News 1/2012 Biomedicine. 11 A. M. Aartsma-Rus, Leiden University Medical Center, The Netherlands (Ed) Exon Skipping Methods and Protocols Contents DNA Diagnostics and Exon Skipping.-Bio- informatics and Mutations Leading to Exon Skipping.-Minigenes to Confirm Exon Skip- ping Mutations.-Analysis and Interpretation of RNA Splicing Alterations in Genes Involved in Genetic Disorders.-Exon Skipping Mutations in Neurofibromatosis.-Overview on Applications of Antisense-mediated Exon Skipping.-Overview on DMD Exon Skipping.-Overview on AON Design.- Optimizing RNA/ENA Chimeric Antisense Oli- gonucleotides Using in vitro Splicing.-Optimizing Antisense Oligonucleotides using Phosphorodia- midate Morpholino Oligomers.-Optimizing Splice Switching Oligomer Sequences using 2’-O-methyl Phosphorothioate Chemistry.-Exon Skipping Quantification by Real Time PCR.-Antisense- mediated Exon Skipping to Shiſt Alternative Splicing to Treat Cancer.-Antisense-mediated Exon Skipping to Generate Soluble Receptors.- Antisense-mediated Exon Skipping to Reframe Transcripts.-U1 snRNA as an Effective Vector for Stable Expression of Antisense Molecules andfor the Inhibition of the Splicing Reaction.-Enginee- ring U7snRNA Gene to Reframe Transcripts.-Dy- namic Fluorescent and Luminescent Reporters for Cell Based Splicing Screens.-Antisense-mediated Exon Skipping to Induce Gene Knockdown.- Antisense-mediated Exon Inclusion.-Antisense Genes to Induce Exon Inclusion.-Using Mini-ge- nes to Identify Factors that Modulate Alternative Splicing.-Overview of Alternative Oligonucleotide Chemistries for Exon Skipping.-Identification of Peptides for Tissue Specific Delivery .-Systemic Delivery of Antisense Oligomer in Animal Models and its Implications for Treating DMD. [...] Fields of interest Human Genetics Target groups Professional/practitioner Product category Contributed volume Due April 2012 2012. X, 498 p. 70 illus., 15 in color. (Methods in Molecular Biology, Volume 867) Hardcover 7 * € (D) 117,65 | € (A) 120,95 | sFr 146,50 7 € 109,95 | £99.00 ISBN 978-1-61779-766-8 9<HTMGMH=hjhggi> M. Balls, FRAME, Nottingham, UK; R. D. Combes, Independent Consultant, Norwich, UK; N. Bhogal, Independent Consultant, Nottingham, UK (Eds) New Technologies for Toxicity Testing e central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced tech- niques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Features 7 Provides valuable and detailed insight into many of the latest techniques 7 Describes several techniques, which broaden the range and improve the sensitivity and relevance of toxicity endpoints, investigated both in vitro and in vivo 7 Introdu- ces new methods and systems Contents Current Developments in Cell Culture Technolo- gy.- Embryonic Stem Cells in Safety Pharmacology and Toxicology.- Trends in Cell Culture Techno- logy.- Tissue Engineering in the Development of Replacement Technologies.- Toxicity Testing of Nanomaterials.- Physiologically-Based Pharma- cokinetic (PBPK) Models in Toxicity Testing and Risk Assessment.- In Silico Methods for Toxicity Prediction.- Luminescent Quantum Dots for Molecular Toxicology.- Engineering Quasi-Vivo® In-Vitro Organ Models.- ECVAM and New Tech- nologies for Toxicity Testing.- Medium to High roughput Screening: Microfabricat ion and Chip-Based Technology.- e Use of Genomics in Model In Vitro Systems.- e Use of Integrated and Intelligent Testing Strategies in the Prediction of Toxic Hazard and in Risk Assessment. Fields of interests Pharmacology/Toxicology; Biomedicine general Target groups Professional/practitioner Product category Contributed volume Due March 2012 2012. XXVIII, 245 p. 65 illus., 3 in color. (Advances in Experimental Medicine and Biology, Volume 745) Hardcover 7 approx. * € (D) 149,75 | € (A) 153,94 | sFr 186,50 7 approx. € 139,95 | £126.50 ISBN 978-1-4614-3054-4 9<HTMERB=edafee> R. M. Bill, Aston University, Birmingham, UK (Ed) Recombinant Protein Production in Yeast Methods and Protocols Contents Optimising Yeast as a Host for Recombinant Protein Production( review).