years. Based on the group with the shorter follow-up time, the
estimated 5-year survival rate was 91.4% (95% CI: 86.7% - 94.4%) and from the group with the longer
follow-up time, the 10-year survival rate was estimated to be 82.9% (95% CI: 73.2% - 89.3%) (Table
2). The reported survival was also analyzed according to study design. Twelve of the included studies
that reported on survival rates were prospective cohort or case series, one study had a retro- and
prospective design and the remaining ten studies that reported on survival rates were retrospective
case series. The 5-year survival rate of the prospective studies was 91.4% (95% CI: 86.8%-94.5%)
compared to a 5-year survival rate of 92.2% (95% CI: 87.2% - 95.3%) in the retrospective studies. The
difference between the groups did not reach statistical significance (p=0.779).
The studies were also divided according to the material utilized (Table 3). For metal-ceramic RBBs, 8
studies provided data on 977 RBBs resulting in an estimated 5-year survival rate of 91.3% (95% CI:
85.1% - 94.9%). One study with 203 reconstructions reported an estimated 5-year survival rate of
88.9% (95% CI: 85.0%-92.1%) for metal-resin RBBs. One study reporting on 38 RBBs with glass-
infiltrated ceramic as framework material and another study reporting on 49 RBBs with reinforced
glass ceramic framework, were analyzed. The estimated 5-year survival rate in these studies was
93.4% (95% CI: 85.3% - 97.8%) and 95.3% (95% CI: 84.4% - 99.4%), respectively. Three studies with
68 RBBs with zirconia as framework material estimated a 5-year survival rate of 100% (95% CI: 94.5%
- 100%) and three studies reporting on 267 RBBs with fiber-reinforced composite as framework
material estimated the 5-year survival rate to be 92.8% (95% CI: 47.9%-99.2%). For fiber-reinforced
composite RBBs, the results from the three included studies varied significantly. Two of the studies
reported a 5-year survival rate of 99.4% and 100%, respectively. The third study, however, reported a
5-year survival rate of only 72.9% (Table 3) The analysis by type of material showed that RBBs with
zirconia frameworks had a significantly (p<0.0001) higher 5-year survival than metal-ceramic RBBs.
The difference between metal-ceramic RBBs and other material groups did not reach statistical
significance.
11
The survival rate of RBBs was also analyzed by the number of retainers utilized. A group of 350 RBBs
with one retainer was compared with a group of 1376 RBBs with two or more retainers using
multivariable Poisson regression. The 1-retainer group had significantly (p<0.0001) lower annual
failure rate of 0.87 compared with an annual failure rate of 2.17 for the 2-retainers group. Moreover,
the survival rate of RBBs was analyzed regarding the RBB location in the oral cavity. The annual
failure rate of RBBs inserted in the anterior area was 1.20 compared with an annual failure rate of 3.65
for RBBs placed in the posterior part of the mouth, this difference was at the margin of statistical
significance (p=0.056). The annual failure rate of RBBs placed in the maxilla was 1.03 compared with
a failure rate of 2.71 for RBBs placed in the mandible. This difference, however, did not reach
statistical significance (p=0.119) (Table 4).
Biological complications
Dental caries
Eleven studies with a total of 2030 abutment teeth reported on the incidence of caries on the abutment
level. In robust Poisson model analysis, the overall annual complication rate was 0.34 translating into
a 5-year complication rate of 1.7 % (95% CI: 0.7 - 4.0) (Table 5).
Loss of vitality of abutment teeth
Two studies (Kumbuloglu & Ozcan 2015; Sailer et al. 2013) reported that none of the abutment teeth
lost vitality during the observation period. However, as the studies did not report the number of vital
abutment teeth at the beginning of the study, hence, statistical analysis was not possible.
Recurrent periodontitis
The incidence of RBBs lost due to recurrent periodontal disease was reported in 15 studies evaluating
1156 FDPs, out of which 12 were lost. In robust Poisson model analysis, the overall annual
complication rate was 0.17, translating into a 5-year complication rate of 0.8% (95% CI: 0.4 - 1.8)
(Table 5).
