AGRAZINC AGRAZINC 100100

www.agranco.com

WHAT IS AGRAZINC 100

AGRAZINC 100 is a concentrated for of micro-encapsulated ZINC OXIDE

For a more effective release int the gastrointestinal tract of animals.

For treatment against DIARREAH.

MODE OF ACTION

The lipid coating in AGRAZINC 100 is disolved by hy lipase enzyme when it reached the duodenum and ZINC OXIDE is slow released into the area for immediate action.

The micro-encapsulation prevents the AGRAZINC 100 from being adosorbed or changed before it gets to the duodenum.

The micro-encapsulation PREVENTS the natural negative effect on palatibility by ZINC OXIDE.

AGRAZINC 100: Effects on post weaned piglets 1

Design

90 hds at avg. 24 days, 3 hds per pen(30 pens) Place and Period: Florida (US), for 28 days

(OCT, 2006)

AGRAZINC 100: Effects on post weaned piglets 1

Diet design(normal) 1-12 days : CP 22%, Total lysine 1.6% 13-28 days : CP 18%, Total lysine 1.25% * all diets are included with 100ppm ZnSO4

Treatments

Control: normal diet+ZnO, 150ppm Zn Treated 1(T1): normal diet+ ZnO, 3000ppm Zn Treated 2(T2): normal diet+ AGRAZINC 100,

200g/T

AGRAZINC 100: Effects on post weaned piglets 1

0

0.1

0.2

0.3

0.4

0.5

ZnO,150ppm

ZnO,3000ppm

AGZ 200g

ADG, kg/ d

P<0.05

[United States, 2006]

0.345

0.4570.462

AGRAZINC 100: Effects on post weaned piglets 1

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

ZnO,150ppm

ZnO,3000ppm

AGZ 200g

ADFI , kg/ d

P<0.05

[United States, 2006]

0.578

0.70.694

AGRAZINC 100: Effects on post weaned piglets 1

0.560.570.580.59

0.60.610.620.630.640.650.660.67

ZnO,150ppm

ZnO,3000ppm

AGZ 200g

Gain/ Feed, kg/ kg

P<0.05

[United States, 2006]

0.6

0.65

0.67

AGRAZINC 100: Effects on post weaned piglets 1

0

2

4

6

8

10

12

14

ZnO,150ppm

ZnO,3000ppm

AGZ 200g

Diarreah, %

13.4 %

3.2%3.7%

P<0.05

[United States, 2006]

AGRAZINC 100: Effects on post weaned piglets 2

Design Post weaned piglets 90 hds at avg. 20 days, 5

hds/pen(18pens), 3 replications Place and Period: Florida (US), 28 days (DEC,

2006) Diets design (normal) and materials

1-8 days: 1.5% total lysine 9-28 days: 1.3% total lysine ZnO: Zn 72% Antibacterial agent: Carbadox 55mg/kg

AGRAZINC 100: Effects on post weaned piglets 2

Treatments control: normal diet Treated 1(T1): control+ AGZ 200g/T T2: control+ ZnO 3000ppm T3: control+ Carbadox 55mg/kg T4: T3+ AGZ 200g/T T5: T4+ ZnO 3000ppm

AGRAZINC 100: Effects on post weaned piglets 2

300

310

320

330

340

350

360

370

380

대조구 T1 T2 T3 T4 T5

Carbadox 55mg/kg, No Carbadox

Daily Gain, g

[United States, 2006]

P<0.05

AGRAZINC 100: Effects on post weaned piglets 2

500

510

520

530

540

550

560

570

580

대조구 T1 T2 T3 T4 T5

Daily Feed Intake, g

P<0.05

[United States, 2006]Carbadox 55mg/kg, No Carbadox

AGRAZINC 100: Effects on post weaned piglets 2

AGRAZINC 100 give ‘synergy effect’ to producers when it was used with AGPs

AGRAZINC 100 200g/t can replace the effect of ZnO at 3000 ppm, effectively.

AGRAZINC 100: Effects on post weaned piglets 3 Place and Period

National Swine Reaserch and Training Center(Thailand), 35 days

Design Post weaned piglets 32 hds at 35 days, 8

hds/pen(4pens) Infected 10 ml of 107cfu of E. coli and 10 ml of 107 cfu

of haemolytic E. coli(K88) in every pig in the 3th days after weaning and keep the data same parameter

Antibiotics(Colistin 100ppm)

AGRAZINC 100: Effects on post weaned piglets 3

250260270280290300310320330340350

대조구AZ100g+Colistin100ppm

AZ300g+Colistin100ppm

ZnO 3000ppm

AZ 300g

ADG, g

AGRAZINC 100: Effects on post weaned piglets 3

0

0.5

1

1.5

2

2.5

대조구 AZ100g+Colistin100ppm

AZ300g+Colistin100ppm

ZnO 3000ppmAZ 300g

FCR

AGRAZINC 100: Effects on post weaned piglets 3

AGRAZINC 100 treatment had better performance, even in case of haemolytic E. coli(K88) infection.

