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INVITED SEMINARS AND MEETINGS

Dr. David J. BrennerInvited Speaker, International Conference on the F ratio as a Cytogenetic Marker,Hiroshima, February

Invited speaker, American Statistical Society Bi-annual Conference on Radiation &Health, San Diego, June

Invited Speaker, RSNA Annual Meeting, Chicago, December

Invited Speaker, ASTRO Annual Meeting, Orlando, October

Invited Speaker, “Transcatheter Cardiovacular Therapeutics” Washington, DC, October

Dr. Gloria CalafInvited speaker at Symposium of Physiology Research Society of Chile, Linares, Chile,April 5th, 1998

1998 Annual meeting of Radiation Research Society at Louisville, Kentucky, April.

Dr. Charles GeardMicroscopy and Microanalysis, Cleveland OH., August 10-14

Chemical Pathology Study Section, Chevy Chase MD, October 15-17

Maxwell Abramson Basic Science Course in Otolaryngology New York Academy ofMedicine, NY, October 21

29th Annual Meeting of the Environmental Mutagen Society, Anaheim, CA, March 21-26

National Cancer Institute Contractors Meeting Chernobyl Leukemia Study, Kiev,Ukraine, February 7-13

89th Annual Meeting of the American Association for Cancer Research, New Orleans,LA, March 28-April 1

46th Annual Meeting of the Radiation Research Society, Louisville, KY, April 25-29

NASA Johnston Space Center Facilities Review, Houston, TX, February 26-28

34th Annual Meeting of the National Council on Radiological Protection, Arlington, VA,April 1-2

NASA Space Radiation Research Workshop, Loma Linda, CA, June 14-17

Dr. Eric J. HallReview Course, University of Tennessee at Memphis, TN July 1997

NCRP Board of Directors, Bethesda, MD, July 1997

International Microdosimetry Meeting, Oxford, UK, September 1997

Invited Seminar, Duke University, Durham, North Carolina, October 1997

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ASTRO Annual Meeting , Orlando, FL, October 1997

1997 Yuhas Lecturer, University of Pennsylvania, PA, October 1997

NCRP SC1-6 Committee Meeting, Bethesda, MD, October 1997

National Academy of Sciences, BEIR IV Meeting, November 1997

Invited Seminar, International Conference on Low Doses of Ionizing Radiation –Biological Effects of Regulatory Control, IAEA, WHO and UNSCEAR, Seville,Spain,November 1997

RSNA Annual Meeting, Chicago, IL, December 1997

NCRP Committee SC-1, San Francisco, CA, December 1997

NCRP Board of Directors, San Francisco, CA, December 1997

Tenth International Conference on Chemical Modifiers of Cancer Treatment, Clearwater,Fl, January 1998

American Board of Radiology Test Writing Committee, San Antonio, TX, February1998

BEIR VI Committee, National Academy of Sciences, Washington, DC, January 1997

University of Florida Research Seminar Series, Gainesville & Orlando, FL, February1997

Advances in Cardiovascular Radiation Therapy II Symposium, Washington, D.C., March1998

1998 Lauriston S. Taylor Lecturer, Arlington, VA, April 1998

Radiation Research Society Annual Meeting, Louisville, KY, April 1998

American Radium Society Annual Meeting, Monte Carlo, France, May 1998

Invited Lecturer, Umeå University, Sweden, May 1998

Dr. Haiying Hang46th Annual Meeting of the Radiation Research Society, Louisville, KY, April 1988

Dr. Tom K. HeiAnnual meeting of the American Association for Cancer Research, New Orleans, LA.,

March, 1998

Annual meeting of the Radiation Research Society, Louisville, Ky., April, 1998

Invited seminar- Department of Medicine, University of Louisville, Ky., April, 1998

Invited meeting- International Workshop on Responses to Heavy Particles Irradiation.

Chiba, Japan, July, 1998

Invited meeting- International Congress of the Committee on Space Research, Nagoya,

Japan, July, 1998.

Invited seminar- Division of Radiation Biology, Faculty of Pharmaceutical Sciences,

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Nagasaki University, Japan, July, 1998.

