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8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Lelcror kg gkxdlc`nm`n oe hckk` kg xlpr`~xoef le` lgpnx oemlclpoke n}ykr~xn
Rykerkx1
Xnrnlxbm clhkxlpkx1
Y%K% Hk} =002699 LW QnorpPmn Enpmnxcle`r
P *2< == =77 8= 99oegkIpek%pxorjncoke%ecvvv%pxorjncoke%ec
Yxnrnepnx1
@x% L%A% Jcnoeeoanem~or
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oepxk`~bpoke
Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg rnx~d lch~doele` oe hckk`
MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk`
Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr
K~pcoen
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Gkxdlc`nm`n -GL/ or r~rynbpn` kg hnoef lrrkbolpn` vopm cn~jndol%
Ykrrohcn dnbmleord1 GL nepnxr pmn hckk` lgpnx oemlclpoke le` or lhcn pk xnlbm pmnhken dlxxkv%
GkxdlBlxn xn|~nrpn` PEK Pxorjncoke pk oewnrpoflpn vmnpmnx GL ble nepnx pmnhckk` rpxnld wol oemlclpoke%
GL or le ne`kfnek~r bkdyk~e` vopm l bkebnepxlpoke kg 8$2 df+C oe hckk` le` mlrl rmkxp mlcg cogn%
Pmn dkrp kbb~xxoef n}ykr~xn xk~pn gkx GL or oemlclpoke% Yxnwok~r oemlclpoke rp~`onr
mlwn rmkve ek xlorn` GL cnwnc oe pmn hckk` kg n}ykrn` leodlcr%
Oepxk`~bpoke -
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oepxk`~bpoke -8/
Lrr~dypoke1 nopmnx GL bleekp nepnx pmn hckk` wol oemlclpoke kx hckk` bkebnepxlpoker
xnp~xe pk pmnox ymrokckfoblc wlc~n wnx glrp -ek bkebnepxlpoke oebxnlrn `npnbplhcn/%
PEK Pxorjncoke `nwnckyn` l ekwnc# rneropown dnpmk` gkx rncnbpown `npnbpoke kgn}kfnek~r GL oe hckk`%
Pk `orpoef~orm n}kfnek~r GL le` ne`kfnek~r GL op vlr `nbo`n` pk n}ykrn xlpr pk
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oepxk`~bpoke
Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg rnx~d lch~doe
le` oe hckk`
MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk`
Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr
K~pcoen
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL -
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL -8/
Gxnn GL oe pmn yxnrnebn kg hkwoen rnx~d lch~doe -HRL/1
Pmn bkebnepxlpoke kg GL vlr df+C
Pmn bkebnepxlpoke kg HRL vlr 0> f+C oe ymrokckfoblcrlcoen
Pmn do}p~xnr vnxn oeb~hlpn` gkx 80 mk~xr
Lp p49 pmn xnbkwnx vlr ==. le` fxl`~lcc `nbxnlrn` pk6>. lgpnx 80$mx oeb~hlpoke%
45 ^y pk 8>. kg pmn GL hoe`r pk HRL
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Xnbkwnx kg GL gxkd l >% f+C HRL oe @YHR%
Podn f+C
Pmn do}p~xnr vnxn oeb~hlpn` gkx 80 mk~xr
Lp p49 pmn xnbkwnx vlr ?>. vopm XR@ 3 0. le` vlrrpocc 5?9. lgpnx 80$mx oeb~hlpoke%
45 GL mlx`c hoe`r pk XRL -3 >./
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL ->/
Gxnn GL oe pmn yxnrnebn kg m~dle rnx~d lch~doe -MRL/1
Pmn bkebnepxlpoke kg GL vlr < le` /
Pmn bkebnepxlpoke kg MRL vlr 0> f+C
Pmn do}p~xnr vnxn oeb~hlpn` gkx 80 mk~xr
Lp p49 pmn xnbkwnx vlr 66. vopm XR@ 3 >. le` vlr>9. lgpnx 80$mx oeb~hlpoke%
45 ^y pk >9. kg pmn GL hoe`r pk MRL
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg RL -7/
^en}ynbpn`c# pmnxn or l `oggnxnebn oe GL hoe`oef hnpvnne HRL#
XRL le` MRL
Hoe`oef oe`nyne`nep kg GL bkebnepxlpoke
XRL mlx`c hoe`r GL# HRL ~y pk 8>. le` MRL ~y pk >9.
