Atropin Dosage Weight Total (mg) Total (ml) 77 014 Atropinsulfat Braun 3.00 0.15 0.30 Syringe (ml) 1.00 3.50 0.18 0.35 Dosage (mg/kg) 0.05 4.00 0.20 0.40 Concentration (mg/ m 0.50 4.50 0.23 0.45 Dosage (ml/kg) 0.10 5.00 0.25 0.50 Description 5.50 0.28 0.55 6.00 0.30 0.60 6.50 0.33 0.65 7.00 0.35 0.70 7.50 0.38 0.75 8.00 0.40 0.80 8.50 0.43 0.85 9.00 0.45 0.90 9.50 0.48 0.95 10.00 0.50 1.00 10.50 0.53 1.05 11.00 0.55 1.10 11.50 0.58 1.15 12.00 0.60 1.20 12.50 0.63 1.25 13.00 0.65 1.30 13.50 0.68 1.35 14.00 0.70 1.40 14.50 0.73 1.45 15.00 0.75 1.50 15.50 0.78 1.55 16.00 0.80 1.60 16.50 0.83 1.65 17.00 0.85 1.70 17.50 0.88 1.75 18.00 0.90 1.80 Class: Anticholinergics Administration: IM or IV Description: It acts directly on the smooth muscles and secretory glands innervated by postganglionic cholinergic nerves, blocking the para- sympathomimetic effects of acetylcholine. Penetrates BB barrier. Usage in the lab: • A • F s preanesthetic to cause mild respiratory stimulation and to inhibit salivary secretions. Administer before or together with Ketamine. or stimulating the heart if the anesthesia is p rolonged. or reversing paralysis in conjunction with the administration of prostigmin to block the muscarinic receptors. Overdose: In case of CNS symptoms (excitement, restlessness, convulsions, psychotic behavior) slowly administer 0.5 to 2 mg physostigmine IV. If needed repeat every 45 to 60 minutes. Storage: Store the solution at controlled room temperature, 15 deg C-25 deg C (59 deg F-77 deg F). • F
Transcript
Atropin
Dosa ge W eig ht Total (mg ) Total (ml)7 7 0 1 4 A tro p insulfa t B ra un 3 .0 0 0 .1 5 0 .3 0S yringe (m l) 1.00 3 .5 0 0 .1 8 0 .3 5Dosa ge (m g/kg) 0.05 4 .0 0 0 .2 0 0 .4 0Conce ntra tion (m g/m 0.50 4 .5 0 0 .2 3 0 .4 5Dosa ge (m l/kg) 0.10 5 .0 0 0 .2 5 0 .5 0D e s criptio n 5 .5 0 0 .2 8 0 .5 5
Cla s s : An t ich olin er gicsAd m in is tra t io n : IM or IVD e s c rip t io n : It a ct s dir ect ly on t h e sm oot h m u sclesa n d secr et or y gla n ds in n er va t ed by post ga n glion icch olin er gic n er ves, block in g t h e pa r a -sym pa th om im et ic effect s of a cetylch olin e. P en et r a t esBB ba r r ier .U s a g e in th e la b:• A
• F
s pr ea n est h et ic t o ca u se m ild r espir a tor yst im u la t ion a n d t o in h ibit sa liva r y secr et ion s.Adm in ist er befor e or t ogeth er wit h Ket a m in e.
or s t im u la t in g t h e h ea r t if t h e a n est h esia ispr olon ged.
or r ever sin g pa r a lysis in con ju n ct ion wit h t h ea dm in ist r a t ion of pr ost igm in t o block t h e m u sca r in icr eceptor s.Ov e rd o s e : In ca se of CN S sym pt om s (excit em en t ,r est lessn ess, con vu lsion s, psych ot ic beh a vior ) s lowlya dm in ist er 0.5 t o 2 m g ph ysost igm in e IV. If n eededr epea t ever y 45 t o 60 m in u t es.S to ra g e : Stor e t h e solu t ion a t con t r olled r oomtem per a t u r e, 15 deg C-25 deg C (59 deg F -77 deg F ).
• F
Baytril (Enrofloxacin)
Dosa ge W eig ht Total (mg ) Total (ml)LL B a ytril 2 ,5 % inj.so lutio n 3 .0 0 0 1 5 .0 0 0 0 .6 0 0S yringe (m l) 5.000 3 .5 0 0 1 7 .5 0 0 0 .7 0 0Dosa ge (m g/kg/da y) 5.000 4 .0 0 0 2 0 .0 0 0 0 .8 0 0Conce ntra tion (m g/m 25.000 4 .5 0 0 2 2 .5 0 0 0 .9 0 0Dosa ge (m l/kg/da y) 0.200 5 .0 0 0 2 5 .0 0 0 1 .0 0 0D e s criptio n 5 .5 0 0 2 7 .5 0 0 1 .1 0 0
Cla s s : An t ibiot icAd m in is tra t io n : IMD e s crip t io n : Ba yt r il (E n r ofloxa cin ) h a s a br oa dr an ge of a ct ivit y, a n d it pen et r a t es a ll t issu es a n d bodyflu ids, in clu din g t he br a in .Ba yt r il is on e of t h e ver y few dr u gs we h a ve t h a t canbe a dm in ist er ed on ce a day, th er eby elim in a t in g t h eneed of in ject in g t h e a n im a l m u lt iple t im es da ily. Itsh ou ld be u sed wh en ever m ild t o m oder a t e in fect ion sa r e n ot iced, an d defin it ely befor e an d a ft er ever ysu r gica l oper a t ion . If t h e an im a l is an esth et ized(du r in g su r ger y) t h e dosa ge can be divided in two orth r ee in ject ion s given ever y few h ou r s.U s a g e in th e la b: U se a ga in st der m a l in fect ion scau sed by su scept ible st r a in s of E sch erich ia coli an dS taph ylococcu s au reu s, t h e 2 m ost com m on ba ct er iaa rou n d t he im pla n t s.S to ra g e : Stor e a t r oom t em per a tu r e.
