Food and Chemical

Toxicology (formerly Food and Cosmetic Toxicology)

An International Journal published for the British Industrial Biological Research Association

AUTHOR AND SUBJECT INDEXES TO VOLUME 23 1985

Pergamon Press OXFORD NEW YORK TORONTO SYDNEY FRANKFURT

FOOD AND CHEMICAL TOXICOLOGY

An International Journal published for the British Industrial Biological Research Association

Editors L. GOLBERG, Duke University Medical Center, P.O. Box 2914, Durham, NC 27710, USA

GORJXN C. HARD, BIBRA, Woodmansterne Road, Carshalton, Surrey SMS 4DS

Managing Editor A. M. SEELEY, BIBRA, Woodmansterne Road, Carshalton, Surrey SMS 4DS

Editorial Board R. J. ALLEN, Brentford D. HENSCHLER, Wiirzburg B. A. BRIDGES, Brighton X. HUANG, Hangzhou D. B. CLAYSON, Ottawa P. M. NEWLIERNE, Cambridge, MA J. W. DANIEL, Eye D. V. PARKE, Guildford W. G. FLAMM, Washington, DC I. F. H. PURCHASE, Alderley Park M. A. GALLO, Piscataway, NJ H. REMMER, Tubingen P. GRA~~o, Sunbury-on-Thames D. SCHMLHL, Heidelberg A. W. HAYES, Winston-Salem, NC J. ZHOU, Zhongshan

Regional Editors on Editorial Board

R. DEIUCHE, Toulouse for France H. C. GIUCE. Ottawa for Canada

Y. JKEDA, Tokyo for Japan

Honorary Advisory Board F. CQULSTON, Albany, NY P. ELIAS, Karlsruhe F. J. C. ROE. London

R. TRUHAUT, Paris H. VAN GENDEREN, Utrecht J. H. WEISBURGER, Valhalla, NY A. N. WORDEN, Cambridge

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Index of Authors

The Index of Authors contains the names of all authors of original contributions to the Journal. The various types of contribution are distinguished by the use of the following superscripts inserted after the appropriate page number:

A = Abstract; C = Conference; P = Papers (original); R = Review articles; L = Letters to the Editor

Aeschbacher H. U. 747’ Ahmad M. U. 841’ Airoldi L. 1011’ Akamizu H. 575’ Albertini S. 593’ Albrecht R. 805’ Alterman E. 1063’ Altmann H.-J. 723’ Ambani L. M. 625’ Anai K. 575’ Anderson D. II’, 115’, 1091’ Anderson J. 111’ Anderson R. L. 457’, 465’ Andresen B. D. 1035’ Andrews I. J. 313’ Angi M. R. 303’ Anthony A. 559’ Aoki Y. 575’ Appelbaum A. E. 887’ Arnold D. L. 779’ Ashby J. 43’, 507’ Atteba S. 805’

Baeder C. 377’ Bakhitova L. M. 373’ Balabaud Ch. 870* Baldwin S. 1049’ Balls M. 209’ Bannasch P. 864A Barbason H. 873A Barbour J. F. 841’ Barone J. 389’ Barthel G. 874A Bearne C. A. 1029’ Beems R. B. 945’ Benassi C. A. 303’ Bendele A. M. 911’ Benford D. J. 325A Bentley P. 875A, 878A, 879A Bernard B. K. 559’ Better0 A. 303’ Bewsey B. J. 911’ Bhandarkar S. D. 625’ Bianchi M. 975’ Bieri F. 875A, 878A, 879* Bille N. 967’ Bjeldanes L. F. 57’, 899’, 905’, 1035’ Blanck A. 882A Bock K. W. 866A Bolt H. M. 869A, 882A Bonfanti M. 1011’ Borenfreund 259’ Borzelleca J. F. 551p, 719’ Bos P. M. J. 669’ Bosshard E. 149’ Bradfield C. A. 899’ Bradlaw J. A. 1063’ Bridges J. W. 325A, 985’ Brinkley F. B. 326* Bronaugh R. L. 111’

Brown K. R. 705’ Brunn H. 876*, 931’ Brunskill J. E. 93’ Bryce F. R. 779’ Bucher Th. 868* Bucks D. 111’ Buehler E. V. 689’, 919’ Burgess B. A. 87’ Bursch W. 874A Byard J. L. 661’

Cabrol Telle A.-M. 100lp Caldwell J. 559’ Canas B. J. 991’ Cardinaals J. M. 669’ Carlborg F. W. 475’, 499’ Carlton W. W. 795’, 911’ Castelain Ph. 877A Castelli M. G. 1011’ Chamberlain M. 93’ Chang Y. 899’, 905’ Charbonneau S. M. 779’ Chellquist E. M. 327* Chow F. I. 51’ Clayton R. M. 239’ Cohen S. M. 521’ Cole R. J. 831p, 1069’ Coleman T. H. 1057’ Collins B. T. 779’ Columbano A. 863A, 874A Conge G. A. 1099’ Cook J. M. 419’ Cotgreave I. A. 559’ Couache P. 1099’ Coulombe R. A. 827p Cross M. F. 115’

