Retinitis Pigmentosa Research
► Johns Hopkins University, Maryland - 2012
► NOVA Southeastern University - 2014
Vision & The Eye
► The Eye contains more than 50% of the total sensory receptors in the body.
► The Eye - 2.5 cm diameter
► Anterior eye is only 1/6 of the eye
► Vision is the Interplay of Matter & Energy Material/Structure (Eye Structure-Yin)
Immaterial/Function (Vision-Yang)
Anatomy of the Eye
Three coats or tunics
Fibrous: Consists of sclera and cornea
Vascular: Consists of choroid, ciliary body, iris
Nervous: Consists of retina 15-9
How the Eye Works
The eye functions like a camera
Iris allows light into eye
Lens, cornea, humors focus light onto retina
Light striking retina is converted into action potentials (images) relayed to brain for interpretation.
15-10
What Causes of Failing Vision?
Genetic Predisposition Trauma/ Injury/ Illness Drugs/Medications Metabolic Imbalances Poor Nutrition Eye Strain Epigenetic Stress Factors Poor Circulation Systemic Disease
Conventional Medicine
The eye is diagnosed and treated as an
isolated organ pathology.
Decline of vision is said to be
a “natural process,” that can
either stabilize or get worse.
Conventional Approaches for
Eye Disease
“Corrective” Glasses & Contacts Lenses
Medications
Surgical Procedures
“Wait and See What Happens…”
Chinese Medicine Approach
Deals with the body as a whole, rather than in individual “parts.”
Everything is “connected,” and vision can be influenced by all organs in the body.
According to Chinese Medicine, most eye disease is related to Liver (functional) and/or Kidney (structural) dysfunction.
Holistic-Integrative approach producesthe best outcomes for our patients.
How Acupuncture Helps Vision
Increases Blood Flow the eye (O2 + food)
Stimulates Nerve Cells
Charges Dormant Retinal Cells
Regulates the Autonomic Nervous System
Promotes a Parasympathetic Response
Treats BOTH eye condition & underlying cause
Primary Objectives for
Preserving Vision Improve Circulation
Stimulate Photoreceptors, Optic
Nerve & Visual Cortex
Decrease Inflammation
Reduce Oxidative Stress
Identify & Manage Causative Factors
Long term Neuro-Protection
TCM 5-Wheel Theory
Element Yin Organ Yang Organ Structure
Fire Heart Sm. Intestine Inner/Outer canthus
Earth Spleen Stomach Eyelids aqueous
Metal Lung Lg. Intestine Sclera cornea, conjunctiva
Water Kidney Urinary Bladder
Pupil, macula, & retina, choroid
Wood Liver Gall Bladder Iris & eye muscles
Eyes & The Liver
Liver Opens into the Eyes, eyes reflect
the function of the liver.
Liver Qi is connected to the Eye & the
Harmony of the Liver Qi allows the Eyes
to see.
Liver stores the blood; the storage of
blood allows the eyes to see.
The Liver governs the tears; the tears
luster the eyes.
Eyes & The Heart
The Heart Governs the Blood, the blood
nourishes the eyes.
The Heart s connected with the blood
vessels, and all the vessels are related
to the eyes.
The Heart houses the spirit and
liveliness; the eyes command the Heart.
Eyes & The Spleen
The Spleen Transports Essence upward
to the eyes.
The Spring brings clear yang upwards to
the eyes.
The Spleen Qi controls the blood to
circulate within the blood vessels of the
eyes.
Eyes & The Lung
The Lung Dominates Qi; the harmony of
Qi ensures the brightness of the eyes.
The Lung governs dispersing and
descending; the smooth flow of Wei Qi
to the collaterals of the eye.
Lungs Govern the exterior, protecting
the eyes so as to be nourished and
warmed without damage by external
pathogen
Eyes & The Kidney
Kidney Governs the storage of Essence;
sufficiency of Essence ensures the brightness
of the eyes.
Kidney engenders the cerebral marrow; the
eyes are connected with the brain.
The kidney governs fluids & moisten the eye.
The Kidney supplies True Yin and True Yang; it
nourishes and supports the function of the
retina, pupil, chorroid, aqueous & vitreous.
Relationship with the Six Fu
Zang moves Qi to the Fu; Fu Transports
Essence to the Zang.
