Amazon S3 · Web viewAvastin anticancer 2004 ARMC 40 450 B H-101 anticancer 2005 DNP 19 46 B...

generic_name trade_name disease_indication year_introduced volume page sourcefinasteride Proscar 5 alpha-reductase inhibitor 1992 ARMC 28 331 NDlisdexamfetamine mesilate Vyvanse ADHD 2007 ARMC 43 477 NDdexmethylphenidate Focalin ADHD 2002 ARMC 38 352 Satomoxetine Strattera ADHD 2003 ARMC 39 343 S*/NM

Colostrinin Alzheimer's Disease 2007 I 277517 Bgalanthamine HBr Nivalin Alzheimer's Disease 1995 DNP 09 20 Npergolide mesylate Permax Alzheimer's Disease 1988 ARMC 24 308 NDtacrine HCI Cognex Alzheimer's Disease 1993 ARMC 29 346 S/NMdonepezil HCl Aricept Alzheimer's Disease 1997 ARMC 33 332 S/NMrivastigmin Exelon Alzheimer's Disease 1997 ARMC 33 342 S/NMrilonacept Arcalyst CAPS 2008 DNP 22 15 Bcanakinumab Ilaris CAPS 2009 DNP 23 16 B

Celacade CHF 2007 I 285037 Btaltirelin Ceredist CNS Stimulant 2000 DNP 14 15 NDtiotropium bromide Spiriva COPD 2002 ARMC 38 368 S*/NMarformoterol tartrate Brovana COPD 2007 ARMC 43 465 S*/NMindacaterol maleate Onbrez COPD 2009 DNP 23 11 S*/NMFF/GW-642444 Breo COPD 2013 DT 50(1) 55 S*/NMolodaterol hydrochloride Striverdi COPD 2013 DT 50(1) 57 S*/NMroflumilast Daxas COPD 2010 I 224324 S/NMaclidinium bromide Tudorza COPD 2012 I 312471 S/NMumeclidinium bromide Incruse COPD 2014 DT 51(1) 40 S/NMriociguat Adempas CTEPH 2013 DT 50(1) 57 S*siltuximab Sylvant Castleman's Disease 2014 DT 51(1) 53 Binfliximab Remicade Crohn's disease 1998 DNP 12 31 Bcertolizumab pegol Cimzia Crohn's disease 2008 DNP 22 13 Bpasireotide Signifor Cushings Syndrome 2012 I 305198 NDagalsidase alfa Replagal Fabry's disease 2001 DNP 15 39 Bagalsidase beta Fabrazyme Fabry's disease 2001 DNP 15 39 Bimiglucerase Cerezyme Gaucher's Disease 1994 ARMC 30 301 Bvelaglucerase alfa VPRIV Gaucher's Disease 2010 I 362902 Btaliglucerase alfa Elelyso Gaucher's Disease 2012 I 450233 Bmiglustat Zavesca Gaucher's Disease 2003 ARMC 39 255 NDeliglustat tartrate Cerdelga Gaucher's Disease 2014 DT 51(1) 60 S*/NMidursulfase Elaprase Hunter Syndrome 2006 DNP 20 31 B

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iduronate-2-sulfatase Hunterase Hunter Syndrome 2012 I 729600 Bcholic acid Orphacol Inborn errors of bile synthes 2013 DT 50(1) 76 Nvedolizumab Entyvio Inflammatory Bowel Disease 2014 DT 51(1) 44 B

Jebik V Japanese encephalitis 2009 DNP 23 17 VJespect Japanese encephalitis 2009 DNP 23 17 V

3,4-diaminopyridine phosphate FirdapseLambert-Eaton Myasthenic Syndr 2010 I 427501 S

lyme disease LYMErix Lyme disease 1999 ARMC 35 342 Vlevosimendan Simdax MI, acute 2000 DNP 14 16 S/NM

Proquad MMRC 2005 DNP 19 44 Velosulfase alfa Vimizim Morquio A Syndrome 2014 DT 51(1) 60 Bsitaxsentan sodium Thelin PAH 2006 DNP 20 21 S/NMambrisentan Letairis PAH 2007 ARMC 43 463 S/NMmacitentan Opsumit PAH 2013 DT 50(1) 57 S/NMtrimetrexate glucuronate Neutrexin PCP/Toxoplasmosis 1994 ARMC 30 312 NDeculizumab Soliris PNH 2007 ARMC 43 468 Bmelevodopa (CHF-1301) Levomet Parkinson's Disease 1999 ARMC 35 336 NDrasagline mesilate Azilect Parkinson's Disease 2005 DNP 19 35 Sistradefylline Nourlast Parkinson's Disease 2013 DT 50(1) 55 S*droxidopa DOPS Parkinson's Disease 1989 ARMC 25 312 S*/NMropinirole HCl ReQuip Parkinson's Disease 1996 ARMC 32 317 S*/NMtolcapone Tasmar Parkinson's Disease 1997 ARMC 33 343 S*/NMentacapone Comtess Parkinson's Disease 1998 ARMC 34 322 S*/NMselegiline HCl Jumex Parkinson's Disease 1981 I 140055 S/NMtalipexole Domin Parkinson's Disease 1996 ARMC 32 318 S/NMbudipine Parkinsan Parkinson's Disease 1997 ARMC 33 330 S/NMpramipexole HCl Mirapex Parkinson's Disease 1997 ARMC 33 341 S/NMrotigotine Neupro Parkinson's Disease 2006 DNP 20 20 S/NMrh-alphaglucosidase Myozyme Pompe's disease 2006 DNP 20 31 Bsomatotropin rDNA original Accretropin Turner Syndrome 2008 DNP 22 14 Bglycerol phenylbutyrate Ravicti Urea Cycle Disorders 2013 DT 50(1) 76 Ssulprostone Nalador abortifacient 1981 I 125456 NDgemeprost Cervagem abortifacient 1983 ARMC 19 319 NDmifepristone Mifegyne abortifacient 1988 ARMC 24 306 NDpegvisomant Somavert acromelagy 2003 ARMC 39 359 Bnitrefazole Altimol alcohol deterrent 1983 ARMC 19 322 S

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acamprosate Aotal alcohol deterrent 1989 DNP 03 19 S*Oralair Grasses allergic rhinitis 2008 DNP 22 10 NB

tafamidis meglumine Vyndaquel amyloidosis 2011 DT 48(1) 36 Stibolone Livial anabolic metabolism 1988 ARMC 24 312 NDach-02 Acheflan analgesic 2005 I 405058 Nalfentanil HCI Rapifen analgesic 1983 ARMC 19 314 Salminoprofen Minalfene analgesic 1983 ARMC 19 314 Smeptazinol HCl Meptid analgesic 1983 ARMC 19 321 Snefopam HCl Acupan analgesic 1983 I 309878 Ssufentanil Sufenta analgesic 1983 ARMC 19 323 Ssuprofen Maldocil analgesic 1983 ARMC 19 324 Semorfazone Pentoil analgesic 1984 ARMC 20 317 Sflupirtine maleate Katadolan analgesic 1985 ARMC 21 328 Spropacetamol HCl Pro-dafalgan analgesic 1986 ARMC 22 325 Sketorolac tromethamine Toradol IM analgesic 1990 ARMC 26 304 Sremifentanil HCl Ultiva analgesic 1996 ARMC 32 316 Sfosfosal Disdolen analgesic 1984 ARMC 20 319 S*eptazocine HBr Sedapain analgesic 1987 ARMC 23 334 S*dezocine Dalgan analgesic 1991 ARMC 27 326 S/NMparecoxib sodium Dynastat analgesic 2002 ARMC 39 364 S/NMtapentadol HCL Nucynta analgesic 2009 DNP 23 7 S/NMhemoglobin glutamer Hemopure anemia 2001 DNP 15 33 Bpeginesatide Omontys anemia 2012 I 380443 S*/NMNIX-0699 Hemoxin anemia, sickle cell 2006 DNP 20 30 Npropofol Diprivan anesthetic 1986 ARMC 22 325 Ssevoflurane Sevofranc anesthetic 1990 ARMC 26 309 Sdesflurane Suprane anesthetic 1992 ARMC 28 329 Sropivacaine Naropin anesthetic 1996 ARMC 32 318 Slevobupivacaine Chirocaine anesthetic 2000 DNP 14 13 Sanabasine HCl Gamibasin anti-smoking 1987 I 129991 Sisotrentoin Accutane antiacne 1982 I 091113 Nazelaic acid Skinoren antiacne 1989 ARMC 25 310 Sgamolenic acid Epogam antiallergic 1988 I 145695 N

Curemisinin antiallergic 2007 I 465056 NBnedocromil sodium Tildade antiallergic 1986 ARMC 22 324 NDloteprednol etabonate Lotemax antiallergic 1998 ARMC 34 324 ND

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pimecrolimus (SDZ-ASM-981) Elidel antiallergic 2002 ARMC 39 365 NDfluticasone furoate Allermist antiallergic 2007 ARMC 43 469 NDoxatomide Tinset antiallergic 1981 I 091094 Srepirinast Romet antiallergic 1987 ARMC 23 341 Stazanolast Tazalest antiallergic 1990 ARMC 26 309 Slodoxamide tromothamine Almide antiallergic 1992 ARMC 28 333 Semedastine difumarate Daren antiallergic 1993 ARMC 29 336 Sepinastine hydrochloride Alesion antiallergic 1994 ARMC 30 299 Ssuplast tosylate IPD antiallergic 1995 ARMC 31 350 Sfexofenadine Allegra antiallergic 1996 ARMC 32 307 Solopatadine HCl Patanol antiallergic 1997 ARMC 33 340 Sbetotastine besilate Talion antiallergic 2000 ARMC 28 297 Sramatroban Baynas antiallergic 2000 DNP 14 15 Salcaftadine Lastacraft antiallergic 2011 DT 48(1) 48 Sbepridil HCl Cordium antianginal 1981 I 091150 Sisosorbide 5-mononitrate Ismo antianginal 1981 I 133800 SgallopamiI HCl Procorum antianginal 1983 ARMC 19 319 Slinsidomine Corvasal antianginal 1983 I 271635 Sivabrandin hydrochloride Procoralan antianginal 2005 DNP 19 36 Sadenosine Adenocord antiarrhythmic 1989 DNP 03 21 Ntocainide HCl Tonocard antiarrhythmic 1981 I 091525 Sflecainide Tambocor antiarrhythmic 1982 I 091099 Scibenzoline succinate Cipralan antiarrhythmic 1985 ARMC 21 325 Sencainide HCl Enkaid antiarrhythmic 1987 ARMC 23 333 Sindecainide Decabid antiarrhythmic 1989 DNP 03 21 Smoricizine hydrochloride Ethmozine antiarrhythmic 1990 ARMC 26 305 Stiracizine hydrochloride Bonnecor antiarrhythmic 1990 ARMC 26 310 Spilsicainide hydrochloride Sunrhythm antiarrhythmic 1991 ARMC 27 332 Spirmenol hydrochloride Pimenol antiarrhythmic 1994 ARMC 30 307 Sibutilide fumarate Corvert antiarrhythmic 1996 ARMC 32 309 Snifekalant HCl Shinbit antiarrhythmic 1999 ARMC 35 344 Sdofetilide Tikosyn antiarrhythmic 2000 DNP 14 16 Sranolazine Ranexa antiarrhythmic 2006 DNP 20 20 Sdronedarone HCl Multaq antiarrhythmic 2009 DNP 23 11 Sesmolol HCI Brevibloc antiarrhythmic 1987 ARMC 23 334 S*/NMlandiolol Onoact antiarrhythmic 2002 ARMC 38 360 S*/NM

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etanercept Enbrel antiarthritic 1998 DNP 12 34 Banakinra Kineret antiarthritic 2001 DNP 15 37 Badalimumab Humira antiarthritic 2003 ARMC 39 339 B

Orthokine antiarthritic 2005 I 404772 Babatacept Orencia antiarthritic 2006 DNP 19 43 Bgolimumab Simponi antiarthritic 2009 DNP 23 15 B

Citrofen antiarthritic 2007 I 444674 NPG-201 Layla antiarthritic 2012 I 697525 NBhalopredone acetate Haloart antiarthritic 1988 P090741 NDzucapsaicin Zuacta antiarthritic 2011 DT 48(1) 42 NDhyaluronic acid crosslinked Gel-One antiarthritic 2012 I 113957 NDcarprofen Rimadyl antiarthritic 1981 I 091118 Smorniflumate Niflam antiarthritic 1981 I 158711 Sauranofin Ridaura antiarthritic 1983 ARMC 19 314 Siguratimod Iremod antiarthritic 2012 DT 48(1) 41 Stofacitinib Xeljanz antiarthritic 2012 I 306518 S*/NMmeloxicam Mobec antiarthritic 1996 ARMC 32 312 S/NMleflunomide Arava antiarthritic 1998 ARMC 34 324 S/NMcelecoxib Celebrex antiarthritic 1999 ARMC 35 335 S/NMrofecoxib Vioxx antiarthritic 1999 ARMC 35 347 S/NMetoricoxib Arcoxia antiarthritic 2002 ARMC 38 355 S/NMvaldecoxib Bextra antiarthritic 2002 ARMC 38 369 S/NMomalizumab Xolair antiasthmatic 2003 ARMC 39 357 Bbudesonide Pulmicort antiasthmatic 1981 I 091057 NDamlexanox Solfa antiasthmatic 1987 ARMC 23 327 NDciclesonide Alvesco antiasthmatic 2005 DNP 19 36 NDtranilast Rizaben antiasthmatic 1982 I 090998 Spemirolast potassium Pemilaston antiasthmatic 1991 ARMC 27 331 Spranlukast Onon antiasthmatic 1995 ARMC 31 347 S*/NMlevalbuterol HCl Xopenex antiasthmatic 1999 ARMC 35 341 S*/NMibudilast Ketas antiasthmatic 1989 ARMC 25 313 S/NMbroxaterol Summair antiasthmatic 1994 DNP 08 26 S/NMseratrodast Bronica antiasthmatic 1995 ARMC 31 349 S/NMzafirlukast Accolate antiasthmatic 1996 ARMC 32 321 S/NMzileuton Zyflo antiasthmatic 1997 ARMC 33 344 S/NMmontelukast sodium Singulair antiasthmatic 1998 ARMC 34 326 S/NM