Class: AntiarrhythmicAdministration: IM or IVDilution: 1:10 with Aq.iniect.Description: For the treatment oftachycardia/hypertension that may occur (1) duringinduction of anesthesia and of endotracheal intubation,(2) during surgery, and (3) on emergence fromanesthesia or in the postoperative period. Analternative drug is the Propranolol hydrochloride,which can be administered at 10-20 mg dose in a periodof 4-6 hours. The drug is compatible w/Dextrose/Ringer’s IV injections, but not compatible withSodium Bicarbonate (5%) solution.Usage in the lab:• •
Tachycardia during the induction phase of anesthesia.Tachycardia during surgery only if anesthesia levels
are appropriate and heart rate increase is unlikely to bedue to pain.
Droperidol (Drehydrobenzperidol)
Dosa ge W eig ht Total (mg ) Total (ml)6 5 0 2 7 Drehyd ro b enzp erid o l (Dro p erid o l) 3 .0 0 0 .6 0 0 .2 4S yringe (m l) 3.00 3 .5 0 0 .7 0 0 .2 8Dosa ge (m g/kg) 0.20 4 .0 0 0 .8 0 0 .3 2Conce ntra tion (m g/m 2.50 4 .5 0 0 .9 0 0 .3 6Dosa ge (m l/kg) 0.08 5 .0 0 1 .0 0 0 .4 0D e s criptio n 5 .5 0 1 .1 0 0 .4 4
Cla s s : An t iem et ic, N eu r olept a n a lget icAd m in is t ra t io n : IVD e s c rip t io n : Dr oper idol pr odu ces m a r k edt r a n qu iliza t ion a n d seda t ion . It a lla ys a ppr eh en siona n d pr ovides a s t a t e of m en t a l det a ch m en t a n din differ en ce wh ile m a in t a in in g a s t a t e of r eflexa ler t n ess.U s a g e in th e la b: We u se it a s a n a n t iem et ic a gen t . I ta n t a gon izesa pom or ph in e in dogs. I t lower s t h e in ciden ce of n a u seaa n d vom it in g du r in gsu r gica l pr ocedu r es a n d pr ovides a n t iem et ic pr ot ect ionin t h e post oper a t ive per iod. F or m on k eys a r edu ceddose a s low a s 2 t o 3 m g per 10 kg is r ecom m en ded forpr em edica t ion or for in du ct ion of a n est h esia .S to ra g e : P r ot ect fr om ligh t . s t or e a t r oomt em per a t u r e 15 deg C-30 deg C (59 deg F -86 deg F ).
Propofol (Disoprivan)
Dosa ge W eig ht Total (mg ) Total (ml)6 5 0 1 2 Diso p riva n 1 % 3 .0 0 6 .0 0 0 .6 0 (2 0 m l via l) 3 .5 0 7 .0 0 0 .7 0S yringe (m l) 5.00 4 .0 0 8 .0 0 0 .8 0Dosa ge (m g/kg) 2.00 4 .5 0 9 .0 0 0 .9 0Conce ntr. (m g/m l) 10.00 5 .0 0 1 0 .0 0 1 .0 0Dosa ge (m l/kg) 0.20 5 .5 0 1 1 .0 0 1 .1 0D e s criptio n 6 .0 0 1 2 .0 0 1 .2 0
Class: AnestheticAdministration: IV (flush)Description: Disoprivan Injection is an intravenoussedative hypnotic agent for use in the induction andmaintenance of anesthesia or sedation.Usage in the lab: Monkeys should be continuouslymonitored for early signs of significant hypotensionand/or bradycardia. Treatment includes increasing therate of intravenous fluid, elevation of lower extremities,use of pressor agents, or administration of atropine.Apnea often occurs during induction and may persistfor more than 60 seconds. Ventilatory support may berequired. Attention should be paid to minimize pain onadministration of Disoprivan Injection. Transient localpain can be minimized if the larger veins of the forearmor leg (e.g. safenous). Pain during intravenous injectionmay also be reduced by prior injection of IV lidocaine (1mL of a 1% solution).Overdose: If overdosage occurs, Disoprivan Injectionadministration should be discontinued immediately.Overdosage is likely to cause cardiorespiratorydepression. Respiratory depression should be treated byartificial ventilation with oxygen.
Dopram (Doxapram)
Dosa ge W eig ht Total (mg ) Total (ml)LL Do x a p ra m -V 3 .0 0 1 5 .0 0 0 .7 5S yringe (m l) 3.00 3 .5 0 1 7 .5 0 0 .8 8Dosa ge (m g/kg) 5.00 4 .0 0 2 0 .0 0 1 .0 0Conce ntra tion (m g/m 20.00 4 .5 0 2 2 .5 0 1 .1 3Dosa ge (m l/kg) 0.25 5 .0 0 2 5 .0 0 1 .2 5D e s criptio n 5 .5 0 2 7 .5 0 1 .3 8
Cla s s : Respir a t or y St im u la n tAd m in is t ra t io n : IM or IVD e s c rip t io n : It pr odu ces r espir a t or y st im u la t ionm edia t ed t h r ou gh t h e per iph er a l ca r ot idch em or eceptor s. As t h e dosa ge level is in cr ea sed, t h ecen t r a l r espir a tor y cen t er s in t h e m edu lla a r est im u la t ed with pr ogr essive st im u la t ion of oth er pa r t sof t h e br a in a n d spin a l cor d.U s a g e in th e la b:• If you a r e su r e you a r e n ot h a vin g pr oblem s w/ t h een dot r a ch . t u be give doxa pr a m t o st im u la t er espir a t ion in m on k eys sh owin g dr u g-in du cedpost a n est h esia r espir a tor y depr ession or a pn ea .
f r espir a t or y depr ession per sist a ft er r ever sin g• Ipa r a lysis in du ced w/ m u scle r ela xa n t dr u gs.
o st im u la t e r espir a t ion , h a st en a r ou sa l, a n d t oen cou r a ge t h e r etu r n of la r yn goph a r yn gea l r eflexes inm on k eys wit h m ild/m oder a t e r espir a t or y a n d CN Sdepr ession du e t o dr u g over dose.Ov e rd o s e : Th er e is n o specific a n t idot e. If seizu r esoccu r give a n y sh or t a ct in g ba r bit u r a t e, lik eth iopen t a l.S to ra g e : Stor e a t Con t r olled Room Tem per a tu r e,Bet ween 15 deg C a n d 30 deg C (59 deg F a n d 86 degF ).