Daabees T. T. 887’ Dalsis D. E. 419’ Danse L. H. J. C. 1015’ Dawson M. 305’ de Gerlache J. 866A, 871A, 876* de Jong G. 23’ de Kreuk J. F. 33’ Deleener A. 867A, 877A Demetrulias J. 271’ Deml E. 880A Denk H. 868* de Raat W. K. 33c Derache R. 1001’ de Saint Blanquat G. 655’, 1001’ Dessi S. 863A de Wet P. J. 349’ Domer J. W. 831p, 1069’ Dubuisson L. 870*, 871A

Eigenbrodt E. 863A, 876’, 931’ Emura M. 233’ Eng V. W. S. 47’ Ericksson L. C. 865A, 877A

3

Esger R. 877* Eto R. 575p Etter J.-Cl. 321c

Fanelli R. 10llp Farmakalidis E. 741p Fazio T. 991p Feltkamp C. A. 877A Felton J. S. 1035p Feo F. 866A Feringa A. W. 877A Filser J. G. 882* Finkelstein M. W. 887p Finot P. A. 763p Fischer G. 866A Fister P. 931p Ford R. A. 559p Frankel E. N. 1041’ Friederich U. 593’ Frith C. H. 475c Fritsch P. 655p Friihlich E. 876A, 1081p Furuta K. 675p

Gacula M., Jr 271’ Galiano F. 303c Galle P. 879* Galli C. L. 317c Gamble S. H. 267’ Gangolli S. D. 1029p Garattini S. 975p Gardner R. J. 87’ Geil R. G. 475c Gerbracht U. 881* Gfeller W. 16ZIc, 311c Ghezzi P. 975’ Gianera L. 975p Gibson W. T. 93p, 103p Gillatt P. M. 849’ Gloxhuber Ch. 187c, 195c Goldberg A. M. 205c Goldenthal E. I. 475c Gray J. I. 1057p Green K. 239c Greenman D. L. 73p Grice H. C. 389c, 779p Groom M. H. 103’ Gross C. L. 326” Griin M. 870A Grundler 0. J. 615’ Grunow W. 723p

Hacker H. J. 864” Hall A. S. 367p Hagel P. 669p Hamtxon J. E. 183= Hansen E. V. 967’ Hanstveit A. 0. 33c Hardy W. S. 103p Hatch F. T. 1035p

Index of Authors 4

Hathcock J. N. 741* Hauswirth J. W. 1063p Havery D. C. 991p Hayashi Y. 675r Healy S. K. 1035p Heinze J. E. 271c Hess R. 876A, 1081p Heusener A. 615’ Hiasa Y. 619’ Highman B. 73’ Hill L. E. 911’ Hinsman E. J. ?95p Hiraga K. 733’ Hixson C. J. 326* Hogan G. K. 551p, 71sP Hofiande E. 100lp Hoolev J. P. 325* Hoker S. A. 209c Hotchkiss J. H. 883L Hsieh D. P. H. 567*, 809*, 821’ Huang I.-B. 9?9* Hummler H. 377’ Hurng D.-C. 579p

Ikeda G. J. 609’, 7.57’ Inai K. 979* Ito M. 585*

Jack J. 239’ Jackson J. 309c Jederberg W. W. 327A Jetfries T. K. 753’ John-Greene J. A. 753’ Johnson K. A. 753’ Jongen W. M. F, 669’ Joseohv D. 343’ Jung R. 615’, 69Sp

Kado N, Y. 661’ Kaminsky M. 705’ Klstner W. 195c Kato T. 339’ Katz M. 866” Kellerman T. S. 349’ Kemp R. B. 267c Kemppainen B. W. 67’ Kennedy G. L. Jr 87’ Kerler R. 868* Kikugawa K. 339’ King M. T. ?57p Kingston T. 155’ Kirschman J. C. 857R Kirsch-Voiders M. 867A Kitahori Y. 619’ Klein D. 655’ Knize M. G. 1035’ Kobel W. 165=, 311p Kobuke T. 979’ Kodell R. L. 73’ Koeman J. H. 79’ Koestner A. 551’ Koivistoinen P. 985* Konishi N. 619p Konoe Y. 339’ Kool H. J. 79’ Kramer M. 695’ Kraus P. 878A Krewski D. R. 779’ Kriek N. P. J. 349’ Krizus A. 343’ Kuchlbauer J. 870A Kulkarni P. S. 625p Kumagai S. 941p

Kummerow F. 585* Kuper F. 79p

Laib R. J. 869A, 882A Lans M. 871A. 877A Larsen J. C. 967p Lauer B. 874A Lawrie C. A. 445c Le J. 695* Ledda-Columbano G. M. 863A, 874A Lee P. N. 355’ Lee T.-C. 763r, 1077p Leftwich D. 93p Leaner M. 868A Le;lel E. A. 367p Lesna M. 881A Lewis P. R. 1035p Libbey L. M. 84l* Lilienblum W. 866A Lin J.-K. 579* Lindl T. 32SA Lindsay D. G. 767s Linek W. 1?9= Loci s. 93* Loeber J. G. lOIS* Lefberg B. 647* Loury D. J. 66ip Luepke N. P. 287’

