AHA Research Program Overview

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Presentation OutlinePresentation Outline• Mission and GoalsMission and Goals• Budget PriorityBudget Priority• Discoveries and AdvancementsDiscoveries and Advancements• National, Affiliate and State Funding DataNational, Affiliate and State Funding Data• Institutional SnapshotInstitutional Snapshot• Affiliate ReorganizationAffiliate Reorganization• National and Affiliate AwardsNational and Affiliate Awards• Application Volume and Success RatesApplication Volume and Success Rates• Application Process and TimelineApplication Process and Timeline• Peer Review StructurePeer Review Structure• Q&AQ&A

Mission & Impact GoalMission & Impact Goal

MissionMission"Building healthier lives, free of "Building healthier lives, free of cardiovascular diseases and stroke" cardiovascular diseases and stroke"

Impact GoalImpact GoalTo reduce coronary heart disease, stroke To reduce coronary heart disease, stroke and risk by 25% by 2010and risk by 25% by 2010

Research Research AHA Top PriorityAHA Top Priority

The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission.

Knowledge Discovery is a strategic driving force in all that we do.

Research GoalsResearch Goals• Ensure that highly meritorious research and discovery continues, Ensure that highly meritorious research and discovery continues,

including supporting early career investigatorsincluding supporting early career investigators• Increase the capacity of the research community to generate the Increase the capacity of the research community to generate the

highest quality researchhighest quality research• Promote a research infrastructure that expedites the translation of Promote a research infrastructure that expedites the translation of

basic, clinical, behavioral and population research into practicebasic, clinical, behavioral and population research into practice

Publicly Donated DollarPublicly Donated Dollar

Donor Dollar

28¢

25¢ 75¢

National Center

SC Affiliate

ResearchAllocation

15¢13¢

Public Health Education40.6%

Fundraising13.0%

Management& General7.2%

Professional Educ & Training11.7%

Research21.4%

Community Services6.1%

AHA’s 2005-06 AHA’s 2005-06 EXPENDITURESEXPENDITURES

AHA National Budget Expenditures

$0

$20

$40

$60

$80

$100

$120

$140

$160

A B C D E F G H

Research ExpenseResearch Expenseforfor

Major National Health Agencies: 2006Major National Health Agencies: 2006A American Cancer Society

B Alzheimer’s Association

C American Diabetes Association

D National Multiple Sclerosis Society

E March of Dimes

F Muscular Dystrophy Association

G Juvenile Diabetes Association

H American Heart H American Heart AssociationAssociation

AHA-Funded BreakthroughsAHA-Funded Breakthroughs

AHA-funded research has led to the discovery and development of AHA-funded research has led to the discovery and development of many treatments and procedures that were once more like many treatments and procedures that were once more like science fiction: science fiction:

• First artificial heart valveFirst artificial heart valve• Techniques and standards for CPRTechniques and standards for CPR• Implantable pacemakersImplantable pacemakers• Treatment for infant respiratory distress syndromeTreatment for infant respiratory distress syndrome• Cholesterol inhibitorsCholesterol inhibitors• Drug-coated stentsDrug-coated stents• MicrosurgeryMicrosurgery• Links between dietary fat and cholesterolLinks between dietary fat and cholesterol

Selected Research Selected Research AdvancementsAdvancementsAll of the following were funded by the American Heart Association

1956 – Dr. Ancel Keys links dietary fat with cholesterol.

1957 – Dr. William Wierich joined by Drs. Vincent Gott and Walter Lillehei implant the first externally powered pacemaker.

1966 – Dr. Maurice Sokolow announces results of his 20-year study showing hypertension can decrease life expectancy.

1968 – Dr. William Connor employs holestyramine to lower cholesterol in the blood.

1972 – Dr. Arthur Guyton provides evidence of the overriding dominance of the kidneys in long-term regulation of blood pressure and in hypertension.

1985 – Dr. Joseph Goldstein and Dr. Michael Brown provide new insights into the ways fatty cholesterol enters body cells and why cholesterol levels my become too high.

1992 – Dr. Edwin Krebs joined by Dr. Edmond Fischer discover how proteins are switched to perform functions within the cells.

1998 – Dr. Andrew Marks develops a method to reduce re-blocking of the arteries after angioplasty.

