AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY

DECEMBER 8, 2006

VOLUME 281

NUMBER 49

JBC_120806_#49.indd 1JBC_120806_#49.indnddd 11 11/14/06 8:30:33 AM11/14/4/0/06 8:30:33 AM8:30:33 AM

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��������������������������� ������������������������������������ Tony Hunter, The Salk Institute Tyrosine Phosphorylation: From Discovery to the Kinome and Beyond

��������������� �������������������������������������Tony Pawson, Samuel Lunenfeld Research InstitutePhosphotyrosine Signaling: A Prototype for Modular Protein-Protein Interactions

������ ������������������ �������� !��"�Christopher B. BurgeMassachusetts Institute of Technology Towards an RNA Splicing Code

��#�� !��"����$%��������� ������� ����$"����� Sarah C. ElginWashington University The Importance of Research and Research-Oriented Experiences in the Undergraduate Curriculum

��#��#���&� !��"�Judith P. KlinmanUniversity of California, Berkeley Quinoproteins and Cofactors: Expecting the Unexpected

��#�� ��� � !��"�Angelika AmonHHMI/Massachusetts Institute of TechnologyControl of Chromosome Segregation

'� ��� !��"�� �����"�Scott D. EmrHHMI/University of California, San Diego, School of MedicinePhosphoinositide Lipid Signaling and the Regulation of Membrane Traffic

(���)������ �������������Ronald M. EvansThe Salk InstituteNuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology

*��������+����� !��"�Susan S. TaylorHHMI/University of California, San DiegoDynamics of Signaling by PKA

