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A three day event discussing aspects of the innate immune system.
With plenty of opportunity for networking and debate, this informal international meeting will bring you up to date with current research and thinking regarding an organisms first line of defence.
Who Should Attend:
Academic and biotechnology/biopharma research professionals interested in function and potency of immune response components against pathogens and tumours; also scientists interested in how understanding these
mechanisms can inform the design of biological therapeutics and their mechanisms of action, with translational implications for therapy.
This event has an open poster session. Posters can be submitted on any subject related to Innate Immunity
This event has CPD accreditation.
www.regonline.co.uk/innate2014
Table of Contents Program Outline ............................................................................................................................................ 6
Day 1: Innate Immunity Interactions with Pathogens .................................................................. 6
Session Chair: Dr Pietro Mastroeni, Cambridge University, UK .................................................................... 6
Day 2: Investigating interactions of the Innate and Adaptive Immune Systems ........................ 6
Session Chair:................................................................................................................................................. 6
Day 3: Therapeutic applications of the Innate Immune system .................................................. 7
Session Chair:................................................................................................................................................. 7
Agenda ............................................................................................................................................................ 8
Day 1: Innate Immunity Interactions with Pathogens .................................................................. 8
Introduction by the Chair .............................................................................................................................. 8
Exploring pathogen recognition in innate immunity using Drosophila as a model host .............................. 8
ORAL PRESENTATIONS................................................................................................................................... 8
TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15 .............................................. 8
ORAL PRESENTATIONS................................................................................................................................... 8
Reg3 proteins in the mammalian intestine. .................................................................................................. 8
The role of innate immun system on periodontal diseases .......................................................................... 8
ORAL PRESENTATION .................................................................................................................................... 8
ROLE OF INNATE ANTIMICROBIAL MECHANISMS IN INTRACELLULAR SURVIVAL OF M. AVIUM
SUBSPECIES AVIUM IN CHICKEN CELLS ......................................................................................................... 8
Interaction of HIV with plasmacytoid dendritic cells and its relevance for HIV pathogenesis ..................... 8
Lipid rafts influence NLR mediated immune responses against bacterial infections ................................... 8
Cross-talk between Fas and TLR signalling pathways - role in inflammation and cancer ............................. 8
Paramyxovirus Inhibition of Human Complement Pathway ........................................................................ 8
Chairman’s Summing Up ............................................................................................................................... 8
Day 2: Interactions of the Innate and Adaptive Immune Systems ........................................ 9
Introduction by the Chair .............................................................................................................................. 9
The role of gamma delta T cells in melanoma and the effects of bisphosphonate therapy. ........................ 9
B-cells at the interface between innate and acquired immunity to bacterial pathogens ............................ 9
The MHC class II-associated invariant chain controls innate and adaptive immunity in B cells ................... 9
ORAL PRESENTATIONS................................................................................................................................... 9
Sepsis as a Model of Impaired Communication between the Innate and Adaptive Immune Systems: ....... 9
ORAL PRESENTATIONS................................................................................................................................... 9
Immunomodulatory networks controlling cancer metastatic dissemination ............................................... 9
Session Break ................................................................................................................................................. 9
Platelets as immune cells .............................................................................................................................. 9
Day 3: Therapeutic applications of the Innate Immune system ........................................ 10
Introduction by the Chair ............................................................................................................................ 10
Regulation of autoimmune myocarditis and inflammatory cardiomyopathy by innate immunity ............ 10
High-intensity ultra-short electric pulse applications in modulating innate immunity .............................. 10
ORAL PRESENTATIONS................................................................................................................................. 10
ORAL PRESENTATIONS................................................................................................................................. 10
14:00 – 14:15 PHARMACOLOGICAL MODULATION OF THE AKT/MIR199A-5P/CAV1 PATHWAY INCREASES
ENDOTOXIN TOLERANCE IN CYSTIC FIBROSIS (CF)-AFFECTED MACROPHAGES AND DECREASES LUNG
HYPER-INFLAMMATION IN CF MIC .............................................................................................................. 10
Toll-like receptors in atherosclerosis: opportunity for targeting ................................................................ 10
M1/M2 Macrophages: A Copernican Revelation in Immunology ............................................................... 10
About the Speakers ..................................................................................................................................... 11
Day 1 11
Petros Ligoxygakis, ...................................................................................................................................... 11
Uzma Hasan, ................................................................................................................................................ 11
Sinead Miggin, ............................................................................................................................................. 11
Robson Coutinho-Silva, ............................................................................................................................... 11
Jerry Wells, .................................................................................................................................................. 12
