Advances in Biochemical Current Topics in Microbiology ... · Vectors to Tease Apart the Neural...

News 7/2013 Biomedicine

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Advances in Biochemical Engineering/BiotechnologySeries Editors: T. Scheper, I. Endo, B. Mattiasson, Editorial board: K. Schügerl, G. N. Stephanopoulos, Ministry of Education, W. S. Hu, J. Nielsen, R. Ulber, P. M. Doran, M. B. Gu, S. Belkin, A.‑P. Zeng, W. Zhou, J.‑J. Zhong

Volume 1192

P. M. Doran, Swinburne University of Technology, Hawthorn, Australia (Ed)

Biotechnology of Hairy Root SystemsVictor P. Bulgakov, Yuri N. Shkryl, Galina N.

Features 7 Covers trends in modern biotechnology 7 All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer sci-ence, are treated 7 More information as well as the electronic version available at springer.com

Contents Recent Advances in the Understanding of Agro-bacterium rhizogenes-Derived Genes and Their Effects on Stress Resistance and Plant Metabo-lism.- Perspectives of the Metabolic Engineering of Terpenoid Indole Alkaloids in Catharanthus roseus Hairy Roots.- Effective Elicitors and Pro-cess Strategies for Enhancement of Secondary Me-tabolite Production in Hairy Root Cultures.- Hairy Root Culture: Bioreactor Design and Process Intensification.- Hairy Roots as a Vaccine Produc-tion and Delivery System.- Metal Uptake and Nanoparticle Synthesis in Hairy Root Cultures.

Fields of interestVaccine; Biotechnology; Plant Genetics & Genom-ics

Target groupsResearch

Product categoryReviews

Due October 2013

2013. Approx. 200 p. Hardcover7 approx. $259.00ISBN 978-3-642-39018-0

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Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, F. Melchers, Series Editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Y. Gleba, B. Malissen, Y. Kawaoka, K. Aktories, R. Rappuoli, J. E. Galan

Volume 372

L. J. Anderson, Emory Children’s Center, Atlanta, GA, USA; B. S. Graham, Vaccine Research Center, Bethesda, MD, USA (Eds)

Challenges and Opportunities for Respiratory Syncytial Virus VaccinesContents Respiratory Syncytial Virus: Virology, Reverse Ge-netics, and Pathogenesis of Disease.- Clinical and Epidemiologic Features of Respiratory Syncytial Virus.- Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immuni-ty.- Structure and Function of Respiratory Syncy-tial Virus Surface Glycoproteins.- Respiratory Syn-cytial Virus and Reactive Airway Disease.- Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches.- In-nate Immune Responses to Respiratory Syncytial Virus Infection.- The Adaptive Immune Response to Respiratory Syncytial Virus.- Respiratory Syn-cytial Virus Mechanisms to Interfere with Type 1 Interferons.- Host Gene Expression and Respira-tory Syncytial Virus Infection.- Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus.- Re-spiratory Syncytial Virus Disease: Prevention and Treatment.- Live-Attenuated Respiratory Syncytial Virus Vaccines. [...]

Fields of interestVirology; Vaccine; Infectious Diseases


Product categoryContributed volume

Due July 2013

2013. VIII, 490 p. 38 illus., 22 in color. Hardcover7 $209.00ISBN 978-3-642-38918-4

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S. M. Bailer, University of Stuttgart, Germany; D. Lieber, Ulm University Medical Center, Germany (Eds)

Virus-Host InteractionsMethods and Protocols

Contents A High-Throughput Yeast Two Hybrid Protocol to Determine Virus-Host Protein Interactions.- Analysis of Protein-Protein Interactions Using LUMIER Assay.- Detection of Protein Interactions During Virus Infection by Bimolecular Fluores-cence Complementation.- Discovery of Host-Viral Protein Complexes During Infection.- Screening for Host Proteins with Pro- and Antiviral Activity Using High-Throughput RNAi.- High Resolu-tion Gene Expression Profiling of RNA Synthesis, Processing and Decay by Metabolic Labelling of Newly Transcribed RNA using 4-thiouridine.- Isolation and Characterization of Pathogen-Bearing Endosomes Enables Identification of New Cellular Cofactors and Analysis of Endosomal Escape.- Computational Analysis of Virus-Host Interactomes.- Interspecies Heterokaryon Assay to Characterize the Nucleocytoplasmic Shuttling of Herpesviral Proteins.- Detection of Integrated Herpesvirus Genomes by Fluorescent in situ Hy-bridization (FISH).- Fast Generation of Stable Cell Lines Expressing Fluorescent Marker Molecules to Study Pathogen Induced Processes.- Determi-nation of HSV-1 Infectivity Using a Luciferase Reporter Cell Line.- Generation of a Cell Line for Constitutive Expression of Host or Viral miR-NAs.- Applications for a Dual Fluorescent Human Cytomegalovirus in the Analysis of Viral Entry.- High Temporal Resolution Imaging Reveals Endosomal Membrane Penetration and Escape of Adenoviruses in Real-Time.- Three-Dimensional Visualization of Virus Infected Cells by Serial Sectioning - An Electron Microscopic Study Using Resin Embedded Cells. [...]

Fields of interestImmunology; Virology

Target groupsProfessional/practitioner


Due August 2013

2013. X, 400 p. 64 illus., 45 in color. (Methods in Molecular Biology, Volume 1064) Hardcover7 $139.00ISBN 978-1-62703-600-9

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www.springer.com/978-3-642-39018-0



Biomedicine springer.com/NEWSonline

26

V. Berezin, P. Walmod, University of Copenhagen, Copenhagen, Denmark (Eds)

Cell Adhesion MoleculesImplications in Neurological Diseases

Cell Adhesion Molecules: Implications in Neuro-logical Diseases contains review articles on recent developments in the field of neural cell adhesion molecules (CAMs). The main focus is on the role of cell adhesion molecules in various neurological and neurodegenerative diseases. This perspective has been essentially overlooked in recently pub-lished books on neural CAMs. In addition, the contributors cover many newly identified cell ad-hesion molecules and some that have not received much attention in recent years. This books fills an important gap in the currently available literature.

