+ All Categories

Home > Documents > ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes:...

ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes:...

Date post:	19-Jun-2020
Category:	Documents
Upload:	others
View:	8 times
Download:	0 times

Download Report this document

Share this document with a friend

Embed Size (px):

69

ALLOSTERIC ENZYMES

Transcript

Page 1: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

ALLOSTERIC ENZYMES

Page 2: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 3: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 4: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 5: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 6: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 7: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 8: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 9: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 10: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 11: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 12: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 13: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 14: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 15: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 16: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 17: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 18: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 19: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 20: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 21: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 22: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 23: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 24: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 25: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 26: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 27: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 28: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 29: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 30: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 31: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 32: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 33: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 34: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 35: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 36: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 37: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 38: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 39: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 40: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 41: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 42: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 43: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 44: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 45: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 46: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 47: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

MWC MODEL

Page 48: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 49: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

MONOD-WYMAN-CHANGEUX (MWC)MODEL

KOSHLAND- MEMETHY-FILMER(KNF) MODEL

Page 50: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 51: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 52: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 53: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 54: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 55: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 56: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 57: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 58: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 59: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 60: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 61: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 62: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 63: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 64: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 65: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 66: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 67: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 68: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Page 69: ALLOSTERIC ENZYMEStumkuruniversity.ac.in/oc_pg/bc/Allosteric enzymes.pdf · Allosteric enzymes: Binding of ligands to proteins Co-operativity, the Hill equation, equilibrmm dialysis

Recommended

Positive Heterotropic Allosteric Regulators of Dihydropyridine ...

Structural Determinants Deﬁning the Allosteric Inhibition ... · Structure Article Structural Determinants Deﬁning the Allosteric Inhibition of an Essential Antibiotic Target

Allosteric Site Communication Pathways Revealed Using Hybrid ...

Discovery of Novel GABAAR Allosteric Modulators Through ...

Integrated allosteric regulation in the S. cerevisiae ...

Enzyme 221 Allosteric Enzyme

Are the Apo Proteins Suitable for the Rational Discovery of Allosteric Drugs · 4 allosteric sites in proteins because identification of allosteric sites is the first step for in

On the nature of allosteric transitions: A plausible model€¦ · ALLOSTERIC TRANSITIONS 89 Before summanzmg these properties, it will be useful to define two classes of allosteric

M1 muscarinic allosteric modulators slow prion ...

Allosteric EGFRand HER2Oncogenic Mutations...3 The Allosteric HER2 / EGFR Mutant Oncogene Family Represents an Undrugged Opportunity for MasterKey Precision Medicine 48 a allosteric

Identification of a Putative Intracellular Allosteric ...

Synthesis of Allosteric Modulators for Nicotinic ...

Allosteric interactions between agonists and antagonists ...

From Enzymatic Adaptation to Allosteric Transitionsweb2.uconn.edu/gage/MCB3617/monod_nobellect_science_196.pdf · From Enzymatic Adaptation to Allosteric Transitions Jacques Monod

Identification and pharmacological characterisation of novel positive allosteric ... · 2020. 8. 4. · Identification and pharmacological characterisation of novel positive allosteric

Statistical Mechanics of Allosteric Enzymesrpdata.caltech.edu/publications/EinavMazutis_J_Phys_Chem_B_2016… · Statistical Mechanics of Allosteric Enzymes Tal Einav,† Linas Mazutis,‡

Allosteric Modulation - Royal Society of Chemistry · The properties of allosteric modulation • Saturability – the effect of an allosteric modulator is inherently limited. •

Regulation of Metabolism - Tumkur Universitytumkuruniversity.ac.in/oc_pg/bc/Integration of Metabolism- Hormonal… · • Liver takes up glucose, increases glycogen production •