Sema Becerik, .............................................................................................................................................. 12
Adriano Boasso, ........................................................................................................................................... 12
Elizabeth Brint, ............................................................................................................................................ 12
Day 2 13
Katie Lacy, .................................................................................................................................................... 13
Pietro Mastroeni .......................................................................................................................................... 13
Manoury Bénédicte, .................................................................................................................................... 13
James D. Faix, .............................................................................................................................................. 13
Victoria Sanz-Moreno, ................................................................................................................................. 13
Stephen A Beers, ......................................................................................................................................... 13
Day 3 14
Sunil Joshi .................................................................................................................................................... 14
Vinod Singh .................................................................................................................................................. 14
Claudia Monaco, .......................................................................................................................................... 14
Charles Mills ................................................................................................................................................ 14
Discussion Sessions ..................................................................................................................................... 14
Session breaks ............................................................................................................................................. 14
Lunch ............................................................................................................................................................ 14
All the chicken in our lunch buffet is Halal ........................................................................................ 15
We have a number of dishes that are gluten free .............................................................................. 15
We have a range of vegetarian dishes which are separated from the meat and fish dishes ......... 15
Frequently asked questions about our events .......................................................................................... 15
Is the delegate list available? ......................................................................................................... 15
Can I have the speakers slides? ..................................................................................................... 15
Can I have a notepad? ..................................................................................................................... 15
How can I keep up to date with Euroscicon Events? ................................................................... 15
I don’t want my photograph on any Euroscicon promotional material ..................................... 15
Is there WIFI? .................................................................................................................................. 15
Can I have a CPD certificate? .......................................................................................................... 15
Program Outline
Day 1: Innate Immunity Interactions with Pathogens Infectious diseases are still a major cause of morbidity and mortality worldwide. Innate immunity is of paramount importance for the control of pathogens in the early stages of the infection and for the engenderment and expansion of acquired immunity. This will be a premier forum for the presentation of cutting-edge research on how the interaction between innate immune mechanisms and pathogens impacts on host resistance, immunoevasion, immunodeficiencies and vaccine efficacy, providing a deep insight into future research and more rational measures to prevent and treat infectious diseases of humans and animals.
Session Chair: Dr Pietro Mastroeni, Cambridge University, UK Pietro Mastroeni is a Reader at the University of Cambridge. He obtained a Degree in Medicine and Surgery at the Univerisity of Messina, Italy prior to moving to the UK where he obtained a PhD at the Department of Pathology of the University of Cambridge and worked as a postdoctoral Fellow at Imperial College, London. His research has established several landmarks in the fields of pathogenesis of bacterial infections, immunity, immunoevasion and vaccine development. His research group is currently engaged in immunological and molecular approaches towards a global understanding of infection dynamics in the face of immunity and vaccination. Day 2: Investigating interactions of the Innate and Adaptive Immune Systems The cells of the innate immune system play a crucial part in immune defense against disease but also respond to the presence of malignant cells, initiating and subsequently directing adaptive immune responses. The session will discuss the roles of different components of the innate immune system, with focus on disease mechanisms and interactions between inflammatory cells, antibodies and pathogenic or tumour antigens and how these impact on disease progression. The session will draw on new cutting edge research and will provide ample opportunity for networking and informal discussions. Session Chair: Dr Sophia N. Karagiannis, Senior Lecturer in Translational Cancer Immunology, Head of Cancer Antibody Discovery and Immunotherapy, St John’s Institute of Dermatology, Division of Genetics and Molecular Medicine, King’s College London School of Medicine, UK Sophia Karagiannis is a translational cancer immunologist specialising in antibody therapies for melanoma, ovarian and breast carcinomas. She received BA and MS degrees at Rutgers University, USA, through scholarship awards and a teaching assistantship (1987, 1991), and a PhD at King’s College London in Biochemistry under SERC and SmithKline Beecham-funded scholarships (1995). She subsequently developed immunotherapeutic strategies for cancer and inflammatory diseases in academic and biotechnology environments in London and Cambridge as a postdoctoral associate and scientific investigator. She was appointed as NIHR Senior Research Fellow in 2007 and a Senior Lecturer at 2013 at King's College London. She heads a translational cancer immunology and antibody immunotherapy group adopting an interdisciplinary lab bench-to-bedside approach. The team’s activities are focused on dissecting the humoral immune response to solid tumours, forming the basis for the development of novel approaches to discover novel monoclonal antibodies for the diagnosis and therapy of clinically-challenging solid tumours such as melanoma, ovarian and breast carcinomas. Sophia co-founded the International Task Force on AllergoOncology and has pioneered IgE therapeutics for solid tumours. Her research and development initiative on the first IgE class antibody for cancer therapy is conducted in close collaboration with clinical and academic groups at King’s College London and the CR-UK Drug Development Office.