Features 7 Fills a hole in the current research 7 Full-col-or figures illustrate difficult concepts 7 Chapters are written by distinguished experts

Fields of interestNeurosciences; Human Physiology


Product categoryMonograph

Due September 2013

2013. 400 p. 125 illus., 25 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-8089-1

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R. Brambilla, San Raffaele Scientific Institute, Milan, Italy (Ed)

Viral Vector Approaches in Neurobiology and Brain DiseasesFeatures 7 Covers relevant aspects with a major emphasis on basic mechanisms of synaptic plasticity, learn-ing/memory, molecular neuropharmacology, and experimental animal models 7 Focuses on use of practical genetic approaches in current neurosci-ence research 7 Features proven applications and techniques

Contents Lentiviral Vectors as Research Tools in Neuro-biology: Design and Production.- Recombinant Adenovirus in Neurobiology.- Adeno-Associated Virus-Based Vectors.- Herpes Simplex Virus 1 (HSV-1)-Based Vectors.- Alphavirus-Based Vec-tors.- Viral Vectors to Study Synaptic Function.- Using Viral Vectors to Study the Memory Trace in Mice.- Development of Cell-Type Specific Viral Vectors to Tease Apart the Neural Circuitry that Contributes to Drug Addiction.- Using Viral-Mediated Gene Transfer to Study Depressive-Like Behavior.- Gene Therapy for Parkinson’s Dis-ease.- Lentiviral Vectors in Huntington’s Disease Research and Therapy.- Application of Viral Vec-tors to Motor Neuron Disorders.- In Vivo Gene Silencing by Virally Delivered MicroRNA.- Viral Manipulation of Neural Stem/Precursor Cells.- Viral Vector-Based Techniques for Optogenetic Modulation In Vivo.- Viral Vectors for Optogenet-ics of Hypothalamic Neuropeptides.- Viral Vectors in Primate Research: Examples from Parkinson’s Disease Research.

Fields of interestNeurosciences; Human Genetics



Due August 2013

2013. X, 566 p. 51 illus., 34 in color. (Neuromethods, Volume 82) Hardcover7 $139.00ISBN 978-1-62703-609-2

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Y. Cao, Karolinska Institutet, Stockholm, Sweden (Ed)

Angiogenesis in Adipose TissueFeatures 7 Examines critical role of angiogenesis in regulation of adipose tissue expansion and regression 7 Discusses roles of hematopoietic, endothelial, and mesenchymal cell populations in controlling or promoting cancer progres-sion 7 Explores evidence that white adipose tis-sue may contain relevant amounts of multipotent progenitors

Contents Preface.- Angiogenesis in diseases and therapy.- Spatiotemporal relation of adipocytes and vascular cells during development.- Adipose stem cells.- Adipose stromal cells.- Vascular adipose com-plex.- Blood vessels in white and brown adipose tissue.- Lymphatic system in adipose tissues.- The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells.- Vascular and endothelial regeneration.- Angiogenic factors and adipokines in adipose tissue.- Role of NPY in brown adipose tissue and obesity.- Leptin, adiponectin and other angiogenic adipokines in regulation of adipose angiogenesis.- Regulation of adipose angiogenesis by inflammatory cells.- Immune cells in adipose tissue: key players in metabolic.- Adipose tissue hypoxia in regulation of angiogenesis and obesity.- Mouse models to study adipose angiogenesis.- Adipose angiogenesis models in mice and methodology.- Mouse genetic models in studying adipose angiogenesis.- Adi-pose tissue facilitates tumor angiogenesis and growth.- Adipose tissue-derived progenitor cells and cancer.- Adipose-derived endothelial precur-sor cells in supporting.- Engineering of vascular-ized adipose constructs.- Index.

Fields of interestCancer Research; Lipidology; Cell Biology



Due August 2013

2014. VIII, 348 p. 74 illus., 53 in color. Hardcover7 $209.00ISBN 978-1-4614-8068-6

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L. A. Coward, Australian National University, Canberra, ACT, Australia

Towards a Theoretical Neuroscience: from Cell Chemistry to CognitionThe book explains how to understand cognition in terms of brain anatomy, physiology and chemis-try, using an approach adapted from techniques for understanding complex electronic systems. These techniques create hierarchies of information process based descriptions on different levels of detail, where higher levels contain less informa-tion and can therefore describe complete cognitive phenomena, but are more approximate.

Features 7 Reviews of current knowledge in major areas of psychology, neuroanatomy, neurophysiology and neurochemistry 7 Review of theoretical constraints on brain architecture imposed by natural selection 7 Understanding of memory, attention and complex cognitive phenomena in terms of neuroanatomy, neurophysiology and neurochemistry

Contents The nature of scientific understanding.- Higher Cognition.- Brain Anatomy.- Neuron Physiology.- Intracellular message chains.- Major Anatomical Structures.- Constraints on the physical archi-tecture of the brain.- Appearance of architec-tural constraints in the brain.- Memory and the organisation of experience.- Attention and work-ing memory.- Understanding complex cognitive phenomena.- Towards a Theoretical Neuroscience.

Fields of interestBiomedicine general; Neuropsychology; Neurosci-ences



Due August 2013

2014. XXVI, 420 p. 132 illus., 28 in color. (Springer Series in Cognitive and Neural Systems) Hardcover7 $189.00ISBN 978-94-007-7106-2

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H. Cuntz, Goethe-University, Frankfurt, Germany; M. W. Remme, Humboldt-Universitaet zu Berlin, Berlin, Germany; B. Torben‑Nielsen, Hebrew University of Jerusalem, Jerusalem, Israel (Eds)