• T
Fentanyl
Dosa ge W eig ht Total (mg ) Total (ml)6 5 0 2 8 F enta nyl 0 ,5 m g C ura m ed 3 .0 0 0 0 .0 0 9 0 .1 8 0S yringe (m l) 1.00 3 .5 0 0 0 .0 1 1 0 .2 1 0Dosa ge (m g/kg) 0.003 4 .0 0 0 0 .0 1 2 0 .2 4 0Conce ntra tion (m g/m 0.05 4 .5 0 0 0 .0 1 4 0 .2 7 0Dosa ge (m l/kg) 0.06 5 .0 0 0 0 .0 1 5 0 .3 0 0D e s criptio n 5 .5 0 0 0 .0 1 7 0 .3 3 0
Cla s s : Opioid An a lgesic, N a r cot icAd m in is t ra t io n : IM or slow IVD e s c rip t io n : F en t a n yl is a sh or t a ct in g n a r cot ica n a lgesic. I t is 100 t im es m or e pot en t t h a n m or ph in e.Th e on set of t h e dr u g is im m edia t e wh en it is given IVa n d t h e du r a t ion of a ct ion of 100 m icr ogr a m s is 30 t o60 m in . F ollowin g IM in ject ion t h e on set is 7 t o 8 m ina n d t h e du r a t ion is 1 t o 2 h r .U s a g e in th e la b: U sed for post su r gica l pa in r elief(in dica t ed for t h e r elief of m oder a t e t o sever e pa in ).Also u sed befor e en dot r a ch ea l in tu ba t ion . To dilu t e itu se isoton ic N a Cl. U se a bolu s of 0.5 m l (cor r espon din gt o 0.025 m g of F en t a n yl) 45 m in u t es befor e su r ger y. Inca se of em esis u se Dr oper idol. Also, u se At r opin e t oa void br a dyca r dia s.Ov e rd o s e : U se Doxa pr a m or N a loxon e.S to ra g e : Avoid excessive h ea t (over 104 deg F or 40deg C). P r ot ect fr om pr olon ged exposu r e t o ligh t .
Dexamethasone (Fortecortin)
Dosa ge W eig ht Total (mg ) Total (ml)3 1 0 2 5 F o rteco rtin M o no 4 3 .0 0 1 .5 0 0 .3 8 (1 m l v ia l) 3 .5 0 1 .7 5 0 .4 4S yringe (m l) 5.00 4 .0 0 2 .0 0 0 .5 0Dosa ge (m g/kg/da y) 0.50 4 .5 0 2 .2 5 0 .5 6Conce ntra tion (m g/m 4.00 5 .0 0 2 .5 0 0 .6 3Dosa ge (m l/kg/da y) 0.13 5 .5 0 2 .7 5 0 .6 9D e s criptio n 6 .0 0 3 .0 0 0 .7 5
Cla s s : Adr en ocor t ica l s t er oidAd m in is t ra t io n : IV or IMD e s c rip t io n : Dexa m eth a son e sodiu m ph osph a t e, asyn th et ic a dr en ocor t ica l st er oid. We u se t h e st er ilein ject ion .U s a g e in th e la b:• B
• I
efor e a n y in t r a cr a n ia l su r ger y for r edu cin gin t r a cr a n ia l pr essu r e. In ca se of cer ebr a l edem a u se 8t im es (4m g/k g), a n d in ca se of ca r dia c a r r est 40 t im es(20m g/k g)th e dose given in t h e t a ble.
n ca se of cer ebr a l edem a . F ir st a dm in ist er a dosa geof 10 m g IV followed by 4 m g ever y six h ou r s IM u n t ilt h e sym ptom s of cer ebr a l edem a su bside. Respon se isu su a lly n ot ed wit h in 12 t o 24 h ou r s.Ov e rd o s e : Acu t e t oxicit y a n d/or dea t h followin gover dose of glu cocor t icoids a r e r a r e. So, n o specifica n t idot e is a va ila ble.S to ra g e : Sen sit ive t o h ea t . P r ot ect fr om fr eezin g.P r ot ect fr om ligh t . St or e con t a in er in ca r t on u n t ilcon t en t s h a ve been u sed.
Class: AnticholinergicsAdministration: IM or IVDescription: Non-narcotic, non-barbiturate anestheticwhich produces a dissociative mental statecharacterized by sedation, amnesia and analgesia.NOTE: Will cause vomiting if the monkey had food 2-4hours before administration.Usage in the lab:• As chemical restraint (for collars) using half of thedose shown in the table.• As preanesthetic to place the vein catheter used foranesthesia induction.Overdose: Salivation, emesis, vocalization, spasticjerking movements, or convulsions can occur. Respiratethe animal with the bag-mask (AMPU), and if neededadminister barbiturates in one 6th of their dose.Storage: Store the solution at controlled roomtemperature, 15 -30 deg. precipitateappears. Slightly yellowish (that can be darker ifexposed to light) appearance does not affect potency.So, you can still use the drug.
C la s s : An t ich olin e r gicsAd m i n i s t ra t i o n : IM or IVD e s c r i p t i o n : N on -n a r cot ic, n on -ba r bit u r a t ea n es t h e t ic w h ich p r odu ces a d is socia t ive m en t a l s t a t ech a r a ct er ized by s eda t ion , a m n es ia a n d a n a lges ia .N O TE : W ill ca u se vom it in g if t h e m on k ey h a d food 2-4h ou r s befor e a dm in is t r a t ion .U s a g e i n t h e la b :•
•
As ch em ica l r es t r a in t (for colla r s ) u s in g h a lf of t h edose sh ow n in t h e t a ble .