-Which Yeast Species Shall I Choose? Saccharomyces cerevisiae versus Pichia pastoris (review).-Preparation of Pichia pastoris Expression Plasmids.-Preparation of Saccharomyces cerevisiae Expression Plasmids.- Codon Optimisation for Heterologous Gene Expression in Yeast.-Yeast Transformation to Generate High-yielding Clones.-Screening for High-yielding Pichia pastoris Clones: the Produc- tion of G Protein-Coupled Receptors as a Case Study.-Screening for High-yielding Saccharomyces cerevisiae Clones: Using a Green Fluorescent Pro- tein Fusion Strategy in the Production of Membra- ne Proteins.-e Effect of Antifoam Addition on Protein Production Yields.-Setting up a Bioreactor for Recombinant Protein Production in Yeast.-e Implementation of a Design of Experiments Stra- tegy to Increase Recombinant Protein Yields in Yeast (review).-On-line Analysis and Process Con- trol in Recombinant Protein Production (review).- Monitoring the Biomass Accumulation of Recom- binant Yeast Cultures: Off-line Estimations of Dry Cell Mass and Cell Counts.-On-line Monitoring of Biomass Accumulation in Recombinant Yeast Cultures.-Optimising P. pastoris Induction-Op- timizing S. cerevisiae Induction Regimes.-Large Scale Production of Membrane Proteins in Pichia pastoris: e Production of G Protein-coupled Re- ceptors as a Case Study.-Large-scale Production of Membrane Proteins in Saccharomyces cerevisiae: Using a Green Fluorescent Protein Fusion Strategy in the Production of Membrane Proteinsl. [...] Fields of interest Human Genetics Target groups Professional/practitioner Product category Contributed volume Due April 2012 2012. X, 270 p. 46 illus., 20 in color. (Methods in Molecular Biology, Volume 866) Hardcover 7 * € (D) 101,60 | € (A) 104,45 | sFr 126,50 7 € 94,95 | £85.50 ISBN 978-1-61779-769-9 9<HTMGMH=hjhgjj>
Transcript
News 1/2012 Biomedicine.
11
A. M. Aartsma-Rus, Leiden University Medical Center, The Netherlands (Ed)
Exon SkippingMethods and Protocols
Contents DNA Diagnostics and Exon Skipping.-Bio-informatics and Mutations Leading to Exon Skipping.-Minigenes to Confirm Exon Skip-ping Mutations.-Analysis and Interpretation of RNA Splicing Alterations in Genes Involved in Genetic Disorders.-Exon Skipping Mutations in Neurofibromatosis.-Overview on Applications of Antisense-mediated Exon Skipping.-Overview on DMD Exon Skipping.-Overview on AON Design.-Optimizing RNA/ENA Chimeric Antisense Oli-gonucleotides Using in vitro Splicing.-Optimizing Antisense Oligonucleotides using Phosphorodia-midate Morpholino Oligomers.-Optimizing Splice Switching Oligomer Sequences using 2’-O-methyl Phosphorothioate Chemistry.-Exon Skipping Quantification by Real Time PCR.-Antisense-mediated Exon Skipping to Shift Alternative Splicing to Treat Cancer.-Antisense-mediated Exon Skipping to Generate Soluble Receptors.-Antisense-mediated Exon Skipping to Reframe Transcripts.-U1 snRNA as an Effective Vector for Stable Expression of Antisense Molecules andfor the Inhibition of the Splicing Reaction.-Enginee-ring U7snRNA Gene to Reframe Transcripts.-Dy-namic Fluorescent and Luminescent Reporters for Cell Based Splicing Screens.-Antisense-mediated Exon Skipping to Induce Gene Knockdown.-Antisense-mediated Exon Inclusion.-Antisense Genes to Induce Exon Inclusion.-Using Mini-ge-nes to Identify Factors that Modulate Alternative Splicing.-Overview of Alternative Oligonucleotide Chemistries for Exon Skipping.-Identification of Peptides for Tissue Specific Delivery .-Systemic Delivery of Antisense Oligomer in Animal Models and its Implications for Treating DMD. [...]
M. Balls, FRAME, Nottingham, UK; R. D. Combes, Independent Consultant, Norwich, UK; N. Bhogal, Independent Consultant, Nottingham, UK (Eds)
New Technologies for Toxicity TestingThe central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced tech-niques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment.