Invited seminar-Departrnent of cell Biology, Okayama University Medical School,

Okayama, Japan, July, 1998.

Invited seminar- Research Institute for Radiation Biology & Medicine, Hiroshima

University, Japan, July, 1998.

Invited seminar- Department of Biochemistry, Chinese University of Hong Kong, August,1998.

Invited seminar- Institute of Radiation Medicine, Chinese Academy of Sciences, Beijing,China, August, 1998.

Invited seminar- Laboratory of Industrial Hygiene, Beijing, China, August, 1998.

Invited seminar- Laboratory of Rice Genetics, Anhui Agricultural University, Anhiu,China, August, 1998

Invited seminar- Department of Ion Beain Bioengineering, Chinese Academy of Sciences,Hefei, China, August, 1998.

Dr. Howard B. LiebermanRadiation Research Society Annual Meeting

Department of Energy, Environmental Management Science Program Workshop

Mr. Steve Marino46th Annual Meeting of the Radiation Research Society, Louisville, Kentucky, May 1998

Dr. Richard C. MillerInvited speaker, Dept. of Radiation Oncology, Cleveland Clinic, Cleveland, OH, 1997

Invited speaker, Dept. of Radiation Oncology, St. Barnabas Medical Center, NJ, Sept.,Oct and Nov, 1997

Invited speaker, Dept. of Radiation Oncology, Univ. of Alabama, Birmingham, AL, 1998

The International Bioelectromagnetics Conference in Bologna, Italy, 1997

Annual Bioelectromagnetics Society meeting, Tampa, Florida, 1998

Radiation Research Society, Louisville, Ky, 1998

COSPAR 98, Nagoya, Japan, July, 1998

Satellite Meeting to COSPAR, Chiba, Japan, July 1998

Dr. Tej K. PanditaInvited speaker at International Symposium on Ataxia-telangiectasia and ATM:Functional, Genetic and Clinical Ramifications. Baltimore, Maryland, USA August 8-10,1997.

Invited speaker at Affymetrix, San Francisco, CA, Feb 1997

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Invited speaker at International Center for Genetic Engineering and Biotechnology, NewDelhi, Delhi, 1997.

Invited speaker at Regional Research Laboratory, Jammu, India, 1997.

Invited speaker at The Third Meeting of the New York Human Genetics Club, New York,1997.

1998 Annual meeting of AACR at San Diego, CA

Dr. Gerhard Randers-Pehrson46th Annual Meeting of the Radiation Research Society, Louisville, KY, April 1998

Dr. Lubomir SmilenovAnnual meeting of the American Association for Cancer Research, New Orleans, LA,March 1998

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PROFESSIONAL ACTIVITIES

Dr. David J. BrennerMember:

Joint Taskforce on Vascular Radiation Therapy

NCRP

NAS BEIR VI Committee on radon risks

NCRP Committee 1-6 on Risk Linearity

Radiation Research Society Program Committee

American Statistical Association Program Committee.

Chairperson, Columbia University Radiation Safety Committee

Dr. Gloria CalafMember:

The New York Academy of Sciences

International Association for Breast Cancer Research

American Association for Cancer Research, USA

Tissue Culture Association, USA

Cancer Research Society, Chile

Cytology Society, Chile

Experimental Biology and Medicine Society, Chile

Society of Mastology of Chile

Society of Biology of Chile

Radiation Research Society, USA

Dr. Charles GeardMember:

American Society of Therapeutic Radiology and Oncology (ASTRO)

Environmental Mutagen Society

Radiation Research Society

Advisory Committee on Radiobiology of the Brookhaven National Laboratory

Associate Member of the Radiobiology Advisory Team (AMRAT) of the Armed ForcesRadiobiology Research Institute (AFRRI)

Columbia University, Faculty Council (Voting Member)

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Editorial Work:

Editorial Board of the International Journal of Radiation Biology.