As p r ea n es t h e t ic t o p la ce t h e ve in ca t h e t e r u sed fora n es t h es ia in du ct ion .O v e r d o s e : E m es is , s a liva t ion , voca liza t ion , spa s t icje r k in g m ovem en t s , or con vu ls ion s ca n occu r .Resp ir a t e t h e a n im a l w it h t h e ba g-m a sk (AM P U ), a n dif n eeded a dm in is t er ba r bit u r a t es in on e 6 t h of t h e irdose .S t o ra g e : S t or e t h e solu t ion a t con t r olled r oomt em per a t u r e , 15 -30 deg. p r ecip it a t ea ppea r s . S ligh t ly ye llow ish (t h a t ca n be da r k er ifexposed t o ligh t ) a ppea r a n ce does n ot a ffect pot en cy.S o, you ca n s t ill u se t h e d r u g.
D o n ot u se if
Dosa ge W eig ht Total (mg ) Total (ml)6 5 0 1 7 K eta vet 1 0 0 m g /m l 3 .0 0 4 5 .0 0 0 .4 5S yringe (m l) 3.00 3 .5 0 5 2 .5 0 0 .5 3Dosa ge (m g/kg) 15.00 4 .0 0 6 0 .0 0 0 .6 0Conce ntra tion (m g/m 100.00 4 .5 0 6 7 .5 0 0 .6 8Dosa ge (m l/kg) 0.15 5 .0 0 7 5 .0 0 0 .7 5D e s criptio n 5 .5 0 8 2 .5 0 0 .8 3
Class: AnticholergicsAdministration: IM or IVDescription: Non-narcotic, non-barbiturate anestheticwhich produces a dissociative mental statecharacterized by sedation, amnesia and analgesia.NOTE: Will cause vomiting if the monkey had food 2-4hours before administration.Usage in the lab:- As chmical restraint (for collars) using half of the
dose shown in the table- As preanesthetic to place the vein catheter used
for anesthesia introduction.Overdose: Emesis, salivation, vocalization,convulsions, or spastic jerking movements can occur.Respirate the animal with the bag-mask (AMPU), and ifneeded administer barbiturates in one 6th of their dose.Storage: Store the solution at controlled roomtemperature, 15-30 deg. Do not use if precipitateappears. Slightly yellowish (that can be darker ifexposed to light) appearance does not affect potency.So, you can still use the drug.
Phenobarbital (Luminal)
Dosa ge W eig ht Total (mg ) Total (ml)1 5 0 0 4 Lum ina l inj.so lutio n 3 .0 0 0 1 5 .0 0 0 0 .0 7 5S yringe (m l) 1.000 3 .5 0 0 1 7 .5 0 0 0 .0 8 8Dosa ge (m g/kg/da y) 5.000 4 .0 0 0 2 0 .0 0 0 0 .1 0 0Conce ntra tion (m g/m200.000 4 .5 0 0 2 2 .5 0 0 0 .1 1 3Dosa ge (m l/kg/da y) 0.025 5 .0 0 0 2 5 .0 0 0 0 .1 2 5D e s criptio n 5 .5 0 0 2 7 .5 0 0 0 .1 3 8
Cla s s : An t icon vu lsa n t , Ba r bit u r a t eD e s crip t io n : N on select ive CN S depr essan t of t h eba rbitu ra te cla ss, t h a t pr odu ces dr owsin ess,seda t ion , h ypn osis, a n d an t icon vu lsa n t effect s bydepr essin g sen sor im otor a ct ivit y a n d cer ebella rfu n ct ion . It h a s a r a pid on set of a ct ion (abou t 5m in u t es), with pea k effect s with in 30 m in u t es, a n dla st s for abou t 10 h ou r s.U s a g e in th e la b:F or depr essin g seizu r e a ct ivit y in a n im a ls t h a t m aydevelop an im plan t in fect ion , or a m in or st r oke a s ar esu lt of r ecor din g-gu ide-tu be pla cem en t .Ad m in is tra t io n : IM or slow IVN o te : if t h e m on key is in epilept ic st a tu s m u lt iply t h etot a l a m ou n t dr u g by 3 (i.e. 15 m g/kg) an d in jec t i tov er 10-15 m in u t es . F or an t icon vu lsa n t t h er apyadm in ist er t h e tot a l da ily am ou n t in 2 doses. Ma kesan t ibiot ics su ch a s ch lor a m ph en icol le s s e ffe c i tv e .Ov e rd o s e : If r espir a tor y depr ession occu r s r espir a t eth e m on key u sin g ou r ba g-m a sk r esu scit a tor (Am bu ).If depr ession per sist adm in ist er doxa pr am .S to ra g e : Stor e a t r oom t em per a tu r e.
C la s s : An t i-in fla m m a t or yD e s c r i p t io n : M et h ylp r edn isolon e is a pot en t a n t i-in fla m m a t or y s t e r oid .U s a g e i n t h e la b :• F or r edu cin g in fla m m a t ion w h en a m in or s t r ok e issu spect ed a s a r esu lt of t h e p la cem en t of a r ecor d in ggu ide t u be .Ad m in i s t ra t io n : IM or s low IVW h en you s t a r t t h er a py a dm in is t er 30 m g/k g IV over30 m in u t es . Th is sh ou ld be r epea t ed 2 t o 4 t im es ada y. Th e h igh dose t h e r a py sh ou ld be con t in u ed u n t ilt h e m on k ey’s con d it ion h a s s t a bilized ; bu t n ot beyon d48 t o 72 h ou r s . Aft e r t h e h igh t h er a py con t in u e wit h15 m g/k g in on e IM sh ot .O v e rd o s e : I f r e sp ir a t or y depr ess ion occu r s r esp ir a t et h e m on k ey u s in g ou r ba g-m a sk r esu scit a t or (Am bu ).I f dep r ess ion per s is t s a dm in is t er doxa pr a m .S t o ra g e : S t or e u n r econ s t it u t ed p r odu ct a t 15 deg t o30 deg C (59 deg t o 86 deg F ). S t or e solu t ion 15 deg t o30 deg C (59 deg t o 86 deg F ). U se solu t ion wit h in 48h ou r s a ft e r m ixin g.
