Inside this Issue March 2006 – Issue 26 Agilent ICP-MS Journal 2/3 User article: An Application of ICP-MS in Chemical Metrology 4/5 User Profile: LCABIE Drives Speciation Analysis Across Disciplines 6/7 Service and Support News: Choice of Preventive Maintenance Program for 7500 Series, New Maintenance DVD Released for 7500 Series ICP-MS, Risks of Buying Non-Agilent Consumables 8 New 7-minute Video of 7500ce, Up & Coming Events, Welcome to New ICP-MS Users, New Literature NEW! Agilent ICP-MS video released see page 8 for details!
Transcript
Inside this Issue
March 2006 – Issue 26
Agilent ICP-MS Journal
2/3 User article: An Application of ICP-MS in Chemical Metrology
4/5 User Profile: LCABIE Drives Speciation Analysis Across Disciplines
6/7 Service and Support News: Choice of Preventive Maintenance Program for 7500 Series, New Maintenance DVD Released for 7500 Series ICP-MS, Risks of Buying Non-Agilent Consumables
8 New 7-minute Video of 7500ce, Up & Coming Events, Welcome to New ICP-MS Users, New Literature
N E W !Agilent ICP-MS
video released
see page 8 for details!
An Application ofICP-MS in ChemicalMetrologyMike Sargent, LGC Ltd, Teddington, UK
Introduction In recent years we have seen increasing demand from users ofanalytical data and regulators thatmeasurements made in differentlaboratories, often in differentcountries, are in agreement.Reasons for this trend include:• Increasing numbers of analytical
measurements used in support ofregulations
• Reassurance that the data has rigorously proven reliability.
It is essential that enforcement of aregulation has the same outcome nomatter which laboratory made themeasurement. In addition, ever-expanding international tradedepends on laboratories being ableto provide measurement data to acommon basis no matter wherethey are located. To some extent,the requirement can be met byensuring that every analytical labo-ratory operates a quality system,with external accreditation whereappropriate. It has long been recognized, however, that this aloneis insufficient.
The most widely used, and very successful, approach to achievingagreement between different facilitiesis through laboratory comparisonsand proficiency testing (PT) schemes.Laboratory comparisons and PTschemes do, however, have somelimitations. Each comparison or PTround is time-consuming andexpensive, comparability of resultsextends only to the relatively smallnumber of participants, there isusually no means of establishingcomparability between differentcomparisons or PT schemes, and itis impracticable to organize them forevery routine analytical measurementapplication. Thus this approach isgenerally reserved for critical applications where a relativelysmall number of laboratories mustestablish that their results are ingood agreement.
Traceable MeasurementsA potential alternative to using directcomparisons between laboratoriesis to apply the concept of traceabilityto chemical analysis [1]. This conceptis universally accepted for physicalmeasurements and metrologists have
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worked for well over 100 years toachieve international comparabilityof their measurements on this basis.Traceability works by ensuring thateach measurement result of a particular type (e.g. mass, length ortime) is traceable to a unique pointof reference which is acceptedthroughout the world e.g. an artefact(standard meter or kilogram) keptat the Bureau of InternationalWeights and Measures (BIPM) inParis. The international measurementsystem is, of course, recognized bychemists who use traceable balances,volumetric glassware, thermometers,etc. in their analytical methods.Implementation of an exact analogyto physical traceability has, however,not been possible because analyticalmeasurements are often subject tomatrix effects, i.e. the compositionof the sample as a whole has adirect effect on the relationship between analyte concentration andthe response of the measurementprocedure which comprises the laststep of a complex method.
Chemical MetrologyIn 1993 the InternationalCommittee for Weights andMeasures (CIPM) recognized thelimitations of the existing system withregard to analytical measurementsand established a collaborative programme of work in chemistry[2,3]. This programme is organizedthrough the CIPM's ConsultativeCommittee on Amount of Substance(CCQM). The CCQM members areworking to resolve the practical difficulties of achieving widelyaccepted chemical reference measurements and to provide aninternational structure which enablesnational and regional laboratoriesto demonstrate the equivalence oftheir measurement data. This is beingdone through a series of key comparisons, which reflect applicationsrelevant to industry, trade, health,environment, etc, as well as by arequirement for appropriate qualitymanagement systems. The formalarrangements for this collaborationare set out in a Mutual RecognitionArrangement (MRA) co-ordinated bythe BIPM. In the case of chemistry,links to the key comparisons are beingachieved by national measurementinstitutes (NMIs) through provisionof traceable certified referencematerials (CRM), standards, andcalibration services and by encouraging PT schemes to use traceable reference values whereappropriate. The key comparisonsof the CCQM together with relatedactivities of the CIPM MRA form the
basis for a system of metrology inchemistry.
