American Heart AssociationTexas Affiliate

Brent FieldsVice President

Research Administration & State Health Alliances

Research Research AHA Top PriorityAHA Top Priority

The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission:

Impact Goal: By 2010, we will reduce coronary heart disease, stroke and risk by 25 percent.

The AHA’s commitment to research The AHA’s commitment to research is reflected in our strategic plan:is reflected in our strategic plan:

1.1. Increasing the capacity of the Increasing the capacity of the research community to generate research community to generate the highest quality research;the highest quality research;

2.2. Identifying critical research Identifying critical research agendas and increasing the agendas and increasing the understanding of specific understanding of specific cardiovascular issues.cardiovascular issues.

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A B C D E F G H

Research ExpenseResearch Expenseforfor

Major National Health Agencies: 2004Major National Health Agencies: 2004A American Cancer Society

B Alzheimer’s Association

C American Diabetes Association

D National Multiple Sclerosis Society

E March of Dimes

F Muscular Dystrophy Association

G Juvenile Diabetes Association

H American Heart H American Heart AssociationAssociation

Public Health Education36%

Fundraising15%

Management& General7%

Professional Educ & Training12%

Research23%

Community Services7%

AHA’s 2004-05 AHA’s 2004-05 EXPENDITURESEXPENDITURES

AHA National Budget Expenditures

How each dollar is spentHow each dollar is spent

Donor Dollar

28.5%

25¢ 75¢

National Center

Texas Affiliate

ResearchAllocation

15¢13.5¢

Nobel Prize Recipients funded by Nobel Prize Recipients funded by AHAAHA

• 1937 – Dr. Albert Szent-Gyorgyi1937 – Dr. Albert Szent-Gyorgyi• 1971 – Dr. Earl Sutherland1971 – Dr. Earl Sutherland• 1985 – Dr. Joseph Goldstein1985 – Dr. Joseph Goldstein• 1985 – Dr. Michael Brown1985 – Dr. Michael Brown• 1992 – Dr. Edwin Krebs1992 – Dr. Edwin Krebs• 1998 – Dr. Robert Furchgott1998 – Dr. Robert Furchgott• 2003 – Dr. Peter Agre2003 – Dr. Peter Agre

MilestonesMilestones1956 - Dr. Ancel Keys, supported by funding from the Minnesota Affiliate, first 1956 - Dr. Ancel Keys, supported by funding from the Minnesota Affiliate, first links dietary fat withlinks dietary fat with

cholesterolcholesterol. This discovery spurs the AHA to assume a leading role in urging Americans to . This discovery spurs the AHA to assume a leading role in urging Americans to change their eating habits.change their eating habits.

1956 - Dr. Paul Zoll, aided by the Massachusetts Affiliate, publishes the first report of the successful1956 - Dr. Paul Zoll, aided by the Massachusetts Affiliate, publishes the first report of the successful ending of ending of ventricular fibrillationventricular fibrillation in humans by externally applied in humans by externally applied countershockcountershock..

1957 - Dr. William Wierich, assisted by support from the Minnesota Affiliate and joined by Drs. 1957 - Dr. William Wierich, assisted by support from the Minnesota Affiliate and joined by Drs. Vincent Gott and Walter Lillehei, implants the first externally powered Vincent Gott and Walter Lillehei, implants the first externally powered pacemakerpacemaker in a patient in a patient with a surgical heart blockage.with a surgical heart blockage.

1960 - Dr. Albert Starr performs the first long-term successful 1960 - Dr. Albert Starr performs the first long-term successful mitral valve replacementmitral valve replacement with a caged with a caged ball valve, ushering in a new era of valve replacement. He was supported in developing theball valve, ushering in a new era of valve replacement. He was supported in developing the artificial heart valveartificial heart valve by the Oregon Affiliate and assisted by engineer Lowell Edwards. by the Oregon Affiliate and assisted by engineer Lowell Edwards.

1961 - Dr. Julius Jacobsen, with funding from the Vermont Affiliate, begins performing surgery with1961 - Dr. Julius Jacobsen, with funding from the Vermont Affiliate, begins performing surgery with the aid of a microscope. the aid of a microscope. MicrosurgeryMicrosurgery ultimately leads to changes in coronary artery surgery, ultimately leads to changes in coronary artery surgery, plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor surgery.surgery.

