Author Index

Page Numbers printed in italics refer to References

Abdallah, M.A. 205-207,211,213,214, 217, 219, 223-225, 22~ 228, 230, 231, 235-237

Abdullaev, N.D. 237 Achouak, W. 215,225 Acred, P. 207 Actis, L.A. 219 Adam, J. 231 Adam, W. 75 Adams, P. 212 Adanin, Y.M. 221 Adkinson, R.A. 235 Aebersold, R. 216 Alarcon-Chaidez, F. 207 Alatossava, T. 226 Albesa, L 205, 214 Albrecht, A.M. 213 Albrecht-Gary, A.M. 206 Allison, J. 223 Al-Shibib, A. 206 Amann, C. 206, 222, 233 Amano, S. 219 Ambrosi, C. 206 Amornpunch, S. 230 Ams, D.A. 206 Anderegg, G. 206 Andersen, R.J. 236 Andrews, S.c. 226 Angelini, P. 215 Anjaiah, Y. 226 Ankel-Fuchs, D. 217, 236 Ankenbauer, R.G. 206, 230 Anthoni, U. 206 Applegate, H.E. 80

Arinbasarov, M.U. 221 Arm, C. 79 Armbruster, W. 214 Aroulanda, C. 206 Arpin, N. 232 Askeland, R.A. 206 Atkinson, R.A. 206

Atta-ur-Rahman 75 Awataguchi, S. 214 Azadi, P. 223 Azelvandre, P. 206, 225

Baesler, S. 75 Baida, N. 225 Baker, T.R. 206 Bakker, P.A.H.M. 222, 224 Balashova, N.V. 207 Bally, M. 236 Banert, K. 75 Barberis, L.L 205 Barbier, M. 229 Barelmann, L 207, 225, 230 Barker, W.R. 207 Barnes, C.L. 234 Bar-Ness, E. 2Jl Bassi, A.S. 224 Bateman, A. 213 Bauminger, R. 226 Baysse, C. 207,212,215,225,226 Beanan, M. 227 Beare, P.A. 207, 222 Beatson, S.A. 212 Begley, T.P. 213 Beiderbeck, H. 207, 230 Beier, R.c. 207 Beijerinck, M.W. 153, 207 Bella, P. 215 Bellama, J.M. 2l7, 235 Beitnin, J.P. 234 Bender, C.L. 207 Benoni, H. 226 Benz, J. 232 Berenschot, D.R. 78 Berg, A. 217 Berge, J.P. 210 Bernard, F. 219 Bernardini, J.J. 207, 236 Bessonova, LA. 237

240

Beutler, J.A. 78 Beyeler, M. 229, 231 Bezbaruah, B. 221 Bhandaru, S. 75, 76, 78 Bialas, J. 75 Billard, I. 208 Birkofer, A. 94, 207 Birkofer, L. 94, 207 Bishop, G.G. 223 Bitter, W. 207, 221, 222 Bladon, P. 46, 58, 75 Blagbrough,I.S. 231 Blanc, S. 206 Blanchard, G.C. 220 Blaszczyk, K. 78 B1azhevich, O.v. 208, 223 Blondeaux, A. 208 Bloom, M.L. 236 Blunt, J.w. 80 Biickmann, M. 208 Biihnke, R. 208 Bollet, e. 233 Boltjes, T.Y.K. 234 Bonde, GJ. 94, 208 Bonner, D.P. 223 Boopathi, E. 208 Borek, V. 211 Boronin, A.M. 207 Boruah, H.P.D. 208 Bossis, E. 208 Boswell, G.A. 75 Bothe, H. 235 Botzenbart, K. 208 Bouby, M. 208 Bouchard, e. 83, 194, 208 Boucher, J.e. 237 Boukbalfa, H. 205 Bovicelli, P. 65, 66, 75 Boyd, A.e. 75 Boyd, M.R. 75, 78-80 Boyd, R.K. 233 Boyer, G.L. 206 Boyler, D. 76 Brack, A. 232 Brandon, M.S. 208 Braun, M. 208 Braun, V. 208 Breslow, R. 51, 52, 56, 75 Brinkac, L. 227 Brinkman, F.S.L. 216, 232