Ykrrohcn n}yclelpoke1
Rpx~bp~xlc oggnxnebnr# lcpmk~fm pnxpolx rpx~bp~xn or mofmc
bkernxwn` @oggnxnep ykrppxlerclpokelc dk`ogoblpoker
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Gxnn gkxdlc`nm`n oe hckk` -6/
Pmn GL bkebnepxlpoke oe hclej xlp hckk` yclrdl vlr ckv% Pmn GLbkebnepxlpoke oe hclej hckk` yclrdl le` mndkcrlpn rcofmpc `nbxnlrn`
`~xoef df+C GLle` oeb~hlpn` gkx < mx lp XP%
Gkxpogon` GL vlr xnclpownc rplhcn oe hckk` yclrdl%
Gkxpogon` GL bkebnepxlpoke xlyo`c `nbxnlrn` oe mndkcrlpn%
Lgpnx gkxpogoblpoke kg vmkcn hckk`# ek gxnn GL vlr `npnbpn` oe hckk` yclrdl
kx mndkcrlpn% GL rnndr pk xlyo`c dofxlpn pk pmn xn` hckk` bnccr le` hn`nfxl`n`+hk~e` d~bm glrpnx pmle pmn lcxnl` yxnrnep ne`kfnek~r GL%
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oepxk`~bpoke
Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg rnx~d lch~doe
le` oe hckk`
MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk`
Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr
K~pcoen
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Lelcpoblc bmlccnefn1 GL or le ne`kfnek~r bkdyk~e`% N}kfnek~r
le` ne`kfnek~r GL rmk~c` hn `orpoef~ormn`%
Rkc~poke
Clhncn`
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Yxkykrn` dnpmk`1 `nxowlpoqlpoke vopm @EYM le` MofmYnxgkxdlebn Co|~o` Bmxkdlpkfxlym Dlrr Rynbpxkdnpx -MYCB$
DR/ lgpnx mn}len n}pxlbpoke% @nyxkpkelpn` GL$@EYM -d+q 89?/`nxowlpown vocc hn `npnbpn`%
MYCB$DR
MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk` -8/
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Pk `orpoef~orm n}kfnek~r le` ne`kfnek~r GL oe hckk` pmn orkpkyob
xlpok kg pmn `nyxkpkelpn` @EYM `nxowlpown -d+q 89?+8
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Lelcpoblc bmlccnefn1 GL or xlyo`c dnplhkcoqn` le`+kx xlyo`c hoe`r
pk GL$lbbnypkxr oe hckk` 45 ckv xnbkwnx
Rkc~poke
N}ynxodneplc yxkbn`~xn vlr kypodoqn` 45 @nxowlpoqlpoke vopmoe 2doe~pnr
Ckv xnbkwnx bk~c` ekp hn rkcwn` bkdycnpnc# xnynlplhocop vlrkypodoqn`1
Glrp le` xnynlplhcn rldycn yxnylxlpoke -en}p pk n}ykrn`xlpr/ Orkpkyob `orpxoh~poke or ekp lggnbpn` h xnbkwnx
MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk` -0/
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Lelcpoblc bmlccnefn1 rneropowop 45 n}kfnek~r -clhncn`/ GL rmk~c`
hn `npnbpn` lr rneropownc lr ykrrohcnRkc~poke
L``opoke kg
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk` -7/
Xnbkwnx gxkd ymrokckfoblc rlcoen vlr hnpvnne =? le` ?2. lp le` 6?. lp
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk` -6/
Goelc dnpmk`1
L`` 899 c vmkcn hckk` pk >99 c N@PL rkc~poke -lepo$bklf~cleple` mndkcror/