MacGregor J. T. 1041p McGuire P. F. 779p Maekawa A. 675p Maibach H. I. Ill’, 919’ Malik C. 876A Mallett A. K. 1029* Manz D. 876* Marks R. 155c Marks V. 985’ Marsboom R. 19c Marshall M. R. 809’ Marty J.-P. L. 919p Matsuki K. 979* Matthiaschk G. 723p Meier H. 747’ Meier H. L. 326* Melis S. 317’ Meredith R. W. J. 267c Merkle J. 3?7* Merski J. A. 923p Meyers M. C. 923* Michel T. C. 609p, 757’ Miladi N. 805* Miller E. 609p, 757* Mohr U. 233c Moodie C. A. 7?9p Morgan R. W. 529’ Morrissey R. E. 9959 1069P Milller L. 868A Munoz-Box R. 747p Munro I. C. 779’ Miirmann P. 615’ Murphy P. A. 741* Mustafa A. F. 305’

Nambu S. 979* Narbonne J. F. 805p Neal S. B. 911p Neff W. E. 1041p Nera E. A. 779’ Neumann H.-G. 870A Newark H. L. 47p Newmann E. A. 683*, 689’ Nishida T. 575’

Nishie K. 831’ Nishihara Y. 599p Nishina H. 979* Norred W. P. 995p, 1069’ North-Root H. 27lc Norvell M. 73p

Oberly T. J. 911P Oesterle D. 880A Ogata A. 733* Ogiu T. 6?5* Ohe K. 979’ Oliver G. J. A. 229’ Omaye S. T. 51p Onodera H. 675’ Oser B. L. 535c Ouellette J. H. 753p

Palmer R. C. 849p Pani P. 863A Papirmeister B. 326A Parish W. E. 21Sc, 275c Parker R. D. 683p, 689p Parker R. S. 1049p Parsons J. F. 93p Parzefall W. 879* Paschin Yu. 373p Paul D. 871A Pearson A. M. 1057p Pelissier M. A. 805p Pelli D. A. 247c Pemberton M. A. 229c Perciballi M. 737p Perdu-Durand E. F. 363p Perfetti G. A. 991p Periquet B. lOtlIp Pestka J. J. 105?p Petrali J. P. 326A PhiliDDOSSian G. ?63* Phil& B, J. 1091p Pintauro S. J. 737p, 763p Plakas S. M. 1077p Pollock J. R. A. ?Of* Potokar M. 615p Preat V. 8?lA Price J. B. 313p Probst G. S. 911p

Rabes H. M. 868* Rabie C. J. 349p Radford T. 419c Rao K. S. 753* Reed P. I. 849p Reifenrath W. G. 32?A Reinacher M. 865A, 876* Reinhardt Ch. A. 145c, 247c Render J. A. ?95p Renwick A. G. 429=, 437c, 445c.

451= Rexroat M. A. 9ll* Richter W. R. 47Sc Riley R. T. 67p, 1069’ Ritter F. 877A Robcrfroid M. 87iA Roberts A. 451’ Rode G. 868A Roe F. J. C. 35jp Rowland I. R. 1029’ Ruth E. 747’ Rutty D. A. 309c

Safford R. J. 93’ Sager A. 0. 609’. 757’

Index of Authors 5

Salbe A. D. 57’ Sahninen E. 985” Salminen S. 985’ Salmona M. 975’ Sangster S. A. 559’ Sapienza P. P. 609p, 751p Sarma D. S. R. 874A Sawamura A. 339’ Scaife M. C. 253’ Scanlan R. A. 841’ Schauer A. 866A Scherer E. 869A, 871A Schieferstein G. J. 73’ Schirmer R. E. 367p Schlatter Ch. 145’, 593’ Schmid B. 326A Schmidt E. 876A Schobel C. 615’ Schoenig G. P. 465’, 475’ Schijn H. 377’ Schulte Hermann R. 867A, 874A, 879A,

881A Schuppler J. 874A Schuster Ch. 868A Scientific Review Group Expert Panel

543c Searle L. 239c Seifert G. 165’ Sharma R. P. 827 Shame R. 139’ ShenN. H. 1035’ Shimoyama T. 619p Shipwash E. A. 327A Shopsis C. 259’ Silcock S. R. 183’ Sims J. 437c, 445c Smith P. L. R. 849’ Smith T. 585p Speijers G. J. A. 1015’ Sauire R. A. 491’ Stark D. M. 259c Staubli W. 875A, 878A, 879A Stegink L. D. 887’ Stewart R. F. 1 II’

Stofberg J. 857s Stojanovic V. 931p Sturtevant F. 961L Subden R. E. 343p Subera H. 615p Sutton J. D. 559p Swanston D. W. 169c Swentzel K. C. 1063 Szivos M. M. 705’

Takahashi 0. 937’ Takemoto T. 979p Tanigawa H. 675’ Taper H. S. 871A Tassignon J.-P. 5’ Taylor M. J. 51p Taylor W. 857A, 881A Thompson C. Z. 911p Thouvenot J.-P. 1001’ Timmermann-Trosiener I. 874A, 881A Tjllve H. 647’ Toda T. 585’ Toda Y. 585’ Tokuoka S. 575’, 979’ Tragni E. 317’ Tubaro A. 317c Tuchmann-Duplessis H. 377’ Tulliez J. E. 363’ Turek J. J. 795p Turnbull G. J. 355’

Ullrich D. 866* Utsumi K. 599’

van Beek L. 945’ van der Heijden C. A. 723’ Van Der Westhuizen G. C. A. 349’ VanDerWouden A. W. M. 877A van Haeringen H. 79’ van Leeuwen F. X. R. 1015’ Vanparys Ph. 19’ van Sittert N. J. 23’ Vesonder R. F. 995’