2003 – Dr. Peter Agre discovers aquaporins, proteins that govern the movement of water in and out of cells.

National Research StatisticsNational Research Statistics• AHA has spent over $2.9 billion on research since 1949 and currently funds AHA has spent over $2.9 billion on research since 1949 and currently funds

about 2,500 scientists around the countryabout 2,500 scientists around the country

• AHA is second only to NHLBI in funding heart researchAHA is second only to NHLBI in funding heart research

• AHA spent almost $148 million on research last yearAHA spent almost $148 million on research last year

• AHA’s administrative costs represents only 3.9% ($5.7 of the $148 million AHA’s administrative costs represents only 3.9% ($5.7 of the $148 million spent)spent)

• AHA needed an additional $92.7 million to fund 608 highly meritorious AHA needed an additional $92.7 million to fund 608 highly meritorious applications that went unfunded last yearapplications that went unfunded last year

• AHA has funded the winners of 9 Nobel PrizesAHA has funded the winners of 9 Nobel Prizes

• About 75% of the AHA’s award dollars support research career development About 75% of the AHA’s award dollars support research career development – helping the scientists of tomorrow– helping the scientists of tomorrow

SCA Research StatisticsSCA Research Statistics• AHA is currently providing support to 197 researchers in 19 citiesAHA is currently providing support to 197 researchers in 19 cities

• AHA will spend $12 million supporting SCA research in 2008AHA will spend $12 million supporting SCA research in 2008

• AHA currently has a research commitment of over $38 million in SCAAHA currently has a research commitment of over $38 million in SCA

• AHA received over 308 applications from SCA researchers in 2008AHA received over 308 applications from SCA researchers in 2008

• AHA lacked the additional $8,304,474 to fund all the highly meritorious AHA lacked the additional $8,304,474 to fund all the highly meritorious applications from SCA – even though our overall success rate was about applications from SCA – even though our overall success rate was about 22%22%

SCA State OverviewSCA State OverviewArkansas: 11 AHA awards worth $1,876,000Arkansas: 11 AHA awards worth $1,876,000

New Mexico: 12 AHA awards worth $1,848,856New Mexico: 12 AHA awards worth $1,848,856

Oklahoma: 10 AHA awards worth $1,452,924Oklahoma: 10 AHA awards worth $1,452,924

Texas: 164 AHA awards worth $33,719,505Texas: 164 AHA awards worth $33,719,505

ReorganizationReorganization

• Change in AffiliatesChange in Affiliates• Effect on award offeringsEffect on award offerings• Effect on peer reviewEffect on peer review

AHA Research ProgramAHA Research ProgramThe AHA supports research broadly related to cardiovascular function The AHA supports research broadly related to cardiovascular function

and disease, stroke or to related clinical, basic science, bioengineering and disease, stroke or to related clinical, basic science, bioengineering or biotechnology, and public health problems.or biotechnology, and public health problems.

NATIONAL CENTER AWARDSNATIONAL CENTER AWARDS::• Clinical Research Program (Clinical Research Program (NEW in 2008NEW in 2008))• Scientist Development GrantScientist Development Grant• Fellow-to-Faculty AwardFellow-to-Faculty Award• Established Investigator AwardEstablished Investigator Award

SOUTH CENTRAL AFFILIATE AWARDSSOUTH CENTRAL AFFILIATE AWARDS::• Predoctoral FellowshipPredoctoral Fellowship• Postdoctoral FellowshipPostdoctoral Fellowship• Beginning Grant-in-AidBeginning Grant-in-Aid• Grant-in-AidGrant-in-Aid

National AwardsNational AwardsFellow-to-Faculty Transition AwardFellow-to-Faculty Transition Award• To provide funding for To provide funding for traineestrainees with outstanding potential for careers as with outstanding potential for careers as

physician-scientists in cardiovascular or stroke research during the crucial physician-scientists in cardiovascular or stroke research during the crucial period of career development that spans the completion of research training period of career development that spans the completion of research training through the early years of the first faculty/staff positionsthrough the early years of the first faculty/staff positions<Maximum of <Maximum of 5 years5 years of support with maximum annual amounts of of support with maximum annual amounts of $65,000$65,000 for the training stage and for the training stage and $132,000$132,000 for the faculty stage> for the faculty stage>

