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Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by...

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Activation of an IL6 Inﬂammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya, Gwang-il Kim, April Davis, Fayaz Malik, N. Lynn Henry, Suthinee Ithimakin, Ahmed A. Quraishi, Nader Tawakkol, Rosemarie D'Angelo, Amanda K. Paulson, Susan Chung, Tahra Luther, Hayley J. Paholak, Suling Liu, Khaled A. Hassan, Qin Zen, Shawn G. Clouthier, Max S. Wicha Molecular Cell Volume 47, Issue 4, Pages 570-584 (August 2012) DOI: 10.1016/j.molcel.2012.06.014 Copyright © 2012 Elsevier Inc. Terms and Conditions

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Page 1: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

Hasan Korkaya, Gwang-il Kim, April Davis, Fayaz Malik, N. Lynn Henry, Suthinee Ithimakin, Ahmed A. Quraishi, Nader Tawakkol, Rosemarie D'Angelo, Amanda K. Paulson, Susan Chung, Tahra Luther, Hayley J. Paholak, Suling Liu, Khaled A. Hassan, Qin Zen,

Shawn G. Clouthier, Max S. Wicha

Molecular Cell Volume 47, Issue 4, Pages 570-584 (August 2012)

DOI: 10.1016/j.molcel.2012.06.014

Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 2: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 1

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 3: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 2

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 4: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 3

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 5: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 4

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 6: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 5

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 7: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 6

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 8: Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population Hasan Korkaya,

Figure 7

Molecular Cell 2012 47, 570-584DOI: (10.1016/j.molcel.2012.06.014) Copyright © 2012 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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