SCENAR therapy efficiency inSCENAR therapy efficiency in rehabilitation treatment: approaches and techniques

A.V.Tarakanov M.D., Professor, Rostov State Medical University, Russia

Th th d lThe author declares no conflict of interestsconflict of interests

concerning the topic of this g preport.

Rehabilitation originates from the Latin word habilis «ability» rehabilis «restorativehabilis – «ability», rehabilis – «restorative

abilities».

Rehabilitation represents the set ofpmeasures directed at providing thepersons with affected functions (as a resultpersons with affected functions (as a resultof diseases, traumas and congenitaldefects) with adaptation to new lifedefects) with adaptation to new lifecircumstances in a society where they live.

WHOWHO

3 rehabilitation types(medical, labor, and social)The first and the leading

rehabilitation direction (medical andrehabilitation direction (medical andphysical) lies in the patient’s healthrestoration by means of complex applicationof various means directed at the maximumrestoration of the affected body functions,and in the case if it is impossible – inand in the case if it is impossible indevelopment of the compensatory andsubstitutive mechanisms (functions)substitutive mechanisms (functions).

Early rehabilitation principleEarly rehabilitation principle

treatment

rehabilitation

durationduration

Example of simultaneous therapy…. : ifi i i b k«nonspecific pains in back»

Pain relief dynamics in visual analogue scale (% of the initial level) of prehospital patients suffering ( ) p p p g

pains in cervical spine region, * - Р<0,05.

30

‐20

‐10

010 мин 20 мин 30 мин

%

10 min. 20 min. 30 min.

70

‐60

‐50

‐40

‐30а

*

**‐80

‐70

1 гр.(СКЭНАР ‐ разнесенные  электр.) 2 гр. (CКЭНАР)

%

*

1 gr. (SCENAR– spread electrodes) 2 gr. (SCENAR)

‐20

‐10

010 мин 20 мин 30 мин10 min. 20 min. 30 min.

‐50

‐40

‐30б

*

‐70

‐60

3 гр. (метамизол) 4 гр. (кеторолак) 5 гр. (кетопрофен)3 gr. (Metamisol) 4 gr. (Ketorolac) 5 gr. (Ketoprofen)

Pain and the muscle spasmpMuscles, ligaments, fascia, joints, vertebra, j , ,intervertebral discs

R fl lDisorder

Reflex muscle spasm

Arachidonic acid cycle•Prostaglandins•Prostacyclins•ThromboxaneOther proinflammatory agents PAIN

Spinal marrow

The program of patient’s medical rehabilitation includes:

l t ti l ti1) Physical rehabilitation methods (electrotreatment, electrostimulation, laser therapy, barotherapy, balneotherapy and others),

2) Mechanical rehabilitation methods (mechanotherapy, kinesitherapy),3) massage3) massage4) Traditional treatment methods (acupuncture, phytotherapy, manual therapy and others),5) Labour therapy,6) Psychological therapy,7) Speech therapist training,8) Treatment gymnastics,9) Reconstructive surgery,10) O th di t t t ( th th l th di h )10) Orthopaedic treatment (protheses, ortheses, complex orthopedic shoes),11) Sanatorium-and-spa treatment,12) Technical means of medical rehabilitation (faeces bag, urinal, trainers, devices for food

introduction through stoma, parenteral, other technical means),g , p , ),13) Information and consultation on the medical rehabilitation issues,14) Other measures, services, technical means.

The principal rehabilitation methods include:include:

1) Early onset of rehabilitation measures (RM) performance,SCENARth) y ( ) p ,

2) Complexity of application of all the accessible and required RM,therapy

can take pa3) Consistency,

4) Individualized approach in every rehabilitation program,in realizatioof all and an

5) Active patient’s participation in the rehabilitation program,6) Rehabilitation staging,

of all and anof the

rehabilitatio7) Continuity and succession in course of all the rehabilitation stages,

8) Social orientation,

rehabilitatioprinciples

9) Application of controlling methods for adequacy of the loads and rehabilitation performance.

Place and Objectivesjof SCENAR therapy in rehabilitation

What to do and what NOT toWhat to do and what NOT to do!do!

Discussion!!!1. Search for methods applicable in ALL cases!

