Anatomic Pathology Histology Services
Central Laboratory Services
Oncology and Beyond...
Thereisnoquestionthatinnovationsintechnologyhavethepotentialtosignificantlyimpactanumberofclinicalapplications.Buttechnologyalonecan never fully actualize its potential.
Itisnotuntiladvancedtechnologiesareplacedintheskillfulhandsofanexperienced team of experts–experts in science, in process, in medicine, and logistics–that we will fully realize the value of these advances.
Inresponsetotheevolvingneedsoftheindustry–consistency,specimenintegrity,andefficiency–wechallengedourselvestolook beyond and deliver.
That is, until you look beyond.
Tissue Processing ServicesQUALITY AND CONSISTENCY BEGINS . . . AT THE
BEGINNING!
Our dedication to consistency is evident from the very beginning. Combining extensive automation with manual customization capabilities, our automated kit production facility delivers globally uniform specimen collection kits to assure consistent collection across all sites.
Consistency – Assuring quality trial data
• Standardizedbiopsycollectionkitsforconsistent site-to-site specimen collection
• Strictadherencebyexperiencedin-househistotechnologiststoSOPsforgrossdescription
• Specialhandlingforspecimensthatwillundergoimmunohistochemistry(IHC),fluorescentin situ hybridization (FISH),ornucleicacidpreparation
Specimen Integrity – Protecting your valuable assets• Datarecordsfolloweachspecimenforameticulousaudittrail• Reducedexposuretoexcessfixatives
Uniform sample collection kits • To reduce errors and
increase global consistencySuperior logistics solutions • To mitigate risk of lost or
damaged samplesIn-house tissue processing • For sample integrity
Collection & Processing
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[ ]Histochemical Staining ServicesCONSISTENCY DOWN TO A SCIENCE–LITERALLY.
Our in-house automated stainers are capable of performing a wide rangeofstains,includingroutineH&Estainingalongwithavarietyofspecialstains.Automationoffrequentlyperformedstainingdeliverstheutmostefficiencyandconsistency.Forlowervolumestainingtasks,ourhighlytrainedhistotechnologistsfollowstrictmanualstainingSOPstodeliverconsistentresultswhilemaintainingefficiencyforyourstudies.
Genomics & Biomarker AssaysTHE FINE ART OF TISSUE SCIENCE.
Theanswersareinthedetail.Andourattentiontodetailisexacting!Frompreciseinterpretationtoon-timedeliverytoreal-timeflexibility,we offer solutions to meet the precise standards of your trial.Tissue biomarker assaysExtensive options for customized solutions: We utilize a global network ofreferralandin-houselaboratoriestoprovidethemostefficientsolutionforyourIHCorFISHassays.Forrapidturn-aroundtimes,weworkwithseverallaboratoriesintheUSthatprovideaccesstoacomprehensive menu of biomarkers. Diverse pharmacogenomics capabilitiesGenomics solutions you can depend on: We combine the capabilities ofourin-houselaboratoriesatCovanceCLSsitesandourSeattle-basedCovanceGenomicsLaboratory,aswellasspecializedreferrallaboratories to deliver a complete genomics solution.Global pathologist expertiseSpecialists you can trust: Tissue biomarker specialist interpretations are provided via our network of referral lab pathologists to provide the right specialist for your study, or we can utilize a pathologist of yourchoosing.Eitherway,youwillgettherightexperttoprovideaccuracy and consistency.
Automated staining • For superior consistencyTissue biomarker expertiseNetwork of referral labs • Complete global solutions
Staining & Assays
Human breast tissue immunohistochemically stained to demonstrate estrogen receptor production.
Digital Pathology Services• Digitalslidescanningforarchivalimagestorage• Copies of images available on media• In-housetargetlesiontissueidentificationby
CovanceCLSpathologists• Target lesion percent and area determination• Remoteaccesstospecimenimages• Target lesion macrodissection for enrichment
Digital Pathology Services TAKING TECHNOLOGY AND MAKING IT BETTER.
Often, the most powerful innovation is the process that supports the technology. Covance looked beyond to imagine how to deploy the power of digital pathology to better meet the needs of your uniquetrials.
Specimen Security and Integrity. YourCovanceDigitalPathologyServicesteamcandeliverthesamehigh-qualityresultsfrompatientsnextdoororaroundtheglobe.Scienceandoperationsworktogethertoanticipateandrespond to the rigors of managing your delicate pathology samples.