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gemfibrozal Lopid antiathersclerotic 1982 I 091114 Sraxibacumab ABthrax antibacterial 2012 I 336061 Bnetilimicin sulfate Netromicine antibacterial 1981 I 070366 Nmicronomicin sulfate Sagamicin antibacterial 1982 I 091082 Nmiokamycin Miocamycin antibacterial 1985 ARMC 21 329 Nmupirocin Bactroban antibacterial 1985 ARMC 21 330 Ncarumonam Amasulin antibacterial 1988 ARMC 24 298 Nfosfomycin trometamol Monuril antibacterial 1988 I 112334 Nisepamicin Isepacin antibacterial 1988 ARMC 24 305 Nteicoplanin Targocid antibacterial 1988 ARMC 24 311 NRV-11 Zalig antibacterial 1989 ARMC 25 318 Ndaptomycin Cubicin antibacterial 2003 ARMC 39 347 Nfidaxomicin Dificid antibacterial 2011 DT 48(1) 40 Ncefoperazone sodium Cefobis antibacterial 1981 I 127130 NDcefotiam HCl Pansporin antibacterial 1981 I 091106 NDcefsoludin sodium Takesulin antibacterial 1981 I 091108 NDapalcillin sodium Lumota antibacterial 1982 I 091130 NDceftizoxime sodium Epocelin antibacterial 1982 I 070260 NDceftriaxone sodium Rocephin antibacterial 1982 I 091136 NDmoxalactam disodium Shiomarin antibacterial 1982 I 070301 NDcefmenoxime HCl Tacef antibacterial 1983 ARMC 19 316 NDceftazidime Fortam antibacterial 1983 ARMC 19 316 NDaztreonam Azactam antibacterial 1984 ARMC 20 315 NDcefonicid sodium Monocid antibacterial 1984 ARMC 20 316 NDceforanide Precef antibacterial 1984 ARMC 20 317 NDcefotetan disodium Yamatetan antibacterial 1984 ARMC 20 317 NDtemocillin disodium Temopen antibacterial 1984 ARMC 20 323 NDastromycin sulfate Fortimicin antibacterial 1985 ARMC 21 324 NDcefbuperazone sodium Tomiporan antibacterial 1985 ARMC 21 325 NDcefpiramide sodium Sepatren antibacterial 1985 ARMC 21 325 NDimipenem/cilastatin Zienam antibacterial 1985 ARMC 21 328 NDrifaximin Rifacol antibacterial 1985 ARMC 21 332 NDrokitamycin Ricamycin antibacterial 1986 ARMC 22 325 NDaspoxicillin Doyle antibacterial 1987 ARMC 23 328 NDcefixime Cefspan antibacterial 1987 ARMC 23 329 NDcefminox sodium Meicelin antibacterial 1987 ARMC 23 330 ND

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cefpimizole Ajicef antibacterial 1987 ARMC 23 330 NDcefteram pivoxil Tomiron antibacterial 1987 ARMC 23 330 NDcefuroxime axetil Zinnat antibacterial 1987 ARMC 23 331 NDcefuzonam sodium Cosmosin antibacterial 1987 ARMC 23 331 NDlenampicillin HCI Varacillin antibacterial 1987 ARMC 23 336 NDrifamixin Normix antibacterial 1987 ARMC 23 341 NDroxithromycin Rulid antibacterial 1987 ARMC 23 342 NDsultamycillin tosylate Unasyn antibacterial 1987 ARMC 23 343 NDazithromycin Sunamed antibacterial 1988 ARMC 24 298 NDerythromycin acistrate Erasis antibacterial 1988 ARMC 24 301 NDflomoxef sodium Flumarin antibacterial 1988 ARMC 24 302 NDrifapentine Rifampin antibacterial 1988 ARMC 24 310 NDcefpodoxime proxetil Banan antibacterial 1989 ARMC 25 310 NDarbekacin Habekacin antibacterial 1990 ARMC 26 298 NDcefodizime sodium Neucef antibacterial 1990 ARMC 26 300 NDclarithromycin Klaricid antibacterial 1990 ARMC 26 302 NDcefdinir Cefzon antibacterial 1991 ARMC 27 323 NDcefetamet pivoxil HCl Globocef antibacterial 1992 ARMC 28 327 NDcefpirome sulfate Cefrom antibacterial 1992 ARMC 28 328 NDcefprozil Cefzil antibacterial 1992 ARMC 28 328 NDceftibuten Seftem antibacterial 1992 ARMC 28 329 NDloracarbef Lorabid antibacterial 1992 ARMC 28 333 NDrifabutin Mycobutin antibacterial 1992 ARMC 28 335 NDtazobactam sodium Tazocillin antibacterial 1992 ARMC 28 336 NDcefepime Maxipime antibacterial 1993 ARMC 29 334 NDdirithromycin Nortron antibacterial 1993 ARMC 29 336 NDcefditoren pivoxil Meiact antibacterial 1994 ARMC 30 297 NDmeropenem Merrem antibacterial 1994 ARMC 30 303 NDpanipenem/betamipron Carbenin antibacterial 1994 ARMC 30 305 NDcefozopran HCl Firstcin antibacterial 1995 ARMC 31 339 NDcefcapene pivoxil Flomox antibacterial 1997 ARMC 33 330 NDflurithromycin ethylsuccinate Ritro antibacterial 1997 ARMC 33 333 NDfropenam Farom antibacterial 1997 ARMC 33 334 NDcefoselis Wincef antibacterial 1998 ARMC 34 319 NDdalfopristin Synercid antibacterial 1999 ARMC 35 338 NDquinupristin Synercid antibacterial 1999 ARMC 35 338 ND

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telithromycin Ketek antibacterial 2001 DNP 15 35 NDbiapenem Omegacin antibacterial 2002 ARMC 38 351 NDertapenem sodium Invanz antibacterial 2002 ARMC 38 353 NDdoripenem Finibax antibacterial 2005 DNP 19 42 NDtigecycline Tygacil antibacterial 2005 DNP 19 42 NDretapamulin Altabax antibacterial 2007 ARMC 43 486 NDceftobiprole medocaril Zeftera antibacterial 2008 ARMC 44 589 NDtelavancin HCl Vibativ antibacterial 2009 DNP 23 15 NDceftaroline fosamil acetate Teflaro antibacterial 2011 DT 48(1) 40 NDdalbavancin Dalvance antibacterial 2014 DT 51(!) 47 NDoritavancin Orbactiv antibacterial 2014 DT 51(1) 47 NDcetolozane/tazobactam Zerbaxa antibacterial 2014 DT 51(1) 47 NDnorfloxacin Noroxin antibacterial 1983 ARMC 19 322 Sofloxacin Tarivid antibacterial 1985 ARMC 21 331 Spefloxacin mesylate Perflacine antibacterial 1985 ARMC 21 331 Sciprofloxacin Ciprobay antibacterial 1986 ARMC 22 318 Senoxacin Flumark antibacterial 1986 ARMC 22 320 Staurolidine Taurolin antibacterial 1988 I 107771 Slomefloxacin Uniquin antibacterial 1989 ARMC 25 315 Stosufloxacin Ozex antibacterial 1990 ARMC 26 310 Stemafloxacin hydrochloride Temac antibacterial 1991 ARMC 27 334 Sfleroxacin Quinodis antibacterial 1992 ARMC 28 331 Srufloxacin hydrochloride Qari antibacterial 1992 ARMC 28 335 Slevofloxacin Floxacin antibacterial 1993 ARMC 29 340 Snadifloxacin Acuatim antibacterial 1993 ARMC 29 340 Ssparfloxacin Spara antibacterial 1993 ARMC 29 345 Sgrepafloxacin Vaxor antibacterial 1997 DNP 11 23 Strovafloxacin mesylate Trovan antibacterial 1998 ARMC 34 332 Sgatilfloxacin Tequin antibacterial 1999 ARMC 35 340 Smoxifloxacin HCl Avelox antibacterial 1999 ARMC 35 343 Slinezolid Zyvox antibacterial 2000 DNP 14 21 Sbalafloxacin Q-Roxin antibacterial 2002 ARMC 38 351 Spazufloxacin Pasil antibacterial 2002 ARMC 38 364 Sprulifloxacin Sword antibacterial 2002 ARMC 38 366 Sgemifloxacin mesilate Factive antibacterial 2003 ARMC 40 458 Sgarenoxacin Geninax antibacterial 2007 ARMC 43 471 S

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besifloxacin Besivance antibacterial 2009 DNP 23 20 Sbedaquiline Sirturo antibacterial 2012 I 386239 Stedizolid phosphate sodium Sivextro antibacterial 2014 DT 51(1) 47 Snemonoxacin Taigexyn antibacterial 2014 DT 51(1) 48 Sfinafloxacin hydrochloride Xtoro antibacterial 2014 DT 51(1) 48 Sbrodimoprin Hyprim antibacterial 1993 ARMC 29 333 S*/NMACWY meningoccal PS vaccine Mencevax antibacterial 1981 I 420128 Vh influenzae b vaccine Hibtitek antibacterial 1989 DNP 03 24 Vh influenzae b vaccine Prohibit antibacterial 1989 DNP 03 24 Voral cholera vaccine Orochol antibacterial 1994 DNP 08 30 Vvi polysaccharide typhoid vacc Typherix antibacterial 1998 DNP 12 35 Vmeningococcal vaccine Menigetec antibacterial 1999 DNP 14 22 Vmeningococcal vaccine NeisVac-C antibacterial 2000 DNP 14 22 Vmeningococcal vaccine Menjugate antibacterial 2000 DNP 14 22 Vpneumococcal vaccine Prevnar antibacterial 2000 DNP 14 22 Vmeningitis b vaccine MeNZB antibacterial 2004 DNP 18 29 VMCV-4 Menactra antibacterial 2005 DNP 19 43 VDTPw-HepB-Hib Quinvaxem antibacterial 2006 DNP 20 26 VmenACWY-CRM Menveo antibacterial 2010 I 341212 VPsA-TT MenAfriVac antibacterial 2010 I 437718 Vhib-mency-tt Menhibrix antibacterial 2012 I 421742 VBK-4SP Tetrabik antibacterial 2012 I 697562 V

Quattrovac antibacterial 2012 I 770186 VMenACWY-TT Nimenrix antibacterial 2012 I 421745 Vbotulism antitoxin Bat antibacterial 2013 DT 50(1) 77 Vhexavalent vaccine Hexavac antibacterial (dpt) 2000 DNP 14 22 Vhexavalent vaccine Infantrix HeXa antibacterial (dpt) 2000 DNP 14 22 Vdpt vaccines Daptacel antibacterial (dpt) 2002 I 319668 V

Bexsero antibacterial (memingo type B) 2013 DT 50(1) 69 VMnB rLP2086 Trumenba antibacterial (meningitis) 2014 DT 51(1) 51 V

Prevenar 13 antibacterial (pneumococcal) 2009 DNP 23 17 VSynflorix antibacterial (pneumococcal) 2009 DNP 23 17 VTypbar antibacterial (typhoid) 2013 DT 50(1) 68 V

interferon alfa2a Roferon-A anticancer 1986 I 204503 Binterleukin-2 Proleukin anticancer 1989 ARMC 25 314 B

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celmoleukin Celeuk anticancer 1992 DNP 06 102 Binterferon, gamma-1a Biogamma anticancer 1992 ARMC 28 332 Bteceleukin Imumace anticancer 1992 DNP 06 102 Bpegaspargase Oncaspar anticancer 1994 ARMC 30 306 Brituximab Rituxan anticancer 1997 DNP 11 25 Btrastuzumab Herceptin anticancer 1998 DNP 12 35 Bdenileukin diftitox Ontak anticancer 1999 ARMC 35 338 Bmobenakin Octin anticancer 1999 ARMC 35 345 Btasonermin Beromun anticancer 1999 ARMC 35 349 Balemtuzumab Campath anticancer 2001 DNP 15 38 Bibritumomab Zevalin anticancer 2002 ARMC 38 359 Bcetuximab Erbitux anticancer 2003 ARMC 39 346 Btositumomab Bexxar anticancer 2003 ARMC 39 364 Bbevacizumab Avastin anticancer 2004 ARMC 40 450 BH-101 anticancer 2005 DNP 19 46 Bnimotuzumab BIOMAb EFGR anticancer 2006 DNP 20 29 Bpanitumumab Vectibix anticancer 2006 DNP 20 28 B

Rexin-G anticancer 2007 I 346431 B131I-chTNT anticancer 2007 I 393351 Bcatumaxomab Removab anticancer 2009 DNP 23 18 Bofatumumab Arzerra anticancer 2009 DNP 23 18 Bsipuleucel-T Provenge anticancer 2010 I 259673 Bipilimumab Yervoy anticancer 2011 DT 48(1) 45 Bmogamulizumab Poteligeo anticancer 2012 I 433141 Bpertuzumab Omnitarg anticancer 2012 I 300439 Bobinutuzumab Gazyva anticancer 2013 DT 50(1) 70 Bracotumomab Vaxira anticancer 2013 DT 50(1) 72 Bnivolumab Optivo anticancer 2014 DT 51(1) 55 Bpembrolizumab Keytruda anticancer 2014 DT 51(1) 55 Bblinatumomab Blincyto anticancer 2014 DT 51(1) 55 Bramucirumab Cyramza anticancer 2014 DT 51(1) 55 Baclarubicin Aclacin anticancer 1981 I 090013 Npeplomycin Pepleo anticancer 1981 I 090889 Nmasoprocol Actinex anticancer 1992 ARMC 28 333 Npentostatin Nipent anticancer 1992 ARMC 28 334 Npaclitaxel Taxol anticancer 1993 ARMC 29 342 N

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angiotensin II Delivert anticancer 1994 ARMC 30 296 Narglabin ? anticancer 1999 ARMC 35 335 Naminolevulinic acid HCl Levulan anticancer 2000 DNP 14 20 Npaclitaxel liposomal Lipusu anticancer 2003 I 834256 Npaclitaxel nanoparticles Abraxane anticancer 2005 DNP 19 45 Ntrabectedin Yondelis anticancer 2007 ARMC 43 492 Npaclitaxel nanoparticles Nanoxel anticancer 2007 I 422122 Npaclitaxel nanoparticles Genexol-PM anticancer 2007 I 811264 Nromidepsin Istodax anticancer 2010 DNP 23 18 Ningenol mebutate Picato anticancer 2012 I 328987 Nhomoharringtonine Ceflatonin anticancer 2012 I 090682 N

PICN anticancer 2014 DT 51(1) 58 Nsolamargines Curaderm anticancer 1989 DNP 03 25 NBelliptinium acetate Celiptium anticancer 1983 I 091123 NDepirubicin HCI Farmorubicin anticancer 1984 ARMC 20 318 NDtriptorelin Decapeptyl anticancer 1986 I 090485 NDpirarubicin Pinorubicin anticancer 1988 ARMC 24 309 NDvinorelbine Navelbine anticancer 1989 ARMC 25 320 NDidarubicin hydrochloride Zavedos anticancer 1990 ARMC 26 303 NDcladribine Leustatin anticancer 1993 ARMC 29 335 NDcytarabine ocfosfate Starsaid anticancer 1993 ARMC 29 335 NDformestane Lentaron anticancer 1993 ARMC 29 337 NDmiltefosine Miltex anticancer 1993 ARMC 29 340 NDirinotecan hydrochloride Campto anticancer 1994 ARMC 30 301 NDzinostatin stimalamer Smancs anticancer 1994 ARMC 30 313 NDdocetaxel Taxotere anticancer 1995 ARMC 31 341 NDetoposide phosphate Etopophos anticancer 1996 DNP 10 13 NDtopotecan HCl Hycamptin anticancer 1996 ARMC 32 320 NDalitretinoin Panretin anticancer 1999 ARMC 35 333 NDexemestane Aromasin anticancer 1999 DNP 13 46 NDvalrubicin Valstar anticancer 1999 ARMC 35 350 NDgemtuzumab ozogamicin Mylotarg anticancer 2000 DNP 14 23 NDaminolevulinic acid me ester Metvix anticancer 2001 DNP 15 34 NDamrubicin HCl Calsed anticancer 2002 ARMC 38 349 NDfulvestrant Faslodex anticancer 2002 ARMC 38 357 NDbelotecan hydrochloride Camtobell anticancer 2004 ARMC 40 449 ND