Day 3: Therapeutic applications of the Innate Immune system The identification of antigen recognition receptors for innate immunity has sparked great interest in therapeutic manipulation of the innate immune system. For example Toll-like receptor agonists are being developed for the treatment of cancer, allergies and viral infections, and as adjuvants for cancer and disease vaccines. This session will explore current research and applications of the innate system for therapeutic applications. There will be plenty of opportunity for discussion and debate and we encourage submission of abstracts for both oral and poster presentation. Session Chair: Przemyslaw Blyszczuk studied Molecular Biology at Jagiellonian University (1995-2000) and achieved his PhD at Martin-Luther University in Halle-Wittenberg, Germany. He held a PhD student position at the IPK Gatersleben, Germany (2000-2004), where he worked on embryonic stem cells before his interest switched to autoimmune myocarditis and inflammatory cardiomyopathy. In 2004 he joined Prof. Urs Eriksson as a Post-doctoral fellow at the University Hospital, Basel, Switzerland (2004-09) and became 2009 research associate in the Cardioimmunology division, Cardiovascular Research, Institute of Physiology, University of Zurich with Professor Eriksson. In 2013 he moved to his current position as junior group leader and head of the Cardioimmunology laboratory.
Agenda (Talk times include 5 – 10 minutes for questions)
Day 1: Innate Immunity Interactions with Pathogens 09:30 – 10:15 Exhibitions open Registration and Refreshments 10:15 – 10:20 Introduction by the Chair Dr Pietro Mastroeni, Cambridge University, UK 10:20 – 10:40 Exploring pathogen recognition in innate
immunity using Drosophila as a model host Dr Petros Ligoxygakis, Associate Professor of Genetics, University of Oxford, UK
10:40 – 11:00 Is Immune Activation Necessary for HIV?
Professor Wenzhe Ho, Temple University School of Medicine, USA
11:00 – 11:20 Non-specific Stressors: Under-appreciated Innate Defenses
Dr Edmund LeGrand, University of Tennessee, Knoxville, TN, USA
11:20 – 11:40 Session Break
Speakers’ photo, Refreshments, Poster viewing Sponsors exhibition
11:40 – 12:00 HPV16 deregulation of the inflammasome response
Dr Uzma Hasan,University Lyon, Hopital Lyon Sud, France
12-00 – 12:20 ORAL PRESENTATIONS 12:00 – 12:10 THE HUMAN DEAD-BOX HELICASE 3 IN INNATE ANTIVIRAL IMMUNE SIGNALLING L Gu, A Fullam, Y Höhn, R Brennan and M Schröder University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland 12:10 – 12:20 THE ROLE OF EXTRACELLULAR GALECTIN-3 (GAL-3) IN HOST RESPONSE TO HELICOBACTER PYLORI INFECTION. V. Vijayasubhash V. and B. Ho Department of Microbiology, Yong Loo Lin, National University of Singapore, Singapore
12:20 – 12:40 TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15
Dr Sinead Miggin, National University of Ireland Maynooth, Ireland
12:40 – 13:00 Purinergic signalling in controlling of intracellular parasites
Dr Robson Coutinho-Silva, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil
13:00 – 13:50 Session Break Lunch, Poster viewing, Sponsors exhibition 13:50 – 14:10 ORAL PRESENTATIONS
13:50 – 14:00 IL28B AND IL10 GENE VARIABILITY AND HUMAN PREDISPOSITION TO CHRONIC HEPATITIS C AND TICK-BORNE ENCEPHALITIS, CAUSED BY RELATED VIRUSES A. V. Barkhash1, G. V. Kochneva2, E. V. Chub2, M. I. Voevoda1,3, A. G. Romaschenko1
1 Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090 Russia; 2 State Research Center of Virology and Biotechnology “Vector”, Russia 3 Institute of Internal Medicine SB RAMS, Novosibirsk, Russia 14:00 – 14:10 INNATE LYMPHOCYTE CELL ‘MEMORY’ AGAINST BACTERIAL INFECTION A Monahan, A Dubois, R, Allen, R Ingram Queen’s University Belfast, Centre for Infection and Immunity, Lisburn Rd, Belfast, Ireland
14:10 – 14:30 Reg3 proteins in the mammalian intestine. Professor Jerry Wells, Host-Microbe Interactomics - Wageningen, The Netherlands
14:30 – 14:50 The role of innate immun system on periodontal diseases
Dr Sema Becerik, Ege University, Turkey
14:50 – 15:10 Soluble pattern recognition molecules and associated proteins – update on the lectin pathway of the complement system
Professor Steffen Thiel, Aarhus University, Denmark
15:10 – 15:30 Session Break Refreshments, Last poster viewing and Sponsors exhibition
15:30 – 15:40 ORAL PRESENTATION ROLE OF INNATE ANTIMICROBIAL MECHANISMS IN INTRACELLULAR SURVIVAL OF M. AVIUM SUBSPECIES AVIUM IN CHICKEN CELLS Nawzat A. Issa1, Mohammed shukur1, Sabine Tötemeyer1, Paul Barrow1, Michael A. Jones 1 School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington LE12 5RD.
