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Flora
Microorganisms that occur or have adapted to live in a specific environment.
Two types: Resident (always present)
Transient (episodic)
Virulence
Definition: The frequency with which a pathogen causes disease.
Factors affecting virulence include: Strength of pathogen to adhere to healthy cells.
Ability of pathogen to damage cells or interfere with the body’s normal regulating systems.
Ability of pathogen to evade attach of white blood cells.
Pathogens
Microorganisms that cause disease These include:
Bacteria
Fungi
Viruses
Protozoa
Rickettsia
Bacteria
Small, one-celled microorganisms that lack a true nucleus or mechanism to provide metabolism
Only small percent of bacteria are pathogenic Common bacterial infections include diarrhea,
pneumonia, gonorrhea, meningitis, impetigo, and urinary tract infections.
Viruses
Organisms that live only inside cells. They cannot get nourishment or reproduce outside
cells. Common viral infections include influenza, measles,
common cold, chickenpox, hepatitis B, genital herpes, and HIV.
Fungi
Grow in single cells, as in yeast, or in colonies, as in molds.
Most are not pathogenic and make up many of the body’s normal flora.
Fungi can cause infections of the hair, skin, nails, and mucous membranes.
Protozoa
Single-celled parasitic organisms with the ability to move.
Common protozoan infections include malaria, gastroenteritis, and vaginal infections.
Rickettsia
Intracellular parasites that need to be in living cells to reproduce.
Spread through fleas, ticks, mites, and lice. Common rickettsia infections include typhus, Rocky
Mountain spotted fever, and Lyme disease.
Infection
An invasion and multiplication of pathogenic microorganisms that occurs in body tissue and results in cellular injury.
Infectious Agent
Reservoir or Source
Portal of Exit from Reservoir
or Source
Mode of Transmission
Portal of entry to Host
Susceptible Host
Chainof
Infection
Infectious Agent
Definition: An entity capable of causing disease. These may be:
Biological (bacteria, viruses, fungi, protozoa, Rickettsia). Chemical (pesticides, food additives, medications, industrial
chemicals). Physical (environmental factors, like heat, light, noise,
radiation, and machinery).
Reservoir of Source
Definition: A place where the agent can survive. The most common reservoirs are:
Humans
Animals
Environment
Fomites (objects contaminated with an infectious agent, such as bed pans, urinals, linens, instruments, dressings, etc.)
Portal of Exit
Definition: The route by which an infectious agent leaves the reservoir to be transferred to a susceptible host.
These include: Sputum from respiratory tract Semen, vaginal secretions, or urine, from the genito-urinary tract Saliva and feces, from the gastrointestinal tract Blood Draining wounds Tears
Mode of Transmission
Definition: The process that bridges the gap between the portal of exit of the infectious agent from the reservoir or source and the portal of entry of the susceptible “new” host.
These include: Contact transmission (direct contact with infected person, indirect
contact through fomite, or close contact with contaminated secretions)
Airborne transmission Vehicle transmission (through contaminated substances such as
water, milk, drugs, or blood) Vectorborne transmission (through fleas, ticks, lice, and other
animals)
Host
Definition: A simple or complex organism that can be affected by an agent.
A susceptible host lacks resistance to an agent and is vulnerable to disease.
A compromised host has impaired defense mechanisms and is susceptible to infection.
Factors Affecting Susceptibility to Infection
Age Concurrent diseases Stress Immunization and
vaccination status
Occupation Nutritional status Heredity Lifestyle
Cleansing
Definition: The removal of soil or organic material from instruments and equipment.
Four steps:1. Rinsing the object under cold water
2. Applying detergent and scrubbing the object
3. Rinsing the object under warm water
4. Drying the object prior to sterilization or disinfection
Disinfection
Definition: The elimination of pathogens (except spores) from inanimate objects.
Disinfectants are chemical solutions used to clean inanimate objects.
Germicides are chemicals that can be applied to both animate (living) and inanimate objects for the purpose of eliminating pathogens.
Sterilization
Definition: The total elimination of all microorganisms including spores.
Instruments used for invasive procedures must be sterilized.
Moist heat or steam, radiation, chemicals, and ethylene oxide gas used for sterilization.
Autoclaving sterilization, using moist heat, is used in most hospital settings.
Breaking the Chain of Infection
Between reservoir and portal Proper hygiene
Clean dressings
Clean linen
Clean equipment
Breaking the Chain of Infection
Between portal of exit and mode of transmission Clean dressings on all injuries.
Clients should be encouraged to cover the mouth and nose when sneezing or coughing, as should the nurse.
Gloves must be worn whenever necessary.
Proper disposal of contaminated items.
Breaking the Chain of Infection
Between mode of transmission and portal of entry Nurses wearing barrier protection (gloves, masks, gowns,
goggles)
Proper hand-washing
Proper disposal of contaminated equipment and linens
Breaking the Chain of Infection
Between portal of entry and host Maintaining skin integrity
Using sterile technique for client contacts
Avoiding needle sticks
Proper disposal of sharps
Normal Defense Mechanisms
A host’s immune system serves as a normal defense mechanism against the transmission of infectious agents.
Immune system recognizes presence of antigens, foreign proteins that cause the formation of an antibody.
Nonspecific Immune Defense
Skin and normal flora Mucous membranes Sneezing, coughing, and tearing reflexes Elimination and acidic environment Inflammation
Inflammation
Definition: A nonspecific cellular response to tissue injury.
Characteristics include: Redness (erythema)
Heat
Pain
Swelling (edema)
Loss of function
Pus (purulent exudate)
Specific Immune Defense
Definition: An immune defense mounted specifically against an invading antigen.
Includes: Skin and normal flora
Mucous membranes
Sneezing, coughing, and tearing reflexes
Elimination and acidic environment
Inflammation
Stages of Infection
1. Incubation The time interval between entry of an infectious agent into
host and onset of symptoms.
2. Prodromal Onset of nonspecific symptoms to specific symptoms of
illness
3. Illness Period of specific signs and symptoms of infection.
4. Convalescence From disappearance of acute symptoms until client returns
to previous state of health
Nosocomial Infections
Definition: An infection acquired in a hospital or other health care facility that was not present or incubating at the time of the client’s admission.
Also referred to as hospital-acquired infections.
Asepsis
Definition: The absence of microorganisms. Two types:
1. Medical – Those practices used to reduce the number, growth, and spread of microorganisms.
2. Surgical – Practices that eliminate all microorganisms and spores from an object or area.
Medical Asepsis
Hand-washing is the first line of
defense against infection and is the
single most important practice in
preventing the spread of disease.