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Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
ANIMAL BIOTECHNOLO
GY
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
Animal Biotechnology:Animal biotechnology is the use of science and engineering to modify living organisms.
The goal is to make products, to improve animals and to develop microorganisms for specific agricultural uses.
Examples: creating transgenic animals, using gene knock out or Knock in technology
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
Round Oak Rag Apple Elevation (born 1965)
1. >80,000 daughters,2. 2.3 million granddaughters, and 3. 6.5 million great-granddaughters
1944: 25.6 million animals; total annual milk production of 53.1 billion kg. 1997: 9.2 million animals; total annual milk production of 84.2 billion kg.
About half of this 369% increase in production efficiency is attributable to genetic improvement enabled by AI
Applications
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
GE Chickens That Don't Transmit Bird FluBreakthrough could prevent future bird flu epidemics
Applications
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
OMEGA-3 PIGS(PIGS CLONED AFTER GENETICALLY ENGINEERING CELL)
Applications
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
FAST GROWING SALMONTHE FOUNDER FEMALE WAS GENERATED IN 1989 ~
Applications
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
Extent of use
Public and government acceptance
Current technical
capability for using
technology
Infrastructure and materials and tools available for using
technology
Relative cost
Skills required for application
Potential for generating
impact (time frame <10
years)
ARTIFICIAL INSEMINATION ++ +++ ++ ++ ++ ++ +++PROGESTERONE MONITORING + +++ + + ++ ++ ++ ESTRUS SYNCHRONIZATION + +++ + + ++ ++ ++
IN VITRO FERTILIZATION/ EMBRYO TRANSFER
+ +++ + + +++ +++ ++
MOLECULAR MARKERS + +++ + + ++ +++ +CRYOPRESERVATION + +++ ++ + ++ +++ ++SEMEN AND EMBRYO SEXING + +++ + + +++ ++ ++CLONING + + + + +++ +++ +TRANSGENESIS/GE 0 + + + +++ +++ +
Current status of animal biotechnologies and factors influencing their applicability in developing countries - GENETICS
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
The Technology Involved in ABT
•Transgenics (also known as recombinant DNA) Transgenic animals created by two methods
1. DNA microinjection2. Embryonic stem cells & gene knock-
outs/ also Cre-loxP
•Cloning•knock out technology
DNA microinjectionmethod
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
EDUCATIONAL ACTIVITYThinking Critically
1) Is it acceptable to create an animal that feels no pain through the use of animal biotechnology? Why or why not?
2) An animal has been used to create a promising new drug for the treatment of many types of cancer. However, the process involved might bring pain to the animal used to make the drug. Is this acceptable considering the end result? Why or why not?• Should we make the animal incapable of pain in this case? Why or
why not?
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
ETHICAL AND SOCIAL CONSIDERATIONS: “playing God”
Two main areas of debate:
1. Animal Welfare
2. Religious Issues
Course Outline Animal physiology and metabolism- an overview.
The principles of cell differentiation, growth and differentiation of blood cells, genetic control of muscle cell differentiation, potency of stem cells and prospects for medical uses.
Hormonal control of development.
Introduction to transgenic animals and overview of methodologies for nuclear transfer.
Md. Najmul HossainBiotechnology & Genetic Engineering, UODA
Thank You
&
Welcome to the world of Animal Biotechnology