15:40 – 16:00 Interaction of HIV with plasmacytoid dendritic cells and its relevance for HIV pathogenesis
Dr Adriano Boasso, Imperial College London, UK
16:00 – 16:20 Lipid rafts influence NLR mediated immune responses against bacterial infections
Associate Professor Sanjay Batra, Southern University and A&M College, Baton Rouge, Louisiana, USA
16:20 – 16:40 Cross-talk between Fas and TLR signalling pathways - role in inflammation and cancer
Dr Elizabeth Brint, University College Cork, Ireland
16:40 – 17:00 Paramyxovirus Inhibition of Human Complement Pathway
Professor Griffith Parks, Wake Forest School of Medicine, USA
17:00 Chairman’s Summing Up Close of Session
Day 2: Interactions of the Innate and Adaptive Immune Systems
09:30 – 10:00 Exhibitions open Registration and Refreshments
10:00-10:15 Introduction by the Chair Dr Sophia N. Karagiannis, St John’s Institute of Dermatology, King’s College London School of Medicine, UK
10:15 – 10:45 The role of gamma delta T cells in melanoma and the effects of bisphosphonate therapy.
Dr. Katie Lacy, Kings College London, UK
10:45 – 11:15 B-cells at the interface between innate and acquired immunity to bacterial pathogens
Dr Pietro Mastroeni, University of Cambridge, UK
11:15 – 11:45 Session Break
Speakers’ photo, Refreshments, Poster viewing Sponsors exhibition
11:45 – 12:15 The MHC class II-associated invariant chain controls innate and adaptive immunity in B cells
Dr Bénédicte Manoury, Hôpital Necker; Unité INSERM U1151, Paris, France
12:15 – 12:45 ORAL PRESENTATIONS 12:15 – 12:30NATURAL ANTIBODIES ARE INNATE IMMUNE RESPONSIVE Ding J. L., Panda S. and Ho B. Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543. Email: [email protected] 12:30 – 12:45 SULFORAPHANE EPIGENETICALLY REGULATES THE LPS-INDUCED KINETICS OF INNATE IMMUNE RESPONSE IN PORCINE MONOCYTE-DERIVED DENDRITIC CELLS Xueqi Qu1, Christiane Neuhoff1, Mehmet Ulas Cinar2, Maren Pröll1, Muhammad Jasim Uddin1, Dawit Tesfaye1, Ernst Tholen1, Christian Looft1 and Karl Schellander1
1 Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany 2 Departments of Animal Science, Faculty of Agriculture, Erciyes University, 38039 Kayseri, Turkey
12:45 – 13:15 Sepsis as a Model of Impaired Communication between the Innate and Adaptive Immune Systems:
Dr James D. Faix, Department of Pathology, Stanford University Medical Center, Stanford, USA
13:15 – 13:45 Session Break Lunch, Poster viewing, Sponsors exhibition
13:45 – 14:15 ORAL PRESENTATIONS 13:45 – 14:00 MODULATION OF IL-1 FAMILY CYTOKINES AND RECEPTORS DURING THE ACUTE AND CHRONIC INFLAMMATORY RESPONSE OF HUMAN MONOCYTES P. Italiani1,2, E. Mosca1, R. Alfieri1, L. Milanesi1, and D. Boraschi2 1Institute of Biomedical Technologies (ITB), National Research Council (CNR), Segrate, Milano, Italy 2Institute of Protein Biochemistry (IBP), National Research Council (CNR), Napoli, Italy Naples, Italy 14:00- 14:15 MODELING ANTIMICROBIAL PEPTIDE-INDUCED CHEMOKINE, CYTOKINE, AND BIOLOGICAL MEDIATOR RESPONSES
K. A. Brogden1, C. Fischer1, S. Radhakrishnan2, S. A. Prasad2, R. Vidva2, and S. Vali2 1Dows Institute for Dental Research and Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA 2Cellworks Research India Pvt Ltd, Whitefield, Bangalore-560066, India and Cellworks Group, Inc., Saratoga, CA 95070, USA
14:15 – 14:45 B cells and tumours: novel insights into tumour-induced immune escape
Dr Sophia N. Karagiannis, King’s College London School of Medicine, UK
14:45 – 15:15 Immunomodulatory networks controlling cancer metastatic dissemination
Dr Victoria Sanz-Moreno, Guy's Campus, King's College, London, United Kingdom
15:15 – 15:45 Session Break Refreshments, Last poster viewing, Last Sponsors exhibition
15:45 – 16:15 Understanding the roles of innate and adaptive immunity in the mechanisms of action of immunomodulatory antibodies.