Reviewer:

International Journal of Radiation Oncology, Biology and Physics

Radiotherapy and Oncology

British Journal of Cancer

Clinical Cancer Research, Mutagenesis

Mutation Research

Radiation Research

Ad Hoc Reviewer of Grant Proposals for the American Cancer Society and the NationalInstitutes of Health

Dr. Haiying HangMember:

Radiation Research Society

Dr. Eric Hall Member:

American Board of Radiology

Radiotherapeutic Written-Test Committee

National Academy of Science:

Member of BEIR VI

American Society of Therapeutic Radiology and Oncology (ASTRO)

Radiation Research Society

International Stereotactic Radiosurgery Society:

Member of the Board

American Radium Society:

Secretary

Program Committee Chairman

International Association of Radiation Research

President elect

Columbia University, College of Physicians & Surgeons:

Cancer Center, Internal Advisory Committee/Executive Committee

Columbia-Presbyterian Medical Center:

Chairman, Joint Radiation Safety Committee

Chairman, Radioactive Drug Research Committee

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National Council on Radiation Protection and Measurements:

Member of the Board

Member of Council

Member, Committee 1

Member, Committee 1-6

Editorial Work:

International Journal of Radiation Oncology Biology Physics

International Journal of Brachytherapy

Dr. Tom K. HeiAdjunct Faculty:

Adjunct Faculty, Departmental of Radiological Health Sciences, Colorado State

University, Fort Collins, Colorado

Adjunct Professor, Department of Ion Beam Bioengineering, Chinese Academy of

Sciences, Hefei, China.

Member:

Permanent Member, Chemical Pathology Study Section, 1998- present

Chairman, Ad hoc review panel, Chemical Pathology Study Section, 1998

Radiation Research Society

American Association for Cancer Research

Environmental Mutagen Society

Mentor:

Ph.D. degree student of the Department of Ion Beam Bioengineering, Chinese

Academy of Sciences, China.

Master degree student of Environmental Heath Sciences, Columbia University School ofPublic Health.

Undergraduate Internship students from Marymount College, New York.

Reviewer:

British Journal of Cancer

Cancer Research

Carcinogenesis

Cancer Letters

Occupational and Environmental Medicine

ICRERTT Fellowship- International Union Agai st Cancer

Research Grant Council- Government of Hong Kong

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NIH Molecular Biology Special Review Panel on Small Business Innovative Grants

Dr. Howard B. LiebermanChairman, NIH Radiation Study Section

Reviewer:

Fonds zur F”rderung der wissenschaftlichen Forschung, Vienna

Biotechniques

Radiation Research

Member:

Advisory Board, Summer Research Program for NYC Secondary School ScienceTeachers, Columbia University

American Association for the Advancement of Science

American Society for Microbiology

Environmental Mutagen Society

Genetics Society of America

Radiation Research Society

Elected Biology Councilor

Sigma Xi

Theobald Smith Society

Dr. Richard C. MillerMember:

Radiation Research Society

Associate Member, American Society of Therapeutic Radiology and Oncology (ASTRO)

Reviewer:

Radiation Research

International Journal of Radiation Biology

Mutation Research

Guest Scientist:

Brookhaven National Laboratories (BNL), Upton, NY

St. Barnabas Medical Center, Dept. of Radiation Oncology, Livingston, NJ

Mr. Steve MarinoMember:

Columbia University Radiation Safety Committee

Radiation Research Society

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Sigma Xi

Guest Scientist:

Brookhaven National Laboratories, Upton, NY

Dr. Tej K. PanditaMember:

NIH Study section

American Association for the Advancement of Science.

American Association of Cancer Research.

Radiation Research Society

The American Society for Cell Biology

Reviewer:

Proceedings of National Academy of Science, USA.

Radiation Research

Mutation Research

Oncogene

Clinical Cancer Research

Cytogenetics and Cell Genetics

Cancer Research

Oncology Reports

FASEB Journal

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THE COLUMBIA COLLOQUIUM AND LABORATORY SEMINARS

At intervals of approximately one month during the academic year, a regular colloquium hasbeen held to discuss ongoing research. Dr. Tej Pandita organized them and scheduled thespeakers. These have been attended by the professional staff, graduate students, and seniortechnical staff of this Laboratory and RARAF, as well as scientists from other departments ofthe College of Physicians & Surgeons interested in collaborative research. Attention hasfocused on recent findings and future plans, with special emphasis on the inter-disciplinarynature of our research effort.