(??)(??)2. SCENAR therapy represents sanogenetic py p g

and non-nosological method3 Search for universal effects of SCENAR3. Search for universal effects of SCENAR

therapy!

OZONE LAYER О3

TROPOSPHERE 21 % О2

„Free radical quantities are the chemical O

„ qmeasure of the living substance“

(V. I. Vernadsky)

Oxygen-- 65 %Of the body mass

HYDROSPHERE 96,5 % H2OOxygen – 85,8 %

LITHOSPHEREOxygen – 47,3 %, or 53,8 % of all the atoms

SiO CaCO H Al Si O CaO Fe O Al O

ass

yg , SiO2, CaCO3, H2Al2Si2O8, CaO, Fe2O3, Al2O3

ProoxidantsProoxidantsare activated oxygen metabolites,

active oxygen species (AOS) and free radicals of any originactive oxygen species (AOS) and free radicals of any origin

Free radicals

Oxygen radicalsOxygen radicals Hypohalogenytes

Active oxygen speciesActive oxygen species

Activated oxygen metabolites

System balance shiftSystem balance shift«prooxidants - antioxidants»,

with prevalence of prooxidants, and lack of activity ofyantioxydant systems

is calledis called

oxidative stressoxidative stress

Deformation

Leaf A. et al. Pharmacol Therapeutics 2003; 98: 355-377

AOS

Prooxidant and antioxidant systems

(condition of balance)

Stress signal

Low level of lipid peroxidation

Stress signal

Moderate level of lipid peroxidation

High level of lipid peroxidation

Cell structure disturbance/

Vital activity

Stress signalStress signal

Antioxidant defensive system mobilization

Induction of death programs

Cell structure disturbance/Metabolic disorders

Survival rate Apoptosis Necrosis

p g

Membrane lysis

AOS are capable of provoking of the lipid and protein peroxidation whose active intermediates may treat into reaction with DNA leading to mutations and apoptosis (Amesreaction with DNA leading to mutations and apoptosis (Ames, 1989; Easterbauer et al., 1990; Johnson et al., 1999).

Apoptosis

Li idExcitotoxicityLactate-acidosisDystony

Inflammation Lipid peroxidation Excitotoxicity (of neuroglia)

minutes hours days months

The sequence of the pathologic and chemical reactions development during cerebrum hypoxia, accompanied with its edema.

(Citation from U. Dirnagl, Trends in Neurosci, 1999, edited by A. V. Afanasieva, 2005).

Hypertoniamyocardial infarction

heart

skineyes

myocardial infarctionPsoriasisDermatitismelanoma

RetinopathiesCataract

skineyes

Free radicals, oxidation

Excretory system

blood vessels

stresssystem

Pyelonephritisrenal dysfunction

Atherosclerosisendothelial dysfunction

Respiratory system

immune system

BRAINsystem

Asthmaallergy

Strokedi i l

Autoimmune disease,chronic inflammation processes

discirculatory encephalopathyAlzheimer diseasemigraine

A li ti f th SCENAR d i fApplication of the SCENAR devices for alleviation of the oxidative stress

symptoms in blood and strengthening of the antioxidative defense of the bodyof the antioxidative defense of the body with different pathological conditions

and diseasesand diseases.

(New medical technology)

The impact of the SCENAR therapy on development of disease and oxidative stress process was studied in injured persons with compression trauma complicatedinjured persons with compression trauma complicated with acute renal insufficiency, being treated in the intensive care and reanimation chambers of the department of gravitational blood surgery, sorbtion therapy and acute hemodialysis of the Municipal

h i l f R D iemergency hospital of Rostov-on-Don city.

Results of the clinically-laboratory investigationconducted in 77 patients being treated incardiology departments of Rostov-on-Don forthe period from 2000 to 2004 were studied, withthe purpose of treatment algorithm optimizationof the patients with acute myocardial infarctionwith ST-segment elevation, including theSCENAR therapy application.