The Computing DendriteFrom Structure to Function

Contents Part 1: Dendritic morphology.- The cell biology of dendrite differentiation.- Archetypes and outli-ers in the neuromorphological space.- Neuronal arborizations, spatial innervation and emergent network connectivity.- Shaping of neurons by environmental interaction.- Modelling dendrite shape from wiring principles.- A statistical theory of dendritic morphology.- Reverse engineering the 3D structure and sensory-evoked signal flow of rat vibrissal cortex.- Optimized dendritic morpholo-gies for noisy inputs.- Part 2: Dendritic computa-tion.- Noisy dendrites: models of dendritic inte-gration in vivo.- Distributed parallel processing in retinal amacrine cells.- Dendritic computation of direction in retinal neurons.- Rapid integration across tonotopy by individual auditory brainstem octopus cells.- Computing temporal sequence with dendrites.- Modelling the cellular mechanisms of fly optic flow processing.- Biophysical mechanisms of computation in a looming sensitive neuron.- Biophysics of synaptic inhibition in dendrites.- Role of nonuniform dendrite properties on input processing by GABAergic interneurons.- Sub-threshold resonance and membrane potential oscillations in a neuron with non-uniform active dendritic properties.- A trade-off between den-dritic democracy and independence in neurons with intrinsic subthreshold membrane potential oscillations.- Dendrites enhance both single neuron and network computation.- Dendritic size and topology influence burst firing in pyramidal cells. [...]

Fields of interestNeurosciences; Neurobiology; Computation by Abstract Devices

Target groupsGraduate


Due October 2013

2014. Approx. 350 p. (Springer Series in Computational Neuroscience, Volume 11) Hardcover7 approx. $209.00ISBN 978-1-4614-8093-8

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M. D’Amato, Karolinska Institute, Stockholm, Sweden; J. D. Rioux, Montreal Heart Institute, QC, Canada (Eds)

Molecular Genetics of Inflammatory Bowel DiseaseContents Part 1: The Foundation of IBD Genetics, Human and Animal Studies.- A Primer on IBD: Pheno-types, Diagnosis, Treatment and Clinical Chal-lenges.- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies.- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease.- Part Two: The Genetic and Molecular Makeup of Inflammatory Bowel Disease.- Complex Disease Genes and their Discovery.- The Genetics of Crohn’s Disease.- Genetics of Ulcerative Colitis.- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases.- Molecular Profiling of IBD Subtypes/Response to Therapy.- Epigenetics of Inflamma-tory Bowel Disease.- Part 3: Pathogenetic Path-ways in Inflammatory Bowel Disease.- Nod1 and Nod2 and the Immune Response to Bacteria.- The IL-23-Th17 Axis in Intestinal Inflammation.- In-flammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics.- The Epithelial Barrier.- Host Interac-tions with Bacteria: From “Entente Cordiale” to “Casus Belli”.- Cytokines in Inflammatory Bowel Disease.- Part 4: Concluding Remarks and Future Perspectives.- Towards Personalized Therapy in Inflammatory Bowel Disease.- Index.

Fields of interestHuman Genetics; Molecular Medicine; Biomedi-cine general



Due September 2013

2013. XI, 415 p. 28 illus. in color. Hardcover7 $209.00ISBN 978-1-4614-8255-0

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M. Dwek, University of Westminster, London, UK; U. Schumacher, Universitätsklinikum Hamburg, Germany; S. A. Brooks, Oxford Brookes University,UK (Eds)

Metastasis Research ProtocolsContents In Vitro Invasion Assay Using MatrigelTM - a Reconstituted Basement Membrane Prepara-tion.- Single Cell and Spheroid Collagen Type I Invasion Assay.- Rocking Adhesion Assay System to Study Adhesion and Transendothelial Migra-tion of Cancer Cells.- Small Cell Lung Cancer (SCLC) Cell Adhesion on E- and P-Selectin under Physiological Flow Conditions.- Adhesion of Tumour Cells to Matrices and Endothelium.- Cell Aggregation Assays.- Chick Heart Invasion Assay.- Computer Simulation of the Metastatic Progres-sion.- Theoretical Considerations In Using Animal Models of Metastasis and Brief Methodology for In Vivo Colorectal Cancer Models in SCID and Nude Mice.- Syngeneic Murine Metastasis Models: B16 Melanoma.- Imageable Clinically-relevant Mouse Models of Metastasis.- Imaging Metastatic Cell Trafficking at the Cellular Level in vivo with Fluorescent Proteins.- Ultrasound Techniques for the Detection of Tumours and Metastases in Small Animals.- The PFP/RAG2 Double Knock Out Mouse in Metastasis Research: Small Cell Lung Cancer and Prostate Cancer.- Ultrasound Guided Intracardial Injection and In-vivo Mag-netic Resonance Imaging of Single Cells in Mice as a Paradigm for Haematogenous Metastases.- Magnetic Resonance Imaging of Metastases in Xenograft Mouse Models of Cancer.- Spontaneous and Experimental Metastasis Models: Nude Mice.- Identifying the Origin and Phenotype of Cells in Tumour Xenografts.

Fields of interestCancer Research; Oncology; Cell Culture



Due August 2013

2nd ed. 2013. XVI, 264 p. 34 illus., 10 in color. (Methods in Molecular Biology, Volume 1070) Hardcover7 $119.00ISBN 978-1-4614-8243-7

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K. M. Fulton, S. M. Twine, National Research Council Canada, Ottawa, ON, Canada (Eds)

ImmunoproteomicsMethods and Protocols

Contents Introduction to the Immune System.- Immuno-proteomics: Current Technology and Applica-tions.- Antigen Identification Using SEREX.- An-tigen Discovery Using Whole-Genome Phage Display Libraries.- Methods and Applications of Serological Proteome Analysis.- Pre-Absorbed Immunoproteomics: A Novel Method for the Detection of Bacterial Surface Proteins.- Identifi-cation of the Antigen Content of Electroimmuno-precipitates.- An Immunoproteomics Approach to Screen the Antigenicity of the Influenza Virus.- In Vivo Microbial Antigen Discovery (InMAD) to Identify Diagnostic Proteins and Polysaccharides that Are Circulating During Microbial Infections.- Chemo-Enzymatic Production of O-Glycopep-tides for the Detection of Serum Glycopeptide Antibodies.- Enrichment and Characterization of Glycopeptide Epitopes from Complex Mixtures.- Whole-Cell MALDI-TOF Mass Spectrometry: A Tool for Immune Cell Analysis and Characteriza-tion.- Cell-Based Arrays for the Identification of Interacting Polypeptide Domains or Epitopes.- Identification and Quantitation of MHC Class II-Bound Peptides from Mouse Spleen Dendritic Cells by Immunoprecipitation and Mass Spec-trometry Analysis.- Construction and Screening of an Antigen-Derived Peptide Library Displayed on Yeast Cell Surface for CD4+ T Cell Epitope Identification.- Profiling of Cytokine and Che-mokine Responses Using Multiplex Bead Array Technology.- Preparation of the Low Molecular Weight Serum Proteome for Mass Spectrometry Analysis.- Identification of Protein Biomarkers in Human Serum Using iTRAQ and Shotgun Mass Spectrometry. [...]