�!��"�,+��������� ������������'���� !��"�To Be Determined

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A

AB, Eiso, 37993

Abu-Elneel, Kawther,37468

Adams, Joseph A., 38004

Adio, Sarah, 37782

Agarwal, Manu, 37636

Ahnesorg, Peter, 37517

Ala, Paul J., 38013

Anderson, Jessica N.,37586

Anthony, Richard G., 37536

Arenzana-Seisdedos,Fernando, 37921

Aroca-Aguilar, J. Daniel,38022

Asbury, Carla, 37416

Ascenzi, Paolo, 37803

Attardi, Giuseppe, 37972

Avvakumov, George V.,38061

B

Bachelerie, Francoise,37921

Baehr, Wolfgang, 37697

Bagsiyao, Pamela, 37391

Bajwa, Pratibha, 37270

Baladron, Victoriano,38022

Balko, Natalia, 38022

Barone, Sharon, 37962

Bartolommei, Gianluca,37720

Bauer, Matthias F., 37972

Baum, Christopher, 37381

Becerra, S. Patricia, 38022

Becker, Therese M., 38080

Becker-Pasha, Mary, 38013

Bender Machado, Lilia,37361

Benedetto, Melanie Di,37844

Bennett, Teri A., 37427

Berna, Marc J., 37705

Bezrukov, Sergey M.,37496

Bhaumik, Sukesh R., 37270

Bianchi, Julie, 37517

Bloemink, Marieke, 37782

Bogre, Laszlo, 37536

Bohne, Jens, 37381

Bolli, Alessandro, 37803

Bolognesi, Martino, 37803

Bolshakov, Alexey, 37547

Bond, Judith S., 37404

Bongiorni, Cristina, 37993

Bonnett, Shilah, 37586

Boraston, Alisdair B., 37748

Bosanac, Ivan, 37813

Brannigan, James A.,37993

Braunschweig, Till, 37705

Breit, Andreas, 37447

Brennan, Richard G., 37942

Bresnick, Emery H., 37345

Brian, Leigh, 37758

Bridges, Kristie G., 37877

Bruce, Chris K., 37517

Brustovetsky, Nickolay,37547

Brustovetsky, Tatiana,37547

Buch, Thomas, 37447

Burn, Timothy C., 38013

Burt, Randall W., 37828

Bushman, Frederic D.,38052

C

Cai, Xinjiang, 37758

Cantiello, Horacio F., 37566

Carman, Christopher V.,37904

Carmichael, Jon B., 37646

Caron, Cecile, 37888

Cesare, Anthony J., 37486

Chan, Mitchell C. Y., 37813

Chan, Sic. L., 37391

Chapman, Jeannie M.,37962

Chen, Xing-Zhen, 37566

Chidester, Stephanie,37828

Chomyn, Anne, 37972

Churumova, Valeriya A.,37594

Collins, Sheila, 37794

Combs, Andrew P., 38013

Compton, Sarah A., 37486

Conlon, Donna, 37603

Conrads, Thomas P., 37836

Consler, Thomas G., 37773

Cooper, Terrance G., 37980

Costa, Joana, 37536

Courel, Maıte, 38038

Craig, Sue E., 37686

Crawley, Matthew L.,38013

Crooke, Rosanne M., 37603

Cullen, Joseph J., 37416

Cygler, Miroslaw, 37930

Cyr, Michel, 37794

D

Damirin, Alatangaole,37457

Damoc, Eugen, 37877

Daniel, Kiefer W., 37794

Daniels, David H., 37416

da-Silva, Wagner Seixas,37361

Datta, Jashodeep, 38098

DeBerardinis, Ralph J.,37372

de Crecy-Lagard, Valerie,37586

De Felice, Fernanda G.,37361

de Jong, Rob N., 37993

Dembla-Rajpal, Neetu,38071

Desai, Radhika, 37527

Dhe-Paganon, Sirano,38061

Diercks, Tammo, 37993

Doherty, Aidan J., 37517

Dong, Chun-Hai, 37636

Doroshow, James H.,37330

Doucleff, Michaeleen,37628

Douty, Brent, 38013

Dragoni, Ilaria, 37353

Draper, Olga, 37628

Driessen, Carola A., 37697

Du, Juan, 37416

Dubois, Evelyne, 37980

Dumas, Fabrice, 37921

Dundr, Miroslav, 38098

Duvezin-Caubet,Stephane, 37972

E

Eddy, Edward M., 37888

Egawa, Nagayasu, 37576

Eiki, Jun-ichi, 37668

Eisinger, Annie, 37828

El Yacoubi, Basma, 37586

Escalada, Artur, 37675

Escoffier, Emmanuelle,37888

Escribano, Julio, 38022

Ethier, Stephen P., 37728

Evangelista Meyer,Laudiene, 37361

Exum, Sabrina T., 37758

F

Fan, Guo-Huang, 37616

Felipe, Antonio, 37675

Feller, Andre, 37980