Dosa ge W eig ht Total (mg ) Total (ml)Urb a so n so lub ile fo rte 1 0 0 0 3 .0 0 0 9 0 .0 0 0 0 .9 0 0S yringe (m l) 10.000 3 .5 0 0 1 0 5 .0 0 0 1 .0 5 0Dosa ge (m g/kg/30m i 30.000 4 .0 0 0 1 2 0 .0 0 0 1 .2 0 0Conce ntra tion (m g/m100.000 4 .5 0 0 1 3 5 .0 0 0 1 .3 5 0Dosa ge (m l/kg/30m in 0.300 5 .0 0 0 1 5 0 .0 0 0 1 .5 0 0D e s criptio n 5 .5 0 0 1 6 5 .0 0 0 1 .6 5 0
Cla s s : An t i-in fla m m a t or yD e s crip t io n : Meth ylpr edn isolon e is a pot en t an t i-in fla m m a tor y st er oid.U s a g e in th e la b:• F or r edu cin g in fla m m a t ion wh en a m in or st r oke issu spect ed a s a r esu lt of t h e pla cem en t of a r ecor din ggu ide t u be.Ad m in is tra t io n : IM or slow IVWh en you st a r t t h er apy adm in ist er 30 m g/kg IV over30 m in u t es. Th is sh ou ld be r epea t ed 2 t o 4 t im es ada y. Th e h igh dose t h er apy sh ou ld be con t in u ed u n t ilth e m on key’s con dit ion h as st a bilized; bu t n ot beyon d48 t o 72 h ou r s. Aft er th e h igh t h er apy con t in u e with15 m g/kg in on e IM sh ot .Ov e rd o s e : If r espir a tor y depr ession occu r s r espir a t eth e m on key u sin g ou r ba g-m a sk r esu scit a tor (Am bu ).If depr ession per sist s a dm in ist er doxa pr am .S to ra g e : Stor e u n r econ st it u t ed pr odu ct a t 15 deg t o30 deg C (59 deg t o 86 deg F ). Stor e solu t ion 15 deg t o30 deg C (59 deg t o 86 deg F ). U se solu t ion wit h in 48h ou r s a ft er m ixin g.
Naloxon
Dosa ge W eig ht Total (mg ) Total (ml)1 3 0 1 0 Na lo x o ne 0 ,4 m g C ura m ed Inj. 3 .0 0 0 .1 2 0 .3 0S yringe (m l) 1.00 3 .5 0 0 .1 4 0 .3 5Dosa ge (m g/kg) 0.04 4 .0 0 0 .1 6 0 .4 0Conce ntra tion (m g/m 0.40 4 .5 0 0 .1 8 0 .4 5Dosa ge (m l/kg) 0.10 5 .0 0 0 .2 0 0 .5 0D e s criptio n 5 .5 0 0 .2 2 0 .5 5
Cla s s : Opioid An t a gon istAd m in is t ra t io n : IM, SC, or IVD e s c rip t io n : N a loxon e pr even t s or r ever ses t h eeffect s of opioids in clu din g r espir a t or y depr ession ,seda t ion a n d h ypot en sion . Wh en u sin g it t h e m on k eym u st be k ept u n der con t in u ed su r veilla n ce, beca u seth e du r a t ion of a ct ion of som e n a r cot ics exceeds t h a t ofN a loxon e.U s a g e in th e la b:To r ever se t h e effect s of possible over dose of n a r cot ics .N ote t h a t N a loxon e is n ot effect ive a ga in st r espir a tor ydepr ession du e t o n on -opioid dr u gs.Rever sa l of bu pr en or ph in e-in du ced r espir a tor ydepr ession m a y be in com plet e. If a n in com plet er espon se occu r s, r espir a t ion s sh ou ld be m ech a n ica llya ssist ed u sin g AMBU .S to ra g e : Stor e a t con t r olled r oom t em per a tu r e (59deg-86 deg F , 15 deg-30 deg C)
Nembutal (Pentobarbital)
Dosa ge W eig ht Total (mg ) Total (ml)LL Nembutal 3 .0 0 2 4 .0 0 0 .4 0S yringe (m l) 10.00 3 .5 0 2 8 .0 0 0 .4 7Dosa ge (m g/kg) 8.00 4 .0 0 3 2 .0 0 0 .5 3Conce ntra tion (m g/m 60.00 4 .5 0 3 6 .0 0 0 .6 0Dosa ge (m l/kg) 0.13 5 .0 0 4 0 .0 0 0 .6 7D e s criptio n 5 .5 0 4 4 .0 0 0 .7 3
Cla s s : An esth et ic, Ba r bit u r a t eAd m in is tra t io n : IVD e s c rip t io n : N on select ive cen t r a l n er vou s syst emdepr essa n t , pr im a r ily u sed a s seda t ive h ypn ot ic a n da n t icon vu lsa n t in su bh ypn ot ic doses. N em bu ta l(pen t oba r bit a l) is a sh or t -a ct in g ba r bit u r a t e t h a t ca nbe sa fely u sed in m on keys.U s a g e in th e la b: We u se it for a ll su r gica lpr ocedu r es, followin g t h e r est r a in t of t h e a n im a l wit hKeta m in e.Ov e rd o s e : It is m a n ifest ed by CN S a n d r espir a tor ydepr ession a n d dea th com m on ly occu r s a ft er 2 t o 10gr a m s of in gest ed ba r bit u r a t e. In ca se of over dosem a in t a in a dequ a t e a ir wa y, a n d a ssist r espir a t ion a n doxygen a dm in ist r a t ion u sin g t h e ba g-m a sk .Adm in ist er Dopr a m (Doxa pr a m ) . Th e m on key sh ou ldbe r olled fr om side t o side ever y 30 m in u tes.S to ra g e : Avoid excessive h ea t . P r ot ect fr om fr eezin g.St or e a t r oom t em per a tu r e. Br ief exposu r e u p t o 104deg F (40 deg C) does n ot a dver sely a ffect t h e pr odu ct .