Features 7 Provides valuable and detailed insight into many of the latest techniques 7 Describes several techniques, which broaden the range and improve the sensitivity and relevance of toxicity endpoints, investigated both in vitro and in vivo 7 Introdu-ces new methods and systems
Contents Current Developments in Cell Culture Technolo-gy.- Embryonic Stem Cells in Safety Pharmacology and Toxicology.- Trends in Cell Culture Techno-logy.- Tissue Engineering in the Development of Replacement Technologies.- Toxicity Testing of Nanomaterials.- Physiologically-Based Pharma-cokinetic (PBPK) Models in Toxicity Testing and Risk Assessment.- In Silico Methods for Toxicity Prediction.- Luminescent Quantum Dots for Molecular Toxicology.- Engineering Quasi-Vivo® In-Vitro Organ Models.- ECVAM and New Tech-nologies for Toxicity Testing.- Medium to High Throughput Screening: Microfabricat ion and Chip-Based Technology.- The Use of Genomics in Model In Vitro Systems.- The Use of Integrated and Intelligent Testing Strategies in the Prediction of Toxic Hazard and in Risk Assessment.
Fields of interestsPharmacology/Toxicology; Biomedicine general
Target groupsProfessional/practitioner
Product categoryContributed volume
Due March 2012
2012. XXVIII, 245 p. 65 illus., 3 in color. (Advances in Experimental Medicine and Biology, Volume 745) Hardcover7 approx. * € (D) 149,75 | € (A) 153,94 | sFr 186,507 approx. € 139,95 | £126.50ISBN 978-1-4614-3054-4
9<HTMERB=edafee>
R. M. Bill, Aston University, Birmingham, UK (Ed)
Recombinant Protein Production in YeastMethods and Protocols
Contents Optimising Yeast as a Host for Recombinant Protein Production( review).-Which Yeast Species Shall I Choose? Saccharomyces cerevisiae versus Pichia pastoris (review).-Preparation of Pichia pastoris Expression Plasmids.-Preparation of Saccharomyces cerevisiae Expression Plasmids.-Codon Optimisation for Heterologous Gene Expression in Yeast.-Yeast Transformation to Generate High-yielding Clones.-Screening for High-yielding Pichia pastoris Clones: the Produc-tion of G Protein-Coupled Receptors as a Case Study.-Screening for High-yielding Saccharomyces cerevisiae Clones: Using a Green Fluorescent Pro-tein Fusion Strategy in the Production of Membra-ne Proteins.-The Effect of Antifoam Addition on Protein Production Yields.-Setting up a Bioreactor for Recombinant Protein Production in Yeast.-The Implementation of a Design of Experiments Stra-tegy to Increase Recombinant Protein Yields in Yeast (review).-On-line Analysis and Process Con-trol in Recombinant Protein Production (review).-Monitoring the Biomass Accumulation of Recom-binant Yeast Cultures: Off-line Estimations of Dry Cell Mass and Cell Counts.-On-line Monitoring of Biomass Accumulation in Recombinant Yeast Cultures.-Optimising P. pastoris Induction-Op-timizing S. cerevisiae Induction Regimes.-Large Scale Production of Membrane Proteins in Pichia pastoris: The Production of G Protein-coupled Re-ceptors as a Case Study.-Large-scale Production of Membrane Proteins in Saccharomyces cerevisiae: Using a Green Fluorescent Protein Fusion Strategy in the Production of Membrane Proteinsl. [...]