Ferro, Myriam, 37888

Ficko-Blean, Elizabeth,37748

Fillingame, Robert H.,37861

Finerty, Patrick J., Jr., 38061

Fogg, Mark J., 37993

Folkers, Gert E., 37993

Fouche, Nicole, 37486

Fredenburgh, James C.,37477

Freedman, Neil J., 37758

Fujii, Hiroaki, 37636

Fujii-Kuriyama, Yoshiaki,37507

Fujiki, Yukio, 37311

Futamura, Mayumi, 37668

G

Gaibelet, Gerald, 37921

Galina, Antonio, 37361

Galla, Melanie, 37381

Gan, Boyi, 37321

Garin, Jerome, 37888

Geeves, Michael A., 37782

Genschel, Ulrich, 37435

Gherghe, Cristina, 37952

Ginsberg, Henry N., 37603

Glass, Brian, 38013

Gonneville, Lucie, 38013

Goswami, Robi, 37758

Govin, Jerome, 37888

Graham, Mark J., 37603

Granzin, Joachim, 37594

Grass, Jeffrey A., 37345

Green, Andrew J., 37517

Grenha, Rosa, 37993

Griffith, Jack D., 37486

Groves, Ian J., 37652

Guan, Jun-Lin, 37321

Gudermann, Thomas,37447

Guertin, Michel, 37803

Guida, Elizabeth, 37353

Guidelli, Rolando, 37720

Guo, Li, 37836

H

Hall, Laura A., 38071

Hannink, Mark, 37893

Hansson, Anna, 37972

Hao, Yujin, 37636

Hartel, Michaela, 37782

Hatala, Denise A., 37697

Heise, Tilman, 37381

Henderson, Kelly W., 37962

Hentges, Pierre, 37517

Heredia, Raul, 38022

Hernandez-Ono, Antonio,37603

Hillman, Milton, 38013

Ho, Dona, 37813

Hobman, Tom C., 37646

Hoffhines, Adam J., 37877

Hoffmann, K. Martin,37705

Hofmann, Sabine, 37972

Hollis, Gregory F., 38013

Holmes, William, 38109

Holub, Oliver, 37361

Hood, Brian L., 37836

Hornemann, Thorsten,37275

Hosaka, Hideka, 37668

Huang, Li-Shin, 37603

Huang, Xuewei, 37758

Humphries, Martin J.,37686

Hung, Ming-Ni, 37930

Hwang, Young, 38052

I

Ikebe, Mitsuo, 37291

Ikura, Mitsuhiko, 37813

Im, Doon-Soon, 37457

Imanishi, Yoshikazu, 37697

Inesi, Giuseppe, 37720

Inouye, Masayori, 37559

Ishiwara, Mitsuteru, 37457

Ishizuka, Tamotsu, 37457

Ishmael, Faoud T., 37404

Ishmael, Susan S., 37404

Isobe, Toshiaki, 37576

Itohara, Shigeyoshi, 37853

Iwata-Reuyl, Dirk, 37586

J

Jackson, Antony P., 38038

Jackson, Stephen P., 37517

Jagasia, Ravi, 37972

Janssen, Jacques J., 37697

Jarry, Hubertus, 37447

Jastrzebska, Beata, 37697

Jensen, Robert T., 37705

Jiao, Wan, 38098

Jogl, Gerwald, 38109

Johnson, Farley C., 37270

Jonczyk, Rafal, 37435

Jones, A. Daniel, 37404

Jones, David A., 37828

K

Kadotani, Akito, 37668

Kalwa, Hermann, 37447

Kambara, Taketoshi, 37291

Kapeller, Irit, 37468

Kapoor, Avnish, 37636

Kaptein, Robert, 37993

Karasawa, Satoshi, 37813

Kazemi, Namdar, 37496

Keay, Susan K., 37836

Keely, Patricia J., 37527

Kefford, Richard F., 38080

Khan, Safina, 37536

Khochbin, Saadi, 37888

Kim, Jae-Ho, 37962

Kim, Minsoo, 37904

Kim, Youngho, 37382

Kimura, Takao, 37457

Koch, Karl-Wilhelm, 37594

Koch, Kristopher R., 37836

Kohno, Kimitoshi, 38089

Komaba, Shigeru, 37291

Koshikawa, Naohiko,37576

Kovaleva, Nadezhda A.,37594

Kraunus, Janine, 37381

Kretz, Colin A., 37477

Kuhn, Lauriane, 37888

Kumar, Naresh, 37794

Kuwabara, Atsushi, 37457

Kyriazis, George A., 37391

Kysela, Boris, 37517

L

Labarre, Marie, 37803

Laborda, Jorge, 38022

Ladds, Joanne C., 37993

Lagane, Bernard, 37921

Lake, Andrew C., 37844

Lambert, Millard H., 37773

The Journal of Biological Chemistry

AUTHOR INDEX

DECEMBER 8, 2006 • VOLUME 281 • NUMBER 49 JOURNAL OF BIOLOGICAL CHEMISTRY xi

Lane, M. Daniel, 37265

Langen, Ralf, 37820

Larsson, Nils-Goran, 37972

Lavigne, Damien, 37844

Leary, Julie A., 37877