Role of LGCLGC acts as the UK NMI for inorganic, organic and bio-analyticalmeasurements. It has participatedin the work of the CCQM since itsinception and is well-known for itschemical calibration services [4].These include provision of matrixcertified reference materials (CRM),chemical standards, and traceablereference values for PT schemes.Information about this work,which is part of the DTI ValidAnalytical Measurement (VAM)Programme, can be found on theVAM web site: www.vam.org.uk.
Much, but not all, of the inorganicand organic chemical analysis is basedon mass spectrometry, preferablyusing isotope dilution (IDMS).Analysis using isotope dilutionrequires the addition to the sampleof an isotopically enriched material(often referred to as the 'spike' or'spiking standard') which acts as aninternal standard. Provided theenriched isotope is present in anequivalent state to the natural isotope, it can perform the role of theideal internal standard and exactlycompensate for errors arising at allstages of the analysis, from samplepreparation through to the finalinstrumental measurement.
The rest of this article provides abrief description of two such reference methods based on ICP-MS,together with results from CCQMstudies in which their performancewas compared with methods usedby other NMIs from around theworld. These methods are based onan "approximate matching" IDMStechnique developed at LGC [5] andare very time-consuming (a singleanalysis may take several days orweeks). They would not be suitable forroutine work but offer many advantagesfor reference measurements whereit is essential to minimize the measurement uncertainty.
Analysis of Tributyltin (TBT) in Sediment using HPLC-ICP-MSThis application is a good exampleof the benefit of using species-specificIDMS for speciation analysis. Use ofthe isotopically-enriched species asthe spike ensures that both the spikeand the natural analyte behaveidentically during the measurement.This is particularly important at theextraction stage as it is often difficultto achieve complete extraction of
Agilent ICP-MS Journal March 2006 - Issue 26
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the analyte whilst ensuring that itremains in its original form. With anIDMS measurement, loss of analytein this way will not introduce anerror provided full equilibration ofthe natural and enriched isotopes isachieved prior to extraction. TheIDMS method [6] uses a methanolsolution of TBTCl enriched in 117Sn,prepared at LGC, as the spike. Useof double IDMS for calibrationagainst a natural TBT standard ofknown purity avoids the need for acertified isotopic spike. Sedimentsamples are extracted by acceleratedsolvent extraction (ASE) using aceticacid/methanol (50/50 v/v) as theextraction solvent. The spike solutionis added to each cell before extraction.Each cell is extracted at 100°C and1500psi pressure using a preheat of2 minutes and 5 cycles of 5 minuteduration, followed by a 100 secondflush with nitrogen. The extractsare diluted two-fold with ultra-purewater prior to HPLC-ICP-MS underthe following conditions.
HPLC Conditions:Agilent 1100 HPLC with thermostatedautosampler and column compartmentsColumn: C-18 ACE 3µm particle size,2.1mm x 15 cm.Mobile phase: 65:23:12:0.05 v/v/v/vAcetonitrile/water/acetic acid/ triethylamine.Flow rate: 0.2 mL min-1
Injection volume: 50µL
ICP-MS ConditionsAgilent 7500i ICP-MSIsotopes monitored: 120Sn, 117Sn.Integration time: 0.3 secondsCones: PtO2 added to avoid carbon build-upon cones and interface.
The Agilent Technologies ICP-MSchromatographic software (G1824CVersion C.01.00) is used for integrationof the chromatographic signal andpeak areas are entered into IDMSspreadsheets developed at LGC.This method was used by LGC in aCCQM key comparison (CCQM-K28)which involved analysis of TBT in asediment sample provided by NRCin Canada. Our reference value of1.046 nmol g-1 (with an expandeduncertainty (k=2) of 0.093 nmol g-1)proved to be in excellent agreementwith the other NMIs, as shown inFigure 1. For clarity, the results arenormalized against the consensusvalue for the study.