Abutment tooth fracture
Eighteen studies reported on the incidence of RBBs lost due to abutment tooth fractures, evaluating
1518 RBBs out of which 3 were lost. In robust Poisson model analysis, the overall annual complication
12
rate was 0.03, translating into a 5-year failure rate of 0.2% (95% CI: 0.05 - 0.5) (Table 5).
Technical complications
De-bonding (Loss of retention)
De-bonding was the most frequent technical complication of RBBs. It was addressed in all included
studies, and affected 519 out of the 2619 RBBs. The annual RBB complication rate ranged between 0
and 12.8. In robust Poisson model analysis, the estimated annual rate was 3.3, translating into a 5-
year complication rate of 15% (95% CI: 10.9 - 20.6) (Table 5).
The incidence of de-bonding was significantly dependent of the framework material utilized. For metal-
ceramic RBBs the annual de-bonding rate was 2.89, for metal-acrylic it was 4.17, for fiber-reinforced
composite RBBs it was 1.72 and for zirconiaframework RBBs it was 1.42. However, for RBBs with
glass infiltrated and glass reinforced ceramic frameworks no de-bonding occurred. Investigating
formally the relative de-bonding rates of different material types of RBBs, using metal-ceramic RBBs
as reference, RBBs with glass infiltrated and glass reinforced ceramic frameworks showed
significantly (p<0.0001) lower de-bonding rates. The difference between the de-bonding rates of
metal-ceramic RBBs and other material groups did not reach statistical significance.
The incidence of de-bonding was also analyzed according to the jaw position: A group of 14 studies
with a total of 795 RBBs reported on the outcomes in the maxilla and a group of 12 studies with a total
of 763 RBBs reported on the outcomes in the mandible. For the group of RBBs placed in maxilla, the
annual de-bonding rate was estimated at 2.64 translating into a 5-year rate of de-bonding of 12.4%
(95% CI: 7.6% - 19.9%). Similar results were obtained for the group of RBBs placed in the mandible.
The annual de-bonding rate in the mandible was estimated at 4.01 resulting in a 5-year rate of de-
bonding of 18.2% (95% CI: 11.2% - 28.6%). The difference between maxilla and mandible did not
reach statistical significance (p=0.255) (Table 4).
The studies were also divided according to the position in the mouth. A group of 18 studies with a total
of 1227 RBBs inserted on anterior teeth and a group of 11 studies with a total of 602 RBBs inserted
on posterior teeth. The group with posterior RBBs demonstrated a higher (21.8% (95% CI: 12.1% -
37.5%)) 5-year rate of de-bonding, compared to the de-bonding rate of 11.2% (95% CI: 7.2% - 17.2%)
for the anterior RBBs. This difference also did not reach statistical significance (p=0. 065) (Table 4).
Material complications: framework and veneer fractures
13
The incidence of RBBs lost due to material fractures, was reported in 16 studies evaluating 1345
FDPs, out of which 27 were lost. In robust Poisson model analysis, the overall annual failure rate was
0.34, translating into a 5-year complication rate of 1.7% (95% CI: 0.6% - 4.4%) (Table 5).
Material fractures that might cause the loss of the entire reconstruction are severe fractures of the
veneering material or fractures of the RBBs framework. The incidence of RBBs lost due to material
fractures was material dependent. None of the RBBs made of metal-ceramic, zirconia and reinforced
glass ceramic were lost due to material fractures. Studies on RBBs made of metal-resin, glass
infiltrated ceramic and fiber reinforced composite, however, reported that significantly (p<0.0001) more
RBBs were lost due to material fractures.
Fourteen studies evaluating 1344 RBBs, reported on the rate of minor veneer fractures (ceramic,
acrylic or composite chipping) that could be repaired without losing the reconstruction. In these
studies, out of the 1344 RBBs placed, 64 fractured.
