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What’s in a Mutt? An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019
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Page 1: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

What’s in a Mutt?An Intro to Dog DNA Analysis

Lecture 8Jan 25th, 2019

Page 2: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

From mutt saliva to dog breeds

How did we get there?

Page 3: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Test Accuracy

“ The Living DNA results found that Charlsie has DNA from Scotland and Ireland while Carly has a small percentage of ancestry from England.

The 23andMe results suggested Carly is almost 10 percent more "broadly European" than Charlsie. Meanwhile, Charlsie has 2.6 percent French and German ancestry, which Carly, apparently, does not. Charlsie also came back as 3.3 percent more Eastern European, 1 percent more Italian, and 1 percent more Balkan than her sister. Hey, at least, they can agree that the twins are largely of European descent. ”

Page 4: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Test Accuracy

Page 5: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Mini Assignment: Using IGV (Integrative Genomics Viewer)

IGV is a tool that lets you visualize alignments from second or third generation sequencing to a reference genome

Page 6: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Mini Assignment: Using IGV (Integrative Genomics Viewer)

IGV is a tool that lets you visualize alignments from second or third generation sequencing to a reference genome

Page 7: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Clarence

Even using the same data, different parameters yield slightly different results!

Page 8: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Reilly

Page 9: An Intro to Dog DNA Analysis What’s in a Mutt?ccb.jhu.edu/people/rsherman/EN.601.147.13_Lecture_8.pdf · An Intro to Dog DNA Analysis Lecture 8 Jan 25th, 2019. From mutt saliva

Finch


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