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Alvesco Market Definitions

CombiR3F1

Alvesco MarketR3

T

aked

a

Take

da

Tak

eda

Mar

ket

Seg

men

t 3

Seg

men

t 2

Seg

men

t

MonoR3D1

OtherAll Products from R3

excluding R3D1 and R3F1

NebulsMDI + DPICombined

NebulsMDI + DPICombined

R3D1MDI

R3D1DPI

R3F1MDI

R3F1DPI

R3F1Nebuls

R3D1Nebuls

R3Other

All P

rodu

cts

from

R3D

1w

hen

the

seco

nd le

tter

of t

he3

lett

er F

orm

Cod

e is

‘H’

All P

rodu

cts

from

R3D

1w

hen

the

seco

nd le

tter

of t

he3

lett

er F

orm

Cod

e is

‘E’ o

r ‘C’

All P

rodu

cts

from

R3F

1w

hen

the

seco

nd le

tter

of t

he3

lett

er F

orm

Cod

e is

‘G’

All P

rodu

cts

from

R3D

1w

hen

the

seco

nd le

tter

of t

he3

lett

er F

orm

Cod

e is

‘G’

All P

rodu

cts

from

R3F

1w

hen

the

seco

nd le

tter

of t

he3

lett

er F

orm

Cod

e is

‘H’

All P

rodu

cts

from

R3F

1w

hen

the

seco

nd le

tter

of t

he3

lett

er F

orm

Cod

e is

‘E’ o

r ‘C’

All P

rodu

cts

from

R3

excl

udin

g R3

D1

and

R3F1

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Calcium Market A12ATotal (LOCs + Partners)

T

aked

a

Take

da

M

arke

t

Seg

men

t 2

Seg

men

t

LOCs Partners

LOCs TakedaPerformance

All Takeda sales for A12A from all

countries excluding UK, France,

Germany, Italy and Canada

All sales for A12A forCorporations

excluding Takedafrom all countries

excluding UK, France,Germany, Italy

and Canada

LOCsCompetitors

Partners TakedaPerformance

PartnersCompetitors

All Calcium sales forA12A from countries

UK, France,Germany, Italy

and Canada

All sales for A12A forCorporations

excluding Takedafrom countries

UK, France,Germany, Italy

and Canada

Calcium Market Definitions

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S

Tak

eda

Take

da

M

arke

t

Seg

men

t 2

Segm

ent

Circadin MarketAll N5B1

BenzoAll Products from N5B1where

molecule combination does NOT startwith ‘Z’ and excluding melatonin

CircadinProduct Circadin only

Takeda CircadinAustria, Belgium, Denmark,

Finland, Greece,Netherlands, Norway, Sweden

Note : This market is restricted to the following countries

Austria, Belgium, Czech Republic, Denmark, Finland, France, Greece, Germany, Hungary, IrelandNetherlands, Norway, Poland, Portugal, Slovakia, Spain, Sweden, United Kingdom

Non BenzoAll Products from N5B1 wheremolecule combination DOES

start with ‘Z’

Lundbeck CircadinCzech Republic, France, Germany,Hungary, Ireland, Poland, PortugalSlovakia, Spain, United Kingdom

Circadin Market Definitions

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Daxas MarketATC R3M

arke

t

Daxas Market Definition

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Instanyl MarketInternational Products Actiq, Abstral, Effentora, Instanyl and Pecfent from N2AM

arke

tInstanyl Market Definition

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Ta

keda

Tak

eda

Tak

eda

Tak

eda

M

arke

t Se

gmen

t 4

S

egm

ent 3

Segm

ent 2

S

egm

ent

Matrifen Market N2A

Immediate Release Opioids

Oral Solid Ordinary

N2A NFC A

Sustained Release Opioids

Oral LiquidOrdinary

N2A NFC D

Parental Ordinary

N2A NFC F

Other(Rec. Topic. OTH)

N2A Excl NFCA, B, D, E, F, G

JWM, JWN

Other Molecules /Other Duration Patches

Local Product Ionsysand/or NFC JWM and

molecule sufentanil NFC JWN

Matrifen Market(Fentanyl Patches)

N2A Plain BuprenorphineNFC JWN

Buprenorphine PatchesN2A Plain Buprenorphine

NFC JWN

Oral Solid &Liquid RetardN2A NFC B, E

Transdermal Patches

N2A NFCJWM, JWN

3 – 4 Day Duration PatchesN2A Plain Excl. Local Product

Butrans and Norspan

7 Day Duration Patches Local Product

Butrans and Norspan

Matrifen Market Definitions

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Omnaris MarketAll products from R1A1M

arke

t

Omnaris Market Definition

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A2B2 OthersAll remaining A2B2

Pantoprazole MarketA2B2

Tak

eda

Mar

ket

Se

gmen

t

PPIAll A2B2 combinations of the following

molecules: pantoprazole, esomeprazole,omeprazole, rabeprazole, lansoprazole,

dexlansoprazole

Pantoprazole Market Definitions

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Osteoporosis Market

Ta

keda

Take

da

Mar

ket

Se

gmen

t 2

Se

gmen

t

PTH Market Osteoporosis Others

Preotact Market

All InternationalProducts

Forteo and Preotact

All International ProductProtelos

Preotact Broad Market

Osteoporosis Other Sub

Al Products fromM5B, G3J and H4E

(except Forteo, Preotact, Protelos)