Lee, Jae-Eun, 37382

Leier, Sven, 37782

Letourneur, Didier, 37844

Le Visage, Catherine,37844

Li, Qiang, 37566

Li, Runsheng, 37616

Lieser, Scot A., 38004

Lin, Huei-Min, 38098

Liu, Chia-Jen, 37738

Liu, Dong, 37391

Liu, Jingru, 37416

Lo, Shih-Ching, 37893

Lopez, Andre, 37921

Lopez-Iglesias, Carmen,37675

Luisa Ayub, Ana, 38080

Lum, Julian J., 37372

Luo, Cherry, 37616

M

Mackenzie, Farrell, 38061

Maeda, Akiko, 37697

Maeda, Shin-ichi, 37868

Maeda, Tadao, 37697

Manos, Elizabeth J., 37828

Mantey, Samuel A., 37705

Margittai, Martin, 37820

Margolis, Ben, 37738

Martın-Satue, Mireia,37675

Martowicz, Melissa L.,37345

Matte, Allan, 37930

Mattison, Kirsten, 37942

Mattson, Mark P., 37391

Mazeres, Serge, 37921

McIntyre, Peter, 37353

McKee, David D., 37773

McKenzie, Heather A.,38080

McLaughlin, Erin, 38013

Medvedev, Alexander V.,37794

Meyer, Christina, 38022

Michejda, Christopher J.,37836

Middleton, Rebecca, 37628

Miller, Aaron B., 37773

Mimura, Junsei, 37507

Mines, Marjelo, 37616

Minkah, Nana, 38052

Miyajima, Atsushi, 37913

Miyaoka, Yuichiro, 37913

Miyawaki, Atsushi, 37813

Mizuno, Hideaki, 37813

Modzelewska, Katarzyna,37527

Mogi, Chihiro, 37457

Moncelli, Maria Rosa,37720

Montalbetti, Nicolas,37566

Moody, Terry W., 37705

Moore, Brent C., 37828

Moore, Kevin L., 37877

Moukdar, Fatiha, 37794

Mukai, Satoru, 37311

Mukhopadhyay, Indranil,37330

Murakami, Masami, 37457

N

Nabeshima, Kazuki, 37576

Nadauld, Lincoln D., 37828

Nagata, Yasufumi, 37668

Naiki, Takahiro, 37913

Nakamura, Takahiro,37661

Nakaya, Tadashi, 37853

Nardini, Marco, 37803

Nazipova, Aliya A., 37594

Neupert, Walter, 37972

Newman, Elena M., 38061

Newman, Laura P., 37527

Nguyen, Susan T., 38038

Nishimura, Teruyuki,37668

Nolte, Robert T., 37773

Notari, Luigi, 38022

Notario, Patricia M., 38022

Nueda, Maria-Luisa, 38022

O

Oberley, Larry W., 37416

O’Connor, Daniel T., 38038

Ohyama, Sumika, 37668

Okajima, Fumikazu, 37457

Okuda, Kenji, 37661

Oliveira, Marcus F., 37361

Olson, Steven T., 37302

Omata, Tatsuo, 37868

Onn, Itay, 37468

Orband-Miller, Lisa A.,37773

Ouyang, Xin, 37391

Ozgur, Sezgin, 37486

P

Pais, Maria S., 37536

Palczewski, Krzysztof,37697

Pance, Alena, 38038

Pare, Justin, 37646

Parker, Henry, 37646

Patel, Yatin, 37686

Paul Mould, A., 37686

Peppel, Karsten, 37758

Perego, Marta, 37993

Permyakov, Eugene A.,37594

Permyakov, Sergei E.,37594

Perret, Gerard Y., 37844

Perry, Jennifer L., 38071

Perry, Kay, 38052

Pesce, Alessandra, 37803

Peter Hofmann, Klaus,37697

Peterson, Peter W., 37828

Phelps, Reid, 37828

Philippov, Pavel P., 37594

Pieczynski, Jay N., 37738

Pitcher, Robert S., 37517

Planchenault, Thierry,37921

Polam, Padmaja, 38013

Premont, Richard T., 37758

Pritchard, John B., 38071

Prive, Gilbert G., 37813

Proteau, Ariane, 37930

R

Rahman, Salman, 37686

Ramos, Arnolt, 37566

Rane, Sushil G., 38098

Rangarajan, Erumbi S.,37930

Raychowdhury, Malay K.,37566

Reddy, Laxma G., 37427

Reeves, Matthew B., 37652

Reichert, Andreas S., 37972

Richard, Benjamin, 37302

Richard, Christian, 37803

Richard, Stephane, 37275

Rizos, Helen, 38080

Robidoux, Jacques, 37794

Rodemer, Carrie, 38038

Rostovtseva, Tatiana K.,37496

Roura-Ferrer, Meritxell,37675

Rousseaux, Sophie, 37888

Roy, Krishnendu K., 37330

Roy, Rohini, 37559

Rutti, Markus F., 37275

Rzechorzek, Neil J., 37993

S

Saito, Kazuyoshi, 38089

Saito, Yuhki, 37853