J. Chen, University of Pittsburgh, PA, USA; X.-M. Xu, Z. C. Xu, Indiana University, Indianapolis, IN, USA; J. H. Zhang, Loma Linda University, CA, USA (Eds)
Animal Models of Acute Neurological Injuries IIInjury and Mechanistic Assessments, Volume 1
Contents Histopathological Assessments of Animal Mo-dels of Cerebral Ischemia.- Assessment of Cell Death: Apoptosis, Necrosis, or In Between.- The Stereology and 3D Volume Analyses in Nervous Tissue.- Assessments of Reactive Astrogliosis Fol-lowing CNS Injuries.- Physiological Assessment in Stroke Research.- EEG, Evoked Potential (EP), and Extracellular Single Unit Recordings In Vivo.- Intracellular Recording In Vivo and Patch-Clamp Recording on Brain Slices.- Electrophysiological Evaluation of Synaptic Plasticity in Injured CNS.- Characterization of RNA.- MicroRNA Expression Profiling of Rat Blood and Brain Tissues: TaqMan Real-Time PCR MicroRNA Assays.- Protein Analysis.- Application of Zymographic Methods to Study Matrix Enzymes Following Traumatic Brain Injury.- Rodent Behavioral Assessment in the Home Cage Using the SmartCageTM System.- Assessments of Cognitive Function Following Traumatic Brain Injury.- Assessment of Cognitive and Sensorimotor Deficits.- Emotional and Anxie-ty Assessments in CNS Disorders.- Neuroimaging Assessment of Traumatic Brain Injury.- Imaging of Myelin by Coherent Anti-Stokes Raman Scattering Microscopy.- Grading Scales for Subarachnoid Hemorrhage.- Acute Physiologic and Morphologic Assessment Following Subarachnoid Hemor-rhage.- Aneurysmal Subarachnoid Hemorrhage Grading in Animal Models.- Physiological Assess-ments of Subarachnoid Hemorrhage.- Spreading Depolarization. [...]
Fields of interestsNeurosciences; Neurology; Animal Models
J. Chen, University of Pittsburgh, PA, USA; X.-M. Xu, Z. C. Xu, Indiana University, Indianapolis, IN, USA; J. H. Zhang, Loma Linda University, CA, USA (Eds)
Animal Models of Acute Neurological Injuries IIInjury and Mechanistic Assessments, Volume 2
Contents Introduction (Parts I-III).- Morphological Assessments of Global Cerebral Ischemia: Viable Cells.- Morphological Assessments of Global Cerebral Ischemia: Degenerated Cells.- Morpho-logical Assessments of Global Cerebral Ischemia: Electron Microscopy.- Biochemical and Mole-cular Biological Assessments of Global Cerebral Ischemia: mRNA.- Biochemical and Molecular Biological Assessments of Global Cerebral Ische-mia: Protein.- Neurobehavioral Assessments of Global Cerebral Ischemia.- Assessment of Neuro-genesis in the Dentate Gyrus after Global or Focal Ischemia.- Infarct Measurement in Focal Cerebral Ischemia: TTC Staining.- Morphological Assess-ments of Focal Cerebral Ischemia: White Matter Injury.- Blood Flow Reduction: Laser Doppler, 14C-IAP.- Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: mRNA and MicroRNA.- Biochemical and Molecular Bio-logical Assessments of Focal Cerebral Ischemia: Protein.- Assessments of Inflammation After Focal Cerebral Ischemia.- Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit.- Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit.- Assessment of Neu-rogenesis in Models of Focal Cerebral Ischemia.- Assessment of Angiogenesis in Models of Focal Cerebral Ischemia.- Morphological Assessments of Neonatal Hypoxia-Ischemia: In Situ Cell Dege-neration.- Morphological Assessments of Neonatal Hypoxia-Ischemia: White Matter Injury. [...]
Fields of interestsNeurosciences; Neurology; Animal Models
J. F. Cryan, University College Cork, Ireland; A. Reif, University of Würzburg, Germany (Eds)
Behavioral NeurogeneticsThis book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disor-ders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodeve-lopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
Features 7 Important volume on neurobehavioral genetics 7 Written by leading experts in the field 7 With numerous illustrations
Contents Preface.- Part I. Preclinical Behavioral Genetics.- Part II. Clinical Behavioral Genetics.
Fields of interestsNeurosciences; Psychiatry; Psychopharmacology
Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, H. Koprowski, F. Melchers Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Y. Gleba, B. Malissen, K. Aktories
Volume 357
N. Mantis, Wadsworth Center, Albany, NY, USA (Ed)
Ricin and Shiga ToxinsPathogenesis, Immunity, Vaccines and Therapeutics
In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is cer-tainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventa-tives or therapeutics for ricin toxin.
