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Alice Bian, Saumya Bhatia, Charlotte Lewis, Raymond Fong ...Alice Bian, Saumya Bhatia, Charlotte...

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Concept Analysis EpiCard - Credit card shaped autoinjector with an antihistamine slot that works in three steps to increase safety. 1. User removes a safety cap that unlocks the internal mechanism and activates the epinephrine. 2. By pressing the card against their thigh, the user unlocks the grip. 3. By squeezing the grip, the autoinjector punctures the thigh muscle and dispenses the epinephrine. Prototype Market Analysis Introduction Portable Epinephrine Autoinjector for Anaphylactic Emergencies Alice Bian, Saumya Bhatia, Charlotte Lewis, Raymond Fong 2016 SIMR Bioengineering Bootcamp, Stanford University Need Statement Competitor Analysis Conclusions A way to make an epinephrine autoinjector more portable so that individuals with allergies can have convenient access to an autoinjector in an emergency situation. Need Specifications We set out to create a portable epinephrine autoinjector to address patients’ complaints about current technology. To do this, we created an easily-carried, card-shaped autoinjector and allergy kit, which has a keychain attachment, and is similar in size to an iPhone 5. This prototype includes the various mechanisms that would be present in the final version of our card. EpiPen - Bulky - Limited temperature range - Not very portable - Expensive ($307) Patients with severe allergies may react to an allergen with a full body immune response known as anaphylactic shock. Anaphylactic episodes affect up to 2% of the world’s population, particularly children and young adults 1 . The most dangerous symptoms include decreased blood pressure and constriction of smooth muscles around the heart and airways. To treat an anaphylactic attack, patients inject themselves with the drug epinephrine, commonly known as adrenaline. Those at risk must carry an epinephrine autoinjector. Autoinjectors enable patients and untrained citizens to inject lifesaving medicine without a medical professional. However, users complain that autoinjectors on the market are too expensive, bulky, and temperature sensitive to be carried around easily. We set out to address the portability issues, creating a product geared toward teenagers and young adults which can be readily available in case of an emergency. Auvi-Q - Voice guided - Unreliable - Expensive ($257) Acknowledgments We surveyed 50 young adults to get a better grasp of what our target market identified as problems of the current EpiPen model. References We would like to thank the Bioengineering Bootcamp TAs and mentors: Mandy Li, Heather Rogan, Elaine Ng, Alexa Wnorowski, Derek Croote, Colleen Rhoades, Alec Tarashansky, Arjun Aditham, Ben Kotopka for their wisdom and guidance; the fine folks at the PRL for their help; and the SIMR program for this opportunity. We would also like to give a special thanks to Derek Croote and Lisa Hoyte for their perspectives and help. Thank you to the Amgen Foundation for supporting the SIMR program. 1. Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group Lieberman, Phil et al. Annals of Allergy, Asthma Immunology , Volume 97 , Issue 5 , 596 - 602 Future Work Our next steps: 1. Build a spring mechanism with enough force to inject epinephrine into the thigh 2. Fit electrical components into the card casing 3. Utilize powdered epinephrine to increase portability 4. Research sublingual epinephrine Feature Must-Have Nice-to-Have Size Size of an Auvi-Q (3 x 2.5 x 0.5 in.) Smaller than an Auvi-Q (<3 x 2.5 x 0.5 in.) Mass Less than 45 grams Less than 35 grams Temperature Range 65-75°F 55-85°F Storage In a backpack/purse In a wallet/pocket Cost Same as an Auvi-Q ($257) Less than an Auvi-Q (<$257) Other Can be easily operated by a young adult Can be easily operated by a child Push button activates green LED light for the 10 seconds that the device is inserted, then red LED lights turns on for 5 seconds to signal removal of device.
Transcript
Page 1: Alice Bian, Saumya Bhatia, Charlotte Lewis, Raymond Fong ...Alice Bian, Saumya Bhatia, Charlotte Lewis, Raymond Fong 2016 SIMR Bioengineering Bootcamp, Stanford University Need Statement

Concept Analysis

EpiCard - Credit card shaped autoinjector with an antihistamine slot that works in three steps to increase safety.

1. User removes a safety cap that unlocks the internal mechanism and activates the epinephrine.

2. By pressing the card against their thigh, the user unlocks the grip.

3. By squeezing the grip, the autoinjector punctures the thigh muscle and dispenses the epinephrine.

Prototype

Market Analysis

Introduction

Portable Epinephrine Autoinjector for Anaphylactic EmergenciesAlice Bian, Saumya Bhatia, Charlotte Lewis, Raymond Fong

2016 SIMR Bioengineering Bootcamp, Stanford University

Need Statement

Competitor Analysis

Conclusions

A way to make an epinephrine autoinjector more portable so thatindividuals with allergies can have convenient access to anautoinjector in an emergency situation.

Need Specifications

We set out to create a portable epinephrine autoinjector to address patients’complaints about current technology. To do this, we created an easily-carried,card-shaped autoinjector and allergy kit, which has a keychain attachment,and is similar in size to an iPhone 5. This prototype includes the variousmechanisms that would be present in the final version of our card.

EpiPen- Bulky - Limited temperature

range- Not very portable - Expensive ($307)

Patients with severe allergies may react to an allergen with a fullbody immune response known as anaphylactic shock. Anaphylacticepisodes affect up to 2% of the world’s population, particularly childrenand young adults1. The most dangerous symptoms include decreasedblood pressure and constriction of smooth muscles around the heartand airways. To treat an anaphylactic attack, patients inject themselveswith the drug epinephrine, commonly known as adrenaline.

Those at risk must carry an epinephrine autoinjector. Autoinjectorsenable patients and untrained citizens to inject lifesaving medicinewithout a medical professional. However, users complain thatautoinjectors on the market are too expensive, bulky, and temperaturesensitive to be carried around easily. We set out to address theportability issues, creating a product geared toward teenagers andyoung adults which can be readily available in case of an emergency.

Auvi-Q- Voice guided- Unreliable- Expensive ($257)

Acknowledgments

We surveyed 50 young adults to get a better grasp of what our target market identified as problems of the current EpiPen model.

References

We would like to thank the Bioengineering Bootcamp TAs and mentors: Mandy Li,Heather Rogan, Elaine Ng, Alexa Wnorowski, Derek Croote, Colleen Rhoades, AlecTarashansky, Arjun Aditham, Ben Kotopka for their wisdom and guidance; the finefolks at the PRL for their help; and the SIMR program for this opportunity. We wouldalso like to give a special thanks to Derek Croote and Lisa Hoyte for their perspectivesand help. Thank you to the Amgen Foundation for supporting the SIMR program.

1. Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group Lieberman, Phil et al. Annals of Allergy, Asthma Immunology , Volume 97 , Issue 5 , 596 - 602

Future Work

Our next steps: 1. Build a spring mechanism with enough force to inject epinephrine into the thigh2. Fit electrical components into the card casing3. Utilize powdered epinephrine to increase portability 4. Research sublingual epinephrine

Feature Must-Have Nice-to-Have

Size Size of an Auvi-Q (3 x 2.5 x 0.5 in.)

Smaller than an Auvi-Q (<3 x 2.5 x 0.5 in.)

Mass Less than 45 grams Less than 35 grams

Temperature Range 65-75°F 55-85°F

Storage In a backpack/purse In a wallet/pocket

Cost Same as an Auvi-Q ($257)

Less than an Auvi-Q (<$257)

Other Can be easily operated by a young adult

Can be easily operated by a child

Push button activates green LED light for the 10 seconds that the device is inserted, then red LED lights turns on for 5 seconds to signal removal of device.

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