Neostigmine (Prostigmin)
Dosa ge W eig ht Total (mg ) Total (ml)3 0 0 0 6 Neo stig m in 0 ,5 3 .0 0 0 .1 5 0 .3 0S yringe (m l) 1.00 3 .5 0 0 .1 8 0 .3 5Dosa ge (m g/kg) 0.05 4 .0 0 0 .2 0 0 .4 0Conce ntra tion (m g/m 0.50 4 .5 0 0 .2 3 0 .4 5Dosa ge (m l/kg) 0.10 5 .0 0 0 .2 5 0 .5 0D e s criptio n 5 .5 0 0 .2 8 0 .5 5
Cla s s : An t ich olin est er a seAd m in is t ra t io n : IVD e s c rip t io n : P r ost igm in (N eost igm in e) in h ibit s t h eh ydr olysis of a cetylch olin e by com pet in g witha cetylch olin e for a t t a ch m en t t o a cetylch olin est er a se a tsit es of ch olin er gic t r a n sm ission . I t t h u s en h a n cesch olin er gic a ct ion by fa cilit a t in g t h e t r a n sm ission ofim pu lses a cr oss n eu r om u scu la r ju n ct ion s.U s a g e in th e la b: We u se it for r ever sin g pa r a lysisin du ced wit h N or cu r on . At r opin e (0.6 t o 1.2 m g) m u stbe in ject ed a bou t 10 m in u t es befor e t h e P r ost igm in .Th e u su a l dose is 0.5 m g (for a ppr ox. 10k g m on k ey)P r ost igm in given by slow in t r a ven ou s in ject ion ,r epea t ed a s r equ ir ed. On ly in except ion a l ca ses sh ou ldth e t ot a l dose of P r ost igm in exceed 2 m g. Th eopt im u m t im e for a dm in ist r a t ion of t h e dr u g is du r in gh yper ven t ila t ion wh en t h e ca r bon dioxide level of t h eblood is low. I t sh ou ld n ever be a dm in ist er ed in t h epr esen ce of h igh con cen t r a t ion s of h a loth a n e orcyclopr opa n e. In t h e pr esen ce of br a dyca r dia , t h e pu lser a t e sh ou ld be in cr ea sed t o a bou t 80/m in u t e witha t r opin e befor e a dm in ist er in g P r ost igm in .Ov e rd o s e : Over dosa ge of P r ost igm in ca n ca u sech olin er gic cr is is , wh ich is ch a r a ct er ized by in cr ea sin gm u scle wea k n ess, a n d t h r ou gh in volvem en t of t h em u scles of r espir a t ion , m a y r esu lt in dea t h . So, fo l lo wth e in s tru c t io n s c a re fu lly .
Norcuron (Vecuroniumbromid)
Induct. Maint. Induct. Maint.Dosa ge W eig ht mcg mcg /min ml ml/min6 4 0 0 5 No rcuro n 4 m g 3 .0 0 2 4 0 .0 3 .0 1 .2 0 0 0 .0 1 5 0
Cla s s : Mu scle Rela xa n tAd m in is tra t io n : IVD e s c rip t io n : N or cu r on is a n on depola r izin gn eu r om u scu la r block in g a gen t of t h e cu r a r ifor m cla ss.It a ct s by com pet in g for ch olin er gic r ecept or s a t t h em otor en d-pla t e.U s a g e in th e la b: We u se it for pa r a lyzin g t h eext r a ocu la r m u scles du r in g a cu t e-n eu r oph ysiologysession s. A per iph er a l n er ve st im u la tor is u sed t oa ssess t h e degr ee of m u scu la r r ela xa t ion . Th e doser equ ir ed t o pr odu ce 90% su ppr ession of t h e m u sclet wit ch r espon se is 0.057 m g/kg (0.049 t o 0.062 m g/k g.An in it ia l N or cu r on dose of 0.08 t o 0.10 m g/k ggen er a lly pr odu ces fir st depr ession of twit ch ina ppr oxim a t ely 1 m in u t e, good or excellen t in t u ba t ioncon dit ion s wit h in 2.5 t o 3 m in u t es, a n d m a xim u mn eu r om u scu la r blocka de wit h in 3 t o 5 m in u t es ofin ject ion . U n der ba la n ced a n esth esia , t h e t im e t or ecover y t o 25% of con t r ol is a ppr oxim a tely 25 t o 40m in u t es a ft er in ject ion a n d r ecover y is u su a lly 95%com plet e a ppr oxim a tely 45-65 m in u t es a ft er in ject ionof in tu ba t in g dose. Twen ty t o 40 m in u t es a ft er t h ein du ct ion dose of 80-100 m cgm /k g, a con t in u ou sin fu sion of 1 m cgm /k g/m in is u sed for m a in t a in in gpa r a lysis . In i t ia l c o n c e n tra t io n i s 4m g /m l; d i lu te(x 20) be fo re u s in g . Th e In fu s io n (B AR D ) p u m p isc a libra te d fo r 200m c g /m l.S to ra g e : 15-30 deg C (59-86 deg F ). P r ot ect fr om ligh t .