Vesselinovitch S. T. 864A Vo K. 0. 871* Voigt M. 419c Vonnahme F.-J. 870A. 871A

Waechter F. 875A, 878A, 879A Walberg J. 259c Walker A. P. 175c Walters C. L. 849p Walz D. 199’, 299c Wargovich M. J. 47p Wehner A. P. 367p Wei C. I. 809’, 821p Weller R: E. 367p Wester P. W. 723’ Wester R. C. 11 lp Wever J. 895p Wickramaratne G. A. S. 377p Wiebel F. J. 880A Wildhaber A. 321c Willhite C. C. 51p Williams S. J. 189c Willigan D. A. 705p Wilson M. 239c Wilson R. E. 1041p Wolf E. 419c Wolff T. 880A Wolke R. E. 1077p Wolzak A. 1057p Wong 0. 529c Wiirgler F. E. 593 Wiirtzen G. 967p Wiirzner H. P. 747p

Yackovich F. 271c Yoneyama M. 733p

Zak F. 1081’ Zakova N. 1081’ Zawidzka Z. Z. 779p Zbinden G. 137’, 247’ Zechel H. J. 615p Zehir A. 239c

Index of Subjects*

Abate, book review on toxicology, metabolism, environ- mental distribution and analysis of 633

Acetopbenone, 2,2-di-sec-butoxy- and 2,2-diethoxy-, skin- painting carcinogenicity tests in mice 715

Acrylamide, carcinogenicity study in mice 122. tissue- distribution studies in pregnant dogs and pigs 757p

Acrylate(s), di-, sensitization and cross-sensitization studies 713.. ethyl and butyl esters and free acid, negative mouse skin painting tests 714. ethyl and methyl esters, positive findings in micronucleus tests 714 trimethylol- propane tri-, dermatitic effects of 124

Aflatoxin, B,: and B,, deposition and clearance in hens’ eggs 1057p, and dietary fat level, effects on hepatic lipid composition in rats 1049’, effect of BHT pretreatment on disposition in rats 567’, retention and excretion in rats treated orally or intratracheally with 827”, urinary excre- tion of water-soluble conjugates of, by monkey, rat and mouse 809’, water-soluble conjugates produced in pri- mary rat hepatocyte cultures, negative Ames tests on 821’. risk estimates of human liver cancer from inges- tion of peanuts containing 129’-

Amines, aromatic, species differences in capacity of S-9 fractions to activate 695’

Amino acid pyrolysates, ethanol-enhancement of hepato- cellular genotoxicity of heterocyclic amines in 661p

64minonicotinamide, pathological and ultrastructural effects in rabbits treated ip or SC with 795p

4-Amino-3,5,6_trichloropicolinic acid (see Picloram) Anne&bet&, cytotoxicity studies on 305c Analytical chemistry, book review on HPLC methods used

in nucleic acid research 954, Anthranilic acid, cinnamyl ester: disposition and hepatic

effects in mice 559’, percutaneous absorption in monkey and man 111’

Antibiotics, book review on use as feed additives 950 ArSeniC, mutagenicity testing of arsenobetaine 669p Ascaridole, mouse skin painting study 960 Ascorbic acid, inhibition of simulated gastric drug nitros-

ation by 849p Aspartame, arguments against potential methanol poi-

soning following ingestion of 961L Aspartic acid, sodium salt with glutamate, neuronal necro-

sis in infant mice dosed with 887’

Benomyl, book review on environmental transformation and degradation of 950

Benzoyl peroxide, review of mutagenicity and carcino- genicity studies on 957

Betaine (arseno-, see under Arsenic), tissue-distribution studies in pregnant dogs and pigs 609’

BHA (see Butylated hydroxyanisole) BHT (see Butylated hydroxytoluene) Biotechnology, book review on: applications of 402, devel-

opments in genetic manipulation and other aspects of 954 2,2-Bis-(p-glycidyloxypbenyl)propane, technical, skin car-

cinogenicity study in mice 1081p Blood, book review on toxicology of bone marrow and

1020 Bromocblorodifluorometbane, genotoxicity tests on 1023 Butylated hydroxyanisole, rat forestomach lesions induced

by 639, 723p. reduction of benzo[a]pyrene-induced co- ionic nuclear aberrations by 47p

*The significance of the superscripts A, C, P, R and L is given in paragraph 2 of the Index of Authors (p. 3).

6

Butylated bydroxytoluene, effect on: excretion, distribution and DNA binding of aflatoxin B, in rats 567’, platelet aggregation and fibrin-clotting capacity in rats 937p

reriButyl hydroperoxide, mutagenicity and carcino- genicity studies on 958

terr-Butylisopropylbenzene hydroperoxide, M- and p-, no obvious carcinogenic activity in mouse study on 959

Caffeic acid, reduction of benzo[a]pyrene-induced colonic nuclear aberrations by 47’

Caffeine, reports on toxicological, pharmacological and behavioural effects of and epidemiology studies on 389’

Capsaicin, carcinogenicity feeding study in mice and Ames tests on 713

Carbamates (see also specific compounds), fungicides, herbicides and insecticides, book review on effects and persistence in soils 950

Carbon, Translocation study of bone-black particles from monkey vagina 367’