During the year, we have been pleased to welcome a number of visitors who have presentedformal seminars and/or spent time discussing ongoing research with various members of theLaboratory. These have included Drs. Masao S. Sasaki, Kyoto University, Kyoto, Japan,William Morgan, University of California, SF, CA, Robert Ullrich, University of Texas atGalveston, Texas, Don Chapman, Fox Chase Cancer Center, PA, Gayle Woloschak, ArgonneNational Laboratory, Argonne, IL, Vilhelm A. Bohr, National Institute of Health, MD, SurajBhat, UCLA School of Medicine, Los Angeles, CA, Andrew J. Grosovsky, University ofCalifornia, (Riverside), Freddy Joel Hendler, University of Louisville, Juliana Denekamp,Umeå University, Sweden, Martin Jonas, Cambridge, University, U.K., Jai Parkash,Haverford College, Haverford, PA, Simon J. Hall, Institute of Gene Therapy and MolecularMedicine, The Mount Sinai Medical Center, NY, Harry Scherthan, University ofKaiserlautern, Germany.

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PUBLICATIONS

Azziz, N., Ranogajec-Komor, M., Marino, S.A., Klemic, G.A. and Osvay, M. Fast neutrondetection using aluminum oxide TLDs. In Proc. of the IRPA Regional Symposium onRadiation Protection in Neighboring Countries of Central Europe (J. Sabol, Ed.) pp.495-497, Prague, Czech Republic (1997).

Brenner D.J., Sachs RK, The mechanistic basis of the linear-quadratic formalism. Med. Phys.25:2071-3 (1998).

Brenner D.J., Zaider M, Estimating RBEs at clinical doses from microdosimetric spectra.Med. Phys.25:1055-7 (1998).

Brenner, D.J., and Herbert, D. E. The use of the linear-quadratic model in clinical radiationoncology can be defended on the basis of empirical evidence and theoreticalargument. Med. Phys. 24, 1245-1248 (1997)

Brenner, D.J., Radiation biology in brachytherapy. J. Surg. Oncol. 65, 66-70 (1997).

Brenner, D.J., Armour, E., Corry, P. and Hall, E.J., Sublethal damage repair times for a late-responding tissue relevant to brachytherapy (and external beam radiotherapy):implications for new brachytherapy protocols. Int. J. Radiat. Oncol. Biol. Phys. 41,135-138 (1998).

Brenner, D.J., Hlatky, L.R., Hahnfeldt, P.J. Huang, Y., and Sachs, R.K., The linear-quadraticand other common radiobiological models all predict similar time-dose relationships.Radiat. Res. 150, 83-91 (1998)

Brenner, D.J., Lubin, J.H., and Ron, E. Moving from under the lamppost: Canepidemiologists and radiobiologists work together? Nucl. Energ. 36, 1-7 (1997)

Brenner, D.J., Schiff, P.B., Huang, Y. and Hall, E.J. Pulsed dose-rate (PDR) brachytherapy:Design of convenient (daytime only) schedules. Int. J. Radiat. Oncol. Biol. Phys. 39,809-815 (1997)

Chen, C.-Z., Huang, Y., Hall, E.J., and Brenner, D.J. Pulsed brachytherapy as a substitute forcontinuous low dose-rate: an in vitro study with human carcinoma cells. Int. J. Radiat.Oncol. Biol. Phys. 37, 137-43 (1997).

Davey, S., C.S. Han, S.A. Ramer, J.C. Klassen, A. Jacobson, A. Eisenberger, K.M. Hopkins,H.B. Lieberman, and G.A. Freyer. Fission yeast rad12+ gene regulates cell cyclecheckpoint control and is homologous to the Bloom's syndrome disease gene. Mol.Cell. Biol. 18:2721-2728 (1998).