Fields of interestImmunology; Proteomics



Due August 2013


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M. Hayat, Kean University, NJ, USA (Ed)

Tumors of the Central Nervous System, Volume 11Pineal, Pituitary, and Spinal Tumors

Contents Preface. I Imaging.- An introduction to brain tumor imaging.-Molecular imaging of brain tu-mors.- Use of 11c-4dst-pet for imaging of human brain tumors. II Glioma and glioblastoma.- Dif-fusion tensor magnetic resonance imaging-based tractography for glioma surgery.- Angiocentric glioma, pilomyxoid astrocytoma, and Pituicytoma: new entities in the world health organization classification.- Diffuse intrinsic pontine gliomas in children: treatment (an Update).- Gliomatosis cerebri: implications of genetic findings.- Impact of bevacizumab chemotherapy on glioblastomas.- Glioblastoma microvesicles transport rna and proteins Promoting tumor growth.- Microrna in the pathophysiology of glioblastoma.- Surgical management of incidental low-grade gliomas. III Stereotactic radiosurgery.- Stereotactic radiosur-gery for the treatment of brain metastases.- Local control of low-volume brain metastases using stereotactic radiosurgery.- Tumor seeding after stereotactic brain biopsy.- Intracranial stereotactic radiosurgery in high risk patients with metasta-ses from radioresistant primary tumors.- Brain metastases: treatment with stereotactic iodine-125 brachytherapy.- Stereotactic radiosurgery for skull base meningiomas. IV Spinal cord tumors.- Pediatric spinal cord tumors.- Radiosurgery for intramedullary spinal cord tumors.- Novalis spinal radiosurgery.- Etiology and outcomes of pediatric spinal cord tumors. V Meningioma.- Selection of elderly meningioma patients for surgery using a Clinical-radiological grading system as a predictor of outcome.- Cranial meningioma in neurofibro-matosis type 2 patients: role of mutations. [...]

Fields of interestCancer Research; Oncology; Biomedicine general



Due August 2013

2014. XX, 364 p. 56 illus., 37 in color. (Tumors of the Central Nervous System, Volume 11) Hardcover7 $209.00ISBN 978-94-007-7036-2

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29

R. Kageyama, Kyoto University, Japan; T. Yamamori, National Institute for Basic Biology, Japan (Eds)

Cortical DevelopmentNeural Diversity and Neocortical Organization

This book reviews recent progress in cortical de-velopment research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and con-nections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain re-gions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.

Features 7 Comprises state-of-the-art reviews on neural stem cell regulation and proneural gene func-tions 7 Provides details of the mechanisms of neuronal diversity and connectivity forma-tion 7 Identifies new genes controlling synapse formation and higher brain functions

Fields of interestNeurosciences; Developmental Biology; Cell Biology



Due August 2013

2013. X, 272 p. 67 illus., 56 in color. Hardcover7 $209.00ISBN 978-4-431-54495-1

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K. Kristensson, Karolinska Institute, Stockholm, Sweden; M. Bentivoglio, Department of Neurological Sciences (DSNNMM), Verona, Italy; E. A. Cavalheiro, UNIFESP/EPM, São Paulo, Brazil; N. Patel, University of Nairobi, City, Kenya (Eds)

Neuroscience of Neglected Diseases and ConditionsA number of diseases and conditions that oc-cur primarily in remote rural or poor urban areas of low-income countries have traditionally been neglected by the neuroscience research com-munity. These diseases and conditions affect the nervous system directly (sometimes with lethal consequences) and/or are associated with severe neurological sequels such as epilepsy, cognitive deficits, and sleep disruption. Several diseases also have the effect of promoting poverty by leaving sufferers unable to lead economically produc-tive lives due to cognitive and behavioral distur-bances or severe stigmatization. The pathogenesis of neural dysfunction in the diseases addressed in this book and their sequels remains unclear. The goal of Neuroscience of Neglected Diseases and Conditions is to make available much needed information about how these diseases affect the human nervous system as well as to promote interest in further research. A secondary hope is that further research into neglected diseases and conditions will uncover information that sheds light on more general topics of interest to the neuroscience research community.

Features 7 Covers diseases that affect the severely impov-erished 7 Provides information on how these diseases affect the human nervous systems 7 De-tails areas of interest that are usually neglected by the neuroscience community

Fields of interestNeurosciences; Virology; Public Health



Due September 2013

2013. 400 p. 125 illus., 25 in color. Hardcover7 approx. $239.00ISBN 978-1-4614-8099-0

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R. Kumar, George Washington University, Washington, DC, USA (Ed)

Nuclear Signaling Pathways and Targeting Transcription in CancerContents Preface.- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression.- Role of Alteration/Defi-ciency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer.- RUNX2 Transcriptional Regulation in Development and Disease.- Epigenetic Mechanisms of Cancer Metastasis.- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications.- Nuclear Factors Linking Cancer and Inflammation.- Regulation of the Jak/STATs Pathways by Histone Deacety-lases.- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers.- Nucleolar Signaling Determines Cell Fate – The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis.- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment.- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology.- Domain Specific Targeting of Cancer.- The Potential of Targeting Splicing for Cancer Therapy.- Exploiting Cell Cycle Pathways in Can-cer Therapy: New (and Old) Targets and Potential Strategies.- Histone Demethylases in Prostate Cancer.- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer.- Index.

