Benefits of PGxOne™ Plus

• Recommendations for drugs acrossmultiple therapeutic areas, includingcardiology, pain, psychiatry andoncology

• Life Time Utility

• Easy sample collection:buccal swab, mouth wash,saliva or blood.

• Clear, color-coded, concise reporting

E: keypsychiatry@gmail.com

T: 305-439-0085

240 Crandon Blvd. Ste. 230Key Biscayne, Florida 33149

Are Your Medications On Target?

Ask Your Physician About PGxOne™ Plus Testing.

A pharmacogenomics test that determine which medication is most compatible based

on a individual’s genetic makeup

Learn about PGxOneTM Plus testing www.gentoxmedicalservices.com

2016 Technology Innovation Award

2016 Trailblazer Award

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PGxOneTM Plus Report for Smith, JohnLaboratory Director: Dr. James Dermody CLIS ID: 0005783 CLIA ID: 31D2038676 Page 2 of 20

ActionDrug Impacted

Clinical InterpretationGene

GenotypePhenotypePatient Specific Genotype Results

and Comprehensive Drug Information for

Smith, John

ICD-9: 272.4 OTHER AND UNSPECIFIED HYPERLIPIDEMIA;276.7 HYPERPOTASSEMIA;410.10 ACUTE MYOCARDIAL INFARCTION OF OTHER

ANTERIOR WALL EPISODE OF CARE UNSPECIFIED;433.10 OCCLUSION AND STENOSIS OF CAROTID ARTERY WITHOUT CEREBRAL

INFARCTION;434.91 CEREBRAL ARTERY OCCLUSION UNSPECIFIED WITH CEREBRAL INFARCTION;790.29 OTHER ABNORMAL GLUCOSE

ActionDrug Impacted

Clinical InterpretationGene

GenotypePhenotype

Antiplatelets:

Clopidogrel (Plavix®)CONSIDER

ALTERNATIVES

CYP2C19*1/*2

Intermediate Metabolizer

Beta Blockers:

Metoprolol (Lopressor®)CONSIDER

ALTERNATIVES

(e.g., bisoprolol,

carvedilol)

OR

DECREASE DOSE

by 50% due to heart

failure caused by the

decreased drug

cardioselectivity

CYP2D6

*1/*4xN

Intermediate Metabolizer

Statins:Simvastatin (Zocor®)

CONSIDER

ALTERNATIVES

OR

DECREASE DOSE

to 40mg daily

SLCO1B1*1/*5

Intermediate Activity

Statins:Atorvastatin (Lipitor®),

Pitavastatin (Livalo®),

Pravastatin (Pravachol®),

Rosuvastatin (Crestor®)

DECREASE DOSESLCO1B1

*1/*5Intermediate Activity

Anticoagulants:

Phenprocoumon

(Marcoumar®)

INCREASE DOSECYP4F2

*1/*3Intermediate Metabolizer

Selective Serotonin

Reuptake Inhibitors

(SSRIs):Fluoxetine (Prozac®),

Fluvoxamine (Luvox®),

Paroxetine (Paxil®)

USE CAUTION

due to elevated risk for

drug overdose resulting

in adverse events and

drug interaction

CYP2D6*1/*4xN

Intermediate Metabolizer

Anticoagulants:

Rivaroxaban (Xarelto®)NORMAL RESPONSE

EXPECTED

CYP3A4*1A/*1A

Normal Metabolizer

50 GenesCoverage of ~200 Genetic VariantsOver 300 Commercial Drugss

TRADITIONAL TREATMENT PERSONALIZED MEDICINE“One Size Fits All”

Same Prescription and Standard Dose for All“Pharmacogenomics”

Individualized Drug Therapy, a More Personalized Treatment

INCREASEDOSE

DECREASEDOSE

PROCEEDwith CAUTION

CONSIDERALTERNATIVE

NORMALRESPONSEEXPECTED

Disease Diagnosis

Patient Group

What is Pharmacogenomics Testing?

Analysis of gene variants that influence how a person responds to medications.

• Reduces the need for trial-and-errortreatment planning

• Maximizes drug efficacy whileminimizing adverse drug reactions

• Highly recommended for any patients takingmultiple medications

To view a PGxOne™ Plus sample report visit gentoxmedicalservices.com

PGxOneTM Plus is a clinical pharmacogenomics test that guides physicians’ treatment decisions based on a patient’s genetic profile.

Advanced molecular diagnostics company focused on precision medicine.

To learn more about product portfolio visit

www.gentoxmedicalservices.com

Cardiovascular Test PortfolioRisk Assessment, Disease Diagnosis and Treatment for Cardiovascular Diseases

PGxOne™ Plus Pharmacogenomics Testing to Predict a Patient’s Drug Response

Oncology Test PortfolioTumor Profiling to Guide Selection of Targeted Therapies

Gentox Medical Who We Are

• Predicts patient’s response to select the right drugs

• Improve quality of life

P Right Drug

P Right Dose

P Right Time

P Right Indication