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Advanced Software Features for the LA-950 Particle Size Analyzer

Date post: 18-Nov-2014
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Ian Treviranus from HORIBA Scientific (www.horiba.com/particle) provides short overviews of several software features in the LA-950 Particle Size Analyzer. The software contains many software functions to improve how users make measurements, analyze measurements, and then verify the quality of the measurements. The following functions are covered in this webinar: Method Expert & Navigator for one-button operation, Automatic refractive index optimization, Intensity Graph, Multimodal Report, Automated COV calculation, and much more.
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© 2012 HORIBA, Ltd. All rights reserved. Advanced Software Features for the LA-950 Ian Treviranus [email protected] www.horiba.com/us/particle
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Page 1: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Advanced Software Features for the LA-950

Ian [email protected]/us/particle

Page 2: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

What we’ll talk about

Measurement tools

Data analysis tools

Data verification tools

Q&A

Page 3: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

One-button Measurement

Use the Navigator or Method Expert to create Sequence (.seq) filesManual: NavigatorAuto: Method Expert

Page 4: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

LA-950 Method Expert

Unique guided method developmentOptimize parameters Choose the best refractive index Create “one button” SOPsWebinar TE004 for Method Expert

Page 5: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Collecting and Calculating

The LA-950 hardware collects scattered light data

The LA-950 software calculates the particle size distribution using that scattered light data

Both must be optimized to maximize data quality

Page 6: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

LA-950 Method Expert

Page 7: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Method Expert Hardware

There are four important tests…

CirculationConcentration

DispersionDuration

Page 8: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

There are two important tests…

Real RIImaginary RI

Method Expert Calculation

Page 9: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Why is the test important?What does the test do?How will the results be displayed?What is the best value?

User selects up to 5 values for testing

LA-950 Method Expert

Page 10: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Method Expert guides user to prepare the LA-950 for each test

Results displayed in multiple formats: PSD, D50, R-parameter

LA-950 Method Expert

Page 11: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

LA-950 Method Expert

Page 12: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

LA-950 Method Expert

Page 13: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Dry Measurement

Method Expert currently wet onlyUse “Auto Measurement” for dryWebinar TE016: Optimizing Dry

Powder Measurements

Page 14: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Navigator

LA Navigator function creates Sequence programs to operate the LA-950Maximum flexibility

Page 15: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Navigator

Page 16: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Navigator

Page 17: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automatic Dilution

Concentration controlAdds dispersant, drains, repeat Is not possible without fill pump

Page 18: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automatic Dilution

Page 19: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

What we’ll talk about

Measurement tools

Data analysis tools

Data verification tools

Q&A

Page 20: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Refractive Index

Many, many resources on websiteWebinar TR009: Optimization of RI

Page 21: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Manually Changing RI

Page 22: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Manually Changing RI

Page 23: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Manual Optimization

Page 24: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automated RI ComputationReal part studyNeed to fix imaginary partSet up to 5 real partsSoftware will compute all RI and display R parameter

variation with RI selection

Page 25: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automated RI Computation

Page 26: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automated RI Computation

Page 27: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automated RI Computation Imaginary part studyNeed to fix real partSet up to 5 imaginary partsSoftware will compute all RI and display R parameter

variation with RI selection

Page 28: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automated RI Computation

Imaginary study

Page 29: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Error Calculations

yi The measured scattered light at each channel (i) of the detector.y (xi) The calculated scattered light at each channel (i) of the detector based on the chosen refractive index kernel and

reported particle size distribution.i The standard deviation of the scattered light intensity at each channel (i) of the detector. A larger i indicates lower

reliability of the signal on a given detector.N The number of detectors used for the calculation

Figure 3

Emulsion Sample

Page 30: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Multimodal Report

Hard to use full-distribution metrics to describe multimodal results

D10 D50 D90

Are these meaningful?

Page 31: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Multimodal Report

Page 32: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Multimodal Report

Deconvolute distribution into components

Page 33: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Multimodal Report

Statistics for each distribution mode

Better understanding of entire distribution

Page 34: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Intensity Graph

Diffraction analyzer measures light scattering pattern, algorithm transforms this into a particle size distribution

Page 35: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

LARGE PARTICLE: Low angle scatter Large signal

SMALL PARTICLE: High Angle Scatter Small Signal

Wide Pattern - Low intensity

Narrow Pattern - High intensity

Size affects intensity

Page 36: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Intensity Graph

Page 37: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Intensity Graph

One way to use the Intensity GraphTwo results, one good and one bad

Page 38: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Intensity Graph

Not Passing

Passing

Low AngleLarge Particle

High AngleSmall Particle

Page 39: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Blank Check

Need to explain difference in scatteringTry other tools, i.e. Blank Check

Page 40: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Blank Check

Page 41: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Custom Calculations

Page 42: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

What we’ll talk about

Measurement tools

Data analysis tools

Data verification tools

Q&A

Page 43: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automate COV Calculation

Coefficient of Variation indicates precision of multiple measurements ISO 13320 and USP <429> make

recommendations using COV

Page 44: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automate COV Calculation

Page 45: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Automate COV Calculation

Page 46: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Result Verification

Page 47: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

What we’ll talk about

Measurement tools

Data analysis tools

Data verification tools

Q&A

Page 48: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

Danke

Gracias

Большое спасибо

GrazieاُشْكرΣας ευχαριστούμε

감사합니다Obrigado

Tacka dig

谢谢ขอบคุณครับ

ありがとうございました

ध यवादநன்ற

Page 49: Advanced Software Features for the LA-950 Particle Size Analyzer

© 2012 HORIBA, Ltd. All rights reserved.

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