Dr Stephen A Beers, Antibody and Vaccine Group, Faculty of Medicine, University of Southampton, UK
16:15 – 16:45 Platelets as immune cells
Dr Fabrice Cognasse, Etablissement Français du Sang Auvergne-Loire, France
16:45 Chairman’s Summing Up Close of Session
Day 3: Therapeutic applications of the Innate Immune system 09:30 – 10:15 Exhibitions open Registration and Refreshments
10:15 – 11:00 Introduction by the Chair Regulation of autoimmune myocarditis and inflammatory cardiomyopathy by innate immunity
Dr Przemyslaw Blyszczuk, Cardioimmunology, University of Zurich, Switzerland
11:00 – 11:30 High-intensity ultra-short electric pulse applications in modulating innate immunity
Dr Sunil K. Joshi, College of Health Sciences and Frank Reidy Research Center of Bioelectrics , Old Dominion University, Norfolk, VA, USA
11:30 – 12:00 Session Break
Speakers’ photo, Refreshments, Poster viewing , Sponsors exhibition
12:00 – 12:30 ORAL PRESENTATIONS 12:00 – 12:15 HYPOXIC-INDUCED PROTEOLYSIS OF MER TYROSINE KINASE AND CD36 BY ADAM PROTEASES REGULATES APOPTOTIC CELL ACCUMULATION AND HIF2-REGULATED EFFEROCYTOSIS AND INFLAMMATION-RESOLUTION IN MACROPHAGES TO SUPPRESS FIBROSIS AND CARDIAC FUNCTION. Dr Edward Thorp, Department of Medicine, Columbia University, New York, USA and Department of Pathology and Feinberg Cardiovascular Research Institute, Northwestern University Medical School, Chicago, USA
12:15 – 12:30 MECHANISMS BEHIND IMMUNOREGULATORY EFFECTS OF PROBIOTIC YEASTS IM Smith1,2, A Baker1, N Arneborg2, L Jespersen2 1. Health & Nutrition Division, Chr. Hansen A/S, Hørsholm, Denmark 2. Food Science, University of Copenhagen, Frederiksberg, Denmark
12:30 – 13:30 Session Break
Lunch, Poster viewing Sponsors exhibition
Afternoon Session Chair Dr Sunil K. Joshi, College of Health Sciences and Frank Reidy Research Center of Bioelectrics , Old Dominion University, Norfolk, VA, USA
13:30 – 14:00 Discussion session
14:00 – 14:30 ORAL PRESENTATIONS 14:00 – 14:15 PHARMACOLOGICAL MODULATION OF THE AKT/MIR199A-5P/CAV1 PATHWAY INCREASES ENDOTOXIN TOLERANCE IN CYSTIC FIBROSIS (CF)-AFFECTED MACROPHAGES AND DECREASES LUNG HYPER-INFLAMMATION IN CF MIC Ping-xia Zhang 1,2, Jijun Cheng 3, Siying Zou 4, Anthony D'Souza 2, Jonathan L. Koff 5, Jun Lu 3, Patty J. Lee 5, Diane S. Krause 2,4, Marie E. Egan 1,6 and Emanuela M. Bruscia 1*
Departments of Pediatrics 1, Laboratory Medicine 2, Genetics 3, Cell Biology 4, Internal Medicine 5, and Cellular and Molecular Physiology 6, Yale University School of Medicine, New Haven Connecticut, USA 14:15 – 14:30 TARGETTING THE TRIPEPTIDE PRO-GLY-PRO DEMINISHES INFLAMMATORY EFFECTS OF CIGARETTE SMOKE M. Abdul Roda, X. Xu, T. Abdalla, M. Sadik, L. Viera, CM. Mc Nicholas, D. Sullivan, FA. Redegeld, G. Folkerts, PL. Jackson, A. Gaggar, JE Blalock. Utrecht University, Division of Pharmacology, Universiteitsweg 99, Utrecht The Netherlands
14:30– 15:00 Session Break
Refreshments, Last poster viewing, Last Sponsors exhibition
15:00 – 15:30 Toll-like receptors in atherosclerosis: opportunity for targeting
Dr Claudia Monaco, Imperial College London, United Kingdom
15:30 – 16:00 M1/M2 Macrophages: A Copernican Revelation in Immunology
Dr Charles Mills, BioMedical Consultants, United States
About the Speakers
Day 1 Petros Ligoxygakis, is a Associate Professor and Group Leader at the University of Oxford. He obtained his doctorate in Molecular Genetics at the Institute of Molecular Biology and Biotechnology (IMBB), University of Crete, Greece. He then moved with a Postdoctoral Fellowship from The European Molecular Biology Organisation (EMBO) to CNRS Strasbourg, France and the lab of Prof Jules Hoffmann (Nobel Laureate for Medicine or Physiology 2011). His research is directed in using Drosophila as a model for understanding host-pathogen interaction, how immunity is integrated in host physiology following immune activation and using the fruit fly infected with natural trypanosomid parasites as a blueprint for other more difficult but medically important insects such as sand flies and tsetse flies. Wenzhe Ho, Temple University School of Medicine, USA Dr. Wenzhe Ho did his clinical and research training in Wuhan Univ. China and Univ. Pennsylvania School of Medicine where he worked all the way up to a full professorship. Dr. Ho currently serves as a Tenured Professor at Dept. Pathology, Temple University, Philadelphia and Director/Professor of the Center for Animal Experiments/ABSL-III Laboratory, Wuhan University. Dr.Ho's current research focuses on virus-host interactions and the basic mechanisms that govern virus replication and strategies for enhancing the innate immunity against viral infections, particularly HIV and HCV. He is also interested in non-human primate (NHP) models for SIV and/or TB infections. He has published over 130 peer-reviewed papers. Edmund LeGrand is a board-certified veterinary pathologist who spent most of his career in the pharmaceutical industry developing products for wound healing and in assessing pharmaceutical toxicity. Following retirement and taking an adjunct appointment at the University of Tennessee, he has actively applied his long-standing interest in evolutionary principles to understanding how fever and the anorexia of infection can provide immune benefits. In collaboration with Dr. Judy Day, a biomathematician also at the University of Tennessee, he has developed and used computer models to simulate