Ringer Lactate Solution
IV-S ET of IV-S ET of2 0 Drops /m6 0 Drops /ml
Dosa ge W eig ht Drops /Min Drops /Min Total ml/hr5 2 * * * La cta ted R ing er´s So lutio n 3 .0 0 2 .5 0 7 .5 0 7 .5 0Ba g (m l) 250.00 3 .5 0 2 .9 2 8 .7 5 8 .7 5W a te r Loss (m l/kg/hr 2.50 4 .0 0 3 .3 3 1 0 .0 0 1 0 .0 0IV -S e t of (drops/m l) 20.00 4 .5 0 3 .7 5 1 1 .2 5 1 1 .2 5IV -S e t of (drops/m l) 60.00 5 .0 0 4 .1 7 1 2 .5 0 1 2 .5 0D e s criptio n 5 .5 0 4 .5 8 1 3 .7 5 1 3 .7 5
Cla s s : Mu lt iple E lect r olyt e Solu t ionAd m in is tra t io n : IV or IMD e s crip t io n : P olyion ic, isoton ic solu t ion for flu idth er a py. F or t h e m on key t h e wa ter loss in t er m s ofbody weigh t is (1) Respir a tor y/cu t an eou s losses15m l/kg, (2) F eca l 10 m l/kg, a n d (3) U r in a r y 20 m l/kgper da y, with t ot a l loss of a ppr ox. 40-50 m l/kg/day or 2m l/kg/h r .U s a g e in th e la b: In a ll su r ger ies for m a in t a in in gth e m on key’s flu id r equ ir em en t s du r in g t h e oper a t iveper iod. Du r in g su r ger y wa t er is a lso lost fr om t h esu r gica l sit e, fr om th e vascu la r effect s of a n esth et icagen t s, a n d fr om sequ est r a t ion of in t er st it ia l flu idsfr om su r gica l t r au m a . Tot a l loss is a ppr ox. 2.5m l/kg/h r . F or m a in t en an ce u se isoton ic La ct a t edRin ger ’s (0.18%) with 4% Dext r ose, or pla in La ct a tedRin ger ’s (0.9%). Ou r IV dr ips (pedia t r ic) give 60dr ops/m l (Dr p/m l). Dr ops per m in u t e (dpm ) a r ecom pu ted ba sed on :dpm = (Dr p/m l)*(m l/kg/h r )*Weigh t /60
Robinul (Glycopyrroniumbromid)
Dosage We igh t Tota l (m g) Tota l (m l)77 030 R obin u l 0.2m g 3.000 0.030 0.150Syringe (ml) 1.000 3.500 0.035 0.175Dosage (mg/kg) 0.010 4.000 0.040 0.200Concentration (mg/ml) 0.200 4.500 0.045 0.225Dosage (ml/kg) 0.050 5.000 0.050 0.250De scription 5.500 0.055 0.275
Cla s s : An t ich olin er gicsAd m in is t ra t io n : IM or IVD e s c r ip t io n : Robin u l (Glycopyr ola t e) a ct s dir ect ly ont h e sm oot h m u scles a n d secr et or y gla n ds block in g t h epa r a -sym pa t h om im et ic effect s of a cet ylch olin e. Th eeffect s per sis t for 2 t o 3 h ou r s a n d t h e a n t is ia la gogu eeffect s per sis t u p t o 7 h ou r s . Wit h in t r a ven ou sin ject ion , t h e on set of a ct ion is gen er a lly eviden twit h in on e m in u t e. I t is a qu a t er n a r y a m m on iu mcom pou n d, i.e.does n ot pen et r . BBb.U s a g e in th e la b: As pr ea n est h et ic beca u se it ca u sesm ild r espir a t or y s t im u la t ion a n d it in h ibit s sa liva r ysecr et ion . Th e r ecom m en ded dose is 0.004 m g/k g bodyweigh t by in t r a m u scu la r in ject ion , given 30 t o 60m in u t es pr ior t o t h e a n t icipa t ed t im e of in du ct ion ofa n est h es ia or a t t h e t im e t h e pr ea n est h et ic n a r cot ica n d/or seda t ive a r e a dm in ist er ed.• F or st im u la t in g t h e h ea r t if t h e a n es t h esia ispr olon ged. F or in cr ea s in g H R you ca n give it 1-2m in u t es befor e in du ct ion .Ov e rd o s e : In ca se of CN S sym pt om s (excit em en t ,r es t lessn ess, con vu ls ion s, psych ot ic beh a vior ) s lowlya dm in is t er 0.5 t o 2 m g ph ysost igm in e IV. Do n ot givem or e t h a n 4 m g tot a l/da y.S to ra g e : St or e t h e solu t ion a t con t r olled r oomt em per a t u r e, 15 deg C-25 deg C (59 deg F -77 deg F ).
Sufenta
Dosage We igh t Tota l (m g) Tota l (m l)65 023 S u fen t a 3.00 0.03 0.60 (10 m l v ia l ) 3.50 0.04 0.70Syringe (ml) 1.00 4.00 0.04 0.80Dosage (mg/kg) 0.010 4.50 0.05 0.90Concentration (mg/ml) 0.05 5.00 0.05 1.00Dosage (ml/kg) 0.20 5.50 0.06 1.10De scription 6.00 0.06 1.20
Cla s s : Opioid An a lges ic, N a r cot icAd m in is t ra t io n : IM or s low IVD e s c r ip t io n : Su fen t a (Su fen t a n yldih ydr ogen cit r a t ) isa n opioid a n a lges ic. I t h a s a n im m edia t e on set ofa ct ion a n d pr ovides pr ofou n d a n a lges ia . I t ca n bea dm in is t er ed a s bolu s or a s in fu s ion over 2-10m in u t es .U s a g e in t h e la b : U sed a s m on oa n est h et ic t o a voidcor t ica l depr ess ion . Mu st be u sed wit h 100% Oxygen .In du ct ion dose is 0.010 m g/k g, given a s bolu s or over2-10 m in u t es . Ma in t en a n ce dose is 0.001 m g/k g.Ov e rd o s e : U se Doxa pr a m or N a loxon e.S t o ra g e : Avoid excess ive h ea t (over 104 deg F or 40deg C). P r ot ect fr om pr olon ged exposu r e t o ligh t .
Dosa ge W eig ht Total (mg ) Total (ml)6 5 0 2 3 Sufenta m ite 1 0 3 .0 0 0 .0 3 6 .0 0 (1 0 m l v ia l) 3 .5 0 0 .0 4 7 .0 0S yringe (m l) 40.00 4 .0 0 0 .0 4 8 .0 0Dosa ge (m g/kg) 0.010 4 .5 0 0 .0 5 9 .0 0Conce ntra tion (m g/m 0.005 5 .0 0 0 .0 5 1 0 .0 0Dosa ge (m l/kg) 2.00 5 .5 0 0 .0 6 1 1 .0 0D e s criptio n 6 .0 0 0 .0 6 1 2 .0 0
Cla s s : Opioid An a lgesic, N a r cot icAd m in is t ra t io n : IM or slow IVD e s c rip t io n : Su fen t a m it e 10(Su fen t a n yldih ydr ogen cit r a t ) is a n opioid a n a lgesic. I th a s a n im m edia t e on set of a ct ion a n d pr ovidespr ofou n d a n a lgesia . I t ca n be a dm in ist er ed a s bolu s ora s in fu sion over 2-10 m in u t es.U s a g e in th e la b: U sed a s m on oa n est h et ic t o a voidcor t ica l depr ession . Mu st be u sed wit h 100% Oxygen .In du ct ion dose is 0.010 m g/kg, given a s bolu s or over2-10 m in u t es. Ma in t en a n ce dose is 0.001 m g/k g.Su fen t a m it e 10 is well su it ed for in fu sion w/ la r gesyr in ges.Ov e rd o s e : U se Doxa pr a m or N a loxon e.S to ra g e : Avoid excessive h ea t (over 104 deg F or 40deg C). P r ot ect fr om pr olon ged exposu r e t o ligh t .