For chipping the annual complication rate was estimated at 0.84 translating into a 5-year complication
rate of 4.1% (95% CI: 1.8% - 9.5%) (Table 5). The chipping rates were also dependent of which
material was used. The lowest annual chipping rate of 0 was reported material for zirconia RBBs, for
metal-ceramic RBBs it was 0.29, for reinforced glass ceramic RBBs it was 0.95, for glass infiltrated
ceramic RBBs it was 1.04, for fiber-reinforced composite RBBs it was 1.42 and for metal-acrylic RBBs
it was 2.89. Formally investigating the relative chipping rates of different material types of RBBs, using
metal-ceramic RBBs as reference, zirconia RBBs had significantly (p<0.0001) lower chipping rates,
but all the other material types had significantly (p<0.0001) higher chipping rates then metal-ceramic
RRBs.
Esthetic failures
Eight studies gave information on the number of RBBs removed or remade due to unacceptable
esthetic appearance. Only 2 out of 673 RBBs were removed due to esthetic reasons. In robust
Poisson model analysis, the overall annual complication rate was 0.07, translating into a 5-year failure
rate of 0.3 (95% CI: 0.1 - 1.2) (Table 5).
14
Discussion
The present review showed that RBBs may be considered as well established minimally-invasive
prosthetic treatment option for the replacement of missing anterior teeth today. Specific criteria,
however, were crucial for good outcomes. The factors influencing the outcomes of the RBBs were the
selection of framework material, the design of the RBB and the location in the jaws. The RBBs
exhibited the best outcomes in anterior regions, with a single- retainer design and when made out of
zirconia- ceramic or composite. Still today, RBBs cannot be recommended for posterior regions of the
jaws. The predominant reason for problems was repeated de-bonding. Fracture of the RBB was a rare
complication irrespective of the materials used.
The present systematic review is an update of a previous systematic review on the same topic
(Pjetursson et al. 2008). The review is a part of a series of systematic reviews based on the same
methodology addressing the survival and complication rates of different types of fixed dental
prostheses. A significant amount of information on RBBs has been published in the resent 8 years that
could be included in this update. The results of the present systematic review are based on 29 studies
reporting on more than 2300 RBBs made out of six different material combinations. In the absence of
RCTs comparing RBBs with FDPs of different design, a lower level of evidence with prospective and
retrospective cohort studies and case report was included in this systematic reviews. To formally
investigate whether study design influenced the outcome, 12 included prospective studies were
compared with 10 included retrospective studies. The difference in the 5-year survival rates between
the different study designs was only 0.8% and did not reach statistical significance (p=0.779). Hence,
the authors felt confident including both study designs in the present systematic review.
The survival of the reconstruction in the present review was defined as RBBs remaining in-situ and
functioning without multiple de-bonding. Even though RBBs can be re-bonded several times multiple
de-bonding (two or more) was considered a failure because the failure rate has been shown to
increase with each re-bonding. Creugers & Käyser (1992) for example reported a significantly lower
survival rate for RBBs that were re-bonded when compared with the original RBBs (Creugers &
Kayser 1992). Similar observations on RBBs with multiple de-bonding have also been reported by
other authors (Marinello et al. 1990).
15
The 5-year survival rate of RBBs in the present systematic review was 91.4% based on the 18
included studies reporting on 1755 RBBs, compared with a 5-year survival rate of 87.7% based on 12
studies with 1374 RBBs in the previous review (Pjetursson et al. 2008). Hence, the 5-year survival rate
has increased by 3.7% by including more resent studies representing a positive learning curve with
RBBs. Moreover, in the present systematic review 8 studies report on RBBs made with other
framework materials than metal compared with only one study with ceramic framework in previous
systematic review.
The outcome of the present systematic review clearly shows that different material combinations
experience different complications. The main problem with metal-ceramic RBBs is for example de-
bonding. But, relatively few metal-ceramic RBBs are lost due to framework or material fractures.
Metal-acrylic RBBs have like metal-ceramic RBBs high incidence of de-bonding and in addition
frequent fractures of the veneering material. RBBs made with ceramic framework also behave in a
different way dependent on the material utilized. Studies using densely sintered zirconia, for
examples, do not report any framework or material fractures, but have rather high incidence of de-
bonding. Hence, even though densely sintered zirconia RBBs showed significantly higher 5-year
survival rate than the other material combinations there is still the issue of de-bonding. On the other
hand, a study (Kern & Sasse 2011) using glass infiltrated ceramic as framework material reported no
de-bonding but a high incidence of RBBs lost due to material fracture. Another study (Sailer et al.