Six Fu: govern reception, control digestion,
separate clear and turbid, move waste
through the bowels, transport essence in
the form of “Sensory Jing” to the eyes.
In short, Fu delivers Ying-Nourishment
the eyes to maintain healthy vision.
TCM Pathogens & Eye Diseases
PATHOGEN ORGAN EFFECT ON EYES
Fire/Heat Heart Swelling, redness, inflammation
Cold Kidney Slow onset degenerative eye diseases
Wind Liver Sudden onset eye diseases
Dampness Spleen Mucus, edema, secretions – slow onset
Dryness Lung Dryness, itching, redness
Summer Heat All Organs Inflammation w/ mucus
AGE RELATED MACULAR DEGENERATION
Insufficient oxygen and nutrients damages photoreceptor molecules
With ageing, the ability of RPE cells to digest these molecules decreases
Excessive accumulation of residual bodies (drusen)
RPE membrane and cells degenerate and atrophy sets in and central vision is lost
BMJ 326, 2003; 485-488
AGE RELATED MACULAR DEGENERATION
Alternatively the photoreceptors and pigment epithelium send a distress signal to choroid capillaries to make new vessels
New vessels grow behind the macula
Breakdown in the Bruch’s membrane
Blood vessels are fragile
Leak blood and fluid
Scarring of macula
Potential for rapid severe damage
BMJ 326; 2003: 485-488
DRY MACULAR DEGENERATION
1. Accounts for about 90% of all cases
1. Also called atrophic, non exudative or
drusenoid macular degeneration
DRY MACULAR DEGENERATION
Drusen
Drusen is an aggregation of hyaline material located between Bruch’s membrane and RPE.
Drusen are composed of waste products from photoreceptors.
Drusen > 63 microns in diameter are statistically associated with visual pathology and are termed early ARMD.
Hypo/hyper pigmentation of RPE may be present
NEJM, Vol 342 (7): 483-492
WET MACULAR DEGENERATION
Accounts for about 10%
Also called choroidal neovascularization, subretinal neovascularization or disciform degeneration
Abnormal blood vessels grow beneath the macula
These vessels leak blood and fluid into the macula damaging photo receptors
Progresses rapidly and can cause severe damage to central vision
http://www.blindness.org
Treatment Guidelines for AMD
Acupoints: Sp-3, Ht-8 Qihou, GB-20, Yuyao, St-2, UB-2,
Sp-6, St-36, GB-37, Lv-2
Bleeding – Moxa Sp-1
TC Herb Rx: San Ren Tang Phlegm-Damp
Xiao Yao San – Qi Stagnation
Zhu Jung Wan – Lv/Ki Deficient
Ming Mu Di Huang Wan – Lv/Ki deficient
What is Retinitis Pigmentosa?
Retinitis Pigmentosa, also known as RP, is a group of diseases that usually run in families which causes slow, but progressive and permanent loss of vision.
The retina is a tissue which lines the inside of the eye, and sends images to the brain. RP causes a gradual destruction of the light sensing cells, dark and peripheral vision cells, straight ahead and fine details, and cells responsible for seeing color.
Currently there is no cure for Retinitis Pigmentosa, however there are developments progressing.
Causes
Retinitis Pigmentosa (RP) is a group of inherited diseases that
damage the light-sensitive rods and cones located in the retina,
the back part of our eyes.
Rods, which provide peripheral and night vision are affected
more than the cones that provide color and clear central vision.
Frequency
✓ Internationally: The incidence of primary RP is
approximately 1 in 4000.
✓ Gender: Because of X-linked varieties, men may be affected
slightly more than women.
✓ Age: The age of onset varies depending on the disorder. RP
usually is diagnosed in young adulthood, although it can
occur anywhere from infancy to mid 30s to 50s.