Analysis of Selenium (Se) in Salmonusing ICP-MS with a Collision CellThis analysis also uses LGC's
"approximate matching" IDMS technique with double IDMS toallow calibration against a naturalstandard. In this case it illustrateshow modern ICP-MS instrumentation
ConclusionsAchieving traceable analytical measurements through implementationof the principles of chemical metrologydepends on the availability of reference values with minimal biasand small measurement uncertainty.The use of modern ICP-MS instrumentation greatly facilitatesthe provision of reference values forinorganic analytes using isotopedilution mass spectrometry (IDMS).This approach has been illustratedwith two examples, for both of whichthe data obtained by LGC have beencompared with that from otherNMIs around the world throughparticipation in CCQM key comparisons. Proven measurementcapability of this type is essentialfor applications such as certificationof matrix reference materials andprovision of reference values for PTschemes. Further detailed informationon all aspects of metrology is available on the BIPM web site(http://www.bipm.org/en/home/).Full reports of CCQM-K28 andCCQM-K43, or any other key comparison, may be obtained fromthe Key Comparison Database(KCDB) maintained by BIPM(http://kcdb.bipm.org/).
References1. Traceability. M Sargent in Encyclopaedia Of
2. The UK Chemical Calibration Facility at LGC,M Sargent, The VAM Bulletin, Issue No. 27, 18-22, (LGC, Teddington, UK, Autumn 2002).
3. Metrology in chemistry: a different approach to comparable analytical results. M Sargent, J. Anal. At. Spectrom., 20, 1017-1018 (2005).
4. UK delivery of traceable chemical measurements in the 21st century: building on the foundation of the VAM programme.M Sargent, Accreditation and Quality Assurance, 8(10), 480-482, (2003).
5. Guidelines for achieving high accuracy in IDMS, M Sargent, R Harte, C Harrington, RSC, Cambridge, UK, (2002). ISBN: 0-85404-418-3.
6. A comparison of GC-ICP-MS and HPLC-ICP-MS for the species-specific isotope dilution analysis of TBT in sediment after acceleratedsolvent extraction R Wahlen, C Wolff-Briche, Anal. Bioanal. Chem., 377(1), 140-148, (2003).
AcknowledgementsThe ICP-MS measurements werecarried out by the Inorganic AnalysisTeam at LGC, particularly J. Entwisle,R. Hearn and R. Wahlen. The CCQMkey comparisons were organized byR. Wahlen and C. Wolff-Briche ofLGC, R. Sturgeon of NRC, andY.Aregbe of IRMM. The chemicalmetrology work at LGC is supportedby the DTI VAM Programme.
Normalised results for TBT in sediment, CCQM-K28 (LGC is Lab 3)
can overcome problems which maycause serious errors even whenusing IDMS. The mass spectralinterference due to 40Ar40Ar+ iswell-known as a serious problem formeasurements of the major isotopeof selenium, 80Se+, but Ar-dimer isotopic combinations potentiallyinterfere with most of the Se isotopes.Use of an Agilent 7500ce ICP-MS witha collision cell for measurement ofthe 78Se/77Se isotope ratio helps tosignificantly reduce these isobaricinterferences. A 77Se spike solutionprepared at LGC is added to a 0.4gsample aliquot prior to microwavedigestion in a quartz vessel usingnitric acid (4mL) and hydrogenperoxide (2mL). After digestion, thedigest solutions are diluted byweight to 16g with deionised waterbefore measurement of the 78Se/77Seisotope ratio. The collision cell gasis H2 with a flow rate of 3.5 mL min-1,used with an ICP RF power of 1500 Wand a carrier gas flow rate of 0.92mL min-1. The method was comparedwith those of other NMIs in a recentCCQM key comparison (CCQM-K43),a study which involved analysis ofseveral elements, including Se, in asalmon sample. The LGC referencevalue was 7.04 mmol/kg with anexpanded uncertainty (k=2) of0.034 mmol/kg which is again inexcellent agreement with the otherNMIs, as shown in Figure 2.Results for Se in salmon (CCQM-K43) LGC is Lab. 7
4 Agilent ICP-MS Journal March 2006 - Issue 26 www.agilent.com/chem/icpms
User Profile: LCABIEDrives SpeciationAnalysis AcrossDisciplinesMaïté Bueno, Florence Pannier,LCABIE, Hélioparc, Pau, France
IntroductionCommon interest in the analysis ofchemical forms of trace elementsbrought together the AnalyticalChemistry Group at the University ofPau (led by Martine Potin Gautier,ex colleague of Professor MichelAstruc) and the BioinorganicAnalytical Chemistry Group (led byRyszard Lobinski) to establish amodern ICP-MS facility in Hélioparc(Pau) known as Laboratoire deChimie Analytique Bio-Inorganiqueet Environnement (LCABIE). The teamat LCABIE is dedicated to speciation-related research in environmental,food, and clinical chemistry.