1985 - Drs. Joseph Goldstein and Michael Brown, sponsored by the AHA in 1972, 1973 and 1975, are1985 - Drs. Joseph Goldstein and Michael Brown, sponsored by the AHA in 1972, 1973 and 1975, are awarded the Nobel Prize in Physiology or Medicine for their research on the role ofawarded the Nobel Prize in Physiology or Medicine for their research on the role of low- low- density lipoprotein receptorsdensity lipoprotein receptors in controlling blood cholesterol levels. Their research provides in controlling blood cholesterol levels. Their research provides new insights into the ways fatty cholesterol enters body cells and why new insights into the ways fatty cholesterol enters body cells and why cholesterol levelscholesterol levels may may become too high.become too high.

Texas Research StatisticsTexas Research Statistics• FY 06-07 there are currently 154 Texas Researchers funded by the AHAFY 06-07 there are currently 154 Texas Researchers funded by the AHA

(TX Affiliate = 96; National = 58)(TX Affiliate = 96; National = 58)

• FY 06-07 total amount funded =$9,152,708 FY 06-07 total amount funded =$9,152,708 (TX Affiliate = $4,974,265; National = $4,178,443)(TX Affiliate = $4,974,265; National = $4,178,443)

• 2000-2008 total funding = $67,993,0772000-2008 total funding = $67,993,077(TX Affiliate = $36,611,162; National $31,381,915)(TX Affiliate = $36,611,162; National $31,381,915)

• Currently 11 cities and 22 institutions are represented by funded Currently 11 cities and 22 institutions are represented by funded researchers in Texasresearchers in Texas

• 100+ Texas researchers participated in our TXA Peer Review in100+ Texas researchers participated in our TXA Peer Review in 20062006

• There are currently 15 Research Allocations andThere are currently 15 Research Allocations andAdvisory Committee Members (RAAC)Advisory Committee Members (RAAC)

Galveston StatisticsUniversity of Texas Medical Branch

TXA Applications received/funded for the 2006 cycle = 13/2

TXA Applications received/funded 2000-2006 = 100/19

7 Active Researchers = TXA - 6; National – 1

410,500 in Active AHA grants (FY 06-07 actual spent)(TXA - $345,500; National - $65,000)

$3,728,376 in AHA funding (2000-2008 allocated)(TXA - $2,355,981; National - $1,372,395)

Current Research Allocations & Advisory Committee MembersPaul Boor, MD – Professor, Dept. of Pathology

Galveston StatisticsUniversity of Texas Medical BranchUniversity of Texas Medical Branch

Texas Affiliate – Currently Funded Researchers2005-07 Kishor Bhakat, PhD

Beginning Grant-in-AidRole of Human AP-endonuclease (APT1/Ref-1) in Regulation of Blood Pressure

2005-07 Perenlei Enkhbaatar, MD, PhDBeginning Grant-in-AidRole of nitric oxide in pathogenesis of cardiopulmonary derangements

in sepsis induced by smoke inhalation and pnemonia

2005-07 Luis Ruess, MDGrant-in-AidArchitecture of the Pore of Connexin43 Channels and Hemichannels

2005-07 Bruns Watts lll, PhDBeginning Grant in AidRegulation of Renal Transport by Neurotropins

2006-08 Michael Kinsky, PhDBeginning Grant in AidPharmacologic Modulation of Fluid Therapy

2006-08 Sutapa Ray, PhDBeginning Grant in AidSTAT3 Signaling in Acute Phase Response

Galveston StatisticsUniversity of Texas Medical BranchUniversity of Texas Medical Branch

National Center – Currently Funded Researchers

2006-09 Sanjeev Choudhary, PhDScientist Development GrantNovel Role of the NF-kB inducing kinase in Respiratory Syncytial Virus infection

Research FocusResearch Focus

• Training and career development of Training and career development of beginning scientistsbeginning scientists

• Support of cutting edge basic and Support of cutting edge basic and clinical scienceclinical science

What Kinds of Research Do We Support?

The AHA supports research that is The AHA supports research that is broadly related to the cardiovascular area broadly related to the cardiovascular area and stroke.and stroke.