Fields of interestCancer Research; Pharmacology/Toxicology



Due August 2013

2014. X, 792 p. 56 illus., 52 in color. (Cancer Drug Discovery and Development) Hardcover7 $189.00ISBN 978-1-4614-8038-9

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T.‑L. Lee, The Chinese Univeristy of Hong Kong, China; A. C. Shui Luk, The Chinese University of Hong Kong, China (Eds)

Tiling ArraysMethods and Protocols

Features 7 Focuses on key application of tiling microar-rays in genomic discovery 7 Provides step-by-step detail essential for reproducible re-sults 7 Contains key notes and implementation advice from the experts

Contents A Brief Introduction to Tiling Microarrays: Principles, Concepts, and Applications.- Design of Tiling Arrays and their Application to Bacterial Transcriptome Analysis.- Transcript Profiling in Arabidopsis with Genome Tiling Microarrays.- Genome-wide Analysis of Transcription Factor Binding Sites in Skeletal Muscle Cells using ChIP-seq.- Analysis of Allele-Specific Gene Expression Using a Target-Oriented Tiling Microarray Assay.- Detection of Epigenetic Alterations Using Tiling Arrays.- Investigating Gene Promoter Methylation in a Mouse Model of Status Epilepticus.- In-tegrative Analysis of ChIP-chip and ChIP-seq Dataset.- HAT: A Novel Statistical Approach to Discover Functional Regions in the Genome.- In-ference of Alternative Splicing from Tiling Array Data.- Analysis of in vivo Occupancy of Aebp1, a Transcription Factor, using High Resolution Tiling Array.- Application of the Simple and Efficient MPeak Modeling in Binding Peak Identification in CHIP-CHIP Studies.- Evaluation of MeDIP-chip in the Context of Whole Genome Bisulphite Sequencing (WGBS-seq) in Arabidopsis.- Map-ping Genomic Features of Tiling Microarray Data by TileMapper.

Fields of interestHuman Genetics; Microarrays



Due August 2013

2013. XV, 160 p. 49 illus., 36 in color. (Methods in Molecular Biology, Volume 1067) Hardcover7 $119.00ISBN 978-1-62703-606-1

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S. Malek, University of Michigan, Ann Arbor, MI, USA (Ed)

Advances in Chronic Lymphocytic LeukemiaChronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course. While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and transla-tional biology of CLL. In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings. This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply.

Features 7 Provides a comprehensive review on chronic lymphocytic leukemia 7 Features paramount research in the field 7 Focuses on crucial aspects of CLL pathogenesis

Contents Preface.- B-cell receptor and antigens in CLL.- The CLL cell microenvironment.- Acquired genomic copy number aberrations in CLL.- Recurrent gene mutations in CLL.- TP53 aberrations in CLL.- Gene expression and epigenetic deregula-tion.- Apoptosis deregulation in CLL.- Richter’s Syndrome.- Molecular biomarkers in chronic lymphocytic leukemia.- Critical Signal Trans-duction Pathways in CLL.- Immunotherapies in CLL.- Novel therapeutic agents in CLL.- Inherited susceptibility to CLL.- miR deregulations in CLL.- Index.

Field of interestCancer Research



Due August 2013

2014. XXVI, 440 p. 25 illus., 24 in color. (Advances in Experimental Medicine and Biology, Volume 792) Hardcover7 $189.00ISBN 978-1-4614-8050-1

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B. R. Moyer, BRMoyer & Associates, LLC, Bedford, NH, USA; N. P. Cheruvu, Covidien, St. Louis, MO, USA; T. C.‑C. Hu, Food and Drug Administration, Washington, DC, USA (Eds)

Pharmaco-Imaging in Drug and Biologics DevelopmentFundamentals and Applications

Contents Imaging Platforms and Drug Development: An Introduction.- Imaging in Drug Development: Animal Models, Handling and Physiological Constraints.- Considerations for Pre-Clinical Laboratory Animal Imaging Center Design, Setup, and Management suitable for Biomedical Inves-tigation for Drug Discovery.- Pharmaco-Imaging in Translational Science and Research.- The Role of Pharmacokinetics and Allometrics in Imaging: Practical Issues and Considerations.- Quantitative Imaging Using Autoradiographic Techniques.- Pre-Clinical Imaging in Oncology: Considerations and Recommendations for the Imaging Scientist.- Use of Radiolabelled Leukocytes for Drug Evalu-ation in Man.- Application of Bioluminescence Imaging (BLI) to the Study of the Animal Models of Human Infectious Diseases.- Pre-Clinical Imag-ing in BSL-3 and BSL-4 Environments: Imaging Pathophysiology of Highly Pathogenic Infectious Diseases.- Magnetic Resonance as a Tool for Pharmaco-Imaging.- Technologies and Principles of Mass Spectral Imaging.- Regulatory Consider-ations Involved In Imaging.

Fields of interestBiomedicine general; Pharmaceutical Sciences/Technology



Due September 2013

2013. VII, 341 p. 130 illus., 101 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 8) Hardcover7 $209.00ISBN 978-1-4614-8246-8

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A. K. Naumova, Ph.D., C. M. Greenwood, Ph.D., McGill University, Montreal, QC, Canada (Eds)

Epigenetics and Complex TraitsContents Part I: Epigenetic phenomena in the germ line and early embryonic development and their effects on the inheritance of genetic traits.- Epi-genetic reprogramming in the mammalian germ line.- Establishment of tissue-specific epigenetic states during development.- X-chromosome Inactivation.- Cis- and trans-effects underlying polar overdominance at the callipyge locus.- Transgenerational epigenetic effects and complex inheritance patterns.- Autosomal monoallelic expression.- Part II: Epigenetic variation in health and disease.- Recurrent CNVs in the etiology of epigenetic neurodevelopmental disorders.- Impact of the early-life environment on the epigenome and behavioral development.- Interaction between genetics and epigenetics in cancer.- Part III: Impact of epigenetics on complex trait genetics and analysis.- Epigenetic variation, phenotypic heritability, and evolution.- Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans.- Transmission ratio distortion: a neglected phenomenon with many consequences in genetic analysis and population genetics.- Epigenome Wide Association Studies: Potential insights into human disease.- Analytical Consid-erations for Epigenome-wide Association Scans of Complex Traits.- Index.