2013) reporting on glass reinforced ceramic as framework material also reported no de-bonding but a
relatively high rate of veneer fractures. The results for composite RBBs are contra-verse. Two of the
included studies report excellent outcomes with 5-year survival rate of 99,4% and 100%. The third
included study (van Heumen et al. 2009), however, reported a 5-year survival rate of only 64%. All
included studies on composite RBBs report incidences of chipping of the veneering material. Celeste
and co-workers also report exceptionally high rates of fractures of the framework and de-bonding.
The outcome with RBBs was also tested regarding the position in the oral cavity. The survival rate in
the maxilla was higher than in the mandible and the survival rate was also higher in the anterior area
compared with posterior position. The difference between the jaws did, however, not reach statistical
significance but the difference between the positions anterior vs. posterior was at the margin of
significance (p=0.056). The de-bonding rate showed the same trend as it was higher in mandible
16
compared with the maxilla and it was also higher in the posterior position compared with the anterior
area. The conclusion from this might be that RBBs work best in the anterior area of the maxilla.
In recent years, RBBs are more frequently designed with 1-retainer bonded to one abutment tooth,
instead of bonding them in the traditional way with two or more retainers to multiple teeth. The idea
behind this is to reduce the risk of fracture of the adhesive cement (de- bonding), induced by un-
synchronized movement of the abutment teeth in different directions under functional load. The
material of the present systematic review allowed formal comparison of RBBs retained with 1-retainer
to RBBs retained with 2-retainers. The 1-retainer design showed significantly higher survival rate and
significantly lower de-bonding rate than the 2-retainer design.
Combining the information and knowledge from the present systematic review, RBBs seems to
function best and last longest in the anterior maxilla. The framework material of choice appears to be
densely sintered zirconia, esthetically modified with buccal veneering ceramic. The need for
improvement today is to decrease the de-bonding rate with surface treatment of the ceramic, new
cementation protocols or new abutment tooth preparation designs.
In the present systematic review an estimated 10 years survival rate of 82.9% was reported based on
5 studies reporting on 545 RBBs with a mean follow-up period around 9 years. Compared with the
previous systematic review on RBBs (Pjetursson et al. 2008) that reported 10 year survival rate of
RBBs of 65.0% based on one study (Zalkind et al. 2003) reporting on 51 RBBs, this is a significant
improvement of the long-term outcome of this low invasive treatment option.
Comparing these results with the results for implant-supported SCs from a resent systematic review
based on the same methodology (Jung et al. 2012) the 5-year survival rate of RBBs is only 4.9% lower
and the 10-year survival rate 6.5% lower than the survival rate reported for implant-supported SCs.
Furthermore, it is interesting to see that the annual failure rate of studies with 5 and 10 years follow-up
is similar, 1.80% and 1.88%, respectively. Hence, RBBs seem to be stable reconstructions as the
failure rate is relatively linear and not suddenly decreasing after between 5 to 10 years follow-up time.
It has to be considered, however, that RBBs cannot be applied as treatment option in all clinical
situations. Deep bite conditions, low or no overjet or the lack of enamel at the abutment teeth are
strong limitations and sometimes even contraindications for the RBBs (Kern 2005).
17
In the present systematic review a positive learning curve can be noticed regarding the way authors
report on the clinical outcome. In the older studies the authors frequently concentrated on the issue of
de-bonding that was the main problem without reporting the entire picture. More recent studies give a
more comprehensive report on everything that happened to the reconstruction over the observation
period. The incidence of biological complications was relatively low in the present systematic review.
Caries at abutment level was 1.7% and incidence of RBBs lost due to periodontal diseases was 0.8%
over and 5-year observation period. For traditional tooth-supported end abutment FDPs the respective
figures are 4.8% and 0.4%. The incidence of RBBs lost due to esthetic failures was only 0.3%. For
implant-supported SCs were 7.1% of the cases were reported to have unacceptable esthetic outcome.