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hexyl aminolevulinate Hexvix anticancer 2004 I 300211 NDtalaporfin sodium Laserphyrin anticancer 2004 ARMC 40 469 NDvapreotide acetate Docrised anticancer 2004 I 135014 NDtemsirolimus Toricel anticancer 2007 ARMC 43 490 NDixabepilone Ixempra anticancer 2007 ARMC 43 473 NDpralatrexate Folotyn anticancer 2009 DNP 23 18 NDmifamurtide Junovan anticancer 2010 DNP 23 18 NDvinflunine Javlor anticancer 2010 I 219585 NDcabazitaxel Jevtana anticancer 2010 I 287186 NDeribulin Halaven anticancer 2010 I 287199 NDabiraterone acetate Zytiga anticancer 2011 DT 48(1) 44 NDbrentuximab vedotin Adcetris anticancer 2011 DT 48(1) 45 NDbf-200 ala Ameluz anticancer 2012 I 431098 NDcarfilzomib Kyprolis anticancer 2012 I 413092 NDtrastuzumab emtansine Kadcyla anticancer 2013 DT 50(1) 69 NDaminoglutethimide Cytadren anticancer 1981 I 070408 Sflutamide Drogenil anticancer 1983 ARMC 19 318 Scarboplatin Paraplatin anticancer 1986 ARMC 22 318 Samsacrine Amsakrin anticancer 1987 ARMC 23 327 Slonidamine Doridamina anticancer 1987 ARMC 23 337 Snilutamide Anadron anticancer 1987 ARMC 23 338 Sranimustine Cymerine anticancer 1987 ARMC 23 341 Sfotemustine Muphoran anticancer 1989 ARMC 25 313 Sbisantrene hydrochloride Zantrene anticancer 1990 ARMC 26 300 Sporfimer sodium Photofrin anticancer 1993 ARMC 29 343 Ssobuzoxane Parazolin anticancer 1994 ARMC 30 310 Snedaplatin Aqupla anticancer 1995 ARMC 31 347 Soxaliplatin Eloxatin anticancer 1996 ARMC 32 313 Slobaplatin Lobaplatin anticancer 1998 DNP 12 35 Sheptaplatin /SK-2053R Sunpla anticancer 1999 ARMC 35 348 Sarsenic trioxide Trisenox anticancer 2000 DNP 14 23 Szoledronic acid Zometa anticancer 2000 DNP 14 24 Ssorafenib Nexavar anticancer 2005 DNP 19 45 Splerixafor hydrochloride Mozobil anticancer 2009 DNP 22 17 Smiriplatin hydrate Miripla anticancer 2010 DNP 23 17 Svismodegib Erivedge anticancer 2012 I 473491 S

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pomalidomide Pomalyst anticancer 2013 DT 50(1) 70 Solaparib Lynparza anticancer 2014 DT 51(1) 56 Scarmofur Mifurol anticancer 1981 I 091100 S*enocitabine Sunrabin anticancer 1983 ARMC 19 318 S*mitoxantrone HCI Novantrone anticancer 1984 ARMC 20 321 S*doxifluridine Furtulon anticancer 1987 ARMC 23 332 S*fludarabine phosphate Fludara anticancer 1991 ARMC 27 327 S*gemcitabine HCl Gemzar anticancer 1995 ARMC 31 344 S*capecitabine Xeloda anticancer 1998 ARMC 34 319 S*azacytidine Vidaza anticancer 2004 ARMC 40 447 S*clofarabine Clolar anticancer 2005 DNP 19 44 S*nelarabine Arranon anticancer 2006 ARMC 42 528 S*decitabine Dacogen anticancer 2006 DNP 20 27 S*pixantrone dimaleate Pixuri anticancer 2012 I 197776 S*tipiracil hydrochloride Lonsurf anticancer 2014 DT 51(1) 58 S*raltitrexed Tomudex anticancer 1996 ARMC 32 315 S*/NMtemozolomide Temodal anticancer 1999 ARMC 35 350 S*/NMbexarotene Targretine anticancer 2000 DNP 14 23 S*/NMabarelix Plenaxis anticancer 2004 ARMC 40 446 S*/NMpemetrexed disodium Alimta anticancer 2004 ARMC 40 463 S*/NMtamibarotene Amnoid anticancer 2005 DNP 19 45 S*/NMvorinostat Zolinza anticancer 2006 DNP 20 27 S*/NMdegarelix Firmagon anticancer 2009 DNP 22 16 S*/NMvandetanib Caprelsa anticancer 2011 DT 48(1) 45 S*/NMcrizotinib Xalkori anticancer 2011 DT 48(1) 45 S*/NMvemurafenib Zeboraf anticancer 2011 DT 48(1) 45 S*/NMruxolitinib phosphate Jakafi anticancer 2011 DT 48(1) 47 S*/NMaxitinib Inlyta anticancer 2012 I 318296 S*/NMbosutiniib Bosulif anticancer 2012 I 301966 S*/NMcabozantinib S-malate Cometriq anticancer 2012 I 379934 S*/NMregorafenib Stivarga anticancer 2012 I 395674 S*/NMradotinib Supect anticancer 2012 I 446133 S*/NMdabrafenib mesilate Tafinlar anticancer 2013 DT 50(1) 69 S*/NMtrametinib DMSO Mekinist anticancer 2013 DT 50(1) 69 S*/NMafatinib Gilotrif anticancer 2013 DT 50(1) 69 S*/NMponatinib Iclusig anticancer 2013 DT 50(1) 70 S*/NM

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ibrutinib Imbruvica anticancer 2013 DT 50(1) 71 S*/NMidelalisib Zydelig anticancer 2014 DT 51(1) 54 S*/NMbelinostat Beleodaq anticancer 2014 DT 51(1) 56 S*/NMcamostat mesylate Foipan anticancer 1985 ARMC 21 325 S/NMtoremifene Fareston anticancer 1989 ARMC 25 319 S/NManastrozole Arimidex anticancer 1995 ARMC 31 338 S/NMbicalutamide Casodex anticancer 1995 ARMC 31 338 S/NMfadrozole HCl Afema anticancer 1995 ARMC 31 342 S/NMletrazole Femara anticancer 1996 ARMC 32 311 S/NMimatinib mesilate Gleevec anticancer 2001 DNP 15 38 S/NMgefitinib Iressa anticancer 2002 ARMC 38 358 S/NMtemoporfin Foscan anticancer 2002 I 158118 S/NMbortezomib Velcade anticancer 2003 ARMC 39 345 S/NMerlotinib hydrochloride Tarceva anticancer 2004 ARMC 40 454 S/NMsunitinib malate Sutent anticancer 2006 DNP 20 27 S/NMdasatinib Sprycel anticancer 2006 DNP 20 27 S/NMlapatinib ditosylate Tykerb anticancer 2007 ARMC 43 475 S/NMnilotinib hydrochloride Tasigna anticancer 2007 ARMC 43 480 S/NMpazopanib Votrient anticancer 2009 DNP 23 18 S/NMenzalutamide Xtandi anticancer 2012 I 438422 S/NMalectinib hydrochloride Alecensa anticancer 2014 DT 51(1) 54 S/NMceritinib Zykadia anticancer 2014 DT 51(1) 55 S/NMapatinib mesylate anticancer 2014 DT 51(1) 56 S/NMbcg live TheraCys anticancer 1990 DNP 04 104 Vmelanoma theraccine Melacine anticancer 2001 DNP 15 38 V

Cervarix anticancer 2007 I 309201 Vautologous tumor cell-BCG OncoVAX anticancer 2008 DNP 22 17 Vvitespen Oncophage anticancer 2008 DNP 22 17 Vantithrombin III Thrombate III anticoagulant 1983 I 113606 Bdermatan sulfate Mistral anticoagulant 1999 DNP 13 40 Bactivated protein C concn Anact C anticoagulant 2001 DNP 15 33 Bantithrombin alfa ATryn anticoagulant 2006 DNP 20 22 Brh-thrombomodulin Recomodulin anticoagulant 2008 DNP 22 12 Bdalteparin sodium Fragmin anticoagulant 1985 I 090088 NDnadroparin calcium Fraxiparine anticoagulant 1985 I 113585 NDenoxaparin Lovenox anticoagulant 1987 ARMC 23 333 ND

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lmw heparin Sandoparin anticoagulant 1989 DNP 03 23 NDlmw heparin Logiparin anticoagulant 1991 DNP 05 96 NDdanaparoid sodium Orgaran anticoagulant 1992 DNP 06 98 NDparnaparin sodium Fluxum anticoagulant 1993 ARMC 29 342 NDreviparin sodium Clivarin anticoagulant 1993 ARMC 29 344 NDcertoparin sodium Alphaparin anticoagulant 1996 DNP 10 9 NDardeparin sodium Normiflo anticoagulant 1997 DNP 11 20 NDbemiparin sodium Hibor anticoagulant 1998 DNP 12 30 NDdesirudin Revasc anticoagulant 1998 DNP 12 30 NDfondaparinux sodium Arixtra anticoagulant 2002 ARMC 38 356 NDximelagatran Exanta anticoagulant 2004 ARMC 40 470 S*dabigatran etexilate Pradaxa anticoagulant 2008 ARMC 44 598 S*/NMapixaban Eliquis anticoagulant 2011 DT 48(1) 38 S*/NMedoxaban tosilate Lixiana anticoagulant 2011 DT 48(1) 38 S*/NMlamotrigine Lamictal anticonvulsant 1990 ARMC 26 304 Soxcarbazepine Trileptal anticonvulsant 1990 ARMC 26 307 Sprogabide Gabrene anticonvulsant 1985 ARMC 21 331 S*amineptine Maneon antidepressant 1983 I 272929 Sindalpine Upstene antidepressant 1983 ARMC 19 320 Stianeptine sodium Stablon antidepressant 1983 ARMC 19 324 Smepixanox Pimexone antidepressant 1984 ARMC 20 320 Smetapramine Timaxel antidepressant 1984 ARMC 20 320 Smedifoxamine fumarate Cledail antidepressant 1986 ARMC 22 323 Sbupropion HCI Wellbutrin antidepressant 1989 ARMC 25 310 Spivagabine Tonerg antidepressant 1997 ARMC 33 341 Scitalopram Cipramil antidepressant 1989 ARMC 25 311 S*/NMescitalopram Cipralex antidepressant 2002 ARMC 38 354 S*/NMfluvoxamine maleate Floxyfral antidepressant 1983 ARMC 19 319 S/NMtoloxatone Humoryl antidepressant 1984 ARMC 20 324 S/NMfluoxetine HCI Prozac antidepressant 1986 ARMC 22 320 S/NMsetiptiline Tecipul antidepressant 1989 ARMC 25 318 S/NMmoclobemide Aurorix antidepressant 1990 ARMC 26 305 S/NMsetraline hydrochloride Lustral antidepressant 1990 ARMC 26 309 S/NMparoxetine Seroxat antidepressant 1991 ARMC 27 331 S/NMmirtazapine Remeron antidepressant 1994 ARMC 30 303 S/NMnefazodone hydrochloride Serzone antidepressant 1994 ARMC 30 305 S/NM

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venlafaxine Effexor antidepressant 1994 ARMC 30 312 S/NMmilnacipran Ixel antidepressant 1997 ARMC 33 338 S/NMreboxetine Edronax antidepressant 1997 ARMC 33 342 S/NMduloxetine hydrochloride Cymbalta antidepressant 2004 ARMC 40 452 S/NMdesvenlafaxine succinate Pristiq antidepressant 2008 ARMC 44 600 S/NMvilazodone hydrochloride Vibryd antidepressant 2011 DT 48(1) 38 S/NMlevomilnacipran Fetzima antidepressant 2013 DT 50(1) 53 S/NMvortioxetine Brintellix antidepressant 2013 DT 50(1) 54 S/NMbiphasic porcine insulin Pork Mixtard 30 antidiabetic 1982 I 303034 Bisophane insulin Humulin N antidiabetic 1982 I 091583 Bporcine isophane insulin Pork Insulatard antidiabetic 1982 I 302757 Bhuman insulin Zn suspension Humulin L antidiabetic 1985 I 302828 Bhuman insulin zinc suspension Humulin Zn antidiabetic 1985 I 091584 Bsoluble insulin Velosulin BR antidiabetic 1986 I 091581 Bhuman neutral insulin Novolin R antidiabetic 1991 I 182551 Bhu neutral insulin Insuman antidiabetic 1992 I 255451 Bmecasermin Somazon antidiabetic 1994 DNP 08 28 Binsulin lispro Humalog antidiabetic 1996 ARMC 32 310 Bporcine neutral insulin Pork Actrapid antidiabetic 1998 I 302749 Binsulin aspart NovoRapid antidiabetic 1999 DNP 13 41 Binsulin glargine Lantus antidiabetic 2000 DNP 14 19 Binsulin aspart/IA protamine NovoMix 30 antidiabetic 2001 DNP 15 34 Binsulin determir Levemir antidiabetic 2004 DNP 18 27 Binsulin glulisine Apidra antidiabetic 2005 DNP 19 39 Boral insulin Oral-lyn antidiabetic 2005 DNP 19 39 Bpulmonary insulin Exubera antidiabetic 2006 DNP 20 23 BInsulin degludec/insulin aspar DegludecPlus antidiabetic 2012 I 419438 Binsulin degludec Degludec antidiabetic 2012 I 470782 Bpulmonary insulin Afrezza antidiabetic 2014 DT 51(1) 45 Balbiglutide Eperzan antidiabetic 2014 DT 51(1) 45 Bdulaglutide Trulicity antidiabetic 2014 DT 51(1) 45 Bvoglibose Basen antidiabetic 1994 ARMC 30 313 Nacarbose Glucobay antidiabetic 1990 DNP 03 23 NDmiglitol Diastabol antidiabetic 1998 ARMC 34 325 NDextenatide Byetta antidiabetic 2005 DNP 19 40 NDtriproamylin acetate Normylin antidiabetic 2005 DNP 19 40 ND

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liraglutide Victoza antidiabetic 2009 DNP 23 13 NDglimepiride Amaryl antidiabetic 1995 ARMC 31 344 Srepaglinide Prandin antidiabetic 1998 ARMC 34 329 Spioglitazone NCl Actos antidiabetic 1999 ARMC 35 346 Smitiglinide calcium hydrate Glufast antidiabetic 2004 ARMC 40 460 Snateglinide Starsis antidiabetic 1999 ARMC 35 344 S*dapagliflozin Forxiga antidiabetic 2012 I 356099 S*/NMtolrestat Alredase antidiabetic 1989 ARMC 25 319 S/NMepalrestat Kinedak antidiabetic 1992 ARMC 28 330 S/NMtroglitazone Rezulin antidiabetic 1997 ARMC 33 344 S/NMrosiglitazone maleate Avandia antidiabetic 1999 ARMC 35 348 S/NMsitagliptin Januvia antidiabetic 2006 DNP 20 23 S/NMvildagliptin Galvus antidiabetic 2007 ARMC 43 494 S/NMsaxagliptin Onglyza antidiabetic 2009 DNP 23 13 S/NMalogliptin benzoate Nesina antidiabetic 2010 I 405286 S/NMlinagliptin Tradjenta antidiabetic 2011 DT 48(1) 39 S/NMteneligliptin hydrobromide Tenelia antidiabetic 2012 I 343981 S/NManagliptin Suiny antidiabetic 2012 I 426247 S/NMlixisenatide Lyxumia antidiabetic (diabeties 2) 2013 DT 50(1) 60 NDcanagliflozin Invokana antidiabetic (diabeties 2) 2013 DT 50(1) 60 S*/NMempagliflozin Jardiance antidiabetic (diabeties 2) 2014 DT 51(1) 45 S*/NMipragliflozin proline Suglat antidiabetic (diabeties 2) 2014 DT 51(1) 45 S*/NMtofogliflozin Apleway antidiabetic (diabeties 2) 2014 DT 51(1) 45 S*/NMluseogliflozin Lusefi antidiabetic (diabeties 2) 2014 DT 51(1) 45 S*/NMnifurzide Ricridene antidiarrheal 1981 I 091025 Sacetorphan Tiorfan antidiarrheal 1993 ARMC 29 332 S*/NMcrofelemer Fulyzaq antidiarrheal (HIV-associated) 2012 I 183950 NBfomepizole Antizol antidote 1998 ARMC 34 323 S/NMsugammadex sodium Bridion antidote (neuromuscular block) 2008 DNP 22 8 NDcarboxypeptidase G2 Voraxaze antidote (toxic medication) 2012 I 230375 Balizapride Liticum antiemetic 1981 I 091475 Sondansetron hydrochloride Zophran antiemetic 1990 ARMC 26 306 S*/NMgranisetron hydrochloride Kytril antiemetic 1991 ARMC 27 329 S*/NMtropisetron Novaban antiemetic 1992 ARMC 28 337 S*/NMnazasetron hydrochloride Serotone antiemetic 1994 ARMC 30 305 S*/NMramosetron Nasea antiemetic 1996 ARMC 32 315 S*/NM