how non-specific stressors can function in host defense. Uzma Hasan, Centre International de Recherche en Infectiologie, University Lyon, Hopital Lyon Sud, France After obtaining my MBBS and after my PhD in London, UK, Dr Hasan did a first post doc in industry (Schering Plough, France and USA lab of Giorgio Trinchieri), where she was introduced to Toll Like Receptor research, focusing on industrial goals and techniques. This is a strong asset in today’s research; as it helps to be part of research projects with applications for identifying new cancer treatments. Dr Hasan then moved into public health working at the International Agency of Research on Cancer (IARC), WHO. This was a key opportunity to work in infectious cancers and to acquire strong technical skills in HPV, EBV, HBV biology and epidemiology in the laboratory of Massimo Tommasino. Here Dr Hasan developed her own line of research in the field of TLR9 regulation and HPV. Towards the end of her 4-year stay in M. Tommasino lab, she competed in national competition for a researcher position at INSERM (CR1) to move to the Hopital Lyon Sud and to establish her own team in the field of oncoviruses and innate immunity. Sinead Miggin, graduated in Toxicology from Athlone Institute of Technology in 1994. She was awarded a PhD in Biochemistry which was undertaken at the Conway Institute, University College Dublin in 2000. She subsequently undertook a Postdoctoral Fellowship in Inflammation research at the Conway Institute (2000-2002) followed by a Senior Postdoctoral Fellowship at the Department of Biochemistry and Immunology, Trinity College Dublin, Ireland (2002-2006). She was appointed Lecturer in Immunology at the National University of Ireland Maynooth in 2006. Robson Coutinho-Silva, Associate Professor, Immunobiology Program, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Brazil Robson received his PhD in Biological Sciences at the Federal University of Rio de Janeiro (Brazil) in 1996, and his Post-Doctoral Fellowship at Royal Free and University College Medical School Londres (2000-2002). He is Associated Professor of Immunology and Physiology at Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, where he was Vice Director (2010-2013), and Coordinator of Immunobiology Program (2004-2006). He is head of the Immunophysiology lab, Vice-
president of Brazilian Purines Club, and President of science museum Espaço Ciência Viva. He has expertise innate immunity and purinergic signalling. Jerry Wells, Host-Microbe Interactomics - Wageningen, The Netherlands Sema Becerik, Ege University, Turkey Sema Becerik was graduated from Ankara University School of Dentistry, Turkey and obtained PhD Degree in periodontology from Ege University School of Dentistry, Turkey. She worked as a visiting fellow at NIDCR (Bethesda, MD, USA) on genetic basis of periodontal disease. She has been working as an associated professor at Ege University School of Dentistry Department of Periodontology. Her research focuses on pathogenezis of periodontitis, effects of hormonel changes on periodontium and drug induced gingival overgrowth. Adriano Boasso, obtained a BSc/MSc in Medical Biotechnology (2001) and a PhD in Molecular Medicine and Immunology (2005) from the University of Milan, Italy. In 2003 he moved to the National Cancer Institute (Bethesda, MD, USA) as a post-doctoral fellow. He joined Imperial College in 2008, initially under a Wellcome Trust Value in People award and subsequently as a Welcome Trust Research Career Development Fellow. His research focuses on the interaction between the human immunodeficiency virus (HIV) and the immune system, aiming at providing a comprehensive model of the pathogenic mechanisms which characterize HIV infection. Sanjay Batra, Southern University and A&M College, Baton Rouge, Louisiana, USA Dr. Sanjay Batra worked as Biochemist /In-charge of the Biochemistry Department at the prestigious Kalawati Saran Children’s Hospital, New Delhi, India (1993-2006). His work in the field of Clinical Biochemistry was awarded with The Regional Service Award at the 8th Asian Pacific Congress of Clinical Biochemistry, Kuala Lumpur, Malaysia in 1998 and Bursary Award at XVII International Congress of Clinical Chemistry and Laboratory Medicine (IFCC-World Lab), Firenze, Italy in 1999. His passion in research led him to emmigrate to the U.S. to pursue his advanced research career at The Ohio State University, Columbus, Ohio in 2006. Dr. Sanjay Batra joined Louisiana State University, Baton Rouge, Louisiana in 2009 and his overall goal was to investigate the role of intracellular pattern recognition receptors (NOD-like receptors -NLRs) during pulmonary bacterial infections and during COPD and Emphysema. During his tenure as a research track scientist, Dr. Batra developed several new independent projects which were funded intramurally or extramurally. His preliminary findings identified significant role of tyrosine phosphorylation and ubiquitination of receptor interacting protein (RIP-2); and of lipid rafts in regulating NLR mediated immune responses against Klebsiella pneumoniae. Dr. Batra recently joined Southern University and A&M College, Baton Rouge and his research focus includes continuous expansion of his projects which include determination of molecular mechanisms associated with Lipid rafts, immunoproteasomes, histone deacetylases and tyrosine kinases during