L`` 899 c mndkcrlpn pk > dc 8#0$@EYM rkc~poke oe lbnpkeopxocnbkeploeoef ynxbmckxob lbo`
Xnlbp gkx doe lp XP le` wkxpn}
Bnepxog~fn $0> . lp 8$7 df+C cnwnc vopm
XR@ 3 6.%
@~n pk fkk` xnynlplhocop dnpmk` or r~oplhcn gkx |~lepoplpown lelcror
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oepxk`~bpoke
Gxnn gkxdlc`nm`n oe pmn yxnrnebn kg rnx~d lch~doe
le` oe hckk`
MYCB$DR dnpmk` `nwnckydnep gkxdlc`nm`n oe hckk`
Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr
K~pcoen
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr - dc 8#0$@EYM rkc~poke oe lbnpkeopxocn
bkeploeoef ynxbmckxob lbo`Xnlbp gkx doe lp XP le` wkxpn}
Bnepxog~fn
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -8/
Dnpmk` wlco`lpoke rnp ~y -orkpkyob `orpxoh~poke/1
$Orkpkyob `orpxoh~poke `npnxdoen` gkx 7 `oggnxnep xlpr1 . bkego`nebn oepnxwlc1 8 }
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -2/
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -0/
Dnpmk` wlco`lpoke rnp ~y -GL |~lepogoblpoke oe hckk`/1
Coenlx blcohxlpoke b~xwn 8%>$8>9 f+C -x 5 9%??7/ Xnbkwnx GL 2>$0>.
Xnynlplhocop 3 6. gxkd ne`kfnek~r 7 df+C gkxpogoblpoke cnwnc
Ckv xnbkwnx xngcnbpr ldk~ep kg gxnn GL oe hckk`# ek bkxxnbpoke
Blcohxlpoke b~xwn GL$@EYM -MYCB$DR/
9%9N*99
8%9N*9>
2%9N*9>
0%9N*9>
>%9N*9>
7%9N*9>
9 >9 9 299
Bkebnepxlp oke GL$@EYM# n}yxnrrn` lr GL -f+C/
Ynljlxnld+q89?4589?-lxhopxlxy
~e
opr/
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr ->/
Dnpmk` wlco`lpoke rnp ~y -Rplhocop GL oe hckk` n}pxlbp/1
@~xoef rpkxlfn lp 8$
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -7/
Oemlclpoke rp~` rnp ~y1
Ryxlf~n @lvcn xlpr -
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -6/
Xnr~cpr1
Pmn lox bkebnepxlpoke vlr lr n}ynbpn`% Pndynxlp~xn vlr 88%8B -R@ 0%9 . -R@ 2%>/%
Pmn `npnxdoen` orkpkyob xlpokr `o` ekp `oggnx rofeogoblepc gxkdwlco`lpoke rnp -
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -=/
Xnr~cpr1
Pmnxn vlr ek oebxnlrn oe hckk` GL bkebnepxlpoke `~xoefn}ykr~xn% Pmn kwnxlcc dnle `npnxdoen` bkebnepxlpoke vlr8%2 df+C%
Hngkxn n}ykr~xn1 8%6 df+C @~xoef n}ykr~xn 2 mxr1 8%7 df+C
@~xoef n}ykr~xn 7 mxr1 8%9 df+C
Lgpnx n}ykr~xn
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Oemlclpoke rp~` vopm gkxdlc`nm`n oe xlpr -?/
@orb~rroke le` bkebc~roke1
Pmn lelcpoblc dnpmk` vlr blylhcn kg `npnbpoef . n}kfnek~r
8/2/2019 Analysis of Formaldehyde in Blood of Rats During and After Inhalation Exposure by Anne Kleinnijenhuis
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Lbjekvcn`fndnepr
PEK Pxorjncoke1
Xknc Nefnc_wkeen RpllcMler D~oarnxNwnxp @~orpnxdllp
PEK1X~~` Vk~pnxrne
GkxdlBlxn1Mnoeq$Ynpnx Fnchjn
\~nrpoker;;