Role of ICP-MSTwo 7500ce ICP-MS have beenpurchased since 2003 and are currently used coupled to laserablation, GC and LC (includingcapillary and nano-LC). These twocollision/reaction cell (CRC) instruments have proved particularlyuseful for the detection of elementsplagued by polyatomic interferences(e.g. selenium). The upgrade of oneof the instruments - adding a 3rdcell gas line for xenon introductionhas made possible the accurate determination of the sulfur isotopes.This current set up of quadrupoleICP-MS at the LCABIE is the resultof an on-going collaboration withAgilent which started in 1997 withthe installation of a 4500 and thebeta testing of a transfer line for GC coupling [1].
Figure 1. a) Effect of the column and interface on the peak shape in HPLC-ICP MS coupling: Analysis of a 250 µg/L selenomethionine standard (ConditionsC18, isocratic 30% ACN); b) cHPLC-ICP-MS chromatogram of a tryptic digest of selenium proteins from yeast.[6,7]
(multidimensional chromatography)is used to purify unknown biologicalcompounds (further identified byelectrospray and MALDI MS techniques). The improvement indetection limits offered by CRC-ICP-MS is particularly profitable formetalloids suffering from argon-relatedinterferences. as shown in Table 1.
Se DL (ng/L)ICP-MS Tot Species7500c - No gas 82Se 110 130-3507500c 78Se 50 140-3203.8 H2 + 0.5 He 80Se 40 70-807500ce 78Se 6 14-305 H2 + 0.5 He 80Se 4 7-15
The research group benefiting fromthe ICP-MS facility consists of 10permanent scientists and a dozenpost-docs and Ph.D. students. Theirmain application areas of interestinclude trace element analysis in water,sediments and biota, interaction ofmetals and metalloids with livingorganisms, and development oftechnologies for treatment of industrial effluents contaminated bymetallic pollutants. The key concernis speciation analysis - defined byIUPAC as "analytical activities ofidentifying and/or measuring thequantities of one or more individualchemical species in a sample" [2]. Itis the chemical form of an elementthat governs its toxicity, essentiality,biological activity, bioavailability andenvironmental impact. Therefore,speciation information has become akey issue in numerous fields includingenvironment, medicine, agriculture,food and nutrition, toxicology, industry, etc.
The major challenge to speciationanalysis is the development of analytical methods coupling effectiveseparation techniques and specificdetection (hyphenated methods).With the growing demand for suchanalytical activities beyond scientificresearch, it is important that developed and validated methods aretransferable to routine laboratories.