Clinical Research Program (NEW)Clinical Research Program (NEW)• To encourage To encourage early career investigatorsearly career investigators who have appropriate and supportive who have appropriate and supportive

mentoring relationships to engage in high quality mentoring relationships to engage in high quality introductory andintroductory and pilot pilot clinical studiesclinical studies that will guide future strategies for reducing cardiovascular that will guide future strategies for reducing cardiovascular disease and stroke while fostering new research in clinical and translational disease and stroke while fostering new research in clinical and translational science, and science, and encouraging community- and population-based activitiesencouraging community- and population-based activities..<<2 years 2 years of project and salary support with maximum annual amount of of project and salary support with maximum annual amount of $55,000$55,000>>

Scientist Development GrantScientist Development Grant• To support highly promising To support highly promising beginning scientistsbeginning scientists in their progress in their progress

toward independence; bridges the gap between completion of toward independence; bridges the gap between completion of research training and readiness for competition as an independent research training and readiness for competition as an independent investigatorinvestigator<<4 years4 years of project and salary support with maximum annual of project and salary support with maximum annual amount of amount of $77,000$77,000>>

Established Investigator AwardEstablished Investigator Award• To support To support mid-term investigators mid-term investigators with unusual promise, a rapidly with unusual promise, a rapidly

growing research career and an growing research career and an established record of established record of accomplishmentsaccomplishments; candidates have ; candidates have demonstrated commitmentdemonstrated commitment to to cardiovascular or cerebrovascular science as indicated by prior cardiovascular or cerebrovascular science as indicated by prior publication history and scientific accomplishmentspublication history and scientific accomplishments<<5 years5 years of project support with a maximum annual amount of of project support with a maximum annual amount of $100,000$100,000>>

offered only in Julyoffered only in July

National Awards cont.National Awards cont.

Programs Offered by the South Central Affiliate

• Predoctoral FellowshipPredoctoral Fellowship

• Postdoctoral FellowshipPostdoctoral Fellowship

• Beginning Grant-in-AidBeginning Grant-in-Aid

• Grant-in-AidGrant-in-Aid

Predoctoral FellowshipPredoctoral Fellowship

To inspire individuals to initiate careers in cardiovascular To inspire individuals to initiate careers in cardiovascular and stroke research and to support students conducting and stroke research and to support students conducting doctoral dissertation projects which broadly relate to the doctoral dissertation projects which broadly relate to the cardiovascular areas, including stroke.cardiovascular areas, including stroke.

• 1 or 2 years 1 or 2 years support at support at $23,000$23,000 per year. per year.

• Support limited to Support limited to doctoral candidatesdoctoral candidates enrolled in an accredited non-profit enrolled in an accredited non-profit institution in Texas, Oklahoma, New Mexico or Arkansas.institution in Texas, Oklahoma, New Mexico or Arkansas.

• SponsorSponsor must be applicant’s major professor and may sponsor only one Affiliate must be applicant’s major professor and may sponsor only one Affiliate Predoctoral Fellow at any one time. Any application for a new award that would Predoctoral Fellow at any one time. Any application for a new award that would exceed this limit will not be reviewed.exceed this limit will not be reviewed.

• Institutional supplementation permissible under certain conditions.Institutional supplementation permissible under certain conditions.

Postdoctoral FellowshipPostdoctoral Fellowship

To provide stipend support to beginning investigators to further research To provide stipend support to beginning investigators to further research training broadly related to the cardiovascular area, Including stroke.training broadly related to the cardiovascular area, Including stroke.

• 1 or 2 years of support at $35,000 - $45,000 stipend, depending on years of training.

• Full-time research effort and sincere interest in pursuing a career in cardiovascular Full-time research effort and sincere interest in pursuing a career in cardiovascular and/or stroke related research expected. and/or stroke related research expected.

• Applicant must hold a Applicant must hold a doctoral degreedoctoral degree and have and have less than 5 yearsless than 5 years of postdoctoral of postdoctoral research training and experience at award activation (July 1, 2008).research training and experience at award activation (July 1, 2008).

• Support limited to work within non-profit institutions in Texas, Oklahoma, New Support limited to work within non-profit institutions in Texas, Oklahoma, New Mexico or Arkansas.Mexico or Arkansas.