Geard, C. R., Randers Pehrson, G., Hei, T. K., Jenkins, G. J., Miller, R. C., Wu, L. J.,Brenner, D. J. and Hall, E. J. Microbeam mediated cellular effects: Single alphaparticle induced chromosomal damage, cell cycle delay, mutation and oncogenictransformation. In: Microdosimetry, An interdisciplinary approach, Eds. Goodhead,D.T., O’Neill, P. and Menzel, H. G., pp327-330 (1997).

Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, Sawant SG, Pandita TK, Apreliminary report: frequency of A-T heterozygotes among prostate cancer patientswith severe late responses to radiation therapy. Cancer J. Sci. Am.4:385-9 (1998).

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Hall, E. J., From chimney sweeps to astronauts: cancer risks in the work place: The 1998Lauriston Taylor Lecture. Health Physics 75:357-366 (1998).

Hall, E.J. and Brenner, D.J. Pulsed dose-rate brachytherapy (editorial). Radiotherapy &Oncology 45:1-2, 1997.Hall, E. J., Molecular mechanisms of radiation effects:Pointand clastogenic mutations. Low doses of ionizing Radiation; biological and regulatorycontrol. Proceedings of an International Conference on low doses of ionizingradiation. Internation Atomic Energy Agency, Vienna (1998).

Hall, E.J. and Brenner, D.J., Pulsed dose-rate brachytherapy. Radiother. Oncol. 45, 1-2(1997).

Hall, E.J. What will molecular biology contribute to our understanding of radiation-inducedcell killing and carcinogenesis? Int. J. Radiat. Biol. 71, No. 6, 667-674 (1997).

Hall, E.J., In Memoriam, Gerald E. Adams (1930-1998). Radiat. Res. 150:706-707 (1998).

Hang, H., S. J. Rauth, K.M. Hopkins, S.K. Davey, and H.B. Lieberman. Molecular cloningand tissue-specific expression of Mrad9, a murine orthologue of theSchizosaccharomyces pombe rad9+ checkpoint control gene. J. Cell. Physiol.177:232-240 (1998).

Hei, T.K., Liu, S.X., and Waldren, C.A., Mutagenicity of arsenic in mammalian cells: Role ofreactive oxygen species. Proc. Natl. Acad Sci., 95: 8103-8107 (1998).

Hei, T.K., Piao, C.Q., Wu, L.X., Willey, J.C., and Hall, E.J., Genomic instability andtumorigenic induction in immortalized human bronchial epithelial cells by heavy ions.Advances in Space Research (in press)

Hei, T.K., Wu, L.J., and Piao, C.Q. Malignant transformation of immortalized humanbronchial epithelial cells by asbestos fibers. Environmental Health Perspective, 105:1085-1089 (1997).

Johnson, K.L., Brenner, D.J., Nath, J., Tucker, J.D. and Geard, C.R., Radiation-inducedbreakpoint misrejoining in human chromosomes: random or non-random?. Int. J.Radiat. Biol. , in press

Kharbanda S., Pandey P., Morris P.L., Whang Y., Xu Y., Sawant S., Zhu L., Kumar N., YuanZ, Weichselbaum R., Sawyers C.L., Pandita T.K. and Kufe D. Functional role for thec-Abl tyrosine kinase meiosis. Oncogene 16: 1773-1777 (1998).

Lindgren, A. L., Riley, E. F., Miller, R. C. and Ainsworth, J. Comparison of recovery fromGo/G1 arrest in lens epithelial cells after X, neutron, and 56Fe irradiations.Submitted for publication (1997).

Miller, R. C. LaNasa, P. and Hanson, W. R. Misoprostol: a potent cytotoxic and oncogenicradioprotector. Adv. Exp. Med. Biol. 400B, 861-864 (1997).

Miller, R. C., Marino, S. A., Brenner, D. J., Napoli, J., Shah, H., Hall, E. J. and Geard C. R.Oncogenic transformation by low-energy neutrons. (In Press 1998).

Morgan S.E., Lovly C., Pandita T.K., Shiloh Y., and Kastan M.BFragments of ATM whichhave dominant-negative or complementing activity. Molecular Cell Biology 17: 2020-2029 (1997).