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dolasetron mesylate Anzemet antiemetic 1998 ARMC 34 321 S*/NMpalonosetron Aloxi antiemetic 2003 ARMC 29 358 S*/NMindisetron hydrochloride Sinseron antiemetic 2004 ARMC 40 459 S*/NMaprepitant Emend antiemetic 2003 ARMC 39 341 S/NMfosaprepitant dimeglumine Ivemend antiemetic 2008 DNP 22 10 S/NMalpha-1 antitrypsin Prolastin antiemphysemic 1988 ARMC 24 297 Balpha-1 proteinase inhibitor Aralast antiemphysemic 2003 DNP 17 46 Bvigabatrin Sabril antiepileptic 1989 ARMC 25 319 NDpregabalin Lyrica antiepileptic 2004 ARMC 40 464 NDvalproate sodium Depacon antiepileptic 1981 I 289554 Sdivalproex sodium Depakote antiepileptic 1983 I 091038 Szonisamide Excegran antiepileptic 1989 ARMC 25 320 Sfelbamate Felbatol antiepileptic 1993 ARMC 29 337 Sfosphenytoin sodium Cerebyx antiepileptic 1996 ARMC 32 308 Slevetiracetam Keppra antiepileptic 2000 DNP 14 15 Srufinamide Xilep antiepileptic 2007 ARMC 43 488 Sstiripentol Diacomit antiepileptic 2007 I 090358 Sretigabine Trobalt antiepileptic 2011 DT 48(1) 35 Sperampanel Fycompa antiepileptic 2012 I 314603 Sgabapentin Neurontin antiepileptic 1993 ARMC 29 338 S*topiramate Topamax antiepileptic 1995 ARMC 31 351 S*tiagabine Gabitril antiepileptic 1996 ARMC 32 319 S*/NMlacosamide Vimpat antiepileptic 2008 DNP 22 9 S*/NMeslicarbazepine acetate Zebinex antieplleptic 2009 DNP 23 9 Sinterferon gamma-n1 OGamma100 antifungal 1996 DNP 10 13 Bcaspofungin acetate Cancidas antifungal 2001 DNP 15 36 NDmicafungin sodium Fungard antifungal 2002 ARMC 38 360 NDanidulafungin Eraxis antifungal 2006 DNP 20 24 NDketoconazole Nizoral antifungal 1981 I 116505 Sciclopirox olamine Loprox antifungal 1982 I 070449 Soxiconazole nitrate Oceral antifungal 1983 ARMC 19 322 Sterconazole Gyno-Terazol antifungal 1983 ARMC 19 324 Stioconazole Trosyl antifungal 1983 ARMC 19 324 Snaftifine HCI Exoderil antifungal 1984 ARMC 20 321 Ssulconazole nitrate Exelderm antifungal 1985 ARMC 21 332 Sbutoconazole Femstat antifungal 1986 ARMC 22 318 S

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cloconazole HCI Pilzcin antifungal 1986 ARMC 22 318 Sfenticonazole nitrate Lomexin antifungal 1987 ARMC 23 334 Sfluconazole Diflucan antifungal 1988 ARMC 24 303 Sitraconazole Sporanox antifungal 1988 ARMC 24 305 Samorolfine hydrochloride Loceryl antifungal 1991 ARMC 27 322 Ssertaconazole nitrate Dermofix antifungal 1992 ARMC 28 336 Sneticonazole HCI Atolant antifungal 1993 ARMC 29 341 Slanoconazole Astat antifungal 1994 ARMC 30 302 Sflutrimazole Micetal antifungal 1995 ARMC 31 343 Svoriconazole Vfend antifungal 2002 ARMC 38 370 Sfosfluconazole Prodif antifungal 2003 DNP 17 49 Seberconazole Ebernet antifungal 2005 DNP 19 42 Sluliconazole Lulicon antifungal 2005 DNP 19 42 Sposaconazole Noxafil antifungal 2005 DNP 19 42 Ssitafloxacin hydrate Gracevit antifungal 2008 DNP 22 15 Sefinaconazole Jublia antifungal 2013 DT 50(1) 66 Stavaborole Kerydin antifungal 2014 DT 51(1) 51 Sterbinafine hydrochloride Lamisil antifungal 1991 ARMC 27 334 S/NMbutenafine hydrochloride Mentax antifungal 1992 ARMC 28 327 S/NMliranaftate Zefnart antifungal 2000 DNP 14 21 S/NMunoprostone isopropyl ester Rescula antiglaucoma 1994 ARMC 30 312 NDlatanoprost Xalatan antiglaucoma 1996 ARMC 32 311 NDbimatoprost Lumigan antiglaucoma 2001 DNP 15 38 NDtravoprost Travatan antiglaucoma 2001 DNP 15 38 NDtafluprost Taflotan antiglaucoma 2008 DNP 22 17 NDbefunolol HCI Bentox antiglaucoma 1983 ARMC 19 315 S*carteolol HCl Teoptic antiglaucoma 1982 I 091513 S*/NMmethypranolol Minims metipranolol antiglaucoma 1982 I 317662 S*/NMlevobunolol HCI Betagan antiglaucoma 1985 ARMC 21 328 S*/NMdapiprazole HCl Glamidolo antiglaucoma 1987 ARMC 23 332 S/NMapraclonidine HCl Lopidine antiglaucoma 1988 ARMC 24 297 S/NMdorzolamide HCl Trusopt antiglaucoma 1995 ARMC 31 341 S/NMbrimonidine Alphagan antiglaucoma 1996 ARMC 32 306 S/NMbrinzolamide Azopt antiglaucoma 1998 ARMC 34 318 S/NMastemizole Hismanal antihistamine 1983 ARMC 19 314 Sazelastine HCI Azeptin antihistamine 1986 ARMC 22 316 S

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cetirizine HCI Zyrtec antihistamine 1987 ARMC 23 331 Ssetastine HCI Loderix antihistamine 1987 ARMC 23 342 Sacrivastine Semprex antihistamine 1988 ARMC 24 295 Sloratadine Claritan antihistamine 1988 ARMC 24 306 Sebastine Ebastel antihistamine 1990 ARMC 26 302 Slevocabastine hydrochloride Livostin antihistamine 1991 ARMC 27 330 Smizolastine Mizollen antihistamine 1998 ARMC 34 325 Sdesloratidine Clarinex / Neoclarityn antihistamine 2001 DNP 15 31 Slevocetirizine Xyzal / Xusal antihistamine 2001 DNP 15 31 Srupatadine fumarate Rupafin antihistamine 2001 DNP 15 31 Sbilastine antihistamine 2010 I 260868 Sbilastine Bilaxten antihistamine 2011 DT 48(1) 36 Slisuride maleate Dopergin antihyperprolactinemia 1982 I 091467 NDmetergolin Liserdol antihyperprolactinemia 1987 I 091331 NDcabergoline Dostinex antihyperprolactinemia 1993 ARMC 29 334 NDquinagolide hydrochloride Norprolac antihyperprolactinemia 1994 ARMC 30 309 NDeplerenone Inspra antihypertensive 2002 I 261466 NDtreprostinil sodium Remodulin antihypertensive 2002 ARMC 38 368 NDnicardipine HCl Perpidine antihypertensive 1981 I 091152 Surapidil Ebrantil antihypertensive 1981 I 172318 Sbudralazine Buteraxine antihypertensive 1983 ARMC 19 315 Sguanadrel sulfate Hylorel antihypertensive 1983 ARMC 19 319 Sterazocin HCl Hytrin antihypertensive 1984 ARMC 20 323 Snitrendipine Bayotensin antihypertensive 1985 ARMC 21 331 Spinacidil Pindac antihypertensive 1987 ARMC 23 340 Salfuzosin HCl Xatral antihypertensive 1988 ARMC 24 296 Scadralazine Cadraten antihypertensive 1988 ARMC 24 298 Scicletanine Tenstaten antihypertensive 1988 ARMC 24 299 Sfelodipine Plendil antihypertensive 1988 ARMC 24 302 Srilmenidine Hyperium antihypertensive 1988 ARMC 24 310 Stiamenidine HCl Sundralen antihypertensive 1988 ARMC 24 311 Sisradipine Prescal antihypertensive 1989 ARMC 25 315 Snilvadipine Nivadil antihypertensive 1989 ARMC 25 316 Samlodipine besylate Istin antihypertensive 1990 ARMC 26 298 Smanidipine hydrochloride Calslot antihypertensive 1990 ARMC 26 304 Snisoldipine Baymycard antihypertensive 1990 ARMC 26 306 S

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benidipine hydrochloride Coniel antihypertensive 1991 ARMC 27 322 Slacidipine Lacipil antihypertensive 1991 ARMC 27 330 Sbarnidipine hydrochloride Hypoca antihypertensive 1992 ARMC 28 326 Sefonidipine hydrochloride Landel antihypertensive 1994 ARMC 30 299 Scinildipine Cinalong antihypertensive 1995 ARMC 31 339 Sarandipine Bec/Sapresta antihypertensive 1996 ARMC 32 306 Slercanidipine Lerdip antihypertensive 1997 ARMC 33 337 Smibefradil hydrochloride Posicor antihypertensive 1997 ARMC 33 338 Sazelnipidine Calblock antihypertensive 2003 ARMC 39 344 Sclevidipine butyrate Cleviprex antihypertensive 2008 DNP 22 10 Sindoramin HCl Wydora antihypertensive 1981 I 091274 S*celiprolol HCl Selectol antihypertensive 1983 ARMC 19 317 S*cloranolol HCl Tobanum antihypertensive 1981 I 115093 S*/NMmepindolol sulfate Corindolan antihypertensive 1981 I 091107 S*/NMpenbutanol sulfate Betapressin antihypertensive 1981 I 091512 S*/NMbetaxolol HCI Kerlone antihypertensive 1983 ARMC 19 315 S*/NMenalapril maleate Reniten antihypertensive 1984 ARMC 20 317 S*/NMbopindolol Sandonorm antihypertensive 1985 ARMC 21 324 S*/NMarotinolol HCI Almarl antihypertensive 1986 ARMC 22 316 S*/NMbisoprolol fumarate Concor antihypertensive 1986 ARMC 22 317 S*/NMbevantolol HCl Ranestol antihypertensive 1987 ARMC 23 328 S*/NMenalaprilat Renitec antihypertensive 1987 ARMC 23 332 S*/NMlisinopril Prinivil antihypertensive 1987 ARMC 23 337 S*/NMtertatolol HCl Artex antihypertensive 1987 ARMC 23 344 S*/NMalacepril Cetapril antihypertensive 1988 ARMC 24 296 S*/NMamosulalol Lowgan antihypertensive 1988 ARMC 24 297 S*/NMnipradilol Hypadil antihypertensive 1988 ARMC 24 307 S*/NMperindopril Coversyl antihypertensive 1988 ARMC 24 309 S*/NMdelapril Adecut antihypertensive 1989 ARMC 25 311 S*/NMdilevalol Levadil antihypertensive 1989 ARMC 25 311 S*/NMquinapril Accupro antihypertensive 1989 ARMC 25 317 S*/NMramipril Triatec antihypertensive 1989 ARMC 25 317 S*/NMbenazepril hydrochloride Cibacen antihypertensive 1990 ARMC 26 299 S*/NMcilazapril Inhibace antihypertensive 1990 ARMC 26 301 S*/NMcarvedilol Dilatrend antihypertensive 1991 ARMC 27 323 S*/NMfosinopril sodium Staril antihypertensive 1991 ARMC 27 328 S*/NM

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moxonidine Cynt antihypertensive 1991 ARMC 27 330 S*/NMtilisolol hydrochloride Daim antihypertensive 1992 ARMC 28 337 S*/NMimidapriI HCI Tanatril antihypertensive 1993 ARMC 29 339 S*/NMtrandolapril Odrik antihypertensive 1993 ARMC 29 348 S*/NMtemocapril hydrochloride Acecol antihypertensive 1994 ARMC 30 311 S*/NMmoexipril HCl Univasc antihypertensive 1995 ARMC 31 346 S*/NMspirapril HCl Setrilan antihypertensive 1995 ARMC 31 349 S*/NMzofenapril calcium Zantipres antihypertensive 2000 DNP 14 16 S*/NMaliskiren fumarate Tekturna antihypertensive 2007 ARMC 43 461 S*/NMbunazosin HCl Detandol antihypertensive 1985 ARMC 21 324 S/NMketanserin Serefrex antihypertensive 1985 ARMC 21 328 S/NMtrimazosin HCl Supres antihypertensive 1985 ARMC 21 333 S/NMdoxazosin mesylate Carduran antihypertensive 1988 ARMC 24 300 S/NMlosartan potassium Cozaar antihypertensive 1994 ARMC 30 302 S/NMvalsartan Diovan antihypertensive 1996 ARMC 32 320 S/NMcandesartan cilexetil Atacand antihypertensive 1997 ARMC 33 330 S/NMeprosartan Teveten antihypertensive 1997 ARMC 33 333 S/NMirbesartan Avapro antihypertensive 1997 ARMC 33 336 S/NMnebivolol Nebilet antihypertensive 1997 ARMC 33 339 S/NMfenoldopam mesylate Corlopam antihypertensive 1998 ARMC 34 322 S/NMtelmisartan Micardis antihypertensive 1999 ARMC 35 349 S/NMbosentan Tra-cleer antihypertensive 2001 DNP 15 32 S/NMolmesartan medoxil Benicar antihypertensive 2002 ARMC 39 363 S/NMazilsartan medoxomil Azilva antihypertensive 2012 I 192016 S/NMrasburicase Fasturtec antihyperuricemia 2001 DNP 15 39 Bamezinium methylsulfate Supratonin antihypotensive 1981 I 091060 Sinterferon, gamma Polyferon antiinflammatory 1989 ARMC 25 314 Bhalometasone Sicorten antiinflammatory 1983 ARMC 19 320 NDhydrocortisone butyrate Pandel antiinflammatory 1983 ARMC 19 320 NDalclometasone dipropionate Vaderm antiinflammatory 1985 ARMC 21 323 NDnabumetone Relifex antiinflammatory 1985 ARMC 21 330 NDdeflazacort Deflan antiinflammatory 1986 ARMC 22 319 NDprednicarbate Dermatop antiinflammatory 1986 ARMC 22 325 NDmometasone furoate Elocon antiinflammatory 1987 ARMC 23 338 NDhydrocortisone aceponate Retef antiinflammatory 1988 ARMC 24 304 NDfluticasone propionate Flixonase antiinflammatory 1990 ARMC 26 303 ND