Classical HPLC CouplingVarious HPLC separation modeshave been coupled to ICP-MS (actingas the detector) mainly for "routine"analysis of As and Se. For example,cation exchange chromatography isused to quantify arsenic species inlandfill leachates [3]. For seleniumspecies, water analysis is performedeither by anion exchange or porousgraphitic carbon stationary phases[4, 5]. The combination of severalseparation modes such as reversedphase, size exclusion, ion exchange
Table 1: Optimized operating CRC conditions andcorresponding Se detection limits (ng/L). Cell gasflow rates in mL/min
Downscaling LC Separation The miniaturisation of HPLC is animportant challenge to bioanalyticalchemistry e.g. when an amount ofless than several micrograms of arare sample is available or whenbiological processes in single cellsor in sub-cellular entities need to beinvestigated. The use of these nanoflowseparation techniques includingcapillary and nano-HPLC is difficultwith ICP-MS because of the flowrates being 100-1000 lower thanconventional nebulizers. However,our lab has developed dedicatedinterfaces based on high-efficiency,low-sample consumption, zero deadvolume sample introduction systems.The first sheathless interface wasdeveloped between capillary HPLC(300 µm column i.d.) and ICP-MS forselenopeptide mapping in a proteinfraction from a selenized yeastextract with absolute detectionlimits 100 to 150 lower than reportedfor HPLC-ICP-MS [6]. For even lowervolumes of sample, a novel nebulizer(nDS-200) working at sample uptakeof less than 500 nL/min was
5www.agilent.com/chem/icpms Agilent ICP-MS Journal March 2006 - Issue 26
Figure 3. Quantification of selenomethionine in serum by 2D SEC - cRP HPLC - ICP MS. a) Size-exclusion ICP MS (no collision cell) chromatogram; b) cHPLC-ICP-MS with collision cell. Total Se: 71 + 7 ng/g, total seleno amino acids: 63.1 + 2.8 ng Se/g, selenomethionine: 12.6 + 0.4 ng Se/g, selenocysteine (50.5+ 2.5 ng Se/g) [9].
Figure 2. Analysis of total extract of selenized yeast by gel electrophoresis LA-ICP-MS [8].
developed for a sheathless interfacingof nano-HPLC (75 µm column i.d.)with ICP-MS, with absolute detectionlimits of 25 fg of Se [7].
Figure 1 shows the comparison ofthe peak shapes and resolution gainfor selenomethionine under the samechromatographic conditions usingthe three different LC couplings.
Laser Ablation-ICP-MS
To analyze in-situ trace elements insolid materials the coupling of laserablation (LA) with ICP-MS has alsobeen investigated. This technique isparticularly suitable for the detectionof heteroatoms containing proteinsor metal biomolecular complexesseparated by mono or bi-dimensionalgel electrophoresis. The use of theLA allows the localisation of thecompounds of interest, which canbe further extracted from the gel forMS analysis. Figure 2 presents anexample of a total extract of selenizedyeast for localisation of seleniumcontaining proteins separated on amono dimensional gel.
Isotope Dilution Capillary HPLC-ICP-MS
A method for the accurate determination of selenoamino acidsin human serum by HPLC-ICP-MSwas developed using the species-specific isotope-dilution analysisprinciple. A serum sample wasenzymatically digested with a mixtureof lipase and protease after derivatization of the selenocysteineresidues with iodoacetamide. Theselenoamino acid fraction was isolatedby size-exclusion LC followed by theseparation of selenomethionine andthe carboxymethylated selenocysteineby capillary HPLC. The isotope specific determination of 77Se and80Se was achieved on-line by CRC-ICP-MS allowing the removal ofpolyatomic interferences.
were 3pg/L in water and 30pg/L inbiological tissue.
AcknowledgementsThe authors wish to thank all themembers of the team involved inthese developments for their precioushelp.
References[1] Anal. Chem., 1999, 71, 4534-
4543[2] Pure Appl. Chem., 2000, 72,
1453-1470[3] Proceedings of "10th
International Waste Managementand Landfill Symposium" 2005
Quantification was carried out byisotope dilution using a 77Se-labelledselenomethionine spike and thedetermination of the 77Se/80Se ratioin the cHPLC - selenomethioninepeak [9], see Figure 3.
Isotopic Dilution for Volatile Compounds Quantification by GC-ICP-MSIsotopic dilution was also developedfor quantification of organomercuryand organotin compounds in variousenvironmental and biological samplesanalyzed by GC-ICP-MS, aftercareful optimization of separationand detection parameters to obtaingood precision and performances.After spiking with the isotopicallyenriched species: (117DBT, 117TBT,Me202Hg, 199Hg2+), extraction of sampleis performed by either microwaveor sonication assistance beforeethylation. A detection limit of 1 pg/L for 202Hgin water was obtained from a 2µLinjection using Reverse IsotopicDilution (RID). The DL for 202Hg inbiological tissue was 12 pg/L and 20pg/L in blood. The DL's for 120Sn
Sample
Molecular weight kDa
6 Agilent ICP-MS Journal March 2006 - Issue 26 www.agilent.com/chem/icpms
New Maintenance DVDReleased for 7500 SeriesICP-MSHidenori Koide, Agilent Technologies
The latest edition of the maintenancevideo has been released and is available on DVD. This DVD containsan easy-to-use menu that combinesover 3 hours of video, text instructionsand detailed maintenance partslists to keep you up-to-date on thelatest techniques and support partsfor the 7500 Series ICP-MS.