SCIENCE AREASSCIENCE AREAS• Basic Cell and Molecular BiologyBasic Cell and Molecular Biology• Behavior Science, Epidemiology & PreventionBehavior Science, Epidemiology & Prevention• Bioengineering & BiotechnologyBioengineering & Biotechnology• BrainBrain• Cardiac Biology/RegulationCardiac Biology/Regulation• Cardiac Electrophysiology & Arrhythmias/RegulationCardiac Electrophysiology & Arrhythmias/Regulation• CardiorenalCardiorenal• Cardiovascular DevelopmentCardiovascular Development• Cell Transort, Physiology & MetabolismCell Transort, Physiology & Metabolism• Immunology and MicrobiologyImmunology and Microbiology• Liporproteins, Lipid Metabolism & NutritionLiporproteins, Lipid Metabolism & Nutrition• Lung, Respiration & ResuscitationLung, Respiration & Resuscitation

SCIENCE AREASSCIENCE AREAS• Molecular SignalingMolecular Signaling• Radiology & ImagingRadiology & Imaging• SurgerySurgery• ThrombosisThrombosis• Vascular Biology & Blood Pressure/RegulationVascular Biology & Blood Pressure/Regulation• Vascular Wall BiologyVascular Wall Biology

Programs Offered by AHA National Center

• Scientist Development GrantScientist Development GrantJanuary and July Application Deadline for January and July Application Deadline for

January January and July activationand July activation

• Fellow to Faculty GrantFellow to Faculty Grant January and July Application Deadline for January and July Application Deadline for January and July activation January and July activation

• Established Investigator AwardEstablished Investigator Award July Application Deadline for January activationJuly Application Deadline for January activation

Programs Offered by the Texas Affiliate

• Postdoctoral FellowshipPostdoctoral FellowshipJanuary application deadline for July activationJanuary application deadline for July activation

• Beginning Grant-in-AidBeginning Grant-in-Aid January application deadline for July activationJanuary application deadline for July activation

• Grant-in-AidGrant-in-Aid January application deadline for July activationJanuary application deadline for July activation

Postdoctoral FellowshipPostdoctoral FellowshipTo provide stipend support to help trainees initiate careers in To provide stipend support to help trainees initiate careers in cardiovascular and stroke research, and further research training while cardiovascular and stroke research, and further research training while obtaining significant research results.obtaining significant research results. (2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded)(2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded)

Deadline:Deadline: January 4, 2007January 4, 2007Award: Award: $30,000 - $46,000 stipend, depending on years of training or experience,$30,000 - $46,000 stipend, depending on years of training or experience,

plus annual $3,000 departmental allowance.plus annual $3,000 departmental allowance.  Term:Term: 1 or 2 years. May apply for competitive one-year award.1 or 2 years. May apply for competitive one-year award.

• Full-time research effort and sincere interest in pursuing a career inFull-time research effort and sincere interest in pursuing a career incardiovascular related research expected.cardiovascular related research expected.

• Applicant must hold a doctoral degree and have less than 6 years of post doctoralApplicant must hold a doctoral degree and have less than 6 years of post doctoralresearch training and experience at award activation (July 1, 2007).research training and experience at award activation (July 1, 2007).

• Support is limited to work within non-profit institutions in Texas.Support is limited to work within non-profit institutions in Texas.• Institutional supplementation permissible under certain conditions.Institutional supplementation permissible under certain conditions.• An investigator may sponsor no more than two Affiliate Post Doctoral Fellows at anyAn investigator may sponsor no more than two Affiliate Post Doctoral Fellows at any

one time. Any application for a new award that would exceed this limit will not be one time. Any application for a new award that would exceed this limit will not be reviewed.reviewed.

• Each of the following criteria will be considered:Each of the following criteria will be considered:– The applicantThe applicant– The sponsor’s qualificationsThe sponsor’s qualifications– The environment and training program resourcesThe environment and training program resources– The specific research projectThe specific research project

Beginning Grant-in-aidBeginning Grant-in-aidTo Promote the Independent Status of Promising Beginning Scientists byTo Promote the Independent Status of Promising Beginning Scientists by Supporting High Quality, Well-defined Research Projects in the Supporting High Quality, Well-defined Research Projects in the Cardiovascular Area, Including Stroke. Cardiovascular Area, Including Stroke. (2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded)(2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded)

Deadline:Deadline: January 4, 2007January 4, 2007Award:Award: $65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI$65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI

salary, including fringe benefits.salary, including fringe benefits.Term:Term: 2 years. Competitive renewal is possible for up to four years of 2 years. Competitive renewal is possible for up to four years of

support.support.