AGRAZINC 100 show ‘synergy effects’ when it was used with antibiotics.

AGRAZINC 100 is the effective alternative for pharmacological level of ZnO in animal diets

AGRAZINC 100: Effects of ZnO sources on piglet’s performance(2007. April) Trial design and Place

6 weeks old piglets weaned at 35 days, 60 heads. 20 heads/group, 3 test groups. 24 days trail Dr. Wang, Ji-Hui(Prof.), Dalian Polytechnic Univ.(China)

Trial diets designControl: normal diet spec. + ZnO 3000ppmT1: normal diet spec. + Agrazinc 300ppmT2: normal diet spec. +Agrazinc 100ppm

* Effects of pharmaceutical dosage of ZnO is well known, so we have conducted this trial without ‘negative control without 3000ppm’ intentionally.

Diet : Corn-soy based diet

Measuring Items Feed Intakes Average Daily Gain(ADG) FCR Diarrhea rate(%) Metabolism value, % pH profile in digestive tract Microorganism profile in digestive

tract

Avg. Daily Feed Intake(ADFI)

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

T1 T2 control

AD

FI,

kg

0.816±0.333

0.897±0.162

0.730±0.074

Avg. Daily Gain(ADG)

0

0.1

0.2

0.3

0.4

0.5

T1 T2 control

0.318±0.166

0.459±0.1090.483±0.050

AD

G,

kg

FCR

0

1

2

3

T1 T2 control

2.753±0.468

1.978±0.169

1.512±0.022

Diarrhea rate (%)

0

1

2

3

4

T1 T2 control

Dia

rrh

ea r

ate

, %

3.45±3.28

2.11±2.40

1.48±1.92

Dry Matter(DM) Metabolism value, %

787980818283848586878889

T1 T2 control

DM

meta

bolism

, %

81.95±1.76

86.90±1.44

88.09±0.86

Metabolism value, %

0

10

20

30

40

50

60

70

80

90

T1 T2 control

Crude Protein

Crude Fat

Ash

Meta

bolism

valu

e,

%

76.34

83.0185.42

65.23

50.19

74.39

48.53

61.7764.02

pH profile in digestive tract

5

6

7

8

Duodenum J ejunum Ileum Caecum

T1

T2

control

pH

valu

e

7.29

6.156.07

6.18

6.19

7.06

6.286.17

6.88

7.70

7.117.08

Microorganism profile in digestive tract: E. coli, log10

3

4

5

6

7

8

Duodenum J ejunum I leum Caecum

T1

T2

control

E.

coli,

log

10

6.26

5.445.42

4.74

6.20

5.525.565.28

7.14

6.73

6.40

5.66

Microorganism profile in digestive tract: Lactobacillus acid., log10

3

4

5

6

7

8

9

Duodenum J ejunum I leum Caecum

T1

T2

control

Lacto

bacillu

s a

cid

., log

10

8.88

7.697.82

8.89

8.667.667.76

8.81

7.35

6.516.14

7.20

Microorganism profile in digestive tract: Bifidobacterium bifidum, log10

5

6

7

8

9

10

Duodenum J ejunum I leum Caecum

T1

T2

control

Bifi

dob

acte

riu

m b

if.

, lo

g10

9.239.409.499.62

9.079.24

9.39

9.80

8.03

7.59

7.10

8.12

Summary AGRAZINC 100…

It showed superior beneficial effects in growth, digestion, diarrhea and microorganism in the gut of piglet in comparison with normal pharmaceutical dosage of ZnO. It means we can reduce inclusion level of ZnO in animal diets with sustainable performances..

..and avoid environmental pollution. In addition, AGRAZINC 100 also showed a good performance in micro organism control in the gut; reduction in E. coli. It may replace AGPs in diets successfully.

AGRAZINC 100: benefits Treat and prevent Diarrhea Minimize the excretion of Zn: prevent

environmental pollution Better Feed Intake Alternative for AGPs ADG & FCR improvement Reduce pH in the gut Increase the activity of beneficial micro organism Reduction in pathogen; E. coli etc.

AGRAZINC 100

INCLUSION RATES:

PIGLETS and CALVES: 200 gr/MT of feed (if they encounter severe case, 300 gr/MT are recommened)

SWINES,LAYERS AND BROILERS:100 gr / MT of feed

DAIRY AND BEEF CATTLE: 4 GRAMS/HEAD PER DAY

HORSES: 2 GRAMS / HEAD PER DAY

SHEEP: 2 GRAMS PER HEAD PER DAY.