pulmonary challenge with microbial toxins or secondhand smoke exposure. Elizabeth Brint, graduated with a BSc in Biochemistry from the University of Sussex, UK and a PhD from Trinity College Dublin. After post doctoral studies performed jointly between Trinity College Dublin and Xoma Ltd, she moved to UCC where she was a postdoctoral researcher in the Alimentary Pharmabiotic Centre and is now a lecturer in the Pathology Department. Her main research interests focus on innate immune signalling and regulation of innate immunity in the intestine and how these are altered in diseases such as inflammatory bowel diseases and colon cancer. Griffith Parks, is Professor and Chairman of the Department of Microbiology and Immunology at Wake Forest School of Medicine in Winston-Salem, North Carolina. He received his Ph.D. in Biochemistry at University of Wisconsin-Madison where he worked on proteolysis of the picornavirus polyprotein. As an American Cancer Society Fellow at Northwestern University, he focused on understanding the biosynthesis and structure of the paramyxo- and orthomyxovirus glycoproteins. His current research addresses the innate immune responses that are elicited by infections with paramyxoviruses and the bioterrorism agent Nipah virus.
Day 2 Katie Lacy, Consultant Dermatologist, Biomedical Research Centre/NIHR Clinical research consultant, Honorary Senior Lecturer KCL, UK Dr. Katie Lacy is a Consultant Dermatologist at the St. John’s Institute of Dermatology, Guys and St. Thomas’ Hospital, London. She has a specialist interest in melanoma and is currently the multidisciplinary team lead for the melanoma unit. Katie Lacy graduated from Pembroke College, Oxford University with a 1st class Honours degree. Having completed a PhD in Immunology at UCL, investigating the role of ageing on cutaneous immune responses, she is currently an Honorary Senior Lecturer at Kings College London. She has a research group investigating immune responses in melanoma with a particular focus on immunomodulation within the tumour microenvironment. Pietro Mastroeni is a Reader at the University of Cambridge.He obtained a Degree in Medicine and Surgery at the Univerisity of Messina, Italy prior to moving to the UK where he obtained a PhD at the Department of Pathology of the University of Cambridge and worked as a postdoctoral Fellow at Imperial College, London. His research has established several landmarks in the fields of pathogenesis of bacterial infections, immunity, immunoevasion and vaccine development. His research group is currently engaged in immunological and molecular approaches towards a global understanding of host pathogen interactions with a primary focus on immunity and vaccination. Manoury Bénédicte, French. Present position: DR2 (CNRS), " Présentation des antigènes: mécanismes et modulation par les récepteurs Toll-like ", Hôpital Necker, INSERM U1151, Paris, France. Education, 1993-1996: PhD thesis on "Antigen presentation in collagen induced arthritis" Université René Descartes, Paris V, Félicitations du jury, 1996-2003: post-doctoral position in the laboratory of Dr Colin Watts, University of Dundee, UK, 2009: HDR Université Paris V, René Descartes. Awards and fellowships, 1997-1998: EMBO long term Fellowship, 2003-2005: Avenir fellowship, 2004-2008: Medical price awarded by the city of Paris, 2011-2014: Prime d’Excellence Scientifique awarded by CNRS. The aim of our work is to investigate how intracellular Tolle like receptors are regulated in primary cells following bacterial and viral infection. Bénédicte Manoury is a french research director at the CNRS and is working on intracellular TLRs signaling in dendritic cells. Bénédicte Manoury's group has shown that TLR9 and TLR7 require proteolytic cleavage in the endosomes to be functional and that TLR7 processing is an important criterion for the immune response to influenza infection. Bénédicte Manoury's work now aims to further investigate how intracellular TLR trafficking and signaling are regulated but also the role of these TLRs and the molecules chaperones such as UNC93B1 in the MHC class I antigen cross presentation pathway. James D. Faix, Director of Chemistry & Immunology, Director of Point-of-Care Testing, Department of Pathology, Stanford University Medical Center, Stanford, USA Dr. Faix obtained his MD at Drexel University in Philadelphia, PA and performed his residency in Anatomic and Clinical Pathology at Massachusetts General Hospital in Boston, MA. He also completed a fellowship in Clinical Immunology there. He served as Director of Clinical Immunology and Associate Director of Clinical Chemistry at Beth Israel Hospital in Boston and as Director of the Clinical Laboratory at Joslin Diabetes Center in Boston before moving to Stanford University in 2001 where he is Director of Clinical Chemistry and Immunology and Clinical Professor of Pathology. Victoria Sanz-Moreno, Guy's Campus, King's College, London, United Kingdom Victoria Sanz Moreno holds a BSc in Chemistry and a Master Degree in Biochemistry (University of Oviedo). She undertook a PhD studying molecular pathways deregulated in cancer (University of Cantabria) and did a postdoctoral at the Institute of Cancer Research (ICR, London). Since 2011, Dr Victoria Sanz-Moreno is a Group leader in the Randall Division of Cell and Molecular Biophysics, King's College London. Victoria's group works on different aspects related to the complex metastatic process. Victoria has received numerous fellowships and prizes during her career, such as Cancer Research UK Career Development Fellowship Award, The Royal Society University Research Fellowship Award (she declined to accept CRUK), Applied Bio systems-EACR 40th Anniversary Research Award, Marie Curie Intra-European Post-doctoral Fellowship, Lady Tata Memorial Trust Post-doctoral Fellowship Award and the University of Cantabria Pre-doctoral Fellowship Award Stephen A Beers, Antibody and Vaccine Group, Faculty of Medicine, University of Southampton, UK Stephen Beers joined the Antibody and Vaccine Group in the Cancer Sciences Unit of the Faculty of Medicine in Southampton in 2002. His research group is interested in how antibodies work to result in
