ACQUITY UPLC EVAPORATIVE LIGHT SCATTERING DETECTOR See what you need—see it faster Take advantage of Waters’ expertise in both evaporative light scattering detection and technology for Ultra Performance LC ™ (UPLC ™ ). Adding a new dimension of performance and system versatility, the Waters ® ACQUITY UPLC ™ Evaporative Light Scattering (ELS) Detector has been specifically designed for applications, such as antibiotics, antivirals, biomolecules and natural products, where compounds have poor to no UV/Vis response and analytes that do not ionize well under mass spectrometry. To ensure dependable results, the ACQUITY UPLC ELS Detector has precise temperature control of the nebulization and desolvation processes. Its unique design allows the ACQUITY UPLC ELS Detector to provide maximum uptime, making it ideal for high throughput laboratories and open access environments. This detector interfaces with the ACQUITY UPLC System console for convenient instrument parameter access and control, and has a snap-in self-aligning lamp and nebulizer for optimized performance. The ACQUITY UPLC nebulizer covers the entire ACQUITY UPLC flow rate range, conveniently addressing the nebulization process and increasing the convenience of running samples under different conditions. For user convenience, this stackable ELS Detector has the same physical size as the ACQUITY UPLC Tunable UV (TUV) and Photodiode Array (PDA) Detectors, and does not require extra bench space for operation. The ACQUITY UPLC ELS Detector can be controlled by Waters’ market-leading informatics platforms, Empower ™ and MassLynx ™ Software. Waters ACQUITY UPLC System with the ELS, SQ and PDA Detectors.
Take advantage of Waters’ expertise in both evaporative light scattering detection and technology for Ultra Performance LC™ (UPLC™).
Adding a new dimension of performance and system versatility, the Waters® ACQUITY UPLC™ Evaporative Light Scattering (ELS) Detector has been specifically designed for applications, such as antibiotics, antivirals, biomolecules and natural products, where compounds have poor to no UV/Vis response and analytes that do not ionize well under mass spectrometry.
To ensure dependable results, the ACQUITY UPLC ELS Detector has precise temperature control of the nebulization and desolvation processes. Its unique design allows the ACQUITY UPLC ELS Detector to provide maximum uptime, making it ideal for high throughput laboratories and open access environments.
This detector interfaces with the ACQUITY UPLC System console for convenient instrument parameter access and control, and has a snap-in self-aligning lamp and nebulizer for optimized performance. The ACQUITY UPLC nebulizer covers the entire ACQUITY UPLC flow rate range, conveniently addressing the nebulization process and increasing the convenience of running samples under different conditions.
For user convenience, this stackable ELS Detector has the same physical size as the ACQUITY UPLC Tunable UV (TUV) and Photodiode Array (PDA) Detectors, and does not require extra bench space for operation.
The ACQUITY UPLC ELS Detector can be controlled by Waters’ market-leading informatics platforms, Empower™ and MassLynx™ Software.
Waters ACQUITY UPLC System with the ELS, SQ and PDA Detectors.
ELS Detector: More information per run
The ACQUITY UPLC ELS Detector enables users to see more information per chromatographic run. Evaporative light scattering technology allows the monitoring of compounds that do not have a UV/Vis response and do not ionize well in mass spectrometry. Therefore, this innovative detector can supplement other detectors. As an example of ACQUITY UPLC ELS Detector applicability, see Figure 1 where monitoring of key ingredients is carried out in the analysis of an extract of Ginko Biloba.
Figure 1. Ginko Biloba Ethyl Acetate Extract: Dual detection mode results using an ACQUITY UPLC System together with ACQUITY TUV and ELS Detectors. 1) Bilobalide 2) Ginkgolide J 3) Ginkgolide C 4) Ginkgolide A and 5) Ginkgolide B.
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70
ELS
TUV 254
Minute
TUV 254 nm
ELSD
ES+ TIC
90Seconds0
Figure 2. Triple detection of a mixture of pharmaceuticals highlights the value of each detector in this separation.
A suite of detectors for samples where some of the components lack chromophores or do not ionize well by mass spectrometry is key to the success of your laboratory. Figure 2 shows the triple detection results for a mixture of nine components, baselined resolved, within only 90 seconds.
Monitoring batches of product and carrying quality control of finished goods is intrinsic in pharmaceutical and chemical analysis laboratories and ACQUITY UPLC line of products is critical for the resolution, sensitivity and speed required in those environments. Figure 3 presents the ELS Detector trace for the analysis of three eye drop formulations that vary significantly in their composition.
Product A
Product B
Product C
Seconds0 90
Figure 3. ACQUITY UPLC ELS Detector trace for the analysis of three eye drop formulations.