New features include:
• Installing the sample line connectorblock and internal standard tubing kit
• A new method for cleaning the Sampling and Skimmer cones
• Maintaining the Micro Flow nebulizer
• Maintaining the 7500ce and 7500cs lenses
• Disassembling the Octopole Reaction System cell
• Cleaning the Octopole• Testing after maintenance
The Agilent part number for theDVD is G3270-65100.
7500cs and 7500ce users will receivetheir copy of the DVD directly fromtheir Agilent engineer, free of charge.If you do not receive your DVD,please contact your nearest Agilentcontact center.
7500a users are encouraged toorder a copy of the DVD throughtheir local Agilent contact center.
Service and SupportNews:Non-Agilent Consumablesfor 7500 and 4500 SeriesGlenn Carey, Agilent Technologies
As the userbase of the Agilent 7500Series grows year on year, so toodoes the sale of performance-criticalrelated consumables manufacturedand supplied by unauthorized dealers.It is understandable that users willpurchase non-Agilent consumableswhich are often sold as Agilentequivalent and are typically 20-40%lower in price than genuine parts.
Unfortunately we are seeing a higherincidence of failure of these parts,which can result in downtime anda costly repair bill. Most often, whenan Agilent ICP-MS isn't working asnormal, the user will call Agilent todiagnose and repair the instrument.If the problem is diagnosed to becaused by a non-Agilent consumable,the customer will be charged forthe engineer time and parts usedduring the repair.
Consumables that are copied mostoften are the sample cone, skimmercone, torch, and spray chamber.
Sample ConesThe main problem with non-Agilentsample cones is the junction between the copper base and thenickel or platinum insert. If the insertis not attached correctly, a vacuumleak can occur, which reduces theperformance of the interface zone.In addition, the tip of the cone willno longer cool correctly because ofpoor conductance between the copperbase and the nickel or platinuminsert.
Case StudyI received a (non-Agilent) cone froma customer recently where it waspossible to push the insert out ofthe copper base with little effort.The cone was made from a materialmix not used by Agilent: copperbase, 25 mm nickel insert with a 7mm platinum insert.
Skimmer ConesThe problems encountered withnon-Agilent skimmer cones aresimilar to the sample cone issues,
although the issue is more complexbecause of the many different typesof skimmer cone: 4500, 7500a, 7500c,7500 (T mode), 7500ce and 7500cs(platinum). The manufacturing detailof each different cone is critical.
TorchThe common design fault with non-Agilent torches is subtle andregards the position of the plasma gasconnector arm. If this is incorrectlypositioned, ignition can be extremelydifficult when using the shield.
Spray ChamberAgain the fault we have seen withsome non-Agilent spray chambersis subtle and regards the location ofthe drain port. If this is incorrectlypositioned, it won't fit onto thedrain seal correctly, causing an airleak; this in turn can lead to ignitionproblems.
Agilent ConsumablesThe Agilent logo is now stamped onauthentic, Agilent consumablesincluding sample cones, skimmercones, torches and spray chambers.Insure you are using consumables withthe Agilent logo: its your guaranteefor instrument performance andreliability.
Look out for the Agilent logo on authentic consumables
7www.agilent.com/chem/icpms Agilent ICP-MS Journal March 2006 - Issue 26
Interface Cone Part Number Guide for Agilent 7500 ICP-MSThe following table has been compiled to help 7500 Series users identify which sampling cone, skimmer cone orbase plate is the right one for their instrument. Operators can check at a glance which part is standard (std) orsuitable (x) for their model.