Contents Preface.- Interaction of ricin and Stx with riboso-mes and the sarcin-ricin loop.- How ricin and Stx enter and intoxicate mammalian cells.- Cellular stress response to Stx-ricin.- Ricin and Stx-Inflam-mation.- Pathogenesis of shiga-toxin producing E.coli.- Ricin and Stx-Interactions with the epi-thelium and intestinal mucosa.- Stx Pathogenesis-Kidney complications and renal failure.- Toxin-induced Apoptosis.- Small Molecule Inhibitors of Ricin and STX.- Antibody-mediated immunity to ricin.- Stx-animal models and immunotherapies.- Ricin- animal models and immunotherapies.- Ri-cin Vaccine Development.- Subject Index
T. Fellin, Italian Institute of Technology, Genova, Italy; M. Halassa, Massachusetts General Hospital, Boston, MA, USA (Eds)
Neuronal Network AnalysisConcepts and Experimental Approaches
Contents Optical Interrogation of Neural Circuits.- In Vivo Functional Imaging of the Olfactory Bulb at Single Cell Resolution.- Two-Photon Imaging of Neural Activity in Awake, Head-Fixed Mice.- Spatial Light Modulators for Complex Spatio-Temporal Illumination of Neuronal Networks.- Voltage-Sen-sitive Dye Imaging of Cortical Function In Vivo.- An Introduction to In Vitro Slice Approaches for the Study of Neuronal Circuitry.- Extracellular Recordings of Synaptic Plasticity and Network Oscillations in Hippocampal Slices.- Use of Dynamic-Clamp as a Tool to Reveal the Compu-tational Properties of Single Neurons Embedded in Cortical Circuits.- Fast Perfusion Methods for the Study of Ligand-Gated Ion Channels.- Electro-physiological Approaches for Studying Neuronal Circuits In Vivo.- Determination of Cortical Circuit Function Using Current Source-Density (CSD) Analysis In Vivo.- Intracellular Whole-Cell Patch-Clamp Recordings of Cortical Neurons in Awake Head-Restrained Mice.- Investigating Sleep Homeostasis with Extracellular Recording of Multiunit Activity from the Neocortex in Freely-Behaving Rats.- Analysis of Hippocampal Memory Replay Using Neural Population Decoding.- High Speed Videography of Embodied Active Sensing in the Rodent Whisker System.- Light-Activated Ion Pumps and Channels for Temporally-Precise Optical Control of Activity in Genetically-Targeted Neurons.- Integrated Optogenetic and Electrophysiological Dissection of Local Cortical Circuits In Vivo.- Combining Optical Stimulation with Extracellular Electrophysiology in Behaving Mice. [...]
Fields of interestsNeurosciences; Human Physiology
JIMD Reports Society for the Study of Inborn Errors o (Ed)
Volume 4
Society for the Study of Inborn Errors o, SSIEM, London, UK (Ed)
JIMD Reports – Case and Research Reports, 2012/1JIMD Reports publishes case and short re-search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to me-tabolic disorders 7 All contributions rigorously peer-reviewed
Contents Different Case Reports.
Fields of interestsHuman Genetics; Metabolic Diseases; Pediatrics
M. Levite, The Academic College of Tel Aviv, Israel (Ed)
Nerve-Driven ImmunityNeurotransmitters and Neuropeptides in the Immune System
Contents Mia Levite: Dopamine in the immune system: Dopamine receptors in immune cells, potent effects, endogenous production and involvement in immune and neuropsychiatric diseases.- Marco Cosentino and Franca Marino: Nerve driven immunity - Noradrenaline and adrenalina.- Eran Nizri and Talma Brenner: Acetylcholine and Cholinergic modulation of immune responses.- Yonatan Ganor and Mia Levite: Glutamate in the immune system: glutamate receptors in immune cells, potent effects, endogenous production and involvement in disease.- Zhe Jin, Suresh Kumar Mendu, Amol Bhandage and Bryndis Birnir: GABA is an effective immunomodulatory molecule in the brain and in the periphery.- Jana Ninković and Sabita Roy: The Effects of Opioids on Immune Cells, Functions and Diseases.- Too-mas Talme and Karl-Gösta Sundqvist: The effects of Somatostatin on immune cells, functions and diseases.- Mirjana Dimitrijević and Stanisla-va Stanojević: Neuropeptide Y – the story, the players, the outcomes.- Mario Delgado and Doina Ganea: Vasoactive Intestinal Peptide: Immune me-diator and potential therapeutic agent.- Bernhard Holzmann: Nerve-driven immunity - The effects of neurotransmitters on immune cells, functions and disease. CGRP.- Radu Tanasescu and Cris S. Constantinescu: The effects of Cannabinoids on immune cells, responses and diseases.