Carcinogenesis, book review on biochemical mechanisms in 119. cancer prestages in liver: biochemical and cyto- logical changes 863S868A, 876-878A, 880*, growth kinet- ics, promotion and cell death 873-875*, 881*, induction, clonal growth and progression 868%873A, 875A, 877A, 881A, 882A, in isolated normal and oreneoolastic heua- tocytes 868A, 871A, 879A, 881A, symposium rep;rt 861c. multi-stage development of model in rat bladder 521’

Cell cultures (see also specific cell types), book review on: serum-free methods for endocrine system cells 1021. techniques for animal cells 403, use of, in toxicity testing 403 use of human embryonic lung cell strain in toxicity testing 209c. use of respiratory tissue/cell cultures in toxicity testing 233c

Chlorine, in drinking-water, haematological effects of 121 Chloromethyl ether, bis-, sensory irritation potential in rats

87p Chlorpropamide, chromosomal studies in diabetics treated

with 625’ Chrysoidine, as dye for maggots used as fish bait, indi-

cations of possible connections with bladder cancer 1108 Cigarette smoking (see under Tobacco) Cinnamic acid, percutaneous absorption in monkey and

man 111’ Cinnamic alcohol, percutaneous absorption in monkey and

man 111’ Cinnamyl anthranilate, disposition and hepatic effects in

mice 559’. percutaneous absorption in monkey and man 111’

Coffee, effects of roasting procedure on mutagen for- mation in 593’. instant and brewed, in titro human lymphocyte mutagenicity tests on 747p. review of car- cinogenicity tests on 407

Corticosteroids, fluorinated, interference with radio- immunoassay of stilbene derivatives in animal samples 931p

Coumarin, 6-methyl-, as model compound in photo- sensitivity tests 689’

Cumene bydroperoxide, mutagenicity and carcinogenicity studies on 958

Curcumin, no effect on benzo[a]pyrene induction of co- ionic aberrations 47’

Cyclamate, metabolic adaptation of rat faecal microflora to

1029p, review of bladder tumour promotion by 637 Cyclobexene bydroperoxide, carcinogenicity studies on 959

Index of Subjects 7

Cyclopiazonic acid, distribution, excretion and skeletal muscle effects in rats 1069’. toxicity and neuro- pharmacology studies on 831p

Cytology, book review on cell ageing and cell death 953

2,4-D (see Dichlorophenoxyacetic acid) Daidzin, oestrogenic potency of, in mice 741’ DDT, book review on potential risk to man 119 effects

on energy-related functions of rat-liver mitochondria 599’ DEF, book review on hazards of human exposure to 633 Deoxynivalenol, DNA repair assay of, in- primary rat

heuatocvte cultures 1063’. subchronic feeding study in rais 995’

- _

Detergents (see under Surface-active agents) Di-rerr-butyl peroxide, negative DNA-transformation and

Ames tests on 958 1,4-Dicbloro-2-butene, sensory irritation potential in rats

87’ 2,4-Dicbloropbenoxyacetic acid, book review on re-

productive toxicity, mutagenicity, carcinogenicity and other studies 633, 950

Dicumyl peroxide, mutagenicity and carcinogenicity stud- ies on 958

Dietbylstilboestrol, factors affecting mammary-tumour in- duction by 73’

Dibydroxydimetbyl peroxide, mutagenicity studies on 960 Dimetbylcarbamoyl chloride, sensory irritation potential in

rats 87’ Diphenylamine, book review on environmental trans-

formation and degradation of 950 Dipropylene glycol methyl ether, bone marrow effects of,

suggested by clinical study of printers 123 Disuccinoyl peroxide, effects on DNA and mutagenicity in

E. coli 958 Drugs, book review on: annual survey of side effects of

1105, assessment of toxicity test procedures 1019, terato- genesis and other problems of exposure in pregnancy 632 susceptibility to nitrosation under simulated gas- tric conditions 849’

Echinacina B, irritation tests on 317’ Ecotoxicology, book review on behavioural responses of

fish to sublethal concentrations of chemicals 119 Ellagic acid, reduction of benzo[a]pyrene-induced colonic

nuclear aberrations by 47’ Emulsifiers, book review on emulsions and 401

Enzymes, effect of cruciferous and other vegetable com- ponents on hepatic and intestinal drug-metabolizing activities 57p. 899p. 905p. hydrocarbon hydroxylation system in liver microsomes from chicken, rabbit, rat and trout 363p microsomal, effect of high-fat diet on induction of, by polychlorinated biphenyls 805’. species differences in: activation of aromatic amines by hepatic microsomal preparations 409, activity of S-9 fractions in in rho mutagenicity studies 695’

Epichlorohydrin, book review on Environmental Health Criteria survey of 710. sensory irritation potential in rats 87’

Epidemiology, book review on methods and issues in 404 Epoxy resin, skin carcinogenicity study of Araldite (GY

250) in mice 1081’ Ethanol, effect of ip injections of, on immune response

in mice 1099p. enhancement of hepatocellular geno- toxicity of amino acid pyrolysate mutagens by pre- treatment with 661’

1,2-EthoxyAphenoxypropane, sensory irritation potential in rats 87p

Ethylbenzene hydroperoxide, metabolism in rats 408 Eye, Draize test: battery of alternative procedures 259’,

correlation with CAM test results 293’. limitations 139c. 149c, 329c, modifications for cosmetics 187’, possible

refinements 169’, 329’, scoring system 337’. . . histamine determinations in normal and inflamed 303c irritation tests: ATP determination in fibroblast suspensions for 267c, cytotoxicity procedures for 247c, 253c, devel- opment, modification and significance 149=, 189=, in isolated eyes 313’. in vitro cornea1 injury and CAM tests 215’, low-volume rabbit eye (P & G) procedure 175c, OECD scoring system 338’, using change in cornea1 permeability to fluorescein 321c, value in risk assessment 145’, W. German approach to 179’. tier scheme for assessing ocular tolerance 309c. variability of perme- ability to surfactants with age 239’

