Amino AcidsAmino Acids
Characteristics and StructuresCharacteristics and Structures
Amino AcidsAmino Acids
There are 20 amino acids derived from proteinsThere are 20 amino acids derived from proteins . .
While there are several methods of categorizing themWhile there are several methods of categorizing them , ,
one of the most common is to group them according to the nature of their side chainsone of the most common is to group them according to the nature of their side chains..
11--Nonpolar Side ChainsNonpolar Side Chains
22--Polar, Uncharged Side ChainsPolar, Uncharged Side Chains
33--Charged Side ChainsCharged Side Chains
Amino AcidsAmino Acids
11 - -Nonpolar Side ChainsNonpolar Side Chains
There are eight amino acids with nonpolar side chainsThere are eight amino acids with nonpolar side chains..
Glycine, alanine, and prolineGlycine, alanine, and proline
have small, nonpolar side chains and are all weakly hydrophobichave small, nonpolar side chains and are all weakly hydrophobic . .
Phenylalanine, valine, leucine, isoleucine, and methioninePhenylalanine, valine, leucine, isoleucine, and methionine
have larger side chains and are more strongly hydrophobichave larger side chains and are more strongly hydrophobic..
Amino AcidsAmino Acids
22 - -Polar, Uncharged Side ChainsPolar, Uncharged Side Chains
There are also eight amino acids with polar, uncharged side chainsThere are also eight amino acids with polar, uncharged side chains . .
Serine and threonineSerine and threonine have hydroxyl groups have hydroxyl groups . .
Asparagine and glutamineAsparagine and glutamine have amide groups have amide groups..
Histidine and tryptophanHistidine and tryptophan have heterocyclic aromatic amine side chains have heterocyclic aromatic amine side chains..
CysteineCysteine has a sulfhydryl group has a sulfhydryl group . .
Tyrosine Tyrosine has a phenolic side chain has a phenolic side chain . .
Amino AcidsAmino Acids
33 - -Charged Side ChainsCharged Side Chains
There are four amino acids with charged side chainsThere are four amino acids with charged side chains . .
Aspartic acid and glutamic acidAspartic acid and glutamic acid
have carboxyl groups on their side chainshave carboxyl groups on their side chains . .
Arginine and lysineArginine and lysine
have side chains with amino groupshave side chains with amino groups . .
NameNameAbbreviationAbbreviationLinear StructureLinear Structure
Alanineala Aala ACH3-CH(NH2)-COOHCH3-CH(NH2)-COOH
Argininearg Rarg RHN=C(NH2)-NH-(CH2)3-CH(NH2)-HN=C(NH2)-NH-(CH2)3-CH(NH2)-COOHCOOH
Asparagineasn Nasn NH2N-CO-CH2-CH(NH2)-COOHH2N-CO-CH2-CH(NH2)-COOH
Aspartic Acidasp Dasp DHOOC-CH2-CH(NH2)-COOHHOOC-CH2-CH(NH2)-COOH
Cysteinecys Ccys CHS-CH2-CH(NH2)-COOHHS-CH2-CH(NH2)-COOH
Glutamic Acidglu Eglu EHOOC-(CH2)2-CH(NH2)-COOHHOOC-(CH2)2-CH(NH2)-COOH
Glutaminegln Qgln QH2N-CO-(CH2)2-CH(NH2)-COOHH2N-CO-(CH2)2-CH(NH2)-COOH
Glycinegly Ggly GNH2-CH2-COOHNH2-CH2-COOH
Histidinehis Hhis HNNH-CH=N-CH=H-CH=N-CH=CC-CH2-CH(NH2)-COOH-CH2-CH(NH2)-COOH
Isoleucineile Iile ICH3-CH2-CH(CH3)-CH(NH2)-COOHCH3-CH2-CH(CH3)-CH(NH2)-COOH
NameNameAbbreviationAbbreviationLinear StructureLinear Structure
Leucineleu Lleu L(CH3)2-CH-CH2-CH(NH2)-COOH(CH3)2-CH-CH2-CH(NH2)-COOH
Lysinelys Klys KH2N-(CH2)4-CH(NH2)-COOHH2N-(CH2)4-CH(NH2)-COOH
Methioninemet Mmet MCH3-S-(CH2)2-CH(NH2)-COOHCH3-S-(CH2)2-CH(NH2)-COOH
Phenylalaninephe Fphe FPh-CH2-CH(NH2)-COOHPh-CH2-CH(NH2)-COOH
Prolinepro Ppro PNNH-(CH2)3-H-(CH2)3-CCH-COOHH-COOH
Serineser Sser SHO-CH2-CH(NH2)-COOHHO-CH2-CH(NH2)-COOH
Threoninethr Tthr TCH3-CH(OH)-CH(NH2)-COOHCH3-CH(OH)-CH(NH2)-COOH
Tryptophantrp Wtrp WPhPh-NH-CH=-NH-CH=CC-CH2-CH(NH2)-COOH-CH2-CH(NH2)-COOH
TyrosineTyrosinetyr Ytyr YHO-Ph-CH2-CH(NH2)-COOHHO-Ph-CH2-CH(NH2)-COOH
ValineValineval Vval V(CH3)2-CH-CH(NH2)-COOH(CH3)2-CH-CH(NH2)-COOH
Amino AcidsAmino Acids
Importance of Amino AcidsImportance of Amino Acids
Amino acids are the building blocks of protein and you get protein from your dietAmino acids are the building blocks of protein and you get protein from your diet..
If you eat a variety of healthy protein-containing foodsIf you eat a variety of healthy protein-containing foods , ,
you will get all of the eight essential amino acids that your body can't make for itselfyou will get all of the eight essential amino acids that your body can't make for itself..
Amino acids combine into small chains via chemical reactions calledAmino acids combine into small chains via chemical reactions called
' ' condensation reactionscondensation reactions‘‘ in which the carboxyl group and the amino group bond to one in which the carboxyl group and the amino group bond to one
another. These small chains that contain a few amino acids linked together are calledanother. These small chains that contain a few amino acids linked together are called
polypeptide chains (the individual amino acids are called petides)polypeptide chains (the individual amino acids are called petides)..
Polypetide chains, in turn, combine into the more complex structures know as proteinsPolypetide chains, in turn, combine into the more complex structures know as proteins
Amino AcidsAmino Acids
Amino AcidsAmino Acids
Essential and Nonessential Amino AcidsEssential and Nonessential Amino Acids
Nonessential amino acids are those that are synthesized by mammalsNonessential amino acids are those that are synthesized by mammals , ,
while the essential amino acids must be obtained from dietary sourceswhile the essential amino acids must be obtained from dietary sources
The twenty amino acids can be divided into two groups of 10 amino acidsThe twenty amino acids can be divided into two groups of 10 amino acids . .
Ten are essential and 10 are nonessential. However, this is really notTen are essential and 10 are nonessential. However, this is really not
accurate , as there is overlap between the two groupsaccurate , as there is overlap between the two groups..
Amino AcidsAmino Acids
The Ten "Nonessential" Amino Acids
Alanine
Asparagine
Aspartate
Cysteine (requires sulfhydryl group from methionine)
Glutamate
Glutamine
Glycine
Proline
Serine
Tyrosine (synthesized from phenylalanine)
The Ten "Essential" Amino Acids
Arginine (see below)
Histidine
Isoleucine
Leucine
Lysine
Methionine
Phenylalanine
Threonine
Tryptophan
Valine
Only twoExamples Will be Enough
Amino AcidsAmino Acids
Strecker amino acid synthesisStrecker amino acid synthesis
Amino AcidsAmino Acids
Amino AcidsAmino Acids