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halobetasol propionate Ultravate antiinflammatory 1991 ARMC 27 329 NDdeprodone propionate Eclar antiinflammatory 1992 ARMC 28 329 NDbetamethasone butyrate propion Antebate antiinflammatory 1994 ARMC 30 297 NDrimexolone Vexol antiinflammatory 1995 ARMC 31 348 NDlonazolac calcium Lonax antiinflammatory 1981 I 091064 Spranoprofen Niflan antiinflammatory 1982 I 110013 Sbutyl flufenamate Fenazole antiinflammatory 1983 ARMC 19 316 Sisoxicam Pacyl antiinflammatory 1983 ARMC 19 320 Soxaprozin Duraprox antiinflammatory 1983 ARMC 19 322 Sisofezolac Sofenac antiinflammatory 1984 ARMC 20 319 Smesalamine Asacol antiinflammatory 1984 ARMC 20 318 Spiketoprofen Calmatel antiinflammatory 1984 ARMC 20 322 Spimaprofen Besicum antiinflammatory 1984 ARMC 20 322 Setodolac Lodine antiinflammatory 1985 ARMC 21 327 Snimesulide Aulin antiinflammatory 1985 ARMC 21 330 Samfenac sodium Fenazox antiinflammatory 1986 ARMC 22 315 Sfelbinac Napageln antiinflammatory 1986 ARMC 22 320 Slobenzarit sodium Carfenil antiinflammatory 1986 ARMC 22 322 Sloxoprofen sodium Loxonin antiinflammatory 1986 ARMC 22 322 Sosalazine sodium Dipentum antiinflammatory 1986 ARMC 22 324 Spiproxen Piproxen antiinflammatory 1986 I 125556 Sflunoxaprofen Priaxim antiinflammatory 1987 ARMC 23 335 Sflurbiprofen sodium Ocufen antiinflammatory 1987 I 137512 Sibuprofen guaiacol ester Benflogin antiinflammatory 1987 ARMC 23 325 Stenoxicam Tilcotil antiinflammatory 1987 ARMC 23 344 Spiroxicam cinnamate Sinartrol antiinflammatory 1988 ARMC 24 309 Sfepradiinol Flexidol antiinflammatory 1989 DNP 03 20 Saminoprofen Aldospray antiinflammatory 1990 ARMC 26 298 Sdroxicam Ombolan antiinflammatory 1990 ARMC 26 302 Stropesin Repanidal antiinflammatory 1990 DNP 04 99 Saceclofenac Airtal antiinflammatory 1992 ARMC 28 325 Sbutibufen Butilopan antiinflammatory 1992 ARMC 28 327 Szaltoprofen Soleton antiinflammatory 1993 ARMC 29 349 Sampiroxicam Nacyl antiinflammatory 1994 ARMC 30 296 Sdexibuprofen Seractyl antiinflammatory 1994 ARMC 30 298 S

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mofezolac Disopain antiinflammatory 1994 ARMC 30 304 Sdexketoprofen trometamol Enantyum antiinflammatory 1996 DNP 10 5 Sbromfenac sodium Duract antiinflammatory 1997 ARMC 33 329 Slornoxicam Xeto antiinflammatory 1997 ARMC 33 337 Samtolmetin guacil Enfans antiinflammatory 1998 DNP 12 35 Snepafenac Nevanac antiinflammatory 2005 DNP 19 46 Sarterolane / piperaquine Synriam antiiparasitic 2012 I 466970 S*HEV-239 Hecolin antiiviral [hepatits E] 2012 I 656910 Vpirprofen Rengasil antimigraine 1982 I 091061 Slomerizine HCl Teranas antimigraine 1999 ARMC 35 342 Ssumatriptan succinate Imigran antimigraine 1991 ARMC 27 333 S*/NMnaratriptan HCl Naramig antimigraine 1997 ARMC 33 339 S*/NMzomitriptan Zomig antimigraine 1997 ARMC 33 345 S*/NMrizatriptan benzoate Maxalt antimigraine 1998 ARMC 34 330 S*/NMalmotriptan Almogran antimigraine 2000 DNP 14 13 S*/NMeletriptan Relpax antimigraine 2001 DNP 15 30 S*/NMfrovatriptan Frova antimigraine 2002 ARMC 38 357 S*/NMalpiropride Rivestel antimigraine 1988 ARMC 24 296 S/NMmodafinil Modiodal antinarcolepsy 1994 ARMC 30 303 Snaltrexone HCI ReVia antinarcotic 1984 ARMC 20 322 NDnalmefene HCl Revex antinarcotic 1995 ARMC 31 347 NDdronabinol Marinol antinauseant 1986 ARMC 22 319 Nnetupitent Akynzeo antinauseant 2014 DT 51(1) 44 S/NMorlistat Xenical antiobesity 1998 ARMC 34 327 NDcetilistat Oblean antiobesity 2013 DT 50(1) 76 Sdexfenfluramine Redux antiobesity 1997 ARMC 33 332 S/NMsibutramine Meridia antiobesity 1998 ARMC 34 331 S/NMrimonabant Acomplia antiobesity 2006 DNP 20 29 S/NMlorcaserin hydrochloride Belviq antiobesity 2012 I 355197 S/NMartemisinin Artemisin antiparasitic 1987 ARMC 23 327 Nivermectin Mectizan antiparasitic 1987 ARMC 23 336 Nmefloquine HCI Fansimef antiparasitic 1985 ARMC 21 329 NDartemether Artemetheri antiparasitic 1987 I 90712 NDartenusate Arinate antiparasitic 1987 I 91299 NDeflornithine HCl Ornidyl antiparasitic 1990 DNP 04 104 NDarteether Artemotil antiparasitic 2000 DNP 14 22 ND

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albendazole Eskazole antiparasitic 1982 I 129625 Squinfamide Amenox antiparasitic 1984 ARMC 20 322 Slumefantrine ? antiparasitic 1987 I 269095 Shalofantrine Halfan antiparasitic 1988 ARMC 24 304 Sdelamanid Deltyba antiparasitic 2014 DF 51(1) 48 Satovaquone Mepron antiparasitic 1992 ARMC 28 326 S*bulaquine / chloroquine Aablaquin antiparasitic 2000 DNP 14 22 S*trichomonas vaccine Gynatren antiparasitic 1986 I 125543 Vlidamidine HCl Lidaral antiperistaltic 1984 ARMC 20 320 Sgestrinone Dimetrose antiprogestogenic 1986 ARMC 22 321 NDalefacept Amevive antipsoriatic 2003 ARMC 39 340 Befalizumab Raptiva antipsoriatic 2003 ARMC 39 349 Bustekinumab Stelara antipsoriatic 2008 DNP 22 14 Bitolizumab Alzumab antipsoriatic 2013 DT 50(1) 61 BXP-828L Dermylex antipsoriatic 2007 I 377490 NBacitretin Neotigason antipsoriatic 1989 ARMC 25 309 NDcalcipotriol Daivonex antipsoriatic 1991 ARMC 27 323 NDtacalcitol Bonalfa antipsoriatic 1993 ARMC 29 346 NDtimodepressin Thymodepressin antipsoriatic 2002 I 423112 S*tazarotene Zorac antipsoriatic 1997 ARMC 33 343 S*/NMapremilast Otezla antipsoriatic 2014 DT 51(1) 46 S/NMazurene Impromen antipsychotic 1981 I 091083 Szotepine Zoleptil antipsychotic 1982 I 091418 Szuclopenthixol acetate Clopixol Acutard antipsychotic 1987 ARMC 23 345 Sremoxipride hydrochloride Roxiam antipsychotic 1990 ARMC 26 308 S*/NMperspirone hydrochloride Lullan antipsychotic 2001 DNP 15 30 S*/NMamisulpride Socian antipsychotic 1986 ARMC 22 316 S/NMlevosulpiride Levopraid antipsychotic 1987 I 126015 S/NMblonanserin Lonasen antipsychotic 2008 DNP 22 9 S/NMasenapine maleate Saphris antipsychotic 2009 DNP 23 9 S/NMiloperidone Fanapt antipsychotic 2010 I 165804 S/NMlurasidone hydrochloride Latuda antipsychotic 2011 DT 48(1) 35 S/NMdiacerein Artrodar antirheumatic 1985 ARMC 21 326 Sactarit Orcl antirheumatic 1994 ARMC 30 296 Stenidap sodium Enablex antirheumatic 1995 DNP 08 30 Soctreotide Sandostatin antisecretory 1988 ARMC 24 307 ND

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HA-1A Centoxin antisepsis 1991 ARMC 27 325 Bdrotrecogin alfa (activated) Xigris antisepsis 2001 DNP 15 37 Badmantanium bromide Amantol antiseptic 1984 ARMC 20 315 Scimetropium bromide Alginor antispasmodic 1985 ARMC 21 326 NDtiropramide Maiorad antispasmodic 1983 ARMC 19 324 Stiquizium bromide Thiaton antispasmodic 1984 ARMC 20 324 Smemantine HCl Akatinol antispastic 1982 I 091101 Sdefibrotide Noravid antithrombotic 1986 ARMC 22 319 Balteplase Activase antithrombotic 1987 ARMC 23 326 Banistreolase Eminase antithrombotic 1987 ARMC 23 326 Btisokinase Plasvata antithrombotic 1990 DNP 04 102 Bsilteplase Plasminer antithrombotic 1991 DNP 05 96 Bpro-urokinase Thrombolyse antithrombotic 1992 DNP 06 98 Babciximab ReoPro antithrombotic 1994 DNP 08 28 Bduteplase Solclot antithrombotic 1995 ARMC 31 342 Bnateplase Milyzer antithrombotic 1996 DNP 10 9 Breteplase Retavase antithrombotic 1996 ARMC 32 316 Bmonteplase Cleactor antithrombotic 1998 DNP 12 30 Bpamiteplase Solinase antithrombotic 1999 DNP 13 40 Btenecteplase TNKase antithrombotic 2000 DNP 14 16 Bganglioside GM1 Sygen antithrombotic 1987 I 134858 Nlimaprost Opalmon antithrombotic 1988 ARMC 24 306 NDethyl icosapentate Epadel antithrombotic 1990 ARMC 26 303 NDcloricromen Proendotal antithrombotic 1991 ARMC 27 325 NDlepirudin Refludan antithrombotic 1997 ARMC 33 336 NDbivalrudin Angiomax antithrombotic 2000 ARMC 36 298 NDtrifusal Disgren antithrombotic 1981 I 091139 Sindobufen Ibustrin antithrombotic 1984 ARMC 20 319 Sargatroban Slonnon antithrombotic 1990 ARMC 26 299 S*/NMeptilfibatide Integrilin antithrombotic 1999 ARMC 35 340 S*/NMticagrelor Britique antithrombotic 2011 DT 48(1) 38 S*/NMpicotamide Plactidil antithrombotic 1987 ARMC 23 340 S/NMcilostazol Retal antithrombotic 1988 ARMC 24 299 S/NMozagrel sodium Xanbon antithrombotic 1988 ARMC 24 308 S/NMclopidogrel hydrogensulfate Plavix antithrombotic 1998 ARMC 34 320 S/NMtirofiban HCl Aggrastat antithrombotic 1998 ARMC 34 332 S/NM

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prasugrel Efient antithrombotic 2009 DNP 23 12 S/NMflutropium bromide Flubron antitussive 1988 ARMC 24 303 NDlevodropropizine Levotuss antitussive 1988 ARMC 24 305 Snitisinone Orfadin antityrosinaemia 2002 ARMC 38 362 Ssulglycotide Gliptide antiulcer 1985 I 206964 Bplaunotol Kelnac antiulcer 1987 ARMC 23 340 Nsofalcone Solon antiulcer 1984 ARMC 20 323 NDteprenone Selbex antiulcer 1984 ARMC 20 323 NDenprostil Gardrin antiulcer 1985 ARMC 21 327 NDmisoprostol Cytotec antiulcer 1985 ARMC 21 329 NDrosaprostol Rosal antiulcer 1985 ARMC 21 332 NDmidoriamin Midoriamine antiulcer 1987 I 137319 NDornoprostil Alloca antiulcer 1987 ARMC 23 339 NDrebamipide Mucosta antiulcer 1990 ARMC 26 308 NDecabet sodium Gastrom antiulcer 1993 ARMC 29 336 NDtretinoin tocoferil Olcenon antiulcer 1993 ARMC 29 348 NDpolaprezinc Promac antiulcer 1994 ARMC 30 307 NDegualen sodium Azuloxa antiulcer 2000 DNP 14 17 NDranitidine HCl Zantac antiulcer 1981 I 091558 Salmagate Almax antiulcer 1984 I 312835 Sfamotidine Gaster / Pepcid antiulcer 1985 ARMC 21 327 Sroxatidine acetate HCI Altat antiulcer 1986 ARMC 22 326 Stroxipide Aplace antiulcer 1986 ARMC 22 327 Sbenexate HCI Lonmiel antiulcer 1987 ARMC 23 328 Snizatidine Axid antiulcer 1987 ARMC 23 339 Sspizofurone Maon antiulcer 1987 ARMC 23 343 Somepraxole Losec antiulcer 1988 ARMC 24 308 Szinc acexamate Copinal antiulcer 1988 I 117282 Sirsogladine Gaslon-N antiulcer 1989 ARMC 25 315 Slansoprazole Ogast antiulcer 1992 ARMC 28 332 Spantoprazole sodium Pantozol antiulcer 1994 ARMC 30 306 Sranitidine bismuth citrate Pylorid antiulcer 1995 ARMC 31 348 Sebrotidine Ebocrit antiulcer 1997 ARMC 33 333 Srabeprazole sodium Pariet antiulcer 1998 ARMC 34 328 Sesomeprazole magnesium Nexium antiulcer 2000 DNP 14 17 Slafutidine Stogar antiulcer 2000 DNP 14 17 S

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revaprazan hydrochlorie Revanex antiulcer 2007 I 272502 Sdexlansoprazole Dexilant antiulcer 2009 DNP 23 13 Sinterferon alfa-2b Viraferon antiviral 1985 I 165805 Binterferon beta Frone antiviral 1985 I 115091 Binterferon alfa-n1 Wellferon antiviral 1986 I 125561 Binterferon alfa Alfaferone antiviral 1987 I 215443 Binterferon alfa-n3 Alferon N antiviral 1990 DNP 04 104 Bresp syncytial virus IG RespiGam antiviral 1996 DNP 10 11 Bthymalfasin Zadaxin antiviral 1996 DNP 10 11 Binterferon alfacon-1 Infergen antiviral 1997 ARMC 33 336 Bpalivizumab Synagis antiviral 1998 DNP 12 33 Bpeginterferon alfa-2b Pegintron antiviral 2000 DNP 14 18 Bpeginterferon alfa-2a Pegasys antiviral 2001 DNP 15 34 Bimmunoglobulin intravenous Gammagard Liquid antiviral 2005 I 231564 B

