Advancing the Eco-Responsible Design and Disposal of Engineered Nanomaterials
9 -10 March 2009Rice University, Houston, Texas
Sponsor Recognition
Participants from:Australia, Austria, Canada, Denmark, France, Mexico, Sweden, Switzerland, UK, USA
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ICON: A New Model for Interaction
Research Commercialization
Gov/Reg/Law Public Oversight
AcademicsIndustryGovernment
Gov Policy MakersRegulatorsLawyers
Non-Governmental OrganizationsSocial/Ethical Researchers
IndustryTrade Groups
Information regarding potential environmental and health risks of nanotechnology to foster risk reduction and maximize societal benefit.
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Quality Information about Risks & Benefits
Survey of current workplace practices
ICONsultations with diverse stakeholdersInternational nanoEHS research needs assessment
Database/VJ on nanoEHS research
Knowledge Base Best Practices
Communications
ICON Working Groups
New ES&T paper:DOI: 10.1021/es702158q
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Good Nano Guide Wiki
• Protected Internet site on occupational practices for the safe handling of nanomaterials• Multiple stakeholders contribute, share and discuss information• Modern, interactive, up-to-date
http://icon.rice.edu/projects.cfm?doc_id=12207
International NanoEHS Research Needs
OVERALL GOAL OF WORKSHOPS: Prioritized Research for Predicting Biointeractions for Nanomaterials of Commercial Relevance
Swiss Re June 2007 NIH Campus Jan 2007
GRAND CHALLENGE: Computational Models that Predict Interactions of Engineered Nanomaterials with Organisms and the Environment
Workshop 1: Towards Nanomaterial Classes Workshop 2: Towards Predictive ModelsDevelop classification of NMs based on material type
Determine present and future applications
Describe potential hot spots in lifecycle
Describe properties important to biointeraction
Elucidate mechanisms of nano-biointeractions
Elucidate interactions at cell-free, cellular, tissue and whole animal levels
Develop prioritized strategies and timelines
GRAND CHALLENGE: Computational Models that Predict Interactions of Engineered Nanomaterials with Organisms and the Environment
OVERALL GOAL OF WORKSHOPS: Prioritized Research for Predicting Biointeractions for Nanomaterials of Commercial Relevance
Swiss Re June 2007 NIH Campus Jan 2007
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Predicting Nano-Biointeractions
• Report downloaded >500 times• Media Event at Wilson Center• Japanese translation of executive
summary• National Academies now studying
NanoEHS research needs• House Science Committee
testimony on research needs
October 31, 2007
“Independent efforts such as this one add tremendous value to the work we’re doing at the governmental
level.” Sally Tinkle, NIEHS
NSF BES-0646107
May 1, 2008
26 research needs prioritized into 2-, 5- and 10-yr goals
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Key Findings from Workshop 1 CHALLENGE: Nanomaterial properties are not static throughout lifecycle
Tools and models must be developed that can describe the dynamic nature of nanomaterials throughout their lifecycle.
CHALLENGE: Chemical composition is not the ideal or sole property on which to focus
A set of screening tools is needed to correlate the functional properties of nanomaterials with their potential for biological interaction.
CHALLENGE: Exposure scenarios are too diverse to draw general conclusions
Exposure assessment studies are needed to enable predictions about implications of physicochemical properties for net dose.
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Key Findings from Workshop 2 CHALLENGE: Nanoparticle surfaces undergo changes during interactions in biological environments
Quantitative models are needed to describe how the properties of NPs control the nature and extent of biomolecular interactions at their surface.
CHALLENGE: Existing mass-based metrics of measuring dose and dose rate may underestimate NP impacts
Dose and dose rate may need to be validated independently for NPs.
CHALLENGE: In vitro assays are practical given nanomaterial diversity but may be poor predictors of in vivo endpoints
Better biomarkers are essential to address the vast diversity of NP types and to develop strong correlative models for predicting in vivo endpoints based on in-vitro results.
Workshop Planning TeamJamie Lead, University of Birmingham (Co-chair)
Pedro Alvarez, Rice University (Co-chair)Vicki Colvin, Rice University
Tracy Hester, Bracewell & Giuliani, LLPBarbara Karn, USEPA
Kristen Kulinowski, Rice UniversityVicki Stone, Napier University
RapporteursJohn Fortner Nastassja LewinskiJaesang Lee Dong Li Shaily Mahendra
Support Personnel David Johnson Denise BenoitMarilu CamposTeresa ChampionCarlos GarciaMatt HuffChris Rodriguez
Monday 3/9/098:15 – 8:30 Logistics and organization8:30 – 8:-45 Overview #1, Colvin8:45 – 9:00 Overview #2, Hughes9:00 – 9:10 Overview #3, Golam Mustafa9:15 – 9:30 Overview #4, Lead9:30 -12:00 Brainstorming 1 on Design priorities (3 min each). 12:00 – 1:00 Lunch1:00 – 3:30 Brainstorming 2 on Disposal priorities (3 min each).3:30 – 4:00 Break4:00 – 5:00 Full group discussion of consolidated themes5:00 – 5:45 Break6:15 – 8:30 Presentation by Michael Depledge and Reception at BIPP
Tuesday 3/10/098:00 Continental breakfast8:15 – 8:30 Summary of day 1 discussion and day 2 logistics8:45 - 12:00 Work in teams to elaborate on assigned issue12:00 – 1:00 Lunch.1:00 – 3:30 Team presentations (10 @ 15 min each including Q&A)3:30 – 4:00 Break 4:00 – 5:00 Group discussion focused on integration and synthesis5:00 – 5:30 Polish write ups, incorporate feedback & group discussion
Nominal Group Technique
Consensus planning tool to prioritize issues according to their importance, intellectual merit, practicality, and achievability.
Day 1 Logistics: Safe Design
• Alphabetically, 3 minutes each to answer:
What critical knowledge gaps and opportunities exist to inform and advance the design of environmentally benign nanomaterials?
• Title of Priority Issue
• Description
• Importance/Significance
Potential Categories for Answers
• Structure-Activity Relationships• Metrology, quantification and tracing NPs in the
environment• Computational Modeling of Nanoparticle
Modifications in the Environment• Towards Predicting Multimedia Fate, Transport
& Exposure
Rapporteurs will record and post your priority issue on the wall under best fitting category
Day 1 Logistics: Safe Disposal
• Alphabetically, 3 minutes each to answer:
What critical knowledge gaps and opportunities exist to inform and advance the management of wastes containing nanomaterials?
• Title of Priority Issue
• Description
• Importance/Significance
Potential Categories for Answers• Minimization and Disposal of Nanomaterial
Production Wastes• Release and Exposure Scenarios/Source
Dynamics• Impact of Nanomaterials on Environmental
Protection Infrastructure• Information Needs for Waste Disposal Companies
and Recyclers
Rapporteurs will record and post your priority issue on the wall under best fitting category
Day 2 Deliverables
• One category will be assigned per group, to discuss research priorities
• 8 PowerPoint presentations (15 min)
• Word document summarizing priority issues and approaches/challenges, to serve as a basis for a white paper
• Optional: review or position paper later