Treatment Guidelines for RP
Main TCM DX: Liver Blood Stasis with lung Deficiency
Acupoints: Lv-8, Ki-10, Ki-7, Sp-3, Ht-8, Lu-10, Taiyang, Yuyao, UB-2, St-1
Herbs: Xue Fu Zhu Yu Tang – blood stasis
Qi Ju Di Huang Tang – Li/Ki Yin
Shi Hu Ye Guang Wan – Night Vision/ Yin Def
Types of Glaucoma
Congenital, Trauma, Steroid Induced Normal Tension Glaucoma Open Angle Glaucoma (Chronic) Closed Angle Glaucoma (Acute) Headaches
No Symptoms
Eye Pain
Nausea
Severely Blurred Vision
Glaucoma Diagnosis
These are four things Ophthalmologist’s
look for:
The eye’s fluid pressure
The shape and color of the optic nerve
The complete field of vision
The angle where the iris meets the cornea
TCM Pattern Differentiation for
Glaucoma
Open Angle (Chronic)
Kidney Deficiency Liver Deficiency
Liver Qi & Blood Stagnation
Stagnation of Fluids
Closed Angle (Acute)
Liver Wind Stirring/ Liver Yang Rising
Treatment Principles
1. Warm & Strengthen the Yang (and Qi)1. Jin Qui Shen Qi Wan
2. Wen Dan Tang
3. You Gui Wan
2. Move the Qi & Blood (and fluids)1. Dai Di Dang Wan – stagnation of essence
2. Xue Fu Zhu Yu Tang
3. Xiao Yao San
TCM Acupuncture
Focus on the GB Xu & UB to being Ying to Eyes to enable Yang
Stagnation of Qi, Blood, fluids & Deficiency of Jing
Locate ah-shi points on these meridians. Common points used: SJ-3, LI-4, GB-4,20, 43, 37 Taiyang, UB-1,2, 62, SI-3, K-7
DO NOT USE LOCAL E-STIM FOR GLAUCOMA PATTIENS AS IT CAN RAISE Inter-Ocular Pressure!
Andy’s Acupuncture Glaucoma
Guidelines
Treatment:
GB-1 (local), GB- 20 (move Qi to the eyes), GB-30 (move Qi in GB), GB-37 (special eye point), GB-43 (tonification), UB-2 (local), St-2 (local), St-36 (horray), Lv-8 (move blood), Ki-7 (tonify yang qi)
Extra Glaucoma points:
Extra Glaucoma #1 – 1 cun superior to SJ-23; and one finger-width lateral. In the tender spot, needle posterior until a strong “de-Qi” sensation is obtained.
Extra Glaucoma #2 – ½ cun anterior to St-5; needle superior in tender area as to obtain a strong “de-Qi” sensation.
Eye Exercises to Reduce IOP – Press & Hold St-1 3x for 10 seconds
Direct Moxa: Knuckle of second joint of thumb & middle finger
Supplements for Glaucoma
Cod Liver Oil
Vitamin C
Taurine
Coleus Forskohlii (Steaming)
Ginko Biloba
Turmeric & Circumen
What is a cataract?
A cataract is a clouding of the lens in the eye that affects vision. Most cataracts are related to aging. Cataracts are very common in older people. By age 80, more than half of all Americans either have a cataract or have had cataract surgery.
A cataract can occur in either or both eyes. It cannot spread from one eye to the other.
TCM Herbs for Cataracts
Kidney & Lung Yin Def. Qi Ju Di Huang Wan
Sha Shen Mai men Dong Tang (Glehnia & Ophiopogon)
Internal Heat/ Fluid Deficiency Qi ju Do Haung Wan
Gou Qi Zi & Ju Hua
Qi & Blood Yu Xue Fu Zhu Yu Tang
TCM Acupuncture for Cataracts
Focus on LI, St and UB to bring Ying to the Eyes.
Taiyang, St-1 UB-2, Lu-10, Lu-7, K-3 & 6, LI-1
Use herbs, diet, fluids, & supplements to hydrate & nourish Yin. Need to cool, moisten, & hydrate.
NOTE: Looks for possible infections or chronic GI inflammation other than cardio stress.
Supplements for Cataracts
Vitamin C & Bioflavonoid
Glutathione (antioxidant)
Alpha Lipoic Acid
NAC Eye Drops, “CAN-C”
Smoking is the WORST thing for cataracts!
What Can Effect the Outcome?
How advanced the condition is
Degree of emotional stress
Other co-existing conditions
Willingness to receive treatment
Compliance with treatment and supplements
Sleep and Adequate Rest during recovery
Smoking, Alcohol, Drugs (Rx and Non-Rx)
Poor Diet & Malnutrition