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Obelic, B., Srdoc, D., Djuric, P. M. and Marino, S. A. The frequency distribution of thenumber of ion pairs in irradiated tissue. Radiat. Res. 149, 411-415 (1998).

Okayasu, R., Wu, L.J., and Hei, T.K., Biological effects of naturally occurring and manmadefibers: in vitro cytotoxicity and mutagenesis in mammalian cells. British J Cancer (inpress)

Pandita T.K., Benvenuto J.A., Pandita R.K., Rakovitch E., Geard C.R., Antman K.H. andNewman R.A. Effect of penclomedine (NSC-338720) on telomere fusions, chromatinblebbing, and cell viability with and without telomerase activity and abrogated p53function. Biochem. Pharm. 53: 409-415 (1997).

Rakovitch E., Mellado W., Hall E.J., Sawant S.G., Geard C.G., Newman R.N.,and PanditaT.K. Penclomedine-induced DNA fragmentation and p53 accumulation correlateswith reproductive cell death in colorectal carcinoma cells with different status of p53.Oncology Reports (in press 1998).

Randers-Pehrson, G. and Brenner, D.J., A practical target system for accelerator-based BNCTwhich may effectively double the dose rate. Med Phys. 25, 894-6. (1998).

Sachs RK, Brenner D.J., Hahnfeldt PJ, Hlatky LR, A formalism for analysing large-scaleclustering of radiation-induced breaks along chromosomes. Int. J. Radiat. Biol.74:185-206 (1998).

Sachs, R. K., Brenner, D. J., Chen, A. M., Hahnfeldt, P. and Hlatky, L.R. Intra-arm andinterarm chromosome interchanges: tools for probing the geometry and dynamics ofchromatin. Radiat. Res. 148, 330-340 (1997).

Sachs, R.K., Chen, A.M., and Brenner, D.J. Review: Proximity effects in the production ofchromosome aberrations by ionizing radiation. Int. J. Radiat. Biol. 71, 1-19 (1997).

Sachs, R.K., Hahnfeld, P, and Brenner, D.J., The link between low-LET dose-responserelations and the underlying kinetics of damage production/repair/misrepair. Int. J.Radiat. Biol. 72, 351-374 (1997)

Sawant S., Antonacci R. and Pandita T.K. Determination of telomerase activity in HeLa cellsafter treatment with ionizing radiation by Telomerase PCR ELISA. Biochemica 4: 22-24 (1997).

Smilenov L.B., Mellado W., Roa P.H., Umbricht C.B., Sukumar S., and Pandita T.K.Cloning and chromosomal localization of Chinese hamster telomeric protein cTRF1.A potential role in chromosomal instability. Oncogene. 17 : 2137-2142 (1998).

Smilenov L.B., Morgan S.E., Mellado W., Sawant S.G., Kastan M.B. and Pandita T.K.,Influence of ATM function on telomere metabolism. Oncogene 15: 2659-2666(1997).

Tsui L.V., Ramagli L.S., Gao C., Pham C.D., Pandita T.K., Arlinghaus R.B. and Singh B.The biological effects of antisense mos expression in fibroblasts. InternationalJournal Of Oncology 11:1171-1178 (1997).

Waldren, C., Vannais, D., Drabek, R., Gustafson, D., Kraemer, S., Lenarczek, M.,Kronenberg, A., Hei, T.K., and Ueno, A., Analysis of mutant quantity and quality in

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human hamster hybrid AL cand AL-179 cells exposed to gamma-rays and HZE-FEions. Advances in Space Research (1997, in press).

Weaver, D.A., Hei, T.K., Hukku, B., McRaven, J.A. M., and Willey, J.A., Cytogenetic andmolecular genetic analysis of tumorigenic human bronchial epithelial cells induced byradon alpha particles. Carcinogenesis 18: 1251-1258, 1997.

Wei-W-Z., Pauley, R., Lichlyter, D., Soule, H., Shi, W-P., Calaf, G., Russo, J., Jones, R. F.Neoplastic progression of breast epithelial cells: a molecular analysis. Br. J. Cancer78:198-204, 1998.