Author Index

Briskot, G. 208, 222, 226 Britigan, B.E. 208,211,213 Brodey, C.L. 226, 227 Brody, L.L. 232 Brown, C. 214 Brown, F.M. 77 Brunck, A. 75 Bruyneel, B. 235 Bu, Y. 231 Buchanan, R.E. 209 Buchanan, S.K. 209 Buchenauer, H. 214 Buchwald, H.D. 209 Buckling, A. 232 Budesinsky, M. 75 Budzikiewicz, H. 205-209, 212, 214-223,

225,236 Bujdakov<i, H. 220 Bukovits, GJ. 209 Bulen, W.A. 94, 153, 210, 211 Bultel-Ponce, V. 210 Bultreys, A. 210 Bunce, R.A. 210 Bums, lL. 232 Burton, M.a. 210 Buyer, J.S. 210, 230 Buysens, S. 218 Bycroft, B.w. 236

Caignan, G.A. 210 Cain, C.K. 217 Calfee, M.W. 210 Callaghan, C. 207 Callao, V. 223 Camara, M. 236 Campbell, J.J.R. 210, 220 Campbell, M.M. 75 Caplan, A.B. 211 Carmeli, S. 210 Carmi, R. 210 Carrano, CJ. 205 Carroll, CJ. 217 Castignetti, D. 210 Celia, H. 214 Cerny, I. 13, 27, 75 Chablain, C. 226 Chablain, P. 212 Chakrabarty, A. 211 Chakrabarty, A.M. 94, 210, 224 Chakraborty, R.N. 209,210

Author Index

Champomier-Verges, M.e. 210 Chandhoke, V. 230 Chapon, V. 236 Charlier, P. 228 Chen, I.L. 210, 222 Chen, Y. 211,220 Cheng, lQ. 78 Chhabra, S.R. 236 Chiancone, E. 235 Chinn, L.J. 46, 75 Chipperfield, lR. 211 Chodat, E 211 Choudary, M.L 75 Choussy, M. 229 Christen, R. 215, 226 Christie, N. 77, 79 Christie, N.D. 79 Christophersen, e. 206 Chugani, S. 205,211,224 Ciervo, A. 235 Clarke, T.E. 211 Cochet, N. 208 Cochez, e. 213 Cody, Y.S. 2Il Coffman, TJ. 211 Cole, PJ. 233 Coleman, J.P. 210 Collinson, S.K 207, 211, 223, 228 Colotti, G. 235 Conrad, N.K. 78 Contopoulou, R. 228 Conway, B. 222 Cook Jr., J.e. 212 Corbin, J.L. 211 Corcoran, RJ. 75 Cordwell, SJ. 212 Cornelis, P. 205,207,211-213,215,218,

219,221,225,226,229,232 Cornforth, I.W. 195, 211 Cornish, A.S. 211 Coroler, L. 211,214 Cortese, M.S. 211 Cottrell, lS. 212 Coulanges, V. 225 Coulter, S.N. 232 Coulton, 1 W. 214 Courtieu, I. 206 Coves, J. 215 Cowart, R.E. 235 Cox,C.D. 178,206,208,211-213,230

Cox, KA. 212 Coxon, B. 217 Craig, R.C. 75 Cram, D.J. 220 Crawford, R.L. 208, 211, 222 Crockett, A.K 219 Crosa, I.H. 219 Crumbliss, A.L. 205 Csizmadia, LG. 236 Cung, M.T. 213, 224 Cuppels, D.A. 212

Dabboussi, F. 212 Diibritz, E. 212 Dallakian, P. 212 Danganan, e. 211 Daubaras, D. 211 Dauben, W.G. 75 Daugherty, S. 227 Dave, B.P. 237 Davey, S. 232 Daykin, M. 215,236 Dean, C. 232 Debitus, e. 210, 212 DeBoy, R.T. 227 De Chial, M. 212, 213 Defago, G. 224 Deguchi, T. 231 De Hoffman, E. 210 Deisenhofer, J. 209 Dekker, KA. 212 De Ley, 1. 213 Delfosse, P. 219, 227 Dell, A. 207, 213, 223, 224, 228, 236 Della Chiesa, V. 231 Delong, G.T. 222 Demange, P. 213, 224, 228, 236 Dennis, I.J. 232 Den Ouden, EM. 222 Denton, M. 213 De Pauw, E. 227, 228 Deretic, V. 237 Derylo, M. 213 Desai, S.B. 210 DeSesso, L.e. 230 Deshmukh, R. 210 Desnottes, J.F. 217 De Vos, D. 207, 213, 225 De Vos, P. 220 De Weger, L.A. 207, 224