Fats/oils, Ames mutagenicity tests of peroxidic lipid ox- idation products 1041’ book review on Spanish toxic oil syndrome (WHO meeting report) 709. dietary level and aflatoxin B,, effects on hepatic lipid composition in rats 1049p. thermally oxidized corn oil fractions, effects on metabolizing enzymes in rats 737’

FD&C Blue No. 2 (see Indigo carmine) Ferulic acid, reduction of benzo[a]pyrene-induced colonic

nuclear aberrations by 47p Fish, book review on behavioural responses of, to sub-

lethal concentrations of chemicals I19 consumption, indications of protection against heart disease by 1107

Flavourings, use of Consumption Ratio concept for set- ting toxicity testing priorities 857a

Food, book review on: genetic factors in human nutrition 1103, toxicology and regulatory control of additives and contaminants in 1103

Formaldehyde, questionable epidemiological evidence for carcinogenicity in man 1024. sensory irritation poten- tial in rats 87’

Fungal toxins (see also specific substances), toxicity of Diplodiu mavdis to cattle. sheep, rats and ducklings 349p

Genistin, oestrogenic potency of, in mice 741p Glutamic acid, monosodium salt: kinetics of human

plasma glutamic acid after MSG dosing 975’, with aspartate, neuronal necrosis in infant mice dosed with 887’

Glycidyl ethers, structureeactivity studies on mutagenicity of 640

Glycyrrhizinate, disodium, oral carcinogenicity study in mice 979’

R-Goitrin, in diet, effects on hepatic and intestinal drug- metabolizing enzymes 905p

Gramine, nitrosation products of 841’ Gut, book review on: human intestinal microflora 402,

precancerous lesions in 401 faecal flora, metabolic adaptation to cyclamate in rats 1029’

Hepatocytes, isolated, cancer prestage studies in 86gA, 871A, 879A, 881A

~Heptadecane, metabolism in vifro by chicken, rabbit, rat and trout hepatic microsomes 363p

Herbicides (see also specific compounds and groups), book review on: prokaryote mutagenicity studies on 633, W. German monographs on toxicology of 120

Hexachlorobenzene, chronic toxicity testing in rats with varying dietary vitamin A levels 779p. oral carcino- genicity study in rats 779’

Hexamethylphosphoramide, sensory irritation potential in rats 87’

Histidine, effect on acute cobalt poisoning in rats 130L Histology, book review on manual of techniques used in

954 Hydrazines, book review on decontamination of labora-

tory wastes containing 634

8 Index of Subjects

Hydrogen peroxide, effects on dimethylamine nitrosation 339p

Hydroperoxides (see also specific compounds), review of possible genotoxic and carcinogenic risks of 957

I-Hydroperoxy-l-vinylcyclohexene-3, mouse skin-painting study on 959

p-Hydroxybenzoic acid, n- and isobutyl esters, oral car- cinogenicity study in mice 575p

Imidazo[4,5-fjquinoline, amino(di)meth enhancement of hepatocellular DNA repair activity of IQ and MeIQ by ethanol 661’. .2-amino-3-methyl-, production in fried ground beef patties 1035p

Imidazo[4,5-j]quinoxaline, 2-amino-3,8-dimethyl- and 2- aminotrimethyl-, production in fried ground beef patties 1035p

Immunology, book review on: immune functions and responses of respiratory tract 95 1, macrophage-mediated antibody-dependent cellular toxicity 405, monoclonal antibodies 952, mucosal immunity 1104

Indigo carmine, oral carcinogenicily study: in mice 719’, in rats 551p

Indole3-carhoxylic acid, as nitrosation product of gram- ine 841p

Industrial hazards, classification of industrial and agricul- tural chemicals as eye irritants 311’. design of skin tests for corrosiveness of chemicals 615’

International Agency for Research on Cancer, monographs on carcinogenic risk of polynuclear aromatic compounds (Vol. 32, parts 1-3) 709

Isothiocyanate, phenyl, 4-wk toxicity study in rats 1015p

Laboratory animals, body weight v. survival, nephropathy and neoplasia in rats 355’. book review on: character- istics and use of germ-free animals 953, welfare of

404 test refinements for protection of 183’ Lauroyl peroxide, review of mutagenicity and carcino-

genicity studies on 957 Linoleic acid, methyl ester of and methyl linolenate, Ames

mutagenicity tests on oxidation products 1041’ Liver (see also Hepatocytes), microsomal hydrocarbon

hydroxylation system from chicken, rabbit, rat and trout 363’ symposium report on biology of cancer prestages in 861c

Lysinoalanine, negative Ames assay on 763’

Malathion, percutaneous absorption in guinea-pig 919’ Meat, production of mutagens in fried ground beef 1035’ p-Menthane hydroperoxide, no obvious carcinogenic ac-

tivity in mouse study on 959 Merphos, book review on hazards of human exposure to