Key: x Can be used on this model, to extend the analytical capability e.g. higher acid concentration or higher matrix tolerancestd Fitted as standard when instrument is shipped
Notes: • 18mm Pt cone insert is recommended for measuring H2SO4 above 2%• Pt T-mode cones are not available• T-mode is not used with ORS models
Sampling cone 7500a 7500i 7500s 7500c 7500ce 7500cs T-modeG1820-65238 Ni Sampling Cone std std x std std xG1820-65239 Pt Sampling Cone (10 mm Insert) x x std x x stdG1820-65360 Pt Sampling Cone (18 mm Insert) x x x x x xG1820-65480 Ni Sampling Cone for T-mode T-mode T-mode T-mode x
Skimmer cone 7500a 7500i 7500s 7500c 7500ce 7500cs T-modeG1820-65050 Ni Skimmer Cone std std xG3270-65024 Ni Skimmer Cone for 7500ce stdG1833-65497 Ni Skimmer Cone for 7500cs std xG1820-65237 Pt Skimmer Cone x x stdG1833-65092 Pt Skimmer Cone for 7500c xG1833-65132 Pt Skimmer Cone for 7500ce and 7500cs x stdG1820-65481 Ni Skimmer Cone for T-mode T-mode T-mode T-mode x
Skimmer base 7500a 7500i 7500s 7500c 7500ce 7500cs T-modeG1833-65407 Stainless skimmer base for Ni Skimmer std std x xG1833-65591 Stainless skimmer base for Ni Skimmer std x
(ce,cs)
G1833-65498 Stainless skimmer base for Ni Skimmer std(7500c)
G1833-65408 Brass skimmer base for Pt Skimmer x x stdG1833-65505 Brass skimmer base for Pt Skimmer x
(7500c)
G1833-65590 Brass skimmer base for Pt Skimmer x std(ce,cs)
Choice of PreventiveMaintenance Program for7500 Series ICP-MSDavid Wilkinson, Agilent Technologies
Following a review of the 7500 SeriesICP-MS Preventive Maintenance(PM) program, some significantchanges have resulted which willallow our customers to maximizeuptime by adhering to the recommended service intervals for thevacuum system - all at a reasonableprice:
• Two PM products have been created: a Major and a Minor PM
• The Major PM (R-20L) is comprehensive, involving all stepsof the previous PM but with the addition of:- A complete clean of the ion lenses- Replacement of the octopole for
ORS instruments • The Minor PM (R-20R) involves
changing the rough pump oil andchecking the instrument.
and octopole replacement for ORSinstruments, the value of the MajorPM is greatly enhanced.
Major PM • Order number R-20L• Included with support bundles
21B and 21P • Includes cleaning of all ion lenses • Replacement of the Octopole for
ORS instruments
Minor PM • Order number R-20R• Not included with any support
bundles - needs to be purchased in addition to 21A, 21B or 21P.
• Customers can purchase additionalminor PM's in the year if their application requires greater frequency of vacuum system maintenance.
• The Minor PM can only be purchased in conjunction with a Major PM, as the Minor PM does not include sufficient maintenanceitems to improve instrument performance or uptime by itself.
Revamping the PM protocols wasdone to allow our customers to runat top performance, since regularscheduled Preventive Maintenancereduces downtime and repair costs.
Studies of instrument repair calls onAgilent's analytical systems concludethat over 60% of all repairs are notfunctional failures but are mainly dueto lack of preventive maintenance.However, if a customer implementsa thorough maintenance program,the overall failure rate for mechanicalsystems decreases by up to 25%.
Why Two PM Packages?