Fields of interestsImmunology; Neurochemistry; Neurosciences
Y. V. Li, Ohio University, Athens, OH, USA; J. H. Zhang, Loma Linda University School of Medicine, CA, USA (Eds)
Metal Ion in StrokeContents Preface.- Metal Ions In Stroke Pathophysiology.- Mechanisms Of Calcium Influx Following Stroke.- Mitochondrial Ca2+ Dysregulation During Stroke And Cell Death.- Calcium Channel Blockers And Stroke Prevention.- Calcium Dyshomeostasis In Astrocytes After Ischemia.- Calcium Signaling At The Blood-Brain Barrier In Stroke.- Zinc Overload In Stroke.- Intracellular Zinc Liberation: A Trigger For Oxidative Stress Induced Toxicity To Neurons And Neuroglia.- Zinc In Stroke: Time For A New Approach?.- Exploring The Zinc Metallome Of Cultured Cortical Neurons Using Synchroton Radiation X-Ray Fluorescence Microscopy.- Iron Neurotoxicity In Ischemic And Hemorrhagic Stro-ke.- Implication Of Oxidative Stress And “Labile Iron” In The Molecular Mechanisms Of Ischemic Stroke.- The Role Of Iron In Brain Following Sub-arachnoid Hemorrhage.- Iron Chelating Therapy In Stroke.- Iron Chelating Therapy In Stroke.- The Role Of Na+/Ca2+ Countertransport And Other Na+-Entry Routes In The Pathophysiology Of Stroke.- Sodium And Potassium MRI In Cerebral Ischemia.- The Impact Of Extracellular Potas-sium Accumulation In Stroke.- Potassium And Mitochondria.- Role Of A Changing Membrane Potential (Em) And Matching Blood Flow With Neuronal Activity.- The Role Of Potassium In Stroke, Cardiovascular Disease And Hyperten-sion.- The Role Of Magnesium In The Patho-physiology And Treatment Of Stroke And Other Neurological Injuries.- The Role Of Magnesium In The Pathophysiology And Treatment Of Stroke And Other Neurological Injuries.- Magnesium And Neuroprotection In Stroke. [...]
Fields of interestNeurosciences
Target groupsGraduate
Product categoryContributed volume
Due May 2012
2012. XIV, 843 p. 93 illus., 66 in color. (Springer Series in Translational Stroke Research) Hardcover7 approx. * € (D) 192,55 | € (A) 197,94 | sFr 236,007 approx. € 179,95 | £159.50ISBN 978-1-4419-9662-6
9<HTMEPB=jjggcg>
A. K. Patra, West Bengal University of Animal and Fishery Sciences, Kolkata, India (Ed)
Dietary Phytochemicals and Microbes
Features 7 Presents comprehensive reviews on the effects of various phytochemicals on microbes 7 Focu-ses on exploitation of antimicrobial properties of phytochemicals against drug-resistant pathogenic microbes 7 Contains information on the utiliza-tion of antimicrobial properties of phytochemicals in herbs for food preservation 7 Features the ef-fects of phytochemicals on beneficial and harmful microbes of the gastrointestinal tract of humans and animals
Contents List of contributors.- Preface .- 1 An overview of antimicrobial properties of different classes of phytochemicals.- 2 Antimicrobial properties of flavonoids.- 3 Antiviral properties of Phytoche-micals.- 4 Antimicrobial properties of organo-sulfur compounds.- 5 Antimicrobial activities of essential oils.- 6 Phytochemicals against drug-resistant microbes.- 7 Phytochemicals as anti-microbial food preservatives.- 8 Dietary tannins on microbial ecology of the gastrointesti-nal tract in ruminants.- 9 Manipulating ruminal biohydrogenation by the use of plants bioactive compounds.- 10 Essentials oils and rumen micro-bial populations.- 11 Saponins: effects on rumen microbial ecosystem and metabolism in the ru-men.- 12 Effect of plant secondary metabolites on rumen methanogens and methane emissions by ruminants.- 13 Phytochemicals and gut microbial populations in non-ruminants.- Index.