241

242

DeWitte, J.J. 213 Diederichs, K. 214 Dirkx, EP.M. 222 Djerassi, C. 75 Dobisova, M. 219 Dodson, R.J. 227 Doisy, E.A. 217 Doll, R.J. 75 Dongre, A.R. 213 Donohue, S. 230 Doodlett, D.R. 216 Dore, S. 77 Dorrestein, P.C. 213 Dostal, L. 237 Doubek, D.L. 79 Doucette, GJ. 206 Doudoroff, M. 228, 232 Doye, S. 76 Drasar, P. 75 Drechsel, H. 214 Driigemiiller, M. 75, 76 Dube, H.C. 237 Dubey, R.C. 216 Dubis, E.N. 78 Dubus, A. 224 Duddeck, H. 80 Dufresne, C. 77, 79 Dugave, C. 231 Durham, L. 209 DiisterhOf, A. 227

Eagles, B.A. 210, 220 Eastman, M.A. 210 Eberhard, A. 228 Eberl, L. 215 Ebu-Talb, A. 206 Edeker, B.L. 211 Eder, U. 76 Egawa, Y. 214, 219 Eisen, 1. 227 Elliott, R.P. 94, 214 Elomari, M. 211,214 Emery, T. 214 Endo, A. 237 Eng, J. 216 Eng-Wilmot, D.L. 214 Eraso, A.J. 205, 214 Ernst, R. K. 216 Erwin, A.L. 232 Espinet, P. 214

Author Index

Esser, L. 209 Ezaki, N. 219

Fakhouri, W. 214 Faulkner, DJ. 236 Feistner, G. 214 Fekete, EA. 214, 236 Ferguson, A.D. 214 Fernandes, D.U. 229 Fernandez, R.E 222 Fieser, L.E 76 Fieser, M. 76 Filonov, A.E. 207 Filsak, G. 214 Fischer, H.G. 209 Fishbein, 1.R. 220 Fisher, S.M. 223 Flessner, T. 76 F1etton, R.A. 207 Foglino, M. 236 Fohlman, J. 230 Folger, K.R. 232 Folschweiller, N. 214 FOrrUchev, Yu.K. 223 Fontecave, M. 215 For, R.J. 207 Forsythe, J.H. 206, 217 Fouts, D.E. 227 Fowler, EW. 77 Fracassi, D. 75 Frank, H. 213 Fraser, C.M. 227 Fray, R.G. 215 Freeman, L.R. 215 Frejd, T. 228 Frere,I.M. 224 Fritz, H. 80 Fuchs, P.L. 4, 11-18,30,42-47,50,55,

62-64, 68-70, 75-80 Fuchs, R. 207,209,215,218-220,

230-232,234,235 Fuhrman, EA. 209 Fujino, A. 78 Fukasawa, K. 215 Fukuzawa, S. 76 Funabashi, Y. 234 Fiirst, A. 35, 76 Furumai, T. 230 Fuse, H. 219 Fusetani, N. 3, 4, 16, 43, 66, 76, 80

Author Index

Gaballa, A. 215, 221 Gaby, WL. 217 Gaille, C. 215 Gallay, J. 214 Ganesan, A. 76 Garai, S. 76 Garber, R.L. 232 Garcia-Rodriguez, J.A. 226 Gardan, L. 208, 215, 220, 225, 226, 233 Gaskell, SJ. 212 Gaudemer, A. 229 Gayazov, R.R. 207 Gehrke, C.W. 222 Geisen, K 215 Geisenberger, O. 215 Gelleni, M. 224 Gensberg, K. 215 Geoffroy, V. 205,207,212,215,216,220,

225,226,231,232,234,236 Georges, C. 215,225 Georgia, ER 216 Georgias, H. 209,216 Gems,1. 221 Gessard, M.C. 91,92,216 Ghei, R 230 Gheysen, 1. 210 Ghysels, B. 212 Gibson, D.T. 218 Gierson, D. 215 Gilbert, 1.M. 75 Gill, S.R. 227 Gillis, A. 221 Gillis, M. 211,213,214,220 Gipp, S. 216 Giral, E 93, 94, 216 Givskov, M. 215 Glennon, J.D. 216 Goel, R. 216 Goltry, L. 232 Gondol, D. 231 Gonzales, D. 218 Goon, DJ.W 227 Goor, M. 213 Gootz, T.D. 212 Gordon-Wylie, S.W 222 Gore, M. 214 Goto, M. 215 Gouda, S. 211,216 Gough, FJ. 210 Gougoutos, J.Z. 223