Agilent has always recommendedchanging the rough pump oil at sixmonthly intervals for its ICP-MSproducts. To obtain this service fromAgilent in the past was expensivesince it was only available as part ofa full PM. Now customers have greater flexibility in managing the PM for their instrument.Furthermore, with the addition of ionlens cleaning for all instruments,
New Agilent ICP-MS Users A very warm welcome to the following companies and institutions thathave recently added an Agilent ICP-MS to their analytical facilities.•Tsumura Medicine Company, China • Tang-Shan Waste Water TreatmentFactory, China • The National Forensic Testing Center, China • TheNational Ocean Research Testing Center, DaLian, China • Arkema, France• Laboratoire Central de la Police de Paris, France • Labor Dr Wessling 3Altenberge, Germany • Labor Dr Wessling 4 Opin,Germany • LUABremen, Germany • Merck 2, Germany • MUVA Kempten, Germany •Schott, Germany • TUV Munich, Germany • UFZ Leipzig, Germany •Kerry County Council, Ireland • ENI Spa per San Nazzaro dei Burgundi,Italy • Istituto San Michele All' Adige Trento, Italy • JRC ISPRA II, Italy• Neotron, Italy • Pluri Acque Salerno, Italy • SGS Ecologia, Italy •Analytico Agrifood, Netherlands • Victoria University, New Zealand • IAEAMinsk, Russia • Belgrade Health Institute, Serbia • Hydrometrologicalinstitute of Serbia, Serbia • BOC Edwards, Singapore • Escom Koeberg,South Africa • CNTA Laboratorio del Ebro, Spain • Lab Sanidad Albacete,Spain • Minsterio de Agricultura, Spain • Univ Pais Vasco, Spain •Universidad Autónoma de Barcelona, Spain • Universitat de Barcelona,Spain • CENPRO Technology Co., Ltd, Taiwan • Macronix InternationalCo., Ltd, Taiwan • TAC TRI, Taiwan • Yeou Fa Chemical Co., Ltd, Taiwan• Toppoly Optoelectronics Corp, Taiwan • Atomic Weapons EstablishmentII, UK • AWE, UK • University of Birmingham, UK • Battelle MemorialInstitute, USA • Brooks AFB II, USA • California Air Resources Board,USA • Commonwealth of Kentucky, USA • EKC II, USA • EP Scientific,USA • First Solar, USA • Global Nuclear Fuels, USA • Huntington AlloysSpecial Metals, USA • LA County Sanitation, USA • Micron Idaho II, USA• Mitsubishi Polycrystalline Silicon, USA • Mykrolis Integris, USA •Philadelphia Water, USA • STL Denver, USA • STL Edison, USA • UCLA,USA • Univ of California -Riverside, USA • University of Texas at Austin,USA • University of Utah, USA • Washington University, USA • Xenco III,USA • Marine Environmental Monitoring & Analysis Centre, Vietnam •
New ICP-MS VideoOnlineTake a Close Look at the Agilent7500ce ORS
This new 7-minute video describesthe main components and principlesof an ICP-MS system, featuring theAgilent 7500ce. Of special interest isan animated sequence showingevery stage of a sample's journeythrough the ICP-MS - from the samplevial through to the detector, includingan "ion's eye" view of the journeythrough the ion lenses, collision celland mass analyzer. This visualizationof the processes involved in ICP-MSwill aid understanding of the technique.
A link to the ICP-MS video web pagecan be found at www.chem.agilent.com/icpmswhere the video can be downloadedin Windows Media File (.wmv) format.
Karen Morton for Agilent Technologiese-mail: [email protected] ICP-MS Journal Editor
Winter Plasma Conference 2006 ReportThe Winter Plasma Conference recently took place in Tucson, Arizona (Jan8-14th 2006) and was a great success. Attendance was the highest for severalyears with almost 550 conferees and exhibitors attending. The scientificprogram was excellent, as was the great setting in the high desert. Formost of us it was great to actually see the sun for a few days! Agilent tooka large contingent of ICP-MS staff with almost 30 of us attending.Displayed on the Agilent booth was the new 7500ce video which was verywell received by the conferees.
The famous Agilent ICP-MS user meeting was once again a great successwith over 140 people enjoying a great evening. Something new at the usermeeting for this year was a game show - hosted as always by Agilent'sChris Scanlon. This year we played "Who Wants to be a Counts Per SecondMillionaire?" The "CPS Millionaire" winner was Juris Meija from NRC, whoreceived an Apple iPod. Here's looking forward to the next Winter PlasmaConference in Taormina, Sicily, in 2007!
Agilent ICP-MS PublicationsTo view and download these latest publications, go towww.agilent.com/chem/icpms and look under "Library Information"
Primer: ICP-MS Primer, 5989-3526ENApp Note: Determination of Impurities in Semiconductor GradeHydrochloric Acid Using the Agilent 7500cs ICP-MS, 5989-4348ENApp Note: RoHS/ELV Directives - Measurement of Heavy Metals using ICP-MS, 5989-3574EN