Applicants must have:Applicants must have:• an MD, PhD, DO, DVM, or equivalent doctoral degree.an MD, PhD, DO, DVM, or equivalent doctoral degree.• A faculty appointment or equivalent academic or research track position, up toA faculty appointment or equivalent academic or research track position, up to• and including a rank of assistant professor, by the time of award activation (July 1, 2007). and including a rank of assistant professor, by the time of award activation (July 1, 2007). • The applicant must meet institutional requirements for submission of an extramural, peerThe applicant must meet institutional requirements for submission of an extramural, peer• reviewed reviewed grantgrant proposal. proposal.• No more than 7 years of active faculty appointment prior to award activation (July 1, 2007).No more than 7 years of active faculty appointment prior to award activation (July 1, 2007).• No more than $100,000 of all extramural grant support per year, excluding principalNo more than $100,000 of all extramural grant support per year, excluding principal• investigator and collaborating investigators salaries, fringe, and intramural fundinginvestigator and collaborating investigators salaries, fringe, and intramural funding• Each of the following criteria will be considered:Each of the following criteria will be considered:

– Evidence the award will promote the independent status of the applicantEvidence the award will promote the independent status of the applicant– Scientific excellence of the proposalScientific excellence of the proposal– Qualifications of the applicant, including relevant experience, familiarity with published work in theQualifications of the applicant, including relevant experience, familiarity with published work in the

field and productivityfield and productivity– Adequacy of the available resources, including research facilities and institutional environmentAdequacy of the available resources, including research facilities and institutional environment

Grant-in-aidGrant-in-aidTo Support the Most Innovative and Meritorious Research Projects FromTo Support the Most Innovative and Meritorious Research Projects FromIndependent Investigators in the Cardiovascular Area, Including Stroke.Independent Investigators in the Cardiovascular Area, Including Stroke.

(2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded)(2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded)

Deadline:Deadline: January 4, 2007January 4, 2007Award:Award: $65,000 per year maximum, including 10% overhead. Up to $15,000$65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits.annually for PI salary, including fringe benefits.  Term:Term: 2 years. (One year requests are exceptional, but allowed)2 years. (One year requests are exceptional, but allowed)

Continuous support of any one investigator is limited to 4 yearsContinuous support of any one investigator is limited to 4 years

Applicants must have:Applicants must have:• An MD, PhD, DO, DVM, or equivalent doctoral degreeAn MD, PhD, DO, DVM, or equivalent doctoral degree• A faculty appointment or equivalent academic or research track position, up to and including a rank ofA faculty appointment or equivalent academic or research track position, up to and including a rank of

assistant professor, by the time of award activation (July 1, 2007). The applicant must meet assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutionalinstitutionalrequirements for submission of an extramural, peer reviewed grant proposal.requirements for submission of an extramural, peer reviewed grant proposal.

• No more than $200,000 of all extramural grant support per year, excluding principal investigator and No more than $200,000 of all extramural grant support per year, excluding principal investigator and collaborating investigators salaries, fringe, and intramural fundingcollaborating investigators salaries, fringe, and intramural funding

• Grants will not be awarded to supplement or duplicate any work that is being supported by other Grants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards.funding agencies. The only exceptions are career development awards.

• The scientific merit – with emphasis on the innovative nature of the proposal – is the most important The scientific merit – with emphasis on the innovative nature of the proposal – is the most important factor. factor. Other Criteria include:Other Criteria include:

– The presence of new or original ideasThe presence of new or original ideas– Clear statement of researchClear statement of research– Sufficient experimental detail in the research planSufficient experimental detail in the research plan– Understanding of the essential methodologyUnderstanding of the essential methodology– Adequacy of the experimental designAdequacy of the experimental design

20062006Success Rate – Texas AffiliateSuccess Rate – Texas Affiliate

Program Applications Funded %

Postdoctoral 51 8 16

Beginning Grant 90 21 23

Grant-in-Aid 78 16 21

Totals 219 45 21

Awards Funded = 45 ($5,314,314)

11 cities – 18 institutions (New 2006 Awards)

