Date post: | 26-May-2015 |
Category: |
Health & Medicine |
Upload: | subhradip-roychowdhury |
View: | 374 times |
Download: | 0 times |
ANTICANCER ACTIVITY OF INDOLE-3-CARBINOL [I3C]
DERIVATIVES
SUBHRADIP ROYCHOWDHURY* & SATARUPA BHATTACHARJEE**
*M.PHARM 1ST YEAR [PHARMACEUTICAL CHEMISTRY] DEPT. OF PHARM. SC. BIRLA INSTITUTE OF TECHNOLOGY, MESRA-835215
** B.PHARM 4TH YEAR GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, KOLKATA-114
DEFINITION , TYPES AND CAUSES OF CANCER Cancer known medically as a malignant neoplasm, is a broad group of diseases involving uncontrolled , abnormal cell
proliferation
GENESIS OF CANCER
HISTORICAL BACKGROUND OF USE OF I3C
“If a cancerous ulcer appears upon the breasts, apply a crushed cabbage leaf
and it will make it well.”
- Roman statesman, Cato the Elder [234-149 BC]
Crushing or chewing cabbage leaves causes 72% reduction in risk of breast
cancer and also reduces developing prostate and pancreatic cancer.
SOURCES OF I3C
Primarily found in
cruciferous
vegetables.
Family : Cruciferae.
Genus : Brassica.
DERIVATIVES OF I3C
CHEMICAL PROFILE OF I3C
Oral consumption of Cruciferous vegetables Glucobrassicin ,a
glucosinolate Indole-3-glucosinolate Myrosinase in plant cell
Acid autohydrolysis in stomach Condensed oligomeric derivatives
majorly DIM,ICZ & LTr1
Modulates the metabolism of carcinogens, such as Benzopyrene, Aflatoxin B1.
Inhibits activation of various transcription factors.
Anticancer agent for both hormone responsive and triple negative breast
tumors.
PROTEIN TARGETS OF I3C DERIVATIVE DIM
ACTIVITIES ASSIGNED TO I3C
DIM Di Indolyl Methane
ESTROGEN METABOLISM, CANCER AND I3C
I3C increases the urinary excretion ratio of 2-hydroxyestrone to 16 alpha
hydroxyestrone.
Inhibits the 4-hydroxylation of estradiol.
Increases 2-hydroxylation keeping away 16 alpha hydroxylation of
estradiol via induction of two isoenzymes CYP4501A1 and CYP4501A2.
DISEASES THAT CAN BE TREATED WITH I3C
Breast cancer
Lung cancer
Liver cancer
Leukaemia
Cervical cancer
Prostate cancer
Colon cancer
Hepatotoxicity
Systemic lupus
erythematosus
In management
of HSV
Recurrent
respiratory
papillomatosis
DOSE AND SAFETY DATA OF I3C DERIVATIVES
PREGNANCY AND LACTATION : Safety has not been established.
DRUG INTERACTION :
Tamoxifen [Synergistic in Breast Cancer]
Antacids and PPI are contraindicated [As they will prevent acid
condensation to form ICZ]
DOSE : Dosage ranges from 400 mg to 800 mg daily.
CONCLUSION
So from here it can be concluded that
Consumption of Indole-3-carbinol, a component of cruciferous
vegetables, has incredible potential both for prevention
and for treatment of cancer.
While being cytoprotective for the normal cells, it is an
apoptotic agent for the tumor cells.
This potential of Indole-3-carbinol should be further
explored both alone and in combination with various
chemotherapeutic agents for the treatment of cancer.
REFERENCESAggarwal et al; Molecular Targets and Anticancer Potential of Indole-3-
Carbinol and Its Derivatives; [Cell Cycle 4:9, 1201-1215; September
2005];2005 Landes Bioscience.
farmacists.blogspot.in/2009/05/indole-3-carbinol-novel-approach-to.html cited
on 26.09.2013
Bardlow H.L. et al; Long-term responses of women to indole-3-carbinol or a
high fibre diet; Cancer Epidemiol Biomarkers Prev 1994;3:591-595.
cancerres.aacrjournals.org/content/67/16/7815.long cited on 26.09.2013
ncbi.nlm.nih.gov/pubmed/22110194 cited on 26.09.2013
THANK YOU