140 *

*%

100

120 * * * ***

80

*

**

40

60 *

****

*

*

0

20

контр.contrХЛ, Н ХЛ, Sm ДК МДА ШО

до лечения группа ТЛТ традиционное +СКЭНАР

контр.contr.ChL, Н

ChL, Sm Dien conjugate Malon dialdehyde

Schiff bases

Before treatment

Thrombolysis therapy group

Traditional treatment

+SCENAR

Diagram. Intensity of luminol – Н2О2 – inducted chemiluminescence (ChL) and lipid peroxidation products content in blood plasma before and after different treatment methods of acute myocardial infarction (% in relation to control)

py g p

• * - р<0,05; ** - 0,05<p<0,1.

The SCENAR therapy performance study for chronicinsomnia treatment was conducted with participation of

d t f th it f R t D demergency doctors of the city of Rostov-on-Don andRostov oblast.

342 doctors were examined of which 73 suffered342 doctors were examined, of which 73 sufferedfrom chronic insomnia with somatoform vegetativenervous system dysfunction of neurocirculatory dystonianervous system dysfunction of neurocirculatory dystoniatype.

Multi-aspect treatment of transcutaneouselectrostimulation using the SCENAR series devices incomplex treatment of the different pathological conditionsand diseases has proved it’s efficacy in oxidative stressand diseases has proved it s efficacy in oxidative stressalleviation and antioxidative defense stimulation.

In line with this, the higher the excessive activation offree-radical oxidation reactions, the lower the oxidationfree radical oxidation reactions, the lower the oxidationproduct accumulation.

M t i l b i f th i t it iMaterial basis of the «integrity» is the DNA structure, in which the integrity algorithm is implemented.

“One from all, all from one".

Heraclitus - V century B. C.

sugar

sugartimine adenine

g

Т=А

sugarsugar

guaninecytosineC=G

Oxidative stressDiscovery of the ability of endogenous cell

metabolism products (AOS) to cause geneticmetabolism products (AOS) to cause genetic mutations was one of the most prominent discoveries in genetic toxicology over the last 20discoveries in genetic toxicology over the last 20 years.

Free radicals are capable of attacking theFree radicals are capable of attacking the DNA bases and deoxyribose with formation of oxidation bases and chain damagesoxidation bases and chain damages.

(Ward et al. 1987).

“Study of the SCENAR yimpact on the steroid hormones levels andhormones levels and characteristics of the

id ti DNA doxidative DNA damage in healthy volunteers”.

40

30

10

20

0

10

кортизол h8-OHdG тестостерон эстрадиол прогестеронCortisol Testosterone Estradiol Progesterone

20

-10

-30

-20

-40

Контроль СКЭНАРControl SCENARStudied analytes concentration deviation (average values, % ) in a day.

40

30

40

20

10

10

0кортизол h8-OHdG тестостерон эстрадиол прогестерон

*Cortisol Testosterone Estradiole Progesterone

-20

-10

P<0,05

Контроль СКЭНАРControl SCENAR

Studied analytes concentration deviation (average values, % ) in 3 weeks..

Conclusion No 1Conclusion No 1.The study of the results of complex treatment using

SCENAR therapy on the oxidative stress development inpatients with acute and chronic pathology has revealedpatients with acute and chronic pathology has revealedthe inhibition effects on active oxygen production,suppression of the increased activity of the lipidpp y pperoxidation process in blood plasma and erythrocytes,as well as on stabilizing and normalization of the mosti di f h l h bindicators of the structural erythrocyte membranecondition.

Conclusion No. 2.

SCENAR Medical technology is intended fordoctors of all specialties, who in course of theirwork face oxidative stress in patients:surgeons, therapists, anesthesiologists,g p gresuscitation specialists, cardiologists,pulmonologists, endocrinologists, neurologists,g g gophthalmologists,as well as specialists in restorative medicineas well as specialists in restorative medicineof health prevention establishments andhealth resorts.health resorts.

Multifactorial mechanism of action Multifactorial mechanism of action of SCENARof SCENARof SCENARof SCENAR

•Development of •Lipidperoxidation andfree-radicaloxidation

Development of energy metabolism

A tihA tih oxidationinhibition

AntihypoxAntihypoxantant Antioxidant

•Improvement in•Synaptic

Membrane protectorNootrop

•Improvement in membrane plasticity

•Synaptic processes activation

FORMULA OF HAPPINESS

DO YOU HAVE ANY PROBLEMS? No

Now I have Y the SCENAR

professionalYes.. professional

as wellNo,

CAN YOU SOLVE IT? Yes.