Oralgen antiviral 2007 I 415378 BIGIV-HB Niuliva antiviral 2009 DNP 23 16 Boseltamivir Tamiflu antiviral 1999 ARMC 35 346 NDzanamivir Relenza antiviral 1999 ARMC 35 352 NDenfuvirtide Fuzeon antiviral 2003 ARMC 39 350 NDlaninamivir octanoate Inavir antiviral 2010 I 340894 NDrimantadine HCI Roflual antiviral 1987 ARMC 23 342 Sfoscarnet sodium Foscavir antiviral 1989 ARMC 25 313 Spropagermanium Serosion antiviral 1994 ARMC 30 308 Snevirapine Viramune antiviral 1996 ARMC 32 313 Sdelavirdine mesylate Rescriptor antiviral 1997 ARMC 33 331 Simiquimod Aldara antiviral 1997 ARMC 33 335 Sefavirenz Sustiva antiviral 1998 ARMC 34 321 Smaraviroc Celsentri antiviral 2007 ARMC 43 478 Sraltegravir potassium Isentress antiviral 2007 ARMC 43 484 Srilpivirine hydrochloride Edurant antiviral 2011 DT 48(1) 41 Sacyclovir Zovirax antiviral 1981 I 091119 S*inosine pranobex Imunovir antiviral 1981 I 277341 S*zidovudine Retrovir antiviral 1987 ARMC 23 345 S*epervudine Hevizos antiviral 1988 I 157373 S*ganciclovir Cymevene antiviral 1988 ARMC 24 303 S*didanosine Videx antiviral 1991 ARMC 27 326 S*

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zalcitabine Hivid antiviral 1992 ARMC 28 338 S*sorivudine Usevir antiviral 1993 ARMC 29 345 S*famciclovir Famvir antiviral 1994 ARMC 30 300 S*stavudine Zerit antiviral 1994 ARMC 30 311 S*lamivudine Epivir antiviral 1995 ARMC 31 345 S*valaciclovir HCl Valtrex antiviral 1995 ARMC 31 352 S*cidofovir Vistide antiviral 1996 ARMC 32 306 S*penciclovir Vectavir antiviral 1996 ARMC 32 314 S*abacavir sulfate Ziagen antiviral 1999 ARMC 35 333 S*tenofovir disoproxil fumarate Viread antiviral 2001 DNP 15 37 S*valganciclovir Valcyte antiviral 2001 DNP 15 36 S*adefovir dipivoxil Hepsera antiviral 2002 ARMC 38 348 S*emtricitabine Emtriva antiviral 2003 ARMC 39 350 S*entecavir Baraclude antiviral 2005 DNP 19 39 S*telbivudine Sebivo antiviral 2006 DNP 20 22 S*etravirine Intelence antiviral 2008 DNP 22 15 S*saquinavir mesylate Invirase antiviral 1995 ARMC 31 349 S*/NMindinavir sulfate Crixivan antiviral 1996 ARMC 32 310 S*/NMritonavir Norvir antiviral 1996 ARMC 32 317 S*/NMneflinavir mesylate Viracept antiviral 1997 ARMC 33 340 S*/NMfomivirsen sodium Vitravene antiviral 1998 ARMC 34 323 S*/NMamprenavir Agenerase antiviral 1999 ARMC 35 334 S*/NMlopinavir Kaletra antiviral 2000 ARMC 36 310 S*/NMatazanavir Reyataz antiviral 2003 ARMC 39 342 S*/NMfosamprenevir Lexiva antiviral 2003 ARMC 39 353 S*/NMtipranavir Aptivus antiviral 2005 DNP 19 42 S*/NMdarunavir Prezista antiviral 2006 DNP 20 25 S/NMrubella vaccine Ervevax antiviral 1985 I 115078 Vhepatitis b vaccine Engerix B antiviral 1987 I 137797 Vhepatitis a vaccine Havrix antiviral 1992 DNP 06 99 Vattenuated chicken pox vaccine

Merieux Varicella Vaccine antiviral 1993 DNP 07 31 V

hepatitis b vaccine Biken-HB antiviral 1993 DNP 07 31 Vhepatitis a vaccine Aimmugen antiviral 1995 DNP 09 23 Vvaricella virus vaccine Varivax antiviral 1995 DNP 09 25 Vhepatitis a vaccine Vaqta antiviral 1996 DNP 10 11 V

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inact hepatitis a vaccine Avaxim antiviral 1996 DNP 10 12 Vhepatitis b vaccine Meinyu antiviral 1997 DNP 11 24 Vrotavirus vaccine Rota-Shield antiviral 1998 DNP 12 35 Vhepatitis b vaccine Bio-Hep B antiviral 2000 DNP 14 22 Vhepatitis b vaccine Hepacure antiviral 2000 DNP 14 22 Vhepatitis A and B vaccine Ambirix antiviral 2003 I 334416 Vinfluenza virus (live) FluMist antiviral 2003 ARMC 39 353 Vinfluenza vaccine Invivac antiviral 2004 I 391186 V

Bilive antiviral 2005 DNP 19 43 VMR vaccine Mearubik antiviral 2005 DNP 19 44 Vhepatitis B vaccine Fendrix antiviral 2005 DNP 19 43 Vrotavirus vaccine Rotarix antiviral 2005 DNP 18 29 V

VariZIG antiviral 2005 I 230590 Vanti-Hep B immunoglobulin HepaGam B antiviral 2006 DNP 20 27 Vhpv vaccine Gardasil antiviral 2006 DNP 20 26 Vrotavirus vaccine Rotateq antiviral 2006 DNP 20 26 Vzoster vaccine live Zostavax antiviral 2006 DNP 20 26 Vantirabies vaccine Rabirix antiviral 2006 DNP 20 27 V

Optaflu antiviral 2007 I 410266 VDaronix antiviral 2007 I 427024 V

H5N1 avian flu vaccine antiviral 2007 I 440743 Vinfluenza virus vaccine Afluria antiviral 2007 I 449226 V

Grippol Neo antiviral 2009 DNP 23 16 VCelvapan antiviral 2009 DNP 23 17 V

measles/rubella vaccine antiviral 2011 DT 48(1) 44 VFocetria antiviral (H1N1) 2009 DNP 23 17 VPandremix antiviral (H1N1) 2009 DNP 23 17 VCeltura antiviral (H1N1) 2009 DNP 23 17 VPanenza antiviral (H1N1) 2009 DNP 23 17 VFluval P antiviral (H1N1) 2009 DNP 23 17 VVaxiflu-S antiviral (H1N1) 2010 I 698015 V

Influenza A(H1N1) monovalent antiviral (H1N1) 2010 I 678265 VHN-VAC HNVAC antiviral (H1N1) 2010 I 684608 Vperamivir PeramiFlu antiviral (H1N1] 2010 I 273549 S/NMGSK-1562902A Prepandrix antiviral (H5N1) 2008 DNP 22 16 VKD-295 antiviral (H5N1) 2014 DT 51(1) 52 V

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daclatasvir dihydrochloride Daklinza antiviral (HCV) 2014 DT 51(1) 48 Sdasabuvir Exviera antiviral (HCV) 2014 DT 51(1) 50 Ssofosbuvir Sovaldi antiviral (HCV) 2013 DT 50(1) 64 S*simeprevir Sovriad antiviral (HCV) 2013 DT 50(1) 63 S*/NMvaniprevir Vanihep antiviral (HCV) 2014 DT 51(1) 49 S*/NMombitasvir Viekira Pak antiviral (HCV) 2014 DT 51(1) 50 S*/NMparitaprevir Viekira Pak antiviral (HCV) 2014 DT 51(1) 50 S*/NMasunaprevir Sunvepra antiviral (HCV) 2014 DT 51(1) 48 S/NMledipasvir Harvoni antiviral (HCV) 2014 DT 51(1) 48 S/NMdolutegravir Tivicay antiviral (HIV) 2013 DT 50(1) 63 Selvitegravir Viteka antiviral (HIV) 2013 DT 50(1) 63 Scobicistat Tybost antiviral (HIV) 2013 DT 50(1) 63 S/NMchimerivax-JE Imojev antiviral (Japanese enceph) 2012 I 292954 VBBIL/JEV Jenvac antiviral (Japanese enceph) 2013 DT 50(1) 68 Vclevudine Levovir antiviral (hepatitis B) 2007 ARMC 43 466 S*rec hepatitis B vaccine Supervax antiviral (hepatitis B) 2006 DNP 20 27 Vfavipiravir Avigan antiviral (influenza) 2014 DT 51(1) 50 S*/NMsplit influenza vaccine Anflu antiviral (influenza) 2006 DNP 20 26 Vinfluenza vaccine Optaflu antiviral (influenza) 2008 DNP 22 16 VCSL-401 Panvax antiviral (influenza) 2008 DNP 22 16 V

Panflu antiviral (influenza) 2008 DNP 22 16 VGSK-2282512A Fluarix Quadrivalent antiviral (influenza) 2012 I 709665 VFLU-Q-QIV Flulaval Quadrivalent antiviral (influenza) 2013 DT 50(1) 68 V

Fluzone Quadrivalent antiviral (influenza) 2013 DT 50(1) 68 V9vHPV Gardasil 9 antiviral (papilloma virus) 2014 DT 51(1) 52 V

ACAM-2000 antiviral (smallpox) 2007 I 328985 VImvanex antiviral (smallpox) 2013 DT 50(1) 69 VVepacel antiviral [H5N1] 2012 I 768351 V

boceprevir Victrelis antiviral [HCV] 2011 DT 48(1) 41 S*/NMtelaprevir Incivek antiviral [HCV] 2011 DT 48(1) 41 S*/NMMedi-3250 FluMist Quadrivalent antiviral [influenza A, B] 2012 I 669909 VVCIV PreFluCel antiviral [influenza] 2010 I 444826 V

Hexyon antiviral/antibacterial 2013 DT 50(1) 69 Vcevimeline HCl Evoxac antixerostomia 2000 DNP 14 22 S*/NMethyl loflazepate Victan anxiolytic 1982 I 091122 Shalazepam Paxipam anxiolytic 1982 I 091388 S

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etizolam Depas anxiolytic 1984 ARMC 20 318 Sflutazolam Coreminal anxiolytic 1984 ARMC 20 318 Smexazolam Melex anxiolytic 1984 ARMC 20 321 Sbuspirone HCl Bespar anxiolytic 1985 ARMC 21 324 Sflutoprazepam Restas anxiolytic 1986 ARMC 22 320 Smetaclazepam Tallis anxiolytic 1987 ARMC 23 338 Salpidem Ananxyl anxiolytic 1991 ARMC 27 322 S/NMtandospirone Sediel anxiolytic 1996 ARMC 32 319 S/NMvernakalant HCl Brinavess atrial fibrillation 2010 I 299039 Sextract of serenoa repens Permixon benign prostatic hypertrophy 1982 I 288462 Ndutaseride Duagen benign prostatic hypertrophy 2001 DNP 15 32 NDsilodosin Urief benign prostatic hypertrophy 2006 DNP 20 22 Stamsulosin HCI Harnal benign prostatic hypertrophy 1993 ARMC 29 347 S/NMflumazenil Anexate benzodiazepine antagonist 1987 ARMC 23 335 S/NMsulbactam sodium Sulperazone beta-lactamase inhibitor 1986 ARMC 22 326 NDc botulinum type a toxin Dysport blepharospasm 1991 DNP 05 94 Brh-BMP-2/ACS InFuse bone disorders 2002 I 305178 BOP-1 Novos bone morphogenesis 2001 ARMC 37 269 BNaH2PO4/Na2HPO4 Visicol bowel evacuant 2001 DNP 15 33 Soxitropium bromide Oxivent bronchodilator 1983 ARMC 19 323 NDdoxofylline Ansimar bronchodilator 1985 ARMC 21 327 NDtulobuterol HCl Berachin bronchodilator 1981 I 091080 S*/NMpirbuterol HCL Exirel bronchodilator 1983 I 091485 S*/NMformoterol fumarate Atock bronchodilator 1986 ARMC 22 321 S*/NMmabuteroI HCl Broncholin bronchodilator 1986 ARMC 22 323 S*/NMbambuterol Bambec bronchodilator 1990 ARMC 26 299 S*/NMsalmeterol xinafoate Serevent bronchodilator 1990 ARMC 26 308 S*/NMelcatonin Diatin calcium metabolism 1985 I 091284 NDteriparatide acetate Parathar calcium metabolism 1987 I 126659 NDsecalciferol Osteo D calcium metabolism 1988 I 125415 NDipriflavone Osten calcium metabolism 1989 ARMC 25 314 NDalendronate sodium Alendros calcium metabolism 1993 ARMC 29 332 NDparicalcitol Zemplar calcium metabolism 1998 ARMC 34 327 NDdoxercalciferol Hectorol calcium metabolism 1999 ARMC 35 339 NDmaxacalcitol Prezios calcium metabolism 2000 DNP 14 19 NDclodronate disodium Bonefos calcium metabolism 1986 ARMC 22 319 S

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disodium pamidronate Aminomux calcium metabolism 1987 ARMC 23 326 Sgallium nitrate Ganite calcium metabolism 1991 ARMC 27 328 Stiludronate disodium Skelid calcium metabolism 1995 ARMC 31 350 Sibandronic acid Bondronat calcium metabolism 1996 ARMC 32 309 Sincadronic acid Bisphonal calcium metabolism 1997 ARMC 33 335 Srisedronate sodium Actonel calcium metabolism 1998 ARMC 34 330 Sneridronic acid Nerixia calcium metabolism 2002 ARMC 38 361 Sminodronate Bonoteo calcium metabolism 2009 DNP 23 20 Sraloxifene HCl Evista calcium metabolism 1998 ARMC 34 328 S/NMlasofoxifene tartrate Fablyn calcium metabolism 2009 DNP 23 20 S/NMbazedoxifene acetate Conbriza calcium metabolism 2010 DNP 23 20 S/NMmab17-1a Panorex cancer, adjuvant/colorectal 1995 DNP 09 27 Bdexrazoxane Cardioxane cardioprotective 1992 ARMC 28 330 Sibopamine HCI Inopamil /Scandine cardiotonic 1984 ARMC 20 319 NDdocarpamine Tanadopa cardiotonic 1994 ARMC 30 298 NDcolforsin daropate HCl Adele cardiotonic 1999 ARMC 35 337 NDvesnarinone Arkin-Z cardiotonic 1990 ARMC 26 310 Sflosequinan Manoplax cardiotonic 1992 ARMC 28 331 Sbucladesine sodium Actosin cardiotonic 1984 ARMC 20 316 S*/NMdenopamine Kalgut cardiotonic 1988 ARMC 24 300 S*/NMxamoterol fumarate Corwin cardiotonic 1988 ARMC 24 312 S*/NMdopexamine Dopacard cardiotonic 1989 ARMC 25 312 S*/NMloprinone HCl Cortec cardiotonic 1996 ARMC 32 312 S*/NMamrinone Inocor cardiotonic 1983 ARMC 19 314 S/NMenoximone Perfan cardiotonic 1988 ARMC 24 301 S/NMmilrinone Corotrope cardiotonic 1989 ARMC 25 316 S/NMhidrosmin Venosmil cardiovascular disease 1987 I 134924 NDmicinicate Micivas cardiovascular disease 1987 I 090839 ND