Fields of interestHuman Genetics; Developmental Biology; Statis-tics for Life Sciences, Medicine, Health Sciences



Due September 2013

2013. XX, 470 p. 43 illus., 6 in color. Hardcover7 $209.00ISBN 978-1-4614-8077-8

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M. Oresic, VTT Technical Research, Espoo, Finland; A. Vidal‑Puig, University of Cambridge, United Kingdom (Eds)

A Systems Biology Approach to Study Metabolic SyndromeFeatures 7 A comprehensive account of using Sys-tems Biology to study Metabolic Syndrome (MetS) 7 The applications of selected tech-nologies and models to tackle specific patho-physiologically relevant aspects of metabolic syndrome 7 An introduction to key biological processes involved in the pathophysiology of MetS

Contents The metabolic syndrome and its complex patho-physiology.- Systems biology in human health and disease.- The liver in metabolic syndrome.- Role of adipose tissue in the pathogenesis and treatment of metabolic syndrome.- The beta cell in metabolic syndrome.- The skeletal muscle in metabolic syndrome.- The central nervous system in metabolic syndrome.- Lipid metabolism in metabolic syndrome.- Gut microbiota in meta-bolic syndrome.- Proteomics in the systems-level study of the metabolic syndrome.- Metabolomics in the systems-level study of the metabolic syn-drome.- Fluxomics.- In vitro colon model to study metabolic syndrome.- Genome-scale modeling of tissue and cancer metabolism.- Modeling of lipid membranes and lipoproteins.- Computational sta-tistics approaches to study metabolic syndrome.- Towards modeling of metabolic syndrome: Tissue crosstalk in lipid spillover.

Fields of interestBiomedicine general; Molecular Medicine; Human Physiology



Due September 2013

2013. Approx. 350 p. 47 illus., 23 in color. Hardcover7 $209.00ISBN 978-3-319-01007-6

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Reviews of Physiology, Biochemistry and PharmacologySeries Editors: S. G. Amara, R. Jahn, R. Lill, B. Nilius, O. H. Petersen, T. Gudermann, S. Offermanns

Volume 164

B. Nilius, Katholieke Universiteit Leuven Lab. Fysiologie, Leuven, Belgium; S. G. Amara, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; R. Lill, Universität Marburg Inst. Zytobiologie und, Marburg, Germany; S. Offermanns, Max-Planck-Institut für Herz- und Lungen, Bad Nauheim, Germany; T. Gudermann, Ludwig-Maximilians-Universität München Medizinische Fakultät, München, Germany; O. H. Petersen, Cardiff University School of Biosciences, Cardiff, UK; R. Jahn, MPI für Biophysikalische Chemie Abt. Neurobiologie, Göttingen, Germany (Eds)

Reviews of Physiology, Biochemistry and Pharmacology, Vol. 164Features 7 Written by leading experts in the fields 7 Pro-vides current and comprehensive view on topics of special interest in the field 7 Each author is an international, well-respected expert in their particular area of physiology or rather pharmacol-ogy research

Contents T. Hara, I. Kimura, D. Inoue, A. Ichimura, and A. Hirasawa: Free fatty acid receptors and their role in regulation of energy metabolism.- B. Nilius and G. Appendino. Spices: the savory and healthy sci-ence of pungency.

Fields of interestHuman Physiology; Metabolic Diseases; Gastroen-terology



Due July 2013

2013. X, 100 p. 16 illus., 14 in color. Hardcover7 $139.00ISBN 978-3-319-00995-7

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Reviews of Physiology, Biochemistry and PharmacologySeries Editors: S. G. Amara, R. Jahn, R. Lill, B. Nilius, O. H. Petersen, T. Gudermann, S. Offermanns

Volume 165

B. Nilius, KU Leuven, Leuven, Belgium; S. G. Amara, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; T. Gudermann, Ludwig-Maximilians-Universität München Medizinische Fakultät, München, Germany; R. Jahn, MPI für Biophysikalische Chemie Abt. Neurobiologie, Göttingen, Germany; R. Lill, Universität Marburg Inst. Zytobiologie und, Marburg, Germany; S. Offermanns, Max-Planck-Institut für Herz- und Lungen, Bad Nauheim, Germany; O. H. Petersen, Cardiff University School of Biosciences, Cardiff, UK (Eds)

Reviews of Physiology, Biochemistry and Pharmacology, Vol. 165Contents T. Büch, E. Schäfer, D. Steinritz, A. Dietrich, T. Gudermann: Chemosensory TRP Channels in the Respiratory Tract: Role in Toxic Lung Injury and Potential as “Sweet Spots” for Targeted Therapies.- D.C. Zebrowski and F. B. Engel: The Cardiomyocyte Cell Cycle in Hypertrophy, Tissue Homeostasis, and Regeneration.- P. Hegyi and O.H. Petersen: The Exocrine Pancreas: The Acinar -Ductal Tango in Physiology and Pathophysiology.

Fields of interestHuman Physiology; Pharmacology/Toxicology; Cardiology



Due July 2013

2013. X, 110 p. 12 illus., 9 in color. Hardcover7 approx. $139.00ISBN 978-3-319-00998-8

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B. A. Reynolds, L. P. Deleyrolle, University of Florida, Gainesville, FL, USA (Eds)