Fields of interestsBiomedicine general; Science, general; Life Scien-ces, general
S. A. Rifkin, University of Californa, San Diego, CA, USA (Ed)
Quantitative Trait Loci (QTL)Methods and Protocols
Features 7 A practical resource for researchers interested in link between phenotypic and genotypic varia-tion 7 Provides step-by-step detail essentail for reproducible results 7 Contains key notes and implementation advice from the experts
Contents Backcross Populations and Near Isogenic Lines.-F2 Designs for QTL Analysis.-Design and Construction of Recombinant Inbred Lines.-Two Flavors of Bulk Segregant Analysis in Yeast.-Selecting Markers and Evaluating Coverage.-Com-posite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer.-Design Database for Quantitative Trait Loci (QTL) Data Warehouse, Data Mining and Meta Analysis.-Meta-Analysis of QTL Mapping Experiments.-Using eQTLs to Reconstruct Gene Regulatory Networks.-Estimation and Interpretation of Genetic Effects with Epistasis using the NOIA Model.-Identifying QTL for Multiple Complex Traits in Experimental Crosses.-Functional Mapping of Developmental Processes：Theory, Applications and Prospects.-Statistical Models for Genetic Mapping in Polyplo-ids: Challenges and Opportunities.-eQTL.-Genetic Mapping of Quantitative Trait Loci for Disease-Related Phenotypes.-Quantitative Trait Locus Analysis in Haplodiploid Hymenoptera.
S. D. Sarker, University of Wolverhampton, UK; L. Nahar, De Montfort University, Leicester, UK (Eds)
Natural Products Isolation
Features 7 Reflects the significant progress made in natu-ral materials isolation and extraction 7 Features detailed methods and protocols tested and proven in labs around the world 7 Includes expert tips and key implementation advice to ensure success-ful results
Contents An Introduction to Natural Products Isolation.- Initial and Bulk Extraction of Natural Products Isolation.- Supercritical Fluid Extraction in Natural Products Analyses.- Accelerated Solvent Extraction (ASE®) for Natural Products Isolati-on.- Microwave-Assisted Extraction in Natural Products Isolation.- An Introduction to Planar Chromatography and Its Application to Natural Products Isolation.- Isolation of Natural Products by Low-Pressure Column Chromatography.- Isolation of Natural Products by Ion-Exchange Methods.- Separation of Natural Products by Countercurrent Chromatography.- Isolation of Natural Products by Preparative High Perfor-mance Liquid Chromatography (Prep-HPLC).- Isolation of Natural Products by Preparative Gas Chromatography.- Hyphenated Techniques and Their Applications in Natural Products Analy-sis.- Extraction of Plant Secondary Metabolites.- Isolation of Marine Natural Products.- Isolation of Microbial Natural Products.- Extraction and Isolation of Saponins.- Extraction and Isolation of Phenolic Compounds.- Scaling-Up of Natural Products Isolation.- Follow-Up of Natural Pro-ducts Isolation.- Natural Products Isolation in Modern Drug Discovery Programs.
Fields of interestsPharmacology/Toxicology; Medicinal Chemistry
N. T. Ueno, The University of Texas, Houston, TX, USA; M. Cristofanilli, Fox Chase Cancer Center, PA, USA (Eds)
Inflammatory Breast Cancer: An UpdateInflammatory breast cancer is the most deadly subtype of breast cancer because it can spread to other organs despite of multidisciplinary ap-proach. However, the molecular characteristic of this aggressive disease is yet to be established.
Features 7 The latest research of inflammatory breast cancer 7 The latest management of inflammato-ry breast cancer 7 Secret of the most aggressive breast cancer revealed 7 How rare cancer can be tackled in a comprehensive manner 7 Excellent model for studying breast cancer metastasis
Contents Introduction: Why IBC Now.-1. Epidemiology.-2 Diagnosis, Criteria and Controversy.-3 IBC Regis-tration Study.-4 Pathology: Histomorphometrical Features Of IBC: Angiogenesis, Lymphangioge-nesis, and Tumor Emboli.-5 Staging and Ima-ging.-6 Surgery.-7 Radiation Therapy.-8 Systemic Therapies.-9 Metastatic Treatment by Chemothe-rapy.-10 Role of Multidisciplinary Team Formati-on.-11 Role of High-Dose Chemotherapy.-12 Cell Line and Animal Models.-13 Signal Pathway in IBC.-14 Molecules That Drives the Metastasis and Invasion.-15 Inflammation.-16 Immunological Changes.-17 Angiogenesis and Lymphoangioge-nesis.-18 Microarray Analysis Identifies a Peculiar IBC Expression Signature.-19 Stem Cell Gene Expression Signature in IBC.-20 The Effect of Systemic Chemotherapy on Minimal Residual Di-sease in The Blood And Bone Marrow Of Patients With IBC.-21 Patient‘s Perspective.- Index.