ChondroCelect cartilage disorders 2009 DNP 23 16 Bbotulinum toxin type b Myobloc cervical dystonia 2001 DNP 15 31 Btrientine HCl Cuprid chelator 1986 ARMC 22 327 Ssuccimer Chemet chelator 1991 ARMC 27 333 Sdefeiprone Kelfer chelator 1995 ARMC 31 340 Sdeferasirox Exjade chelator 2005 DNP 19 48 Sfenbuprol Valbil choleretic 1983 ARMC 19 318 Saniracetam Draganon cognition enhancer 1993 ARMC 29 333 S

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pramiracetam H2SO4 Remen cognition enhancer 1993 ARMC 29 343 Scarperitide Hanp congestive heart failure 1995 ARMC 31 339 Nnesiritide Natrecor congestive heart failure 2001 DNP 15 32 NDmethylnaltrexone bromide Relistor constipation 2008 DNP 22 14 NDprucalopride Resolor constipation 2010 DNP 23 13 S/NMlubiprostone Amitiza constipation, chronic idiopath 2006 DNP 20 22 NDdesogestrel/ethinylestradiol Marvelon contraception 1981 I 298894 NDgestodene/ethinylestradiol Femodene contraception 1987 ARMC 23 335 NDlevonorgestrel/ethinyl estradi Preven contraception 1998 I 125557 NDdrospirenone Yasmin contraception 2000 DNP 14 20 NDmedroxyprogesterone/estradiol Lunelle contraception 2000 DNP 14 20 NDnorelgestromin/ethinylestradio Ortho Evra contraception 2001 DNP 15 34 NDetonogestrel/ethinylestradiol NuvaRing contraception 2002 I 294942 NDuliprisnil acetate ellaOne contraception 2009 DNP 23 14 NDcentchroman Choice 7 contraception 1991 ARMC 27 324 S/NMvorapaxar Zontivity coronary artery disease 2014 DT 51(1) 42 NDdornase alfa Pulmozyme cyctic fibrosis 1994 ARMC 30 298 Btalniflumate Lomucin cystic fibrosis 1982 I 091053 Sneltenexine Tenoxol cystic fibrosis 1993 ARMC 29 341 Sivacaftor Kalydeco cystic fibrosis 2012 I 418632 Scysteamine hydrochloride Cystaran cystinosis 2012 I 650475 Samifostine Ethyol cytoprotective 1995 ARMC 31 338 Sbecaplermin Regranex diabetic foot ulcers 1998 DNP 11 21 BSF-1019 R-1818 diabetic neuropathies 2008 DNP 22 14 Bdigoxin fab DigiFab digoxin toxicity 2001 DNP 15 39 Bospemifene Osphena dispareunia 2013 DT 50(1) 60 S/NMpiretanide Tauliz diuretic 1981 I 091078 Smuzolimine Edrul diuretic 1983 ARMC 19 321 Sazosemide Luret diuretic 1986 ARMC 22 316 Storasemide Unat diuretic 1993 ARMC 29 348 Sconivaptan HCl Vaprisol diuretic 2006 DNP 19 38 S/NMmozavaptan Physuline diuretic 2006 DNP 20 22 S/NMdiquafosol tetrasodium Diquas dry eye syndrome 2010 I 263630 NDcholine fenofibrate Trilipix dyslipidemia 2008 DNP 22 18 Ssaroglitazar Lipaglyn dyslipidemia 2013 DT 50(1) 73 S

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acotiamide HCl Acofide dyspepsia 2013 DT 50(1) 61 Snaftopidil Flivas dysuria 1999 ARMC 35 344 S/NMdienogest Dinagest endometriosis 2008 DNP 22 14 NDcollagenase Santyl Ointment enzyme 1986 I 217046 Balglucerase Ceredase enzyme 1991 ARMC 27 321 Berythropoietin alfa Epogen erythropoiesis 1988 ARMC 24 301 Berythropoietin beta Epogin erythropoiesis 1990 DNP 04 100 Bdarbepoietin alfa Aranesp erythropoiesis 2001 DNP 15 33 Bmethoxy-PEG-epoetin-beta Mircera erythropoiesis 2007 I 316296 Brh-erythropoietin-alfa Hexal erythropoiesis 2007 I 632868 Bfudosteine Cleanal / Spelear expectorant 2001 DNP 15 31 NDguaimesal Bronteril expectorant 1988 I 142648 Serdosteine Edirel expectorant 1995 ARMC 31 342 Socriplasmin Jetrea eye disorders 2013 DT 50(1) 72 BrFSH/rhFSH Follitrope fertility inducer 2007 I458505 Btasimelteon Hetlioz free-running circadian disorde 2014 DT 51(1) 39 S/NMcisapride Prepulsid gastroprokinetic 1988 ARMC 24 299 Sitopride HCl Ganaton gastroprokinetic 1995 ARMC 31 344 S*/NMcinitapride Cidine gastroprokinetic 1990 ARMC 26 301 S/NMmosapride citrate Gasmotin gastroprokinetic 1998 ARMC 34 326 S/NMdosmalfate Diotul gastroprotectant 2000 DNP 14 18 NDpodophyllotoxin Condyline genital warts 1985 I 070055 Nkunecatechins Veregen genital warts 2006 DNP 20 24 NBripasudil hydrochloride Glanatec glaucoma 2014 DT 51(1) 58 Stopiroxostat Topiloric gout 2013 DT 50(1) 76 S/NManagrelide HCl Agrylin hematological 1997 ARMC 33 328 S*/NMlenogastrim Neutrogin hematopoiesis 1991 DNP 05 97 Bmirimostim Leukoprol hematopoiesis 1991 DNP 05 97 Bmolgramostim Leucomax hematopoiesis 1992 DNP 06 97 Bnartograstim Neu-Up hematopoiesis 1994 ARMC 30 304 Bpegfilgastrim Neulasta hematopoiesis 2002 I 279036 Bepoietin delta Dynepo hematopoiesis 2006 DNP 20 30 BHPC-C Hemacord hematopoiesis 2011 DT 48(1) 43 Bhuman factor VIII Haemate HS hemophilia 1982 I 285224 Bfactor VIII;C, mab purified Monoclate-P hemophilia 1987 I 113601 Bfactor IX human AlphaNine hemophilia 1990 DNP 04 100 B

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factor IX Novact M hemophilia 1992 DNP 06 97 Bfactor Vlll Recombinate hemophilia 1992 ARMC 28 330 Brecombinant factor VIII Kogenate hemophilia 1993 DNP 07 29 Beptacog alfa NovoSeven hemophilia 1996 ARMC 32 307 Bfactor IX Benefix hemophilia 1997 DNP 11 20 Bmoroctocog alfa Refacto hemophilia 1999 DNP 13 41 Brec-antihemophilic factor Advate hemophilia 2003 DNP 17 48 Bfactor 8 Wilate hemophilia 2005 DNP 19 39 Bcoagulation factor IX Haemonine hemophilia 2009 DNP 23 13 Bturoctocog NovoEight hemophilia A 2013 DT 50(1) 59 Befraloctocog alfa Eloctate hemophilia A 2014 DT 51(1) 42 Bsimoctocog alfa Nuwiq hemophilia A 2014 DT 51(1) 44 Bsusoctocog alfa Obizur hemophilia A 2014 DT 51(1) 44 Bnonacog gamma Pixubis hemophilia B 2013 DT 50(1) 59 Beftrenonacog alfa Alprolix hemophilia B 2014 DT 51(1) 42 BMC-710 Byclot hemophilia-related 2014 DT 51(1) 44 B

Wilfactin hemostatic 2004 I 409686 Bhuman thrombin Evithrom hemostatic 2007 I 436182 Brh-thrombin Recothrom hemostatic 2008 ARMC 44 627 Bcatridecacog Tretten hemostatic 2012 I 333060 Bflumecinol Zixoryn hepatoprotectant 1982 I 091283 Smalotilate Kantec hepatoprotectant 1985 ARMC 21 329 Smivotilate ? hepatoprotectant 1999 ARMC 35 343 Secallantide Kalbitor hereditary angioedema 2010 DNP 23 14 Bicatibant acetate Firazyr hereditary angioedema 2008 ARMC 44 608 NDbetain anhydrous Cystadane homocystinuria 1996 DNP 10 14 Nsomatrem Protropin hormone 1985 I 102779 Bsomatropin Humatrope hormone 1987 ARMC 23 343 BrecDNA somatotropin Saizen hormone 1989 DNP 03 23 Bglucagon rDNA GlucaGen hormone 1993 ARMC 29 338 Bsomatomedin-1 Igef hormone 1994 ARMC 30 310 Bsomatotropin Nutropin hormone 1994 ARMC 30 310 Bsomatotropin (biosynthetic) Zomacton hormone 1995 I 230372 Bfollitropin alfa Gonal-F hormone 1996 ARMC 32 307 Bfollitropin beta Puregon hormone 1996 ARMC 32 308 Bsomatropin Norditropin hormone 1997 I 91588 B

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choriogonadotropin alfa Ovidrel hormone 2001 DNP 15 15 Blutropin alfa Luveris hormone 2001 DNP 15 35 Bbuserelin acetate Suprefact hormone 1984 ARMC 20 316 NDleuprolide acetate Enantone hormone 1984 ARMC 20 319 NDgonadoreline-6-D-trp acetate Decapeptyl hormone 1986 ARMC 22 321 NDgoserelin Zoladex hormone 1987 ARMC 23 336 NDdeslorelin Somagard hormone 1989 DNP 03 23 NDnafarelin acetate Synarel hormone 1990 ARMC 26 306 NDhistrelin Supprelin hormone 1993 ARMC 29 338 NDlanreotide acetate Somatuline hormone 1995 ARMC 31 345 NDsermorelin acetate Geref hormone 1998 DNP 12 32 NDcetrorelix Cetrotide hormone 1999 ARMC 35 336 NDestrogen/medroxyproesterone Prempro hormone replacement therapy 1995 DNP 09 24 NDestrogen/medroxyproesterone Premphase hormone replacement therapy 1995 DNP 09 24 NDconjugated estrogens a Conestin hormone replacement therapy 1999 DNP 13 43 NDtrimegestrone/estradiol Totelle Sekvens hormone replacement therapy 2000 DNP 14 20 NDdrospirenone/estradiol Angeliq hormone replacement therapy 2003 DNP 17 49 NDestradiol/nomegestrol acetate Naemis hormone replacement therapy 2003 I 306294 NDestradiol/levonorgestrel Climara Pro hormone replacement therapy 2004 DNP 18 27 NDconjugated estrogens b Enjuvia hormone replacement therapy 2005 I 326277 NDcarglumic acid Carbaglu hyperammonemia 2003 I 309302 NDmipomersen Kynamro hypercholestereolemia (famili) 2013 DT 50(1) 74 Blomitapide Juxtapid hypercholesterolemia 2012 I 235523 Scinacalcet Sensipar hyperparathyroidism 2004 ARMC 40 451 Ssapropterin hydrochloride Biopten hyperphenylalaninemia 1992 ARMC 28 336 NDlanthanum carbonate Fosrenol hyperphosphatemia 2005 DNP 19 38 Ssevelamer carbonate Renvela hyperphosphatemia 2008 DNP 22 11 Sbixalomer Kiklin hyperphosphatemia 2012 I 410010 Ssucroferic oxyhydroxide Velphoro hyperphosphatemia 2013 DT 50(1) 59 Sferric citrate hydrate Riona hyperphosphatemia 2014 DT 51(1) 41 Somega-3-carboxylic acids Epanova hypertriglyceridemia 2014 DT 51(1) 41 Npeg-uricase Krystexxa hyperuricemia 2010 I 298742 Bfebuxostat Adenuric hyperuricemia 2009 DNP 22 18 S/NMbifonazole Mycospor hypnotic 1983 ARMC 19 315 Sbrotizolam Lendormin hypnotic 1983 ARMC 19 315 Sloprazolam mesylate Dormonoct hypnotic 1983 ARMC 19 321 S

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butoctamide Listomin S hypnotic 1984 ARMC 20 316 Sdoxefaxepam Doxans hypnotic 1985 ARMC 21 326 Squazepam Selepam hypnotic 1985 ARMC 21 332 Szopiclone Imovane hypnotic 1986 ARMC 22 327 Szolpidem hemitartrate Stilnox hypnotic 1988 ARMC 24 313 Srilmazafone Rhythmy hypnotic 1989 ARMC 25 317 Scinolazepam Gerodorm hypnotic 1993 ARMC 29 334 Szaleplon Sonata hypnotic 1999 ARMC 35 351 Seszopiclone Lunesta hypnotic 2005 DNP 18 24 Sacetohydroxamic acid Lithostat hypoammonuric 1983 ARMC 19 313 Ssodium cellulose PO4 Calcibind hypocalciuric 1983 ARMC 19 323 Nchenodiol Chenix hypocholesterolemic 1983 ARMC 19 317 Nlovastatin Mevacor hypocholesterolemic 1987 ARMC 23 337 Nsimvastatin Zocor hypocholesterolemic 1988 ARMC 24 311 Npravastatin Mevalotin hypocholesterolemic 1989 ARMC 25 316 Nmelinamide Artes Oil hypocholesterolemic 1984 ARMC 20 320 NDdivistyramine Ipocol hypocholesterolemic 1984 ARMC 20 317 Sezetimibe Zetia hypocholesterolemic 2002 ARMC 38 355 Sfluvastatin sodium Lescol hypocholesterolemic 1994 ARMC 30 300 S*/NMatorvastin calcium Lipitor hypocholesterolemic 1997 ARMC 33 328 S*/NMcerivastatin Lipobay hypocholesterolemic 1997 ARMC 33 331 S*/NMpitavastatin Livalo hypocholesterolemic 2003 ARMC 39 360 S*/NMrosuvastatin Crestor hypocholesterolemic 2003 ARMC 39 361 S*/NMniacin/laropiprant Tredaptive hypocholesterolemic 2009 DNP 23 20 S/NMtestosterone undecanoate Restandol hypogonadism 1981 I 306300 NDmeglutol Lipoglutaren hypolipidemic 1983 ARMC 19 321 Nacipimox Olbetam hypolipidemic 1985 ARMC 21 323 Sciprofibrate Lipanor hypolipidemic 1985 ARMC 21 326 Sbeclobrate Beclosclerin hypolipidemic 1986 ARMC 22 317 Sbinifibrate Biniwas hypolipidemic 1986 ARMC 22 317 Sronifibrate Cloprane hypolipidemic 1986 ARMC 22 326 Scolestimide Cholebine hypolipidemic 1999 ARMC 35 337 Scolesevelam HCl Welchol hypolipidemic 2000 DNP 14 24 Stolvaptan Samsca hyponatremia 2009 DNP 23 12 S/NMpirfenidone Pirespa idiopathic pulmonary fibrosis 2008 DNP 22 10 Snintedanib Ofev idiopathic pulmonary fibrosis 2014 DT 51(1) 41 S/NM

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human immune globulin Privigen idiopathic thrombocytopenia 2007 I 458061 Bromiplostim Nplate idiopathic thrombocytopenia 2008 DNP 22 13 Beltrombopag olamine Promacta idiopathic thrombocytopenia 2008 DNP 22 13 Sjap cedar pollen Cedartolen immediate allergy 2014 DT 51(1) 40 NBragweed pollen extract Ragwitek immediate allergy 2014 DT 51(1) 40 NB