Neural Progenitor CellsMethods and Protocols

Features 7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents Culturing Fetal Precursors Cells Using Free-Float-ing Serum-Free Conditions.- In vitro Expansion of Foetal Neural Progenitors as Adherent Cell Lines.- Isolate and Culture Precursor Cells from the Adult Periventricular Area.- Culturing and Expansion of Precursor Cells from the Adult Hippocampus.- Isolate and Culture Neural Stem Cells from the Mouse Adult Spinal Cord.- Culturing and Expan-sion of “Clinical Grade” Precursors Cells from the Foetal Human Central Nervous System.- Isolating and Culturing of Precursor Cells from the Adult Human Brain.- Isolation and Culture of Precursor Cells from the Adult Human Spinal Cord.- Iso-lation and Enrichment of Defined Neural Cell Populations from Heterogeneous Neural Stem Cell Progeny.- Isolation of Adult Stem Cells from the Human Olfactory Mucosa.- Enumerating Stem Cell Frequency – Neural Colony Forming Cell Assay.- Flow Cytometry of Neural Cells.- Neonatal Transplant in Hypoxic Injury.- Isolation and Pu-rification of Self Renewable Human Neural Stem Cells for Cell Therapy in Experimental Model of Ischemic Stroke.- Transplantation of Foetal Midbrain Dopamine Progenitors into a Rodent Model of Parkinson’s Disease.- Distribution of Neural Precursor Cells in Rodent Brain.- Identify-ing Neural Precursor Cells in the Adult Human Brain.- Clinical Trials for the Treatment of Spinal Cord Injury: Not So Simple.

Fields of interestNeurosciences; Stem Cells; Neurobiology



Due August 2013


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U. Roessner, D. A. Dias, The University of Melbourne, VIC, Australia (Eds)

Metabolomics Tools for Natural Product DiscoveryMethods and Protocols

Contents Bryophytes: Liverworts, Mosses and Hornworts – Extraction and Isolation Procedures.- Plant Tissue Extraction for Metabolomics.- Detection of Polar Metabolites through the use of Gas Chromatog-raphy – Mass Spectrometry.- A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems.- A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation.- Lipidomics –Extraction Protocols for Biological Matrices.- Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy.- NMR Spec-troscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study.- NMR-Based Metabolomics: A Probe to Utilize Biodiversity.- Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts.- Determination of Absolute Configuration Using Single Crystal X-ray Diffraction.- Natural Product Chemistry in Action: The Synthesis of Melatonin Metabolites K1 and K2.- Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemy-cin Polyketide Analogues.- Bioassays for Antican-cer Activities.- Screening for Anti-Diabetic Activi-ties.- Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity.- Metabolomics and Dereplication Strategies in Natural Products.- Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry.- Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR. [...]

Fields of interestPharmacology/Toxicology; Analytical Chemistry



Due August 2013

2013. XII, 328 p. 80 illus., 32 in color. (Methods in Molecular Biology, Volume 1055) Hardcover7 $119.00ISBN 978-1-62703-576-7

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33

A. Singh, M. Kango‑Singh, University of Dayton, OH, USA (Eds)

Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila EyeUndoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular inver-tebrate model organisms, and the work horse for modern day biologists.

Features 7 Most updated title in the past ten years to cover this topic 7 Reviews all molecular genetic aspects of axial patterning in the drosophila eye 7 Reviews the research and relates it to how it can transform our understanding of human diseases like cancer

Contents Early eye development: Specification and Deter-mination.- Molecular genetic mechanisms of axial patterning: Mechanistic insights into generation of axes in the developing eye.- Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow.- Cell Morphogenesis.- Cell Polarity in Drosophila Retina.- Negative regulation for neural patterning in the Drosophila eye.- Cell Adhesion during Drosophila eye devel-opment.- Modulation of Developmental Signaling by the Proteostasis Network.- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways.- Contribution of the Drosophila eye to unraveling the basis of neurodegeneration.- Genetic regulation of early eye development in non-dipteran insects.- Devel-opment and evolution of the Drosophila Bolwig’s organ: a compound eye relict.- Index.

Fields of interestHuman Genetics; Animal Models; Biomedicine general



Due August 2013

2013. I, 476 p. 68 illus., 63 in color. Hardcover7 $209.00ISBN 978-1-4614-8231-4

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S. Staibano, University Federico II of Naples, Italy (Ed)

Prostate Cancer: Shifting from Morphology to BiologyContents Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunopheno-typing of prostate diseases.- II Molecular pathol-ogy.- Molecular determinants of cancer-related inflammation.- Apoptosis and autophagy.- Andro-gen receptor and steroidogenesis pathways.- Neu-roendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy.- Metastatic dissemination.- Resistance to castration - resistance to drugs.- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer.- Gene polymorphisms.- Expression signature.- Mapping prostate cancer aggressiveness loci.- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predic-tive models.- Targeting tumor angiogenesis.- Effi-cacy of signal transduction inhibition in advanced prostate cancer.- Therapeutic targeting of the bone pre-metastatic niche.- Counteracting hypoxia in radio-resistant metastatic lesions.- “Synthetic lethality”: molecular co-targeting to restore the DNA.- Repair mechanisms in prostate cancer cells concluding remarks. Index.

Fields of interestCancer Research; Human Genetics; Gene Expres-sion

Target groupsGraduate


Due August 2013

2014. X, 324 p. 41 illus. in color. Hardcover7 $189.00ISBN 978-94-007-7148-2

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M. Steinitz, The Hebrew University, Jerusalem, Israel (Ed)

Human Monoclonal AntibodiesMethods and Protocols


Contents Human Monoclonal Antibodies - The Residual Challenge of Antibody Immunogenicity.- Techni-cal and Ethical Limitations in Making Human Monoclonal Antibodies.- Therapeutic Human Monoclonal Antibodies in Inflammatory Dis-eases.- Therapeutic Human Monoclonal Antibod-ies Against Cancer.- Polyclonal and Monoclonal Antibodies in the Clinic.- Production of Human Monoclonal Antibodies by the Epstein- Barr Virus Method.- Humanization and Simultaneous Optimization of Monoclonal Antibody.- Chimeric Antibodies.- Recombinant Genetic Libraries and Human Monoclonal Antibodies.- Production of Stabilized scFv Antibody Fragments in the E. coli Bacterial Cytoplasm.- Construction and Production of an IgG-Like Tetravalent Bispecific Antibody, IgG-Single Chain Fv Fusion.- Construc-tion of Human Antibody Gene Libraries and Se-lection of Antibodies by Phage Display.- Antigen –Specific Human Monoclonal Antibodies from Transgenic Mice.- Phage Display Technology for Human Monoclonal Antibodies.- Antigen-Specific in vitro Immunization: A Source for Human Monoclonal Antibodies.- Methods for Radiola-belling of Monoclonal Antibodies.- Purification of Human Monoclonal Antibodies and Their Fragments.- Idiotype-Specific IVIG for Therapy of Autoimmune Diseases.