Fields of interestsBiomedicine general; Cancer Research; Oncology
A. von Gabain, C. Klade, Intercell AG, Vienna, Austria (Eds)
Development of Novel VaccinesSkills, Knowledge and Translational Technologies
Features 7 Gives an overview from basic research to final product 7 Each chapter is written by author teams from basic research to industry 7 Descri-bes latest findings and applications
Contents Preface.- 1. The immunological fundamentals (Şefik Şanal Alkan).- 2. Finding protective bac-terial antigens (Guido Grandi, Eszter Nagy).- 3. Enhancing and tailoring the immunogenicity of vaccines with novel adjuvants (Christopher B. Fox, Benjamin Wizel, Steven G. Reed, Derek T. O’Hagan).- 4. Vaccine Delivery – beyond needles (Flyer).- 5. Employing live microbes for vaccine delivery (Holger Loessner, Astrid Schwantes, Matthias Hamdorf, Uliana Komor, Sara Leschner, Siegfried Weiss).- 6. Synthesizing vaccines with microbes (Michael Wacker, Danilo R. Casimi-ro).- 7. Purification and formulation: silent but important players in vaccine development (Robert Schlegl, Rainer Hahn).- 8. Cutting edge approa-ches towards novel and cross protective influenza vaccines (Ruth Arnon, Tamar Ben-Yedidia).- 9. Cutting edge approaches towards novel and cross-protective influenza vaccines (Kenny Roose, Michael Schotsaert, Karim El Bakkouri, Bert Sche-pens, Walter Fiers, Xavier Saelens).- 10. Examples of novel registered prophylactic vaccines, HPV & JEV (Katrin Dubischar-Kastner, Michelle Vichnin, Carlos Sattler).- 11. The bumpy road towards vaccine registration – how to overcome regulatory hurdles (Michael Pfleiderer).
Fields of interestsVaccine; Pharmaceutical Sciences/Technology; Immunology
Target groupsResearch
Product categoryContributed volume
Due April 2012
2012. X, 340 p. 52 illus., 30 in color. With online files/update. Hardcover7 * € (D) 160,45 | € (A) 164,94 | sFr 215,007 € 149,95 | £135.00ISBN 978-3-7091-0708-9
9<HTOHLJ=bahaij>
R. Yamanaka, Kyoto Prefectural University of Medicine, Japan (Ed)
GliomaImmunotherapeutic Approaches
Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery.
Features 7 Discusses in depth the potential of innovative methods in the broad field of glioma immunology and immunotherapy 7 Useful for clinicians, cli-nical scientists and basic scientists 7 Reviews the basic and clinical background, and proceeds from basic science at the bench to the bedside to give a realistic evaluation of the immunology and immu-notherapy of glioma 7 Written by internationally distinguished experts working in basic science and clinical neurooncology
Contents Molecular Biology of Glioma.- Recent Surgi-cal Management of Gliomas.- Recent Medical Management of Glioblastoma.- Basic Concepts in Glioma Immunology.- Mechanisms of Immune Evasion by Gliomas.- Glioma Antigen.- Cytokine Therapy.- Immunotherapeutic Approach with Oligodeoxynucleotides Containing CpG Motifs (CpG-ODN) in Malignant Glioma.- Adoptive Cell Transfer Therapy for Malignant Gliomas.- Monoclonal Antibody Therapy for Malignant Glioma.- Animal Models for Vaccine Therapy.- Immunogene Therapy.- Peptide Vaccine.- Active Immunotherapy: Oncolytic Virus Therapy Using HSV- 1.- Dendritic Cell Vaccines.- Antigen-Re-ceptor Gene-Modified T Cells for Treatment of Glioma.- Glioma Stem Cell Research for the Development of Immunotherapy.
Fields of interestsBiomedicine general; Immunology; Cancer Research
Target groupsProfessional/practitioner
Product categoryContributed volume
Due May 2012
2012. XX, 226 p. 34 illus., 1 in color. (Advances in Experimental Medicine and Biology, Volume 746) Hardcover7 approx. * € (D) 149,75 | € (A) 153,94 | sFr 186,507 approx. € 139,95 | £126.50ISBN 978-1-4614-3145-9
