Best PracticesThe conundrum of “appropriate data” in biomedical

modeling

Bill Lytton

SUNY Downstate

Mar 7, 2019 11:20

Many parameters

Main local and long-range excitatory connections

L1

L4

L2/3

L5A

L5B

L6

Motor-related Inputs

Sensory-related inputsPT CTIT

Thalamus

Pyramidaltract

A B

Lytton (DMC) Best Practices Mar 7, 2019 11:20 2 / 8

Splitters vs Lumpers

Lytton (DMC) Best Practices Mar 7, 2019 11:20 3 / 8

Chemophysiology ↔ electrophysiology

Lytton (DMC) Best Practices Mar 7, 2019 11:20 4 / 8

Neural scales overlap

Lytton (DMC) Best Practices Mar 7, 2019 11:20 5 / 8

Parameters don’t play nice together

Lytton (DMC) Best Practices Mar 7, 2019 11:20 6 / 8

Original parameters from 1980s

Lytton (DMC) Best Practices Mar 7, 2019 11:20 7 / 8

Parameter exploration & provenancetracking (ICGenealogy)

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