633 Metabolism (see Enzymes) Methacrylate(s), di-, sensitization and cross-sensitization

studies 713 .2-hydroxyethyl-, toxicity to cell culture systems 325A

Methyl bromide, oral toxicity study in rats 121 Methylene chloride, book review on Environmental

He&h Criteria survey of 710 Methvl linoleate hvdroueroxide, effects on dimethylamine

mt;osation 339< _ Methylxanthines (see also Caffeine), book review on

chemistry, consumption in foods and drinks and health effects 949

Monosodium glutamate (see under Glutamic acid) Musk amhrette, as model compound in photosensitivity

tests 689’. neuropathological changes after topical and oral administration to rats 716

Mustard gas, lesions from, in human skin grafts on athymic mice 326A

Mutagenesis, biomonitoring for exposure of industrial populations 23’. book review on UKEMS guidelines on testing for 629. . liposomes as vehicle for water- insoluble test materials in mammalian cell systems 717 screening for: in aquatic ecotoxicology ofindus- trial effluents 33c. in chemical industrv 5’. 43c. in drue industry 19’, in ‘food industry 1 I’, ‘in P388F mousi lymphoma system 1 15p. . species differences in activity of S-9 fractions used in Ames tests 695’. . study of genetic drift in Ames tester strains 126

Nitrate, excretion in dog saliva and bile 655p. human balance studies 883L

Nitrilotriacetic acid, sodium salt, renal tubular cell vacu- elation induced by 923p

Nitrite, excretion in dog saliva and bile 655p Nitrofurazone, genotoxicity studies on 1091p Nitrosamides, book review on decontamination of labora-

tory wastes containing 634 Nitrosamine(s), book review on genotoxicology of

629. dimethyl-, effects of methyl linoleate hydro- peroxide and hydrogen peroxide on formation of 339p. nitrosodiethanolamink, enterohepatic recycling of, in rats lOlIp. nitrosomorpholine, distribution and metabolism in rat tissues 647p. . reduced levels in nip ples for babies’ bottles 991’

Nitroso compounds (see also Nitrosamides, Nitrosamines and specific compounds), book review on genotoxicology of 629. formation from drugs and nitrite under simu- lated gastric conditions 849p

Nitrosoiminodialkanoic acids, formation during dipeptide nitrosation with nitrous acid 701’

N’-Nitroso-3-nitromethylindole, as nitrosation product of gramine 841p

Nitrous oxide, reproductive effects of 641 Nonoxynol-9, sensitivity of rabbit and rat vaginal mucous

membranes to 705’ Nucleic acids, book review on HPLC methods for use

with 954

Ochratoxin A, bacterial and mammalian cell mutagenicity assays on 91 I’. . . plasma levels and excretion (biliary and urinary) in albumin-deficient rats 941’

Oestrogens, potency of genistin and daidzin in mice 741’ Oils (see Fats/oils) Oleic acid, sodium salt, rat carcinogenicity study on

commercial sample of 619’ Organochlorine insecticides (see specific compounds) Organophosphorus pesticides (see specific compounds)

Parathion, cutaneous penetration studies in vitro 67’ Pathology, book review on inflammation, circulation and

neoplasia, immune responses and genetic basis of disease 1104

Peracetic acid, mutagenicity and carcinogenicity studies on 958

Perhenzoic acid, and derivatives, mutagenicity and car- cinogenicity &dies on 959

Performic acid. no effect on B. subtilis DNA 960 1,4-Peroxide-p-menthane-2 (see Ascaridole) Peroxides (see also specific compounds), Ames muta-

genicity tests of lipid oxidation products 1041p. . review of possible genotoxic and carcinogenic risks of 957

o-Phenylphenate, book review on environmental trans- formation and degradation of 950

Phosphine, effects on rats of long-term ingestion of diet fumigated with 1001’

Phthalic acid, di-(2-ethylhexyl) ester, metabolism in man 1023

Index of Subjects 9

Picloram, potassium salt, teratogenicity test in rabbits 753p

Piperonyl butoxide, ileocaecal ulcers but no tumour in- duction in carcinogenicity study of 675’

Polycblorinated biphenyis, book review on immuno- toxicological effects 119. . . effect of high-fat diet on drug-metabolizing enzyme induction by 805’. . . toxicity to keratinocyte culture 325*

Polynuclear aromatic compounds (see also specific com- pounds), IARC monographs on carcinogenic risks of 709

Psoralen, 8-methoxy-, as model compound in photo- sensitivity tests 689’

Pyrido[l,2-a :3’,2’-djimidazoles, enhancement of hepato- cellular DNA repair activity of Glu-P-l and Glu-P-2 by ethanol 661p

Pyrido[4,3_6]indoles, enhancement by hepatocellular DNA repair activity of Trp-P-1 and Trp-P-2 by ethanol 661P

Quercetin, feeding (I-month) toxicity study in rainbow trout 1077p. reduction of benzo[a]pyrene-induced co- ionic nuclear aberrations by 47p

b-Resorcylic acid lactones, occurrence in food, metabo- lism and oestrogenic, teratogenic, genotoxic and carcino- genic activities of 767R