However, these figures can not be compared as it was not reported whether the implant restorations
had to be remade or not. The incidence of technical complications was well reported in the included
studies and as previously mentioned the incidence was very dependent on the material combination
utilized.
The studies included were mainly conducted in an institutional environment, such as universities or
specialists’ clinics. Therefore, for a technique sensitive procedure like making a RBBs the long-term
outcomes observed here could not be generalized to dental services provided in private practice.
Although, both the English and the German dental literature was searched for the present systematic
review, all the included papers were in the English language. This concurred with an empirical study,
which found little effect on the combined effect estimates in meta-analyses of RCTs, with the inclusion
or exclusion of studies published in languages other than English (Egger et al. 2003).
Instead of performing a formal quality assessment of the included studies and sensitivity analysis, this
review used stringent inclusion criteria. For example, only studies with clinical follow-up examinations
were included to avoid the potential inaccuracies in event description in studies that based their
analysis on patient self-reports.
The original idea behind RBBs was to enable fixed reconstruction with minimal or no tooth
preparation, hence, to conserve tooth structure. For anterior RBBs, the use of a minimally- invasive
preparation design is considered sufficient by most authors. The extension of the tooth preparations
with wrap-around design, grooves and rests, that has been recommended (De Kanter et al. 1998) in
18
recent years to increase retention for RBBs placed on posterior teeth, cannot qualify as a conservative
method.
Literature based systematic reviews of prognosis and survival outcomes are hampered by a variety of
problems (Altman & Cates 2001). The present systematic review revealed several shortcomings in the
previous clinical studies. Hence, it appears appropriate to make the following recommendations: Long-
term cohort studies on RBBs should be prospective, have complete follow-up information preferentially
with similar length of follow-up for all patients. This means that data on well-defined time periods
should be reported for the entire cohort, especially for the different years after insertion. Moreover,
future research should look into taking advantage of the best properties from different materials to
make RBBs even more predictable.
Conclusions
In specific and clearly defined patient situations, RBBs may be considered as valid minimally- invasive
treatment alternative to conventional fixed dental prostheses or single implant crowns. Maxillary
anterior RBBs made with zirconia frameworks and single-retainer design, appear to perform best, yet,
other all-ceramic RBBs as well as composite RBBs are very promising as well. Despite the high
survival rate of RBBs after 5 years, technical complications such as de-bonding still are frequent.
The clinical indications for successful outcomes include sufficient inter-occlusal space in the region of
interest and good enamel quality for the adhesive cementation of the RBBs. For their application in
the posterior region of the jaws new treatment concepts and possibly also material options need to be
developed for improved outcomes. There is an urgent need for prospective and comparative studies
with a follow-up time of 10 years or more, to fully assess the long-term outcomes of the RBBs.
19
Acknowledgements and conflict of interest
The authors report no conflict of interest.
20
Figure and table legends
Figure 1. - Search strategy
Figure 2 – Annual failure rates (per 100 years) of RBBs.
Table 1. Study and patient characteristics and manufacturing procedures of the reviewed studies for
resin bonded bridges (RBBs).
Table 2. - Annual failure rates and survival of resin bonded bridges.
Table 3. - Annual failure rates and survival of RBBs divided according to material utilized.
Table 4. – Annual failure and de-bonding rates and estimated 5-year survival and complications rates
of RBBs according to position in the mouth and number of retainers.
Table 5. – Biological and technical complications.
* Based on robust Poisson regression.
CI, confidence interval; n.r., not reported; n.a., not analysed; RBB, resin bonded bridge
21
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Saker, S., El-Fallal, A., Abo-Madina, M., Ghazy, M. & Ozcan, M. (2014) Clinical survival of anterior metal-ceramic and all-ceramic cantilever resin-bonded fixed dental prostheses over a period of 60 months. International Journal of Prosthodontics 27: 422-424.
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1
Figure 1. - Search strategy
2
Figure 2 – Annual failure rates (per 100 years) of RBBs.