tumour regression. The research is currently focused on how the tumour microenvironment affects effector function and how this could be manipulated to enhance antibody efficacy in patients. Fabrice Cognasse: Our group largely addresses emerging topics that focus on inflammation. We work on the platelet belonging to the immune continuum in infectious and transfusion context. My group reported in 2005 the first evidence of the presence of certain toll-like receptors (TLRs) on human platelets. Some of his ongoing research themes include the role of platelets in innate immunity and infection and the role of the platelet CD40-CD40L interaction in transfusion. We considered platelets not as regard to their haemostatic role but to their inflammatory function. Platelets could act as immune sensors, recognizing pathogens and therefore releasing immunomodulatory molecules.
Day 3 Sunil Joshi is an outstanding young scientist, with an excellent education and background, and includes the unusual albeit valuable combination of a veterinary degree as well as a PhD degree. He is an established cellular immunologist and employing novel applications of bioelectrics in modulating innate immunity. Recently, he has established his own laboratory at the Frank Reidy Research Center for Bioelectrics which is newly created multidisciplinary advanced biomedical engineering center at Old Dominion University. His lab is also working to define molecular changes in the plasma membrane in response to various electrical functional waves. Sunil employes multi-dimentional approaches to address key issues in vaccinology particularly vaccination against Malaria and Tuberculosis. He has been awarded Bill & Melinda Gates Foundation Grad Challenge Exploration award to work on use of Bioelectrics in vaccination. Vinod Singh is working as an Associate Professor and Head of the Department of Microbiology at Barkatullah University,Bhopal,(M.P.)India and main thrust area are Immunomodulation against Infectious diseases and Inflammatory Diseases. He is also working on immunity of Oral Microbial Invasions and Herbak Drug Formulation againat Filarial worms since last 15 years. Claudia Monaco, Imperial College London, United Kingdom Claudia Monaco graduated from the Medical School at the Catholic University of Rome, Italy in 1994. She trained as a Cardiologist (1994-1998) with Professor Attilio Maseri in Rome. She relocated to the Kennedy Institute of Rheumatology in London, where she undertook her PhD studies (1998-2001). She was privileged to get involved in the field of inflammation in atherosclerosis when it was still in its infancy with the identification of a cytokine-dependent systemic inflammatory response in patients with acute coronary syndromes. Her research later on demonstrated that human atherosclerotic disease shares features of persistent or chronic inflammation with classic inflammatory diseases, including the dysregulated production of pro-inflammatory cytokines, and that such inflammation is dependent on the innate Toll-like receptors. Charles Mills discovered M1 and M2 Macrophages. M1 and M2 were specifically named such because they are T cell independent responses that are present throughout animal evolution. Even more important, M1 and M2 responses direct T cells in higher animals to make Th1 or Th2 like responses. This caused a sea change in our understanding of how immune responses occur. Macrophages do not need to be “activated” or “alternatively” activated by T cells. The Th1/Th2 paradigm is backward. Instead, Innate Immunity directs Adaptive Immunity. This revelation is stimulating whole new strategies for immunologic interventions in diseases from cancer to atherosclerosis.
Discussion Sessions The discussion sessions are an opportunity for informal questions and answers. This is an ideal opportunity to get advice and opinion from experts in this area. This session is not for questions about specific talks, which can be asked after the speakers session, but for discussing either general topics or specific issues.
Session breaks
All breaks and registrations will take place in the exhibition area where there will be lunch and refreshments. Please try to visit all the exhibition stands during this event. Not only do our sponsors enable Euroscicon to keep the registration fees competitive, but they are also here specifically to talk to you
Lunch
All the chicken in our lunch buffet is Halal We have a number of dishes that are gluten free We have a range of vegetarian dishes which are separated from the meat and fish dishes
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