Rubber, book review on toxicity of chemicals used in 630

Saccharin, bladder tumours: epidemiology studies on pos- sible association with 529’, in rat feeding study of 475’, 491c, multi-stage carcinogenesis model 521c. . . cancer risk assessment for 499’. effect on microbial metabo- lism of amino acids: in man 451c, in rats 437’, 44F. effect on mineral and water balance in rats 465’. effect on urine composition and bladder tissue of rats 457’ . inhibition of gastro-intestinal enzymes by 457c. . metabolic fate and distribution in man and animals 429c. . possible mechanism of genotoxic activ- ities 507’. produced by Maumee process, amino- saccharin impurities in 419c. review of toxicological history of 535c.. status report of Expert Panel 543’. two-generation feeding study in rats 475c, 491c

Safrole, percutaneous absorption in monkey and man 111r

Selenium, oral toxicity study in hamsters 945p Shampoos (see under Surface-active agents) Skin, animal models for predicting percutaneous absorp-

tion of chemicals in man 327A. book review on cutane- ous toxicity 631 cells or slices in tests for acute inflammation of 27S. chemical corrosivity: design of animal tests for 615’, epidermal slice technique for 229’. device for UV irradiation of, in guinea-pig 683’. human, grafted to athymic mice for studying cutaneous damage 326A. irritation tests: development, modification and significance 149c, 165c, quantitative, in mouse 199’, scoring system 337c, using three cytotoxicity assays 247’. value in risk assessment 145c, W. German approach to 179’. mouse intradermal test for chemical tolerance of 195’. occlusive patch use in photo- sensitivity tests in guinea-pigs 689’. . relation between irritancy and pH or buffering capacity 299c. . . tests for and mechanisms of dermatitis 155c

Stilbene, derivatives, fluorinated-corticosteroid inter- ference in radioimmunoassay for 931p

Structure-activity relationships, book review on use of QSAR in environmental toxicology 634

Sucrose, renal tubular cell vacuolation induced by 923p

Sulphite, appearance, with S-sulphonate, in rat plasma after intraduodenal administration of 895p

Sulpbur dioxide, ecotoxicological and respiratory effects of 410

Surface-active agents (see also specific compounds), effect of age on eye penetration by 239’. . . eye irritation potential: of detergents, cytotoxicity test for 253c, of shampoos, in vitro SIRC cell test for 271c

2,4,5-T (see Trichlorophenoxyacetic acid) Talc, no evidence for translocation from monkey vagina

to uterus 367p Temephos, book review on toxicology, metabolism, en-

vironmental distribution and analysis of 633 Teratogenesis, book review on: drug effects 632, occu-

pational/environmental influence on 63 1 . mammalian embryo cultures in study of 326A

Tetrachlorosalicylanilide, as model compound in photo- sensitivity tests 689p

Tetralin hydroperoxide, no increased gene conversion by, in yeast 959

Thiabendazole, book review on environmental trans- formation and degradation of 950. macromolecular binding in pregnant mice, relation to teratogenicity 733p

Thiram, mutagenicity in mammalian somatic cells 373p ThymIne peroxide, mutagenicity study in E. coli 960 Tobacco, genotoxicity tests on cigarette-smoke condensate

603’ Toluene diisocyanate, lung-function effects in workers ex-

posed to 411 Toxicity testing (see also Carcinogenesis, Eye, Mu-

tagenesis, Skin), book review on: developments in human risk assessment 951, needs and priorities in 1019, use of cellular systems in 403. comparison of rat and rabbit as models for irritancy screening of vagina1 products 705p. in mammalian embryo cultures 326A. . of

drugs, assessment of required methods 1019. reproduction studies, ECETOC review and rec- ommendations 377R.. studies of in oitro methods 205’, 209c. . use of: human embryonic lung cell strain in 209c, respiratory tissue/cell cultures in 233c

Toxicology, book review on: design/management of labo- ratories for 710, environmental factors in 632, genetic variations in responses to xenobiotic chemicals 949, use of QSAR for environmental chemicals 634. ethical aspects of animal use in 137’, 329’. human, book review on analytical methods appropriate for 951 reproductive: book review on occupational/ environmental influences 631, ECETOC review and rec- ommendations 377s

Tributylphosphorotrithioate, and -trithioite, book review on human hazards from 633

2,3,4-Trichloro-1-butene, rats 87p

sensory irritation potential in

2,4,5-Trichlorophenoxyacetic acid, book review on tox- icology of 950

3,7,15-Trihydroxy-12,13-epoxytrichothec-9-ene-g-one (see Deoxynivalenol)

Trimethylamine-N-oxide, in squid, thermal conversion to di- and trimethylamines 579p

Trimethylolpropane triacrylate, dermatitic effects of 124 Turmeric,

967’ oleoresin, subchronic oral toxicity study in pigs

Vegetables, cruciferous: effect of R-goitrin component on drug-metabolizing enzymes 905p, effects on rat xenobiotic-metabolizing enzymes 57p. effects on mouse-liver drug-metabolizing enzymes 899p

Vitamin A, pharmacokinetics in rats and hamsters 51p Vitamin D, , damage to swine coronary arteries by 585’ Vomitoxin (see Deoxynivalenol)

10 Index of Subjects

Water, drinking-, rat carcinogenicity study of mutagenic a-Zearnlanol, and zearalenone, occurrence, metabolism, organic concentrates of 79p biological activities and significance of zearalanol-

Wines, yeast-contaminated, mutagen content of 343’ implant residues in meat 767R Zeranol, (see a Zearalanol) Zinc pyrithione, mode of action on cell growth: in vitro

Xylitol, effects on faecal microflora in mouse, rat and man 93p, in vi00 103p 98Sp

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