1.83 (95% CI: 1.3 - 2.56)Creugers & Käyser,1992
Thayer et al.,1993Barrack & Bretz,1993
Priest,1995Samama,1996
Hansson & Bergström,1996Bergbreiter et al.,1996
Pröbster & Henrich,1997de Kanter et al.,1998Corrente et al.,2000
Zalkind et al.,2003Agstaller et al.,2008Celeste et al.,2009Kern & Sasse,2011Boening et al,2012Younes et al.,2013Spinas et al.,2013
Sasse & Kern,2013Sailer et al.,2013
Sasse & Kern,2014Sailer & Hämmerle,2014
Botehlho et al.,2014Kumbuloglu & Özcan,2015
0 5 10 15 20Annual Event Rate (%)
3
4
5
Table 1. Study and patient characteristics and manufacturing procedures of
the reviewed studies for resin bonded bridges (RBBs).
6
Table 2. - Annual failure rates and survival of resin bonded bridges. * Based on robust Poisson regression.
Study Year of publi-cation
Total no. of RBBs
Mean follow-up time
No. of failure
Total RBB exposure
time
Estimated failure rate
(per 100 RBB years)
Estimated survival rate (in percent)
5-years follow-up Kumbuloglu & Özcan 2015 175 5 1 875 0.11 99.4%
Sailer & Hämmerle 2014 12 5.1 0 61 0 100%
Sasse & Kern 2014 42 5.2 0 216 0 100%
Spinas et al. 2013 32 5 0 160 0 100%
Sasse & Kern 2013 14 5.4 0 75 0 100%
Sailer et al. 2013 49 6 2 210 0.95 95.3%
Boening et al. 2012 56 6.3 4 355 1.13 94.5%
van Heumen et al. 2009 60 5 19 300 6.33 72.9%
Agstaller et al. 2008 232 6.3 7 529 1.32 93.6%
Corrente et al. 2000 61 6.1 1 422 0.24 98.8%
de Kanter et al. 1998 201 5 42 1005 4.18 81.1%
Pröbster & Henrich 1997 325 5 29 1625 1.78 91.5%
Hansson & Bergström 1996 34 6.1 6 207 2.90 86.5%
Bergbreiter et al. 1996 74 6.5 8 481 1.66 92.0%
Samama 1996 145 5.8 4 835 0.48 97.6%
Priest 1995 31 5.3 15 164 9.15 63.3%
Barrack & Bretz 1993 127 5.8 9 737 1.22 94.1%
Thayer et al. 1993 85 7.3 13 621 2.09 90.1%
Total 1755 5.1 160 8878 Summary estimate
(95 % CI) * 1.80
(1.13-2.87) 91.4%
(86.7%-94.4%) 10-years follow-up
Botehlho et al. 2014 211 9.4 21 1990 1.06 90.0%
Younes et al. 2013 42 13 10 546 1.83 83.3%
Kern & Sasse 2011 38 9.6 5 364 1.37 87.2%
Zalkind et al. 2003 51 9.1 20 464 4.31 65.0%
Creugers & Käyser 1992 203 7.5 35 1488 2.35 79.0%
Total 545 8.9 91 4852 Summary estimate
(95 % CI) * 1.88 (1.13-3.12)
82.9% (73.2%-89.3%)
Overall total 2300 6.0 251 13730
Overall summary estimate (95 % CI) * 1.83
(1.30-2.56) 91.3%
(88.0%-93.7%)
7
Table 3. - Annual failure rates and survival of RBBs divided according to
material utilized. * Based on robust Poisson regression.
