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Anti-Malaria Anti-Malaria ConsortiumConsortiumDr Maureen WolfsonDr Maureen Wolfson
[email protected]@sanbi.org
South Africa has a rich South Africa has a rich tradition of medicinal plant tradition of medicinal plant useuse
70%+ of the population 70%+ of the population consult approx. 200 000 consult approx. 200 000 Traditional HealersTraditional Healers
400 million usage events / 400 million usage events / yearyear
(N Crouch)(N Crouch)
Indigenous Knowledge on Indigenous Knowledge on Plant UsePlant Use
Plants: Why Drugs Plants: Why Drugs from?from?
• Natural products - historically useful leads
• Extensive ethnomedicinal plant use and knowledge in SA
• SA’s rich floral diversity:
• 10% of earth’s vascular plants on 0.2% of it’s surface
• Between 24 000 - 30 000 taxa
• 80% endemic - 13 families and 560 genera
• The world’s richest botanical hotspot: The Cape Floristic Region (Fynbos), with 6 000 endemic taxa
(N Crouch)
Ethnomedicinal Approach Ethnomedicinal Approach Helps to Narrow the SearchHelps to Narrow the Search (N (N
Crouch)Crouch)
24 000 plant taxa in southern 24 000 plant taxa in southern AfricaAfrica
7000 recorded ethnomedicinal 7000 recorded ethnomedicinal plantsplants
600 associated with malaria or 600 associated with malaria or feverfever
[210 taxa selected for [210 taxa selected for antimalarial screening]antimalarial screening]
Plant Selection Plant Selection ProcedureProcedure
EthnomedicinalEthnomedicinal ChemosystematicChemosystematic
OtherDevelop novel
drugs from PLANTS
Note:Data sourced by literature searching(N Crouch)
Product Development PipelineProduct Development Pipeline
Act 10 requires Access and Benefit Sharing (ABS) Act 10 requires Access and Benefit Sharing (ABS) agreements with communities and genetic resource agreements with communities and genetic resource holders, as well as permits at this stageholders, as well as permits at this stage
BasicResearch
DevelopmentValidationof efficacyand safety
Upscaling ofproduct andinitial agro-processing
Manufacturing
Proof of principle Proof of conceptTechnology
transfer
Plant Product
Consortium Consortium PartnersPartners
Medical Research CouncilMedical Research Council University of Cape TownUniversity of Cape Town Council for Scientific and Industrial Council for Scientific and Industrial
ResearchResearch SANBISANBI University of Western CapeUniversity of Western Cape University of PretoriaUniversity of Pretoria
Genetic Resource usedGenetic Resource used Aim to develop new medicines based Aim to develop new medicines based
on indigenous plants and indigenous on indigenous plants and indigenous knowledge for the treatment of knowledge for the treatment of malaria.malaria.
Agreements:Agreements:Consortium Benefit sharing Consortium Benefit sharing
AgreementAgreementTrust Fund AgreementTrust Fund Agreement
Agreed benefitsAgreed benefits Multidisciplinary scientific activityMultidisciplinary scientific activity Capacity buildingCapacity building Technology transferTechnology transfer Development of affordable Development of affordable
anti-malaria drugsanti-malaria drugs Cultivation and agroprocessingCultivation and agroprocessing Develop a technology platform for SA Develop a technology platform for SA
with the elements of the value chain with the elements of the value chain for drug discovery.for drug discovery.
Benefit-sharingBenefit-sharing Any financial benefits through Any financial benefits through
royalties divided in two with 50% royalties divided in two with 50% benefits being divided equally by benefits being divided equally by consortium partners and 50% to be consortium partners and 50% to be deposited in a Trust Fund to be deposited in a Trust Fund to be shared with stakeholders who shared with stakeholders who provided resources or knowledge.provided resources or knowledge.
Benefits realised to dateBenefits realised to date Couple of promising leads being Couple of promising leads being
investigated furtherinvestigated further Extensive database on medicinal Extensive database on medicinal
plantsplants The consortium approach has The consortium approach has
promoted multidisciplinary research, promoted multidisciplinary research, information, technology transfer, information, technology transfer, capacity building and innovationcapacity building and innovation