Salas, Azucena, 37904

Sanchez-Sanchez,Francisco, 38022

Sandoval, Imelda T., 37828

Sano, Yoshitake, 37853

Santiago, Ana Paula S. A.,37361

Saravanamuthu, Senthil,38022

Sasaki, Kaori, 37668

Sato, Koichi, 37457

Sausville, Edward A., 37330

Schneider, Jessica, 37270

Schweinfest, Clifford W.,37962

Schwem, Brian E., 37861

Scott Wilbur, J., 37942

Scurr, Lyndee L., 38080

Seago, Julian, 37686

Seiki, Motoharu, 37576

Sekiguchi, Akihiro, 37457

Sekine, Hiroki, 37507

Senin, Ivan I., 37594

Shaffer, Jennifer, 38004

Shalbuyeva, Natalia, 37547

Shankar, Raji A., 37427

Shao, Yu, 37427

Shikanai, Toshiharu, 37661

Shilatifard, Ali, 37270

Shimaoka, Motomu, 37904

Shimazaki, Hiroko, 37668

Shimizu, Toshiyuki, 37661

Shlomai, Joseph, 37468

Sinclair, John H., 37652

Siri, Patty, 37603

Sklow, Bradford, 37828

So, Magdalene, 37942

Sobel, Michael, 37686

Soleimani, Manoocher,37962

Soler, Concepcio, 37675

Solsona, Carles, 37675

Sparks, Richard B., 38013

Spitz, Douglas R., 37416

Springer, Timothy A.,37904

Spyropoulos, Demetri D.,37962

Stafford, Alan R., 37477

Stahl, Joachim, 38080

Stoica, Cezar, 37646

Straight, Samuel W., 37738

Sugita, Chieko, 37868

Sugita, Mamoru, 37661,37868

Sumathipala, Rushika,37686

Sun, Wenyu, 37697

Suzuki, Motoo, 37559

Suzuki, Toshiharu, 37853

Swairjo, Manal A., 37586

Swanson, Richard, 37302

Syuzo-Takabatake, Aiko,37853

T

Tadini-Buoninsegni,Francesco, 37720

Takvorian, Amy, 38013

Tamkun, Michael M.,37675

Tanaka, Minoru, 37913

Tanaka, Yoshiya, 38089

Tapia, Jose A., 37705

Tate, Jennifer J., 37980

Taupenot, Laurent, 38038

Texido, Laura, 37675

Thill, Michelle, 37705

Thompson, Craig B., 37372

Tocci, Gillian M., 37836

Tomari, Taizo, 37576

Tomita, Susumu, 37853

Tomura, Hideaki, 37457

Trifunovic, Aleksandra,37972

Truffault, Vincent, 37993

Tsujimura, Shizuyo, 38089

V

Van Duyne, Gregory D.,38052

Vassy, Roger, 37844

Veenstra, Timothy D.,37836

Venkataraman, Sujatha,37416

Vicente, Ruben, 37675

Villalonga, Nuria, 37675

von Eckardstein, Arnold,37275

W

Wagener, Johannes, 37972

Wagner, John, 37930

Walker, John R., 38061

Wang, Jianyong, 37427

Wang, Liping, 37773

Wang, Zhaohui, 37962

Wayland, Brian, 38013

Weeks, Kevin M., 37952

Wei, Yu, 37275

Weiergraber, Oliver H.,37594

Weinrich, Michael, 37496

Weisberg, Stuart, 37603

Weitz, Jeffrey I., 37477

Whiteman, Eileen L., 37738

Wightman, Paul D., 37427

Wijelath, Errol S., 37686

Wilkinson, Anthony J.,37993

Wilkinson, Gavin, 37652

Willcox, Smaranda, 37486

Willmarth, Nicole E., 37728

Willson, Timothy M., 37773

Wilson, Keith S., 37993

Wilson, Thomas E., 37517

Winkens, Huub J., 37697

Woehlke, Gunther, 37782

Wolff, Katharina, 37447

Wolfgang, Michael J.,37265

Woodhall, David L., 37652

Woodruff, Sarah, 38080

Worrell, Roger T., 37962

Woychik, Nancy, 37559

Wu, Jiao-Hui, 37758

Wu, Yuliang, 37566

Wynn, Richard, 38013

X

Xiong, Yan, 37302

Xu, Cunshuan, 37686

Xue, Sheng, 38061

Y

Yamamoto, Masayuki,37507

Yang, Wei, 37904

Yoo, Youngdong, 37321

Yue, Eddy W., 38013

Z

Zambryski, Patricia C.,37628

Zernii, Eugene Yu, 37594

Zhang, Chen-Ou, 37836

Zhang, Jingwu, 37616

Zhang, Lisheng, 37758

Zhang, Weiqing, 37302

Zhang, Yuan-Li, 37603

Zheng, Haiyan, 37559

Zheng, Xianwu, 37636

Zhu, Jian-Kang, 37636

Zuercher, William J., 37773

Zychlinski, Daniela, 37381

xii JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 281 • NUMBER 49 • DECEMBER 8, 2006