(RAAC allocations from May, 2006 Committee Meeting)

2006 2006 Success Rate – National CenterSuccess Rate – National Center

Program Applications Funded %

Pharmaceutical Roundtable Award – Career Development in Implementation

5 1 20

Scientist Development Grant 61 15 25

Established Investigator Award 12 6 50

Totals 78 22 28

Awards Funded = 22 ($7,500,000)

7 cities – 7 institutions

(National allocations to Texas for January & July 2006)

American Heart AssociationTexas Affiliate

2006-07 Funding Outcomes / Critical Funding Gap1

ProgramNumber of Applicants

Number of Applicantsin

Fundable range

Number of Applicants

Funded% Success

Number of Worthy,

Unfunded Applications

Additional DollarsNeeded2

Postdoctoral Fellowship

51 22 8 16% 14 $1,048,000

Beginning Grant-in-Aid

90 42 21 23% 21 $2,730,000

Grant-in-Aid 78 36 16 21% 20 $2,723,996

Total 219 100 45 21% 55 $6,501,996

Amount committed to TXA $5,314,314

1 Established at May TX RAAC meeting for new awards activated July 1.

2 Additional dollars required to fund meritorious proposals which could not be funded due to insufficient resources

Peer Review StructurePeer Review StructureWestern Review Consortium

Texas AffiliateResearch

Committee

ConsortiumSteering

Committee

WSAResearch

Committee

Peer ReviewCommittees

(10)

Peer Review Study Groups2006-07

•Brain, Cardiorenal, Lung, Respiration, SurgeryBrain, Cardiorenal, Lung, Respiration, Surgery•Behavioral Science, Epidemiology & Prevention,Behavioral Science, Epidemiology & Prevention,•CV Regulation, Cardiac (Patho) Physiology, CV Regulation, Cardiac (Patho) Physiology, Radiology & Radiology & ImagingImaging•CV Development, Immunology & Microbiology, CV Development, Immunology & Microbiology, Basic Cell & Basic Cell & Molecular BiologyMolecular Biology•Lipoproteins & Lipid Metabolism, Thrombosis, Lipoproteins & Lipid Metabolism, Thrombosis, Vascular Wall Vascular Wall BiologyBiology•Cell Transport and Metabolism, Cell Transport and Metabolism, •Cellular CV Physiology & Pharmacology, Molecular Cellular CV Physiology & Pharmacology, Molecular SignalingSignaling

Life Cycle of a Research ApplicationLife Cycle of a Research Application

HmmHmm……

Application Application submittedsubmitted

An idea beginsAn idea begins

Peer Review Peer Review CommitteeCommittee

E-mail E-mail notificationnotification

Research Research completedcompleted

Yea!Yea!

Reports Reports PublishedPublished

Findings Findings translatedtranslated

Assigned to Assigned to reviewersreviewers

Critique Critique developeddeveloped

Rank-Rank-ordered listordered list

Research Research CommitteeCommittee $$ Funded Funded

The ProcessThe ProcessTexas AffiliateTexas Affiliate

January February March

April May July

•Application Deadline

•Applications assigned to Committees

•Committee Chairs review assignments

•Committee Chairs finalize assignments

•Reviewers input preference

•Paper copies are sent to reviewers

•Peer Review Committee meets

•Research Committees meet

•Award Notification

•Award activation

September: online applications are available

October: institutional tour to promote program

Other AHA Scientific Products

AHA Professional Membership/Scientific AHA Professional Membership/Scientific CouncilCouncil

Scientific Statements/GuidelinesScientific Statements/Guidelines Scientific Sessions, Conferences and WorkshopsScientific Sessions, Conferences and Workshops AHA Scientific JournalsAHA Scientific Journals My.Americanheart.orgMy.Americanheart.org

QUESTIONS?QUESTIONS?

For Assistance Contact:For Assistance Contact:Brent FieldsBrent Fields

VP, Research AdministrationVP, Research Administration512-433-7103 – Phone512-433-7103 – Phone

Rhonda JenningsRhonda Jennings

Administrative Assistant, Research AdministrationAdministrative Assistant, Research Administration512-433-7108 – Phone512-433-7108 – Phone

512-433-7260 – fax512-433-7260 – fax

texresearch@heart.orgtexresearch@heart.org