Study
Year of publication
Total no. of RBBs
Mean follow-up
time
No. of failure
Total RBBs exposure
time
Estimated annual failure
rate* (per 100 RBB
years)
Estimated survival after 5
years* (in percent)
Metal ceramic Botehlho et al. 2014 211 9.4 21 1990 1.06 94.9% Younes et al. 2013 42 13 10 546 1.83 91.2% Boening et al 2012 56 6.3 4 355 1.13 94.5% Agstaller et al. 2008 232 6.3 7 529 1.32 93.6% de Kanter et al. 1998 201 5 42 1005 4.18 81.1% Hansson & Bergström 1996 34 6.1 6 207 2.90 86.5% Bergbreiter et al. 1996 74 6.5 8 481 1.66 92.0% Barrack & Bretz 1993 127 5.8 9 737 1.22 94.1%
Total 977 6.0 107 5850
Summary estimate (95 % CI) * 1.83
(1.04-3.22) 91.3%
(85.1%-94.9%)
Metal resin Creugers & Käyser 1992 203 7.5 35 1488 2.35 88.9%
Total 203 7.5 35 1488
Summary estimate (95 % CI) * 2.35
(1.64-3.26) 88.9%
(85.0%-92.1%)
Glass infiltrated ceramic Kern & Sasse 2011 38 9.6 5 364 1.37 93.4%
Total 38 9.6 5 364
Summary estimate (95 % CI) * 1.37
(0.45-3.18) 93.4%
(85.3%-97.8%)
Glass reinforced ceramic Sailer et al. 2013 49 6 2 210 0.95 95.3%
Total 49 6 2 210
Summary estimate (95 % CI) * 0.95
(0.12-3.40) 95.3%
(84.4%-99.4%)
Densely sintered zirconia Sailer & Hämmerle 2014 12 5.1 0 61 0 100% Sasse & Kern 2014 42 5.2 0 216 0 100% Sasse & Kern 2013 14 5.4 0 75 0 100%
Total 68 5.2 0 352
Summary estimate (95 % CI) * 0
(0-1.04) 100%
(94.5%-100%)
Composite Kumbuloglu & Özcan 2015 175 5 1 875 0.11 99.4% van Heumen et al. 2009 60 5 19 300 6.33 72.9% Spinas et al. 2013 32 5 0 160 0 100%
Total 267 5 20 1335
Summary estimate (95 % CI) * 1.50
(0.15-14.7) 92.8%
(47.9%-99.2%)
Overall results 1602 6.0 169 9599
9
Table 4. – Annual failure and de-bonding rates and estimated 5-year survival
and complications rates of RBBs according to position in the mouth and
number of retainers. * Based on robust Poisson regression.
Total
number of RBBs
Estimated annual rate
5-year summary estimate (95 % CI)
Total number of
RBBs
Estimated annual rate
5-year summary estimate (95 % CI)
p-value**
Maxilla Mandible
Survival 399 1.03* (0.55-1.96)
95.0%* (90.7%-97.3%) 243 2.71*
(0.92-7.97) 87.3%*
(67.1%-95.5%) p= 0.119
Debonding 795 2.64* (1.57-4.43)
12.4%* (7.6%-19.9%) 763 4.01*
(2.38-6.74) 18.2%*
(11.2%-28.6%) p= 0.255 Anterior Posterior
Survival 479 1.20* (0.39-3.69)
94.2%* (83.1%-98.1%) 242 3.65*
(2.72-4.89) 83.3%*
(78.3%-87.3%) p=0.056
Debonding 1227 2.37* (1.50-3.77)
11.2%* (7.2%-17.2%) 602 4.94*
(2.58-9.40) 21.8%*
(12.1%-37.5%)
p=0.056
1-retainer 2-retainers
Survival 350 0.87* (0.59-1.28)
95.7%* (93.8%-97.1%) 1376 2.17*
(1.44-3.27) 89.7%*
(84.9%-93.1%) p<0.0001
Debonding 383 1.47* (0.95-2.29)
7.1%* (4.6%-10.8%) 1433 4.17*
(2.73-6.36) 18.8%*
(12.8%-27.2%) p=0.001
10
Table 5. – Biological and technical complications.