Fields of interestImmunology; Antibodies



Due August 2013


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34

Y. Sugiyama, University of Tokyo, Japan; B. Steffansen, University of Copenhagen, Denmark (Eds)

Transporters in Drug DevelopmentDiscovery, Optimization, Clinical Study and Regulation

Membrane transporters can be major determi-nants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key ques-tions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are suitable for studying drug interac-tions with these transporters.

Features 7 Answers key questions in drug develop-ment 7 Written by leaders in the field 7 Covers both pharma industry and FDA perspectives

Contents Membrane Transporters in ADME.- In Vitro Characterization of Transporter Mediated Perme-ability.- In Vitro Characterization of Interac-tions with Drug Transporting Proteins.- In Vivo Characterization of Interactions on Transport-ers.- Application of Targeted Proteomics in ADME for IVIVE.- Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data.- Ac-counting for Transporters in Renal Clearance: To-wards a Mechanistic Kidney Model (Mech KiM).- Analysis of Intestinal Transporters.- Analysis of Hepatic Transport Proteins.- Analysis of Renal Transporters.- The Role of Transporters During Drug Development: Regulatory Science Perspec-tive from the FDA.- Industrial Evaluation of Drug Transporters in ADME.

Fields of interestPharmaceutical Sciences/Technology; Biomedi-cine general



Due September 2013

2013. XXII, 370 p. 48 illus., 21 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 7) Hardcover7 $189.00ISBN 978-1-4614-8228-4

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I. Wakabayashi, Hyogo College of Medicine, Japan; K. Groschner, University of Graz, Austria (Eds)

Interdisciplinary Concepts in Cardiovascular HealthVolume II: Secondary Risk Factors

This book provides an introduction to the prin-ciples of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This second volume is focused on all aspects concern-ing “secondary risk factors” in terms of diseases associated with enhanced risk for cardiovascular events. The book promotes the use of interdis-ciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource work for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention

Features 7 Provides comprehensive and well-orga-nized overview of a highly interdisciplinary field 7 Covers a wide range of biomedical re-search areas 7 Clearly arranged to create an easy to use knowledge base

Contents Hypertension and vascular dysfunction.- Obesity and diabetes.- Hyper- and dyslipoproteinemias.- Hyperuricemia.- Proteomics towards biomarkers discovery and risk assessment.

Fields of interestMolecular Medicine; Metabolic Diseases; Health Promotion and Disease Prevention



Due July 2013

2013. XVII, 160 p. 22 illus., 18 in color. Hardcover7 $189.00ISBN 978-3-319-01049-6

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I. Wakabayashi, Hyogo College of Medicine, Japan; K. Groschner, University of Graz, Austria (Eds)

Interdisciplinary Concepts in Cardiovascular HealthVolume III: Cardiovascular Events

This book provides an introduction to the prin-ciples of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common “cardiovascular events” to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiol-ogy. The book offers a valuable resource work for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

Features 7 Provides comprehensive and well-orga-nized overview of a highly interdisciplinary field 7 Covers a wide range of biomedical re-search areas 7 Clearly arranged to create an easy to use knowledge base

Contents Ischemic heart disease.- Stroke.- Heart Failure.- Cardiac arrhytmias.- Pulmonary hypertension.- Peripheral artery disease.- Venous Thromboembo-lism.- Abdominar aortic aneurism.

Fields of interestMolecular Medicine; Health Promotion and Dis-ease Prevention; Metabolic Diseases



Due August 2013

2014. XI, 210 p. 33 illus., 20 in color. Hardcover7 $189.00ISBN 978-3-319-01073-1

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M. J. Wheeler, Consultant Clinical Scientist, Exmouth, UK (Ed)

Hormone Assays in Biological FluidsHormone measurement is necessary for the diagnosis of a wide range of clinical conditions and is essential for monitoring the effectiveness of treatment. As the number of hormone requests in the clinical field rises exponentially, it has become imperative to create hormone assays accessible to researchers with a varied range of equipment.


Contents A Short History of Hormone Measurement.- Im-munoassay Techniques.- Introduction to Gas Chromatography-Mass Spectrometry.- Tandem Mass Spectrometry in Hormone Measure-ment.- Methods for the Investigation of Thyroid Functions.- The Measurement of LH, FSH and Prolactin.- Assays of GH, IGF-1 and IGF Binding Protein-3.- Measurement of Arginine Vaso-pressin.- The Measurement of Anti-Müllerian Hormone.- Measurement of Gut Hormones in Plasma.- Measurement of Melatonin and 6-Sulphatoxymelatonin.- Measurement of Glu-cocorticoids in Biological Fluids.- Measurement of Androgens.- Measurement of Aldosterone in Blood.- Measurement of Plasma Renin Activity.- Measurement of Vitamin D.- Urine Steroid Profil-ing.- Internal Quality Control.- External Quality Assessment Schemes for Immunoassays.

Fields of interestMolecular Medicine; Endocrinology



Due August 2013

2nd ed. 2013. X, 330 p. 34 illus., 14 in color. (Methods in Molecular Biology, Volume 1065) Hardcover7 $139.00ISBN 978-1-62703-615-3

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T. Yoshimoto, Tokyo Medical University, Japan; T. Yoshimoto, Hyogo College of Medicine, Japan (Eds)

Cytokine FrontiersRegulation of Immune Responses in Health and Disease

This book guides the reader through the latest research on the cytokine network, covering signal-ing pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological condi-tions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identi-fied types of innate cells. Part III describes three cytokines that are associated with immunologi-cal tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells.

Fields of interestImmunology; Cytokines and Growth Factors; Cell Biology



Due August 2013

2013. X, 380 p. 42 illus. in color. Hardcover7 $209.00ISBN 978-4-431-54441-8

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