• Institutional supplementation permissible under certain conditions.Institutional supplementation permissible under certain conditions.

• An investigator may sponsor no more than two Affiliate Postdoctoral Fellows at any An investigator may sponsor no more than two Affiliate Postdoctoral Fellows at any one time. Any application for a new award that would exceed this limit will not be one time. Any application for a new award that would exceed this limit will not be reviewedreviewed

Beginning Grant-In-AidBeginning Grant-In-Aid

To promote the independent status of promising beginning scientists by supporting high quality, well-defined research projects in the cardiovascular area, including stroke.

• Two-years. Competitive renewal possible for up to 4 years of support, $70,000 per year maximum, including 10% overhead and up to 50% of total award for P.I. salary-related expenses.

• Applicants may have no more than $150,000 of extramural grant support per year, excluding P.I. and collaborating investigator salaries and indirect costs.

• Applicants must hold a doctoral degree.

• Limited to faculty (or equivalent staff) of non-profit institutions in Texas, Oklahoma, Arkansas and New Mexico, with a rank not exceeding Assistant Professor at award activation (July 1, 2008)

• Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards.

Grant-In-AidGrant-In-AidTo support the most innovative and meritorious research projects

from independent investigators in the cardiovascular area, including stroke.

• Two-years. (One-year requests permitted). Continuous support of any one investigator is limited to 4 years. $70,000 per year maximum, including 10% overhead and up to 50% of total award for P.I. salary-related expenses.

• Applicants may have no more than $250,000 of extramural grant support per year, excluding P.I. and collaborating investigator salaries and indirect costs.

• Applicants must hold a doctoral degree.

• Limited to faculty (or equivalent staff) of non-profit institutions in Texas, Oklahoma, Arkansas and New Mexico.

• Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards.

2008 Success Rate by Program2008 Success Rate by ProgramProgramProgram ApplicationsApplications FundedFunded Success%Success%PREPRE 2828 55 18%18%POSTPOST 8080 1818 23%23%BGIABGIA 8787 2323 26%26%GIAGIA 109109 2222 20%20%TOTALSTOTALS 304304 6868 22%22%

Life Cycle of a Research ApplicationLife Cycle of a Research Application

HmmHmm……

Application Application submittedsubmitted

An idea beginsAn idea begins

Peer Review Peer Review CommitteeCommittee

E-mail E-mail notificationnotification

Research Research completedcompleted

Yea!Yea!

Reports Reports PublishedPublished

Findings Findings translatedtranslated

Assigned to Assigned to reviewersreviewers

Critique Critique developeddeveloped

Rank-Rank-ordered listordered list

Research Research CommitteeCommittee $$ Funded Funded

Peer Review StructurePeer Review StructureRegion III Review Consortium

SCAResearch

Committee

ConsortiumSteering

Committee

WSAResearch

Committee

Peer ReviewCommittees

(10)

SCA Research CommitteeSCA Research Committee• 11 members with a minimum of 2 from each of the four states11 members with a minimum of 2 from each of the four states• Members serve 3 or 4 year termsMembers serve 3 or 4 year terms• No more than 2 members serving from any one institutionNo more than 2 members serving from any one institution• Diversity with regards to gender, PhD & MD, geography and Diversity with regards to gender, PhD & MD, geography and

expertiseexpertise• Chair and Vice Chair each from different statesChair and Vice Chair each from different states• Two meetings each year: Fall Conference call in November Two meetings each year: Fall Conference call in November

and Spring allocations meeting in Mayand Spring allocations meeting in May• Chair serves as leader (chair or co-chair) on consortium Chair serves as leader (chair or co-chair) on consortium

Steering CommitteeSteering Committee• Responsibilities include: program menu, policy concerns, Responsibilities include: program menu, policy concerns,

allocation of funds, promotion of programs and advisory role allocation of funds, promotion of programs and advisory role to affiliateto affiliate

Peer Review Study Groups2007-08

•Brain, Cardiorenal, Lung, Respiration, Surgery

•Behavioral Science, Epidemiology & Prevention,CV Regulation, Cardiac (Patho) Physiology, Radiology & Imaging