Grazax immediate allergy 2006 DNP 20 27 VRU-41740 Biostim immunomodulator 1985 I 193159 Biv human immunoglobulin Gamunex immunomodulator 2003 I 335137 Bbucillamine Rimatil immunomodulator 1987 ARMC 23 329 Nthymopentin Sintomodulina immunomodulator 1985 ARMC 21 333 NDpegademase bovine Adagen immunostimulant 1990 ARMC 26 307 Bfilgrastim Neupogen immunostimulant 1991 ARMC 27 327 Binterferon, gamma-1b Actimmune immunostimulant 1991 ARMC 27 329 Bsargramostim Leukine immunostimulant 1991 ARMC 27 332 BIgPro20 Hizentra immunostimulant 2010 I 676670 BIVIG Bivigam immunostimulant 2012 I 784227 Blentinan Lentinan immunostimulant 1986 ARMC 22 322 Nschizophyllan Sonifilan immunostimulant 1986 ARMC 22 326 Nubenimex Bestatin immunostimulant 1987 ARMC 23 345 Nromurtide Nopla immunostimulant 1991 ARMC 27 332 NDglycopin Likopid immunostimulant 1996 ARMC 32 308 NDpidotimod Polimod immunostimulant 1993 ARMC 29 343 Santi-thymocyte globulin Thymoglobuline immunosuppressant 1984 I 217048 Bmuromonab-CD3 Orthoclone OKT3 immunosuppressant 1986 ARMC 22 323 Bdaclizumab Zenapax immunosuppressant 1997 DNP 11 24 Bbasiliximab Simulect immunosuppressant 1998 DNP 12 35 Bbelatacept Nulogix immunosuppressant 2011 DT 48(1) 43 Bremestemcel-l Prochymal immunosuppressant 2012 I 390378 Bcyclosporine Sandimmun immunosuppressant 1983 ARMC 19 317 Nmizoribine Bredinin immunosuppressant 1984 ARMC 20 321 Ntacrolimus Prograf immunosuppressant 1993 ARMC 29 347 Nsirolimus Rapamune immunosuppressant 1999 DNP 13 45 Nmycophenolate sodium Myfortic immunosuppressant 2003 ARMC 39 356 Ngusperimus trihydrochloride Spanidin immunosuppressant 1994 ARMC 30 300 NDmycophenolate mofetil CellCept immunosuppressant 1995 ARMC 31 346 NDeverolimus Certican immunosuppressant 2004 ARMC 40 455 ND

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urofollitrophin Metrodin HP infertility (female) 1982 I 115071 Bfollitropin alfa/lutropin alfa Pergoveris infertility (female) 2007 I 451606 Bcorifollitropin alfa Elonva infertility (female) 2010 I 275742 Btocilizumab Actemra inflammatory bowel disease 2005 DNP 19 46 Bspinosad Natroba insecticide 2011 DT 48(1) 40 Nramelteon Rozerem insomnia 2005 DNP 19 35 S/NMsuvorexant Belsomra insomnia 2014 DT 51(1) 39 S/NMlinaclotide Constella irritable bowel syndrome 2012 I 379154 NDcalcium polycarbophil Polyful irritable bowel syndrome 2000 DNP 14 18 Salosetron HCL Lotronex irritable bowel syndrome 2000 DNP 14 18 S*/NMtegaserod maleate Zelmac irritable bowel syndrome 2001 DNP 15 33 S*/NMalvimopan hydrate Entereg irritable bowel syndrome 2008 ARMC 44 584 S*/NMhyaluronate sodium Suvenyl joint lubricant 1987 I 090860 Bmetreleptin lipodystrophy 2013 DT 50(1) 76 Btesamorelin Egrifta lipodystrophy syndrome [HIV] 2011 DT 48(1) 49 NDguglipid Guglip lipoprotein disorders 1987 I 125922 Nclinofibrate Lipoclin lipoprotein disorders 1981 I 091117 Salipogene tiparvovec Glybera lipoprotein lipase deficiency 2012 I 363473 Bbelimumab Benlysta lupus erythematosus 2011 DT 48(1) 43 Branibizumab Lucentis macular degeneration 2006 DNP 20 29 Baflibercept Eylea macular degeneration 2011 DT 48(1) 48 Bocriplasmin Jetrea macular degeneration 2012 I316434 Bconbercept Langmu macular degeneration 2014 DT 51(1) 58 Banecortave acetate Retaane macular degeneration 2006 DNP 20 29 NDpegaptanib sodium Macugen macular degeneration 2005 DNP 19 46 Ssildenafil citrate Viagra male sexual dysfunction 1998 ARMC 34 331 S*/NMtadalafil Cialis male sexual dysfunction 2003 ARMC 39 363 S*/NMvardenafil Levitra male sexual dysfunction 2003 ARMC 39 365 S*/NMudenafil Zydena male sexual dysfunction 2005 DNP 19 38 S*/NMavanafil Zepeed male sexual dysfunction 2011 DT 48(1) 38 S*/NMtelmesteine Reolase mucolytic 1992 ARMC 28 337 Slaronidase Aldurazyme mucopolysaccharidosis 2003 ARMC 39 354 Bgalsulfase Aryplase mucopolysaccharidosis 2005 DNP 19 48 Bpalifermin Kepivance mucositis 2005 DNP 19 46 BL-alanyl-L-glutamine Dipeptiven mucositis 2005 I 400914 NDinterferon, b-1b Betaseron multiple sclerosis 1993 ARMC 29 339 B

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interferon, beta-1a Avonex multiple sclerosis 1996 ARMC 32 311 Bnatalizumab Tysabri multiple sclerosis 2004 ARMC 40 462 Bpeginterferon beta-1a Plegridy multiple sclerosis 2014 DT 51(1) 40 Bfingolimod HCl Gilenya multiple sclerosis 2010 I 210392 NDdimethyl fumarate Tecfidera multiple sclerosis 2013 DT 50(1) 54 ND4-aminopyridine Ampyra multiple sclerosis 2010 I 182600 Sataluren Translarna multiple sclerosis 2014 DT 51(1) 51 Sglatiramer acetate Copaxone multiple sclerosis 1997 ARMC 33 334 S*teriflunomide Aubagio multiple sclerosis 2012 I 178777 S*/NMatracurium besilate Nimbex muscle relaxant 1982 I 090979 NDvecuronium bromide Norcuron muscle relaxant 1982 I 090978 NDrocuronium bromide Zemuron muscle relaxant 1994 ARMC 30 309 NDrapacuronium bromide Raplon muscle relaxant 1999 ARMC 35 347 NDafloqualone Arofuto muscle relaxant 1983 ARMC 19 313 Seperisone HCI Myonal muscle relaxant 1983 ARMC 19 318 Sdoxacurium chloride Nuromax muscle relaxant 1991 ARMC 27 326 S*mivacurium chloride Mivacron muscle relaxant 1992 ARMC 28 334 S*cisatracurium besilate Nimbex muscle relaxant 1995 ARMC 31 340 S*tizanidine Sirdalud muscle relaxant 1984 ARMC 20 324 S/NMlenalidomide Revlimid myleodysplasia 2005 DNP 19 45 Ssodium oxybate Xyrem narcolepsy 2002 I 230389 NDarmodafinil Nuvigil narcolepsy 2009 DNP 23 10 Stinazoline Varsyl nasal decongestant 1988 ARMC 24 312 Stimiperone Tolopelon neuroleptic 1984 ARMC 20 323 Ssertindole Serdolect neuroleptic 1996 ARMC 32 318 S*/NMziprasidone HCl Zeldox neuroleptic 2000 DNP 14 14 S*/NMclospipramine hydrochloride Cremin neuroleptic 1991 ARMC 27 325 S/NMnemonapride Emilace neuroleptic 1991 ARMC 27 331 S/NMrisperidone Risperdal neuroleptic 1993 ARMC 29 344 S/NMolanzapine Zyprexa neuroleptic 1996 ARMC 32 313 S/NMquetiapine fumarate Seroquel neuroleptic 1997 ARMC 33 341 S/NMaripiprazole Abilify neuroleptic 2002 ARMC 38 350 S/NMcannabis sativa L extract Sativex neuropathic pain 2005 DNP 19 35 Nziconotide Prialt neuropathic pain 2005 DNP 19 34 Nfasudil HCl Eril neuroprotective 1995 ARMC 31 343 Sriluzole Rilutek neuroprotective 1996 ARMC 32 316 S

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edarvarone Radicut neuroprotective 2001 DNP 15 31 Spegteograstim Neulapeg neutropenia 2014 DT 51(1) 58 Bidebenone Avan nootropic 1986 ARMC 22 321 NDlevacecarnine HCI Nicetile nootropic 1986 ARMC 22 322 NDcholine alfoscerate Delecit nootropic 1988 I 163663 NDbifemelane HCI Alnert nootropic 1987 ARMC 23 329 Soxiracetam Neuromet nootropic 1987 ARMC 23 339 Sexifone Adlone nootropic 1988 ARMC 24 302 Sindeloxazine HCI Elen nootropic 1988 ARMC 24 304 Snizofenone fumarate Ekonal nootropic 1988 ARMC 24 307 Sdifluprednate Durezol ocular inflammation 2008 DNP 22 17 NDlofexidine Britlofex opiate detoxification 1992 DNP 06 96 Snaloxegol Movantik opiod induced constipation 2014 DT 51(1) 45 NDzucapsacin Civanex osteoarthritis 2010 I 214983 NDlumiracoxib Prexige osteoarthritis 2005 DNP 19 35 S/NMsalmon calcitonin Osteotonina osteoporosis 1985 I 70182 BrhPTH(1-84) Preotact osteoporosis 2006 DNP 20 29 Bdenosumab Prolia osteoporosis 2010 I 341320 Bteriparatide Forteo osteoporosis 2002 I 253969 NDeldecalcitol Edirol osteoporosis 2011 DT 48(1) 49 NDstrontium ranelate Protelos osteoporosis 2004 ARMC 40 467 Simidafenacin Uritos overactive bladder 2007 ARMC 43 472 Sganirelix acetate Orgalutran ovulation 2000 DNP 14 20 NDulinastatin Miracid pancreatic disorders 1985 I 090099 Bnafamostat mesylate Futhan pancreatitis 1986 ARMC 22 323 S/NMacellular pertussis vaccine Acelluvax pertussis 1993 DNP 07 31 Vverteporfin Visudyne photosensitizer 2000 ARMC 36 312 S*aafamelanotide Scenesse phototoxicity in adults 2014 DT 51(1) 47 NDmecasermin Increlex pituitary disorders 2005 DNP 19 41 Bepoprostenol sodium Flolan platelet aggreg. inhib. 1983 ARMC 19 318 NDberaprost sodium Dorner platelet aggreg. inhib. 1992 ARMC 28 326 NDiloprost Ilomedin platelet aggreg. inhib. 1992 ARMC 28 332 NDsarpogrelate HCI Anplag platelet aggreg. inhib. 1993 ARMC 29 344 S/NMhaem arginate Normosang porphyria 1985 I 090087 NDatosiban Tractocile premature birth 2000 DNP 14 20 NDdapoxetine HCl Priligy premature ejaculation 2009 DNP 23 12 S/NM

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promegestrone Surgestone progestogen 1983 ARMC 19 323 NDnomegestrol acetate Lutenyl progestogen 1986 ARMC 22 324 NDnorgestimate Cilest progestogen 1986 ARMC 22 324 NDadrafinil Olmifon psychostimulant 1986 ARMC 22 315 Sprotein C concentrate Ceprotin purpura fulminans 2001 DNP 15 39 Bcrotalidae fab CroFab rattlesnake antivenom 2001 DNP 15 39 BrHuPH20 Hylenex reproduction 2005 I 394865 Bsurfactant TA Surfacten respiratory distress syndrome 1987 ARMC 23 344 Bporcine lung surfactant Curoserf respiratory distress syndrome 1992 DNP 06 97 Bcalfactant Infasurf respiratory distress syndrome 1999 DNP 13 39 Blucinactant Surfaxin respiratory distress syndrome 2012 I 257956 Bpumactant Alec respiratory distress syndrome 1990 DNP 04 99 Ncolfoscerid palmitate Exosurf Neonatal respiratory distress syndrome 1990 DNP 04 99 Ssivelestat sodium hydrate Elaspol respiratory distress syndrome 2002 ARMC 38 366 S/NMzotarolimus Endeavor restenosis 2005 DNP 19 37 NDbiolimus a9 BioMatrix restenosis 2008 ARMC 44 586 NDpaliperidone Invega schizophrenia 2007 ARMC 43 482 S/NMethanolamine oleate Ethamolin sclerosant 1989 DNP 03 23 S*falecalcitrol Horner / Fulstan sec. hyperthryoidism 2001 DNP 15 34 NDmidazolam maleate Versed sedative 1982 I 091131 Sdetomidine HCl Domosedan sedative 1984 I 090901 Sdexmedetomidine HCl Precedex sedative 2000 DNP 14 14 S/NMteduglutide Gattex short bowel syndrome 2012 I 246346 NDkinetin Kinerase skin photodamage 1999 ARMC 35 341 S*varenicline tartrate Chantix smoking cessation 2006 DNP 20 31 S/NMbotulinum toxin type a Oculinium strabismus 1990 DNP 04 99 Btirilazad mesylate Freedox subarachnoid hemorrhage 1995 ARMC 31 351 NDoprelvekin Neumega thrombocytopenia 1998 DNP 11 26 Bpralmorelin GHRP Kaken 100 treatment of GH deficiency 2005 DNP 19 49 NDbalsalazide disodium Colazide ulcerative colitis 1997 ARMC 33 329 Ssodium phenylbutyrate Buphenyl urea cycle disorders 1996 DNP 10 14 Snalfurafine HCl Remitch uremic pruritis 2009 DNP 23 14 NDpropiverine hydrochloride Mictonorm urinary incontinence 1992 ARMC 28 335 Ssolifenacin succinate Vesicare urinary incontinence 2004 ARMC 40 466 Smirabegron Betanis urinary incontinence 2011 DT 48(1) 37 S*/NMtolterodine Detrusitol urinary incontinence 1997 DNP 11 21 S/NM

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darifenacin hydrobromide Emselex urinary incontinence 2005 DNP 19 38 S/NMfesoterodine fumarate Toviaz urinary incontinence 2008 ARMC 44 604 S/NMtiopronin Thiota urolithiasis 1989 ARMC 25 318 NDvaccinia immune globulin VIGIV vaccinia complications 2005 DNP 19 44 Vvaricella zoster immune globul VariZIG varicella (chicken pox) 2001 DNP 15 37 Bpimobendan Acardl vasodilator 1994 ARMC 30 307 Sbrovincamine fumarate Sabromin vasodilator; cerebral 1986 ARMC 22 317 NDpropentofylline propionate Hextol vasodilator; cerebral 1988 ARMC 24 310 NDnimodipine Nimotop vasodilator; cerebral 1985 ARMC 21 330 Snicorandil Sigmart vasodilator; coronary 1984 ARMC 20 322 NDclobenoside Arvigol vasoprotective 1988 ARMC 24 300 Srivaroxaban Xarelto venous thromboembolism 2008 DNP 22 12 S*/NMepidermal growth factor Gentel vulnerary 1987 ARMC 23 333 Bacemannan Acemannan hydrogel vulnerary 2001 ARMC 37 259 Bazficel-T LaViv vulnerary 2011 DT 48(1) 40 B

Excellagen vulnerary 2012 I 711043 BGintuit vulnerary 2012 I 765028 B

prezatide copper acetate Lamin gel vulnerary 1996 ARMC 32 314 NDzinc hyaluronate Curioscii vulnerary 1996 DNP 10 10 NDcadexomer iodine Iodosorb vulnerary 1983 ARMC 19 316 S

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