Alzheimer’s Disease

Edwin OnattuP. 3

Basics…• Alzheimer's is a type of dementia that causes problems

with memory, thinking and behavior.• Alzheimer's is the most common form of dementia.• Alzheimer's is not a normal part of aging.• Alzheimer's worsens over time.• NO Cure• No tests, but Physician may perform neurological exam,

mental status test, brain Imaging. • The most common early symptom of Alzheimer's is

difficulty remembering newly learned information.• Fairly new avenue• Risk factors

– The risk gene with the strongest influence is called apolipoprotein E-e4 (APOE-e4).

– Everyone inherits a copy of some form of APOE from each parent.– Deterministic genes– Other

The Brain

• 3 lbs. ; 3 Parts– Cerebrum– Cerebellum– Brain Stem

The Supply Lines

The whole vessel network

The Cortex a.k.a “Wrinkles”

Left vs. right

The Neuron Forest

The Demented brain

So what’s going on?

Plaques

“Tangled”

Progression

Onset

Mild to moderate

Severe Alzheimer’s

Future treatment plans• Cell phone radiation reverses

Alzheimer’s and boosts memory in mice

• Drugs that target Beta-Amyloid• Drugs that keep Tau proteins from

tangling• Anti-inflammatory drugs

La END