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AbortusChromosomal Abnormalities
Denny Suwanto
Chromosome Abnormalities
• Numerical– Euploid---multiple of haploid number (N)– Aneuploid---trisomy or monosomy
• Structural
Milward,K. 2001. Genetics Disease
Nondisjunction Meiosis
Chromosome Numeric Anomalies
Trisomy 21
Aneuplody
Euplody
• 69,XXX• Dyandric• Dygynic
Structural Abnormalities
Chromosomal findings in early miscarriages
40% apparently normal
60% abnormal:Trisomy (47 chromosomes – one extra) 30%
45,X (45 chromosomes – one missing) 10%
Triploidy (69 chromosomes – three sets) 10%
Tetraploidy (92 chromosomes – four sets) 5%
Other chromosome anomalies 5%(e.g. structural anomalies)
National Genetics Education and Development centre, 2009
Effect of Chromosomal Abnormalities
• Preimplantation – Implantation Losses
• Simpson, J, Carson, S, Glob. libr. women's med.,(ISSN: 1756-2228) 2013; DOI 10.3843/GLOWM.10319