Suprarenin (Epinephrine)
Dosa ge W eig ht Total (mg ) Total (ml)1 9 0 4 0 Sup ra renin 3 .0 0 0 .1 5 0 .1 3S yringe (m l) 1.00 3 .5 0 0 .1 8 0 .1 5Dosa ge (m g/kg) 0.05 4 .0 0 0 .2 0 0 .1 7Conce ntra tion (m g/m 1.20 4 .5 0 0 .2 3 0 .1 9Dosa ge (m l/kg) 0.04 5 .0 0 0 .2 5 0 .2 1D e s criptio n 5 .5 0 0 .2 8 0 .2 3
Cla s s : An t ih ypn ot ic/St im u la n tAd m in is t ra t io n : IVD e s c rip t io n : E pin eph r in e is a sym pa th om im et icdr u g. It a ct s on both a lph a a n d bet a r eceptor s . In fa ctit is t h e m ost pot en t a lph a r eceptor a ct iva t or .E pin eph r in e is m a in ly u sed t o r elieve r espir a tor ydist r ess du e t o br on ch ospa sm , t o pr ovide r a pid r elief ofh yper sen sit ivit y r ea ct ion s t o dr u gs, t o r estor e ca r dia cr h yt h m in ca r dia c a r r est du e t o va r iou s ca u ses, a n da lso t o st op bleedin g (h em ost a t ic a gen t ) by ca u sin gva socon st r ict ion .U s a g e in th e la b:We u se E pin eph r in e du r in g t h e eye-coil su r ger y t opr odu ce con ju n ct iva l decon gest ion , con t r olh em or r h a ge, a n d r edu ce in t r a ocu la r pr essu r e. I t isa lso u sed t o pr odu ce m ydr ia sis . F or su ch u sa ge t h econ cen t r a t ion is a ppr ox. 0.1 m g/m l.Befor e t h e eye su r ger y dilu t e 1 Am pou le (1.2 m gE pin eph r in e) in to 10 m l of St er ile Sa lin e, u sin g a 10m l syr in ge. U se a few dr ops a t a t im e wh en bleedin goccu r s. CAU TION : D o n o t k e e p u s in g th i s s o lu t io nfo r re g u la r irr ig a t io n .In ca se of em er gen cies u se 0.5 m g (a bou t 0.5 m l)dilu t ed in to 10m l Sa lin e a n d in ject IV orin t r a ca r dia lly.
Trapanal (Thiopental)
Dosa ge W eig ht Total (mg ) Total (ml)6 5 0 2 5 Tra p a na l 3 .0 0 3 0 .0 0 1 .2 0S yringe (m l) 5.00 3 .5 0 3 5 .0 0 1 .4 0Dosa ge (m g/kg) 10.00 4 .0 0 4 0 .0 0 1 .6 0Conce ntra tion (m g/m 25.00 4 .5 0 4 5 .0 0 1 .8 0Dosa ge (m l/kg) 0.40 5 .0 0 5 0 .0 0 2 .0 0D e s criptio n 5 .5 0 5 5 .0 0 2 .2 0
Class: Anesthetic, BarbiturateAdministration: IVDescription: Trapanal is an ultra-short-acting thio-barbiturate used for induction of anesthesia It ispreferred to pentobarbital since the latter suppressescell activity. Dosage total 10-20 mg/kg IV Should begiven to effect (at 30 sec. intervals) Start with a third toa half of the calculated dosage.Usage in the lab: We use it for our surgicalprocedures, following the restraint of the animal withKetamine. Dilute the 0,5g powder to 20 ml of injectionswater (0.25 mg/ml)Overdose: It is manifested by CNS and respiratorydepression and death commonly occurs after 2 to 10grams of ingested barbiturate. In case of overdosemaintain adequate airway, and assist respiration andoxygen administration using the bag-mask. AdministerDopram (Doxapram) . The monkey should be rolledfrom side to side every 30 minutes.Storage: Avoid excessive heat. Protect from freezing.Store at room temperature. Brief exposure up to 104deg F (40 deg C) does not adversely affect the product.
D e s criptio nCla s s : An t icoagu lan tAd m in is tra t io n : IV (flu sh )D e s crip t io n : H epar in Sodiu m In ject ion , USP is a st er ile solu t ion of h epa r in sodiu m der ived fr om bovin e lu n gt issu e, st an da r dized for an t icoagu lan t a ct ivity.U s a g e in th e la b: We u se it in ver y sm a ll dosages (flu sh in g t h e vein ca ps a ft er ba r bit u r a t e a dm in ist r a t ion ) t oin h ibit r eact ion s th a t lead to th e clot t in g of blood a n d t h e for m a t ion of fibr in clot s in t h e vein or a r t er y lin esdu r in g su r gery. On e Am p (2m l) Vet r en , con ta in in g 200 u n it s is en ou gh for flu sh in g t h e vein s. Befor e su r ger y,dilu t e 1 Am p in to a 250m l bot t le of St er ile Sa lin e (u se 200 m l, to get appr oxim a tely 1 u n it /m l). Mix well. Do n otu se t h is solu t ion for IM in ject ion s, a s oft en h em a tom a will occu r . F ill u p 2 10m l syr in ges an d flu sh wh enn eeded.Ov e rd o s e : No over dose is possible w/ th e con cen t r a t ion s t h a t we u se. If you h a ve excessive bleedin g becau seof h epa r in adm in ist er prota m in e su lfa t e (1% solu t ion ) by slow in fu sion n o m ore th an 50 m g an d ver y slowly, ina 10 m in u t e per iod.S to ra g e : Stor e th e pr odu ct a t con t r olled r oom t em per a tu r e 15 deg to 30 deg C (59 deg t o 86 deg F ).
