ADVANCED NON-INVASIVE TECHNIQUES IN EARLY DETECTION OF ORAL CANCER
PRESENTED BY: Abhishek Ghosh
3rd prof. B.D.S.Dr.R.Ahmed Dental
college &HospitalGUIDED BY:
Dr. Jay Gopal RayH.O.D.
Dept. Of Oral & Maxillofacial
Pathology
ORAL CANCER : SOME DEADLY STATISTICS• Every hour 1 American dies of oral cancer
• Death rate is higher than cervical cancer
• 25%cases have no risk factor
IMPORTANCE OF EARLY DETECTION
70% cases are diagnosed in late stagesIt leads to 5 year survival rate of 57% patientsOral cancer is 90% curable when detected early
Why non-invasive techniques?• Painless and bloodless technique
• Biopsy is not possible in screening examination
• Helpful for follow-up cases
• Easy and simple for operator
• Patient’s medical status is fragile for biopsy• Patient refuses for biopsy
EXFOLIATIVE CYTOLOGYIt is the histo-
pathological examination of
cells obtained by their physical
removal,followed by placement on glass-slide and
then appropriately stained.
Preparation of ‘Pap-smear’
VIZILITESimple painless non-invasive technology to visualize suspicious areas at earlier stages what we may not see by naked eyes .It’s based on the principle of CHEMILUMINESCENCE
ACTION OF VIZILITEUnder vizilite
normal healthy tissue will
absorb light & appear dark.
Abnormal tissue will
appear white.
HOW VIZILITE WORKS?Mouth
rinse
• Removes mucosal glycoprotei-n
• Increase N-C ratio
Light
stick
• Differentia-te between normal & abnormal tissue
STEPSEncourage the
patient after routine exam
Rinse with 1%acetic acid for 30-60 sec
Bend outer light stick breaking
inner vial
Shake vigorously to mix content of
light stick
Insert it into open end of retractor &
assemble
Make the room dark & re-examine the oral cavity with vizilite
Intra-oral vital
stainingWith Toluidine blue helps to identify dysplastic and malignant mucous membrane in the oral cavity.
STEPSDrying of mucosa with gauge
Mouth rinse with 1% T-blue for 1-2 min
1 min rinse with 1% acetic acid for decolourisation
Maligna-nt cells have more metaboli-c rate
They retain the stain
Normal mucosa decolou-rises
VIZILITE &TOLUIDINE BLUEVIZI-LITE
T-BLUE
SITE
FOR BIOPSY
IR THERMOGRAPHYIt uses the heat of
our body to aid in making diagnosis.It is completely safe and uses no radiation.
2 parts-1.IR CAMERA
2.HIGH RESOLUTION COMPUTER
MECHANISMDetection of breast cancer
Use in oral cancer –on way
Malignant tissue has more vascularity
Raised surface temperature
Detected by thermograph
ADJUNCT TO SURGICAL BIOPSY
Confirm diagnosis
Biopsy
Visual examinati-on
Screening
CONCLUSIONThese screening
techniques help in early detection of malignancy with an accuracy of 90 % and thus
%
THANK YOU