ABS Orange Polyphenols PBF

Tomorrow’s Vision… Today!®

Slimming + Antioxidant + Superfruit + Skin Toning

ABS Orange Polyphenols PBF

Technical Information:

Product Code: 16734

INCI Name: Water & Propylene Glycol & Citrus Aurantium Amara (Bitter Orange) Flower Extract

INCI Status: Conforms

Suggested Use Levels: 1.0–10.0%

Suggested Applications: Slimming, Antioxidant, Superfruit, Skin Toning

Natural + Efficacious + Trendy

Addresses:

Lack of natural slimming products

Need for brand differentiation

How:

Polyphenols found in bitter orange promote natural slimming

Branding shifts towards natural products and superfruits rather than typical caffeine and green tea

Traditional Natural Slimming Products

• Firm niche in the personal care market

• Appeals to a broad demographic

• Caffeine and green tea are typical ingredients

Benefits: Increase microcirculation Act as a diuretic Caffeine is lipolytic

Background

• Known as “fat”

• Loose connective tissue composed of adipocites

• Accumulates in the subcutaneous layer

• Provides insulation from heat and cold

• Factors that contribute to the build-up of superficial adipose tissue:- Diet- Hormones- Circulatory insufficiency- Stress- Structure of connective tissues

Adipose Tissue:

Background

Anatomy:

Superficial Fascial System (SFS):

• Connective tissue network extends from the sub-dermal plane to muscle fascia

• Composed of thin, horizontal membranous sheets separated by fat with interconnecting fibrous septae

ABS Orange Polyphenols PBF

Physiology:

• SFS encases, supports, and shapes fat while holding the skin onto the underlying tissue

• Skin-superficial fat-superficial fascial system relaxes and stretches over time which results in soft tissues and cellulite• Relaxation/Stretching is influenced by estrogen and progesterone• Estrogen increases the elastic texture of collagen fibers and contributes

to adipose build-up along the thighs and buttocks

• Adipose tissue becomes swollen as a result of poor circulation in the blood and lymph nodes

Bitter Orange

• Superfruit

• Classic component in teas, liquors, jellies, and fragrances

• Popular slimming ingredient used in dietary supplements

• Rich source of antioxidants• ABS Orange Polyphenols PBF is standardized for polyphenols

Polyphenols

Biological activity:

• Anti-inflammatory

• Vasodilator

• Reduces capillary fragility

• Antioxidant

Slimming Effect:Polyphenols help to minimize the appearance of adipose tissue

Modern Research

Understood to inhibit cAMP-phosphodiesterase (PDE)

cAMP mediates many different cell responses including the breakdown of glycogen and fat

Citrus polyphenols exhibit lipolyticproperties on adipocyte tissue

ABS Orange Polyphenols PBFin-vitro Efficacy Data

Preventing conversion is important:• High levels of cAMP are important

for maximizing lipolysis

• Measure conversion of cAMP to 5’-AMP by purified human phosphodiesterase III

• In vitro method using liquid scintillation quantification

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1.0% ABS OrangePolyphenols PBF

3.0% ABS OrangePolyphenols PBF

5.0% ABS OrangePolyphenols PBF

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Inhibition of Phosphodiesterase III Activity

Results• 1.0, 3.0 & 5.0% ABS Orange

Polyphenols PBF shown to inhibit PDE activity by 62, 92 and 98% respectively

• Indicates ABS Orange Polyphenols PBF is capable of improving lipolysis for slimming effects

Figure 1. ABS Orange Polyphenols PBF inhibits PDE activity and the level of inhibition is concentration dependent

ABS Orange Polyphenols PBF

Technical Information:

Product Code: 16734

INCI Name: Water & Propylene Glycol & Citrus Aurantium Amara (Bitter Orange) Flower Extract

INCI Status: Conforms

Suggested Use Levels: 1.0–10.0%

Suggested Applications: Slimming, Antioxidant, Superfruit, Skin Toning