Specimen handling in a single location, including tissue processing, staining, target feature identification, and even storage, reduces the risk of loss or damage and protects your valuable assets.
Exceptional Data Consistency. Allspecimensarereviewedbyaconsistentteamofpathologistsworkingtogetherunderthesameexactingstandards.Additionally,remote access to slide images can be available for secure and efficientreviewbyyourpathologists.
Greater Accuracy. The deployment of advanced technologies delivers greater consistencyandresultsinfastertrialenrollmentdecisions.Reducedshipment of slides helps to mitigate risk of loss or damage and eliminates costly handling steps and long turn around times.
Customized Solutions–for Greater Flexibility. Our team of experts is dedicated to providing exceptional services from the simplest to the most complex laboratory services. We create customized solutions for every trial, based on tissue andtumortype,stainingrequirements,andtheneedfor customized assays.
Aperio’s ScanScope® system consistently delivers digital slides with superior image quality.
Digital image of a human tissue marked to guide macrodissection
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In-house target identification • Rapid decisionsSpecialist interpretation via referral laboratory network • Options for sponsor-
chosen pathologists
Analysis
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Embedding and Sectioning ServicesSAME ADVANCED EQUIPMENT. SAME EXACTING
STANDARDS.
We can’t overemphasize the need for consistency. That’s why we deploy the same advanced technologies according to the same exacting procedures regardless of where your specimens are processed, producing highly combinable results.
Within this framework of consistency, we are also able to offer a host of options:Routine and nuclease-free services• Specialhandlingofsamplesforgenomicstestingtoeliminate
contamination or degradation• Varietyofnucleicacidpurificationservices,including
formalin-fixed,paraffin-embedded(FFPE)DNA/RNAextraction
Sectioning of paraffin-embedded tissues or cell blocks using microtomes• Standardorcustomizedthickness,dependingonyourprotocolSections mounted on slides or captured in microcentrifuge tubes for downstream processing• Standardorpositivelychargedglassslidesandpolyethylene
naphthalate(PEN)slidesforlasercapturemicrodissection• Standardandnuclease-freemicrocentrifugetubes
Stringent SOPs • For consistent resultsNuclease-free services available • To guard against cross-
contaminationFFPE DNA/RNA isolation • To meet specific study
requirements
Specimen Allocation
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Automated kit production facility assures consistent tissue collection for quality trial data.
Tissue sectioned on a microtome–standardized processes assure consistent quality.
Specimen ManagementYOUR SPECIMENS ARE AMONG YOUR MOST VALUED
ASSETS. Covance looks beyond the slide and understands it represents much more–a clinical trial that could deliver life-saving therapies to the patients represented by that single slide. We are committed to guarding these precious assets at every stage.
Processing – To meet your specific study requirementsTo manage embedded tissue blocks and slides, Covance offers:• Pathologyreportimaging• BlockIDconfirmation• Anatomicsiteandsampleintegrityverification
Storage – Ensuring sample integrity whenever your specimens are neededAnequallyimportantstepintheprocessisthestorageofyourirreplaceable specimens for continued sample integrity. With over 20 years of experience, we utilize sophisticated biorepository systems to store your samples under extreme conditions, ranging from ambient temperature to -150º C. Logistics – Mitigating the risk of loss or damage• Slidesandtissue/cellblocksbar-codedforreliableidentification
and tracking• Logisticsmanagementofshipmentsbetweenstoragefacilities,
investigator sites, and referral laboratories • Specimensandresultstrackedandmanagedusing
ourLabLink+application
THE AMERICAS +1.888.COVANCE (+1.888.268.2623) +1.609.419.2240
EUROPE/AFRICA +800.2682.2682 +44.1423.500888
ASIA PACIFIC +800.6568.3000 +65.6.5677333
www.covance.com
Covance is an independent, publicly held company with headquarters in Princeton, New Jersey, USA.
Covance is the marketing name for Covance Inc. and its subsidiaries around the world.
©Copyright 2012, Covance Inc. BROCLSO21-1012
Now it’s your turn to look beyond.
Look beyond and imagine other services you might need– whether that is unstained slides or customized services provided either in-house or through our network of specialty laboratories. Our goal is to work as partners for the advancement of critically needed pharmaceutical and biotechnical therapies for patients around the globe.
Central Laboratory Services
Specimen tracking via LabLink+ • To protect specimensAdvanced biorepository • For specimen integrity
over time
Storage