Note: This market is limited to the following countries –Austria, Czech Republic, Denmark, Finland, Germany, Greece, Ireland, Italy,

Netherlands, Norway, Portugal, Slovakia, Spain, Sweden and UK

Preotact Market Definitions

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TachoSil MarketAll Products from B2F and B2G M

arke

t

TachoSil Market Definition

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IV Forms

Tak

eda

Take

da

M

arke

t

S

egm

ent 2

Seg

men

t

NSAIDS +Coxibs

All Productsfrom M1A1and M1A3

NSAIDS

Total FormsXefo Market

Other FormsOral Forms

N2BAll

Productsfrom N2B

Coxibs

NSAIDS +Coxibs

All Productsfrom M1A1and M1A3

with NFC1 A or B

N2BAll

Productsfrom N2B

with NFC1 A or B

NSAIDS +Coxibs

All Productsfrom M1A1and M1A3

with NFC1 F or G

N2BAll

Productsfrom N2B

with NFC1 F or G

NSAIDS +Coxibs

All Productsfrom M1A1and M1A3

excl NFC1 A, B,F or G

N2BAll

Productsfrom N2B

excl NFC1 A, B, F or G

NSAIDSNSAIDSNSAIDS Coxibs Coxibs Coxibs

All P

rodu

cts

from

M1A

1

with

NFC

1 A

or B

All P

rodu

cts

from

M1A

3

with

NFC

1 A

or B

All P

rodu

cts

from

M1A

1

All P

rodu

cts

from

M1A

3

All P

rodu

cts

from

M1A

1

with

NFC

1 F

or G

All P

rodu

cts

from

M1A

3

with

NFC

1 F

or G

All P

rodu

cts

from

M1A

1

excl

NFC

1 A

, B, F

or G

All P

rodu

cts

from

M1A

3 ex

cl N

FC1

A, B

, F o

r G

Xefo Market Definitions

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CombiWhere ATC3 = C09D

Azilsartan MarketC09C and C09D

Tak

eda

Mar

ket

Se

gmen

t

MonoWhere ATC3 = C09C

Azilsartan Market Definitions

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CombiWhere ATC3 = C09D

Candesartan MarketC09C and C09D

Tak

eda

Mar

ket

Se

gmen

t

MonoWhere ATC3 = C09C

Candesartan Market Definitions

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A2B2 OthersAll remaining A2B2

Lansoprazole MarketA2B2

Tak

eda

Mar

ket

Se

gmen

t

PPIAll A2B2 combinations of the following

molecules: pantoprazole, esomeprazole,omeprazole, rabeprazole, lansoprazole,

dexlansoprazole

Lansoprazole Market Definitions

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Leuprorelin GnRH Analogues Market

All combinations of the following molecules: leuprorelin,goserelin, histrelin, triptorelin, degarelix, buserelinLimited to NFCs starting with F or G and NFC AAZ

Mar

ket

The following Molecule and International Strength combinations are excluded :Buserelin 1.05mg/1ml, Buserelin 1.14mg/1ml, Buserelin 100Y/Dose, Buserelin 150Y/Dose

Buserelin 182Y/1ml, Buserelin 1mg /1ml, Goserelin + Bicaltamide VARI STR, Triptorelin 1.88mg/1ml, Triptorelin 100Y, Triptorelin 100Y/1ml, Triptorelin 105Y/1ml and Triptorelin 500Y/1ml

Leuprorelin Market Definitions

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Tak

eda

Tak

eda

M

arke

t

Seg

men

t 2

Segm

ent

Pioglitazone MarketWhere ATC3 = A10H, A10J, A10K, A10L, A10M, A10N, A10S

DPP-4 + GLP-1 + TZD Where ATC3 = A10K, A10N, A10S

All OtherWhere ATC3 = A10H, A10J, A10L, A10M

Pioglitazone MonoWhere ATC4 = A10H0,A10J1, A10K1, A10L0

A10M1, A10N1, A10S0

Pioglitazone CombiWhere ATC4 = A10J2,

A10K2, A10K3, A10M3A10N3

The following Molecule and International Strength Combinations are excluded : Astragalus + Glibenclamide + Rehmania + Trichosanthes Combi Str, Thiopropazate 3.5mg, Thiopropazate 1.75mg,

Thiopropazate 1mg, Astragalus Membranaceus + Glibenclamide + Rehmania + Trichosanthes Combi Str, Glycyclamide 500mg, Composition Unknown NA INTSTR, Glisolamide 5mg, Phenformin 25mg, Phenformin 50mg, Glibenclamide + Phenformin 5mg

+25mg, Glibenclamide + Phenformin 2.5mg+25mg, Glibenclamide + Phenformin 2mg+30mg, Tolbutamide 400mg+125mg, Ascorbic Acid + Cyanocobalamin + Pangamic Acid + Phenformin + Pyridoxine + Riboflavin + Thiamine + Tolbutamide Combi Str,

Glibenclamide 2.5mg+500mg, Glibenclamide 2.5mg+400mg, Glibenclamide 2.5mg+12.5mg

Pioglitazone Market Definitions