Applicazioni biologiche dei nanotubi

Tossicità

Nanotubi biocompatibili e biodegradabili

Drug delivery

coniugazione fisica coniugazione chimica

PEGilazione

a

b c d

e

f

g

h

0 5 10 15 20 25 30

1000

days

mean tumor

volume

500

1500

20002500

30003500

4000

Tumor destruction Survival

Tumor growth Death

NIR irradiatio ntratumoral injection (PEG-SWNTs or PBS)

Tumor xenograft

PBS

SWNT

2 Day

14 Day

20 Day

60 Day

I PEG-SWNTs + NIR II Untreated III PBS + NIR IV PEG-SWNTs

NearIR

untreated PEG-SWNT PBS+NIR PEG-SWNT+NIR

NH2(OCH2CH3)45N CO

H

O

OO

O

OO

OOP

Biosensori

Nanotubi nell’ingegneria tessutale

Osteoblasti

Crescita cellulare ALP

Deposizione matrice di calcio Osteopontina

Cardiomiociti

Decontaminazione mediata da nanotubi

Hydrogel

Ingegneria tessutaleImaging

Applicazioni Hydrogel-CNT

BiosensoriCNTs@MNPs@ mSiO2

BibliografiaAlberto Bianco, Kostas Kostarelos and Maurizio Prato,Making carbon nanotubes biocompatible and biodegradable ChemComm 2011

Ken Donaldson, Craig A. Poland, Fiona A. Murphy, Marion MacFarlane, Tatyana Chernova, Anja Schinwald, Pulmonary toxicity of carbon nanotubes and asbestos — Similarities and differences, Elsevier 2013

Ruchir V Mundra, Xia Wu, Jeremy Sauer, Jonathan S Dordick and Ravi S Kane, Nanotubes in biological application, Elsevier 2014

Wenrong Yang, Pall Thordarson, J Justin Gooding, Simon P Ringer and Filip Braet, Carbon nanotubes for biological and biomedical applications, chem rev 2007

Neelesh Kumar Mehra and Srinath Palakurthi, Interactions between carbon nanotubes and bioactives: a drug delivery perspective, drug discovery today 2016

Mingxian Liu, Zhixin Jia, Demin Jia, Changren Zhou, Recent advance in research on halloysite nanotubes-polymer nanocomposite, Elsevier 2014

Jing Ren, Quanfu Xu, Xiaomeng Chen, Wei Li, Kai Guo, Yang Zhao, Qian Wang, Zhitao Zhang, Huisheng Peng,* and Yi-Gang Li, Superaligned Carbon Nanotubes Guide Oriented Cell Growth and Promote Electrophysiological Homogeneity for Synthetic Cardiac Tissues, Adv. Mater. 2017

Ravindra C. Pangule, Sarah J. Brooks, Cerasela Zoica Dinu, Shyam Sundhar Bale, Sharon L. Salmon, Guangyu Zhu, Dennis W. Metzger, Ravi S. Kane, and Jonathan S. Dordick, Antistaphylococcal Nanocomposite Films Based on Enzyme ︎Nanotube Conjugates, Americal Chemical Society

Gustavo Zelada-Guille ́n, Ailis Tweed-Kent, Moritz Niemann, H.Ulrich Go ̈ringer ,Jordi Riu, F. Xavier Rius, Ultrasensitive and real-time detection of proteins in blood using a potentiometric carbon-nanotube aptasensor Elsevier 2012

Arti Vashist, Ajeet Kaushik, Atul Vashist, Vidya Sagar, Anujit Ghosal, Y. K. Gupta, Sharif Ahmad, and Madhavan Nair, Advances in Carbon Nanotubes–Hydrogel Hybrids in Nanomedicine for Therapeutics, Adv. Healthcare Mater. 2018

Balaji Sitharaman, Pramod K. Avti, Kenneth Schaefer, Yahfi Talukdar and Jon P. Longtin, A Novel Nanoparticle-Enhanced Photoacoustic Stimulus for Bone Tissue Engineering, Tissue Engineering 2011