•CV Development, Immunology & Microbiology, Basic Cell & Molecular Biology

•Lipoproteins & Lipid Metabolism, Thrombosis, Vascular Wall Biology

•Cell Transport and Metabolism, Cellular CV Physiology & Pharmacology, Molecular Signaling

Science AreasScience Areas• Health Promotion/PreventionHealth Promotion/Prevention• Human Nutrition (Behavioral and Preventive Aspects)Human Nutrition (Behavioral and Preventive Aspects)• ObesityObesity• NutritionNutrition• Outcomes ResearchOutcomes Research• StrokeStroke• Preventive CardiologyPreventive Cardiology• Quality of LifeQuality of Life• Social Support SystemsSocial Support Systems• Weight ControlWeight Control

Science AreasScience Areas• Basic Cell and Molecular BiologyBasic Cell and Molecular Biology• Behavior StudiesBehavior Studies• Biomedical EthicsBiomedical Ethics• Cardiac RehabilitationCardiac Rehabilitation• Clinical TrialsClinical Trials• ComplianceCompliance• Coping Strategies / Stress MgtCoping Strategies / Stress Mgt• DepressionDepression• EpidemiologyEpidemiology• Exercise / Physical ActivityExercise / Physical Activity• Familial Aggregation / Genetic EpidemiologyFamilial Aggregation / Genetic Epidemiology• Health Care Utilization/Cost EffectivenessHealth Care Utilization/Cost Effectiveness

A New Application Process!A New Application Process!• What can you do in the meantime to prepare What can you do in the meantime to prepare

for the application process?for the application process?– Notify your third parties that you plan to apply Notify your third parties that you plan to apply – Develop your research plan and specific aimsDevelop your research plan and specific aims– Begin to recruit referents if you are a fellowBegin to recruit referents if you are a fellow– Develop your training plan with your sponsor if Develop your training plan with your sponsor if

you are a fellow you are a fellow – Check with your Grants Office for internal Check with your Grants Office for internal

institutional deadlinesinstitutional deadlines– www.americanheart.orgwww.americanheart.org

• Please call our department at 650-259-6700 or Please call our department at 650-259-6700 or email at email at research@heart.org with questions with questions

The ProcessThe ProcessSouth Central AffiliateSouth Central Affiliate

January February March

April May July

•Application Deadline

•Applications assigned to Committees

•Committee Chairs review assignments

•Committee Chairs finalize assignments

•Reviewers input preference

•Paper copies are sent to reviewers

•Peer Review Committee meets

•Research Committees meet

•Award Notification

•Award activation

September: online applications are available

November: institutional tour to promote program

Other AHA Scientific Products

AHA Professional Membership/Scientific AHA Professional Membership/Scientific CouncilCouncil

Scientific Statements/GuidelinesScientific Statements/Guidelines Scientific Sessions, Conferences and WorkshopsScientific Sessions, Conferences and Workshops AHA Scientific JournalsAHA Scientific Journals My.Americanheart.orgMy.Americanheart.org

REMINDERSREMINDERS

• Research broadly related to cardiovascular function and disease, Research broadly related to cardiovascular function and disease, stroke, or to related basic science, clinical, bioengineering or stroke, or to related basic science, clinical, bioengineering or biotechnology, and public health problemsbiotechnology, and public health problems

• Consider criteria and evaluation prioritiesConsider criteria and evaluation priorities• All basic disciplines as well as epidemiological, behavioral, All basic disciplines as well as epidemiological, behavioral,

community and clinical investigationscommunity and clinical investigations• Citizenship: US, permanent resident, Visa, E-3, etc.Citizenship: US, permanent resident, Visa, E-3, etc.• Sponsor criteria and support (see application instructions)Sponsor criteria and support (see application instructions)• Budget amounts for stipend/salary, project support, fringe benefits, Budget amounts for stipend/salary, project support, fringe benefits,

travel, indirect costs and maximum annual amounttravel, indirect costs and maximum annual amount• Eligibility by virtue of degree, faculty rank, independence, years of Eligibility by virtue of degree, faculty rank, independence, years of

experience, percentage of effort, citizenship, sponsor support, experience, percentage of effort, citizenship, sponsor support, restrictions, location of work and overlap of fundingrestrictions, location of work and overlap of funding

• Repeat applications (up to 3 times including original)Repeat applications (up to 3 times including original)

QUESTIONS?QUESTIONS?

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