Study
Year of publi-cation
Total no. of abut-ments
Estimated rate of caries on
abutments (per 100 abutment
years)
Total no. of RBBs
Estimated rate of RBBs lost due to
periodontitis (per 100 RBB years)
Estimated rate of RBBs lost due to
veneer or framework fractures
(per 100 RBB years)
Estimated rate of minor veneer
fractures (per 100 RBB years)
Estimated rate of RBBs lost due to esthetic failures
(per 100 RBB years)
Estimated rate of RBBs lost due to abutment tooth
fracture (per 100 RBB years)
Estimated rate of debonding
(per 100 RBB years)
Kumbuloglu & Özcan 2015 350 0 175 0 0.11 0.46 0 0 0.91 Sailer & Hämmerle 2014 12 0 12 0 0 0 0 0 3.28 Botehlho et al. 2014 211 0.14 211 0.15 0 0.10 n.r. 0.10 1.41 Sasse & Kern 2014 42 0.46 42 0 0 n.r. n.r. 0 0.93 Spinas et al. 2013 64 n.r. 32 0 0 1.25 n.r. 0 0 Sasse & Kern 2013 14 0 14 0 0 n.r. 0 0 1.33 Younes et al. 2013 84 n.r. 42 0.18 0 0.55 n.r. 0 3.30 Sailer et al. 2013 35 0 49 0.48 0 0.95 0 0 0 Boening et al 2012 112 0.45 56 0 0 0.28 0.28 0 1.41 Kern & Sasse 2011 54 n.r. 38 0 2.20 n.r. n.r. 0 0 van Heumen et al. 2009 120 n.r. 60 n.r. 3.00 4.33 n.r. n.r. 5.00 Agstaller et al. 2008 n.r. n.r. 232 0 0 0.19 0.19 0.19 0.76 Garnett et al. 2006 45 n.r. 39 n.r. n.r. n.r. n.r. 0 6.15 Kern 2005 53 n.r. 37 n.r. n.a. 1.04 n.r. n.a. n.a. Zalkind et al. 2003 n.r. n.r. 51 n.r. n.r. n.r. n.r. 0 7.71 Hikage et al. 2003 n.r. n.r. 26 n.r. n.r. n.r. n.r. 0 3.59 Corrente et al. 2000 327 0 61 0 0.24 n.r. n.r. 0 2.84 de Kanter et al. 1998 402 n.r. 201 n.r. n.r. n.r. n.r. 0 9.35 Pröbster & Henrich 1997 650 0.80 325 n.r. n.r. n.r. n.r. n.r 4.80 Hansson & Bergström 1996 68 0 34 0.48 0 0.48 0 0 2.42 Bergbreiter et al. 1996 n.r. n.r. 74 n.r. n.r. 0.62 n.r. n.r 2.29 Samama 1996 n.r. n.r. 145 n.r. n.r. n.r. n.r. n.r 1.32 de Rijk et al. 1996 n.r. n.r. 164 n.r. n.r. n.r. n.r. n.r 3.16 Priest 1995 n.r. n.r. 31 0.31 0.31 n.r. n.r. n.r 12.8 Hosseini 1994 n.r. n.r. 90 n.r. n.r. n.r. n.r. n.r 1.71 Barrack & Bretz 1993 n.r. n.r. 127 0.68 n.r. 0.41 n.r. n.r 1.22 Thayer et al. 1993 209 0.33 85 n.r. 0.64 n.r. 0. n.r 5.31 Creugers & Käyser 1992 n.r. n.r. 203 n.r. n.r. n.r. n.r. 0 4.17 Creugers et al. 1990 n.r. n.r. 203 n.r. 0.32 2.89 n.r. n.r n.r.
Summary estimate event rates (95 % CI)
0.34*
(0.14-0.82) 0.17* (0.08-0.36)
0.34* (0.13-0.90)
0.84* (0.36-2.00)
0.07* (0.02-0.25)
0.03* (0.01-0.10)
3.3* (2.3-4.6)
Cumulative 5 year complication rates
(95 % CI)
1.7%*
(0.7%-4.0%) 0.8%* (0.4%-1.8%)
1.7%* (0.6%-4.4%)
4.1%* (1.8%-9.5%)
0.3%* (0.1%-1.2%)
0.2%* (0.05%-0.5%)
15.0%* (10.9%-20.6%)
11
* Based on robust Poisson regression. CI, confidence interval; n.r., not reported; n.a., not analysed; RBB, resin bonded bridge