Gould, SJ. 227 Graham, R 178, 212 Gram, L. 206,216,218 Gray, KM. 228 Greenberg, E.P. 222, 228, 229, 231 Greppin, H. 216, 226 Grieco, P.A. 39, 76 Gross, D.C. 207, 211 Gross, M.L. 220 Guella, G. 212 Guemas, J.P. 212 Guerinot, M.L. 205 Guertin, KR. 228 Guina, T. 216 Guo, C. 76, 78, 80 Gupta, A. 216 Gupta, c.P. 216 Gupta, S.c. 78 Gustine, D. 230 Gutknecht, H. 77 Gutteridge, J.M.C. 216 Guyot, M. 210 Gwose,1. 216,219,228,233 Gyorgydeak, Z. 233

Haag, H. 214 Haas, D. 215, 229, 231 Haase-Held, M. 77 Habermehl, G.G. 46,47, 77 Hadar, Y. 211, 220 Hadjiarapoglou, L. 75 Hahn, J. 216 Hajos, Z.G. 38, 77 Halle, E 216, 225 Halliwell, B. 216 Hamann, P.E. 47,77 Hamel, J.E 208 Hamze, M. 212 Hance,1. 227 Hancock, D.K 217, 235 Hancock, RE.W. 216,232 Hanson, J.R. 77 Hantke, K 214 Harada, R 209 Harada, S. 220, 234 Harding, R.A. 217 Harper, P.B. 207 Harrison, A.G. 217, 236 Hartmann, R 218,230 Hase, C. 224

243

244

Hasegawa, Y. 219 Hasenfratz, C. 80 Hashimoto, K. 231 Hashimoto, M. 217 Hashizume, K. 221 Hassner, A. 32, 77 Hastings, M. 232 Hattori, K. 217 Hatzis, M. 77 Hayakawa, Y. 231 Hayase, Y. 221 Hayashi, T. 231 Hays, E.E. 195,217

Author Index

Honda, H. 77, 80 Honeychuck, R.y. 230 Horikawa, M. 233 Hornsperger, 1.M. 223, 225 Hossain, M.B. 219, 234 Hoste, B. 211,214 Hotopp, T. 77 Hou, K. 78 Howard, G.T. 218 Hu, H. 78 Huang, A. 217 Huang, HW. 210 Huang, 1.J. 218

Heathcock, C.H. 13, 15, 17,20,28,30,76, Huang, L.H. 212 77

Heim, S. 227, 229, 234 Heinisch, L. 217, 236 Heinrichs, D.E. 217, 229 Hendrickson, W. 211 Hennard, C. 205,217,227,231,236 Herald, D.L. 77, 79 Hersman, L.E. 85,206, 217 Heuer, H. 229 Hickey, MJ. 232 Hickford, SJ.H. 80 Hidaka, S. 221 Hilbert, H. 227 Hildebrand, U. 209,217,218 Hill, L. 207 Hirai, N. 237 Hirano, T. 78 Hirata, Y. 215,230 Hletkova, M. 220 Hoffa, A. 218 Hofmann, E. 214 Hafte, M. 218,221 Hoh, F 207 Hoheisel, 1. 227 Hohlneicher, U. 218,233 Hohnadel, D. 211, 225, 232 Hohnadel, G. 218 H\'liby, N. 215 Holder, LA. 225 Holland, H.L. 77 Holliman, FG. 218 Holm, R.H. 221 Holmes, M. 227 Holmstr\'lm, K. 218 Holt, J.G. 209 Holtzapple, E. 227

Huang, Z.H. 223, 230 Huber, L 216 Hubner, A. 211 Hiibner,1. 217, 218 HudJicky, T. 218 Hufnagle, W.O. 232 Hughes, H.K. 231 Hughes, K. 215 Hu1cher, FH. 95,218,223,227 Hunault, G. 233 Hunt, DJ. 237 Huston, W.M. 219 Huyer, M. 219, 228 Hwang, D.F 231 Hwang, S.Y. 219

Ichihara, Y. 79 Igarashi, Y. 230 Iglewski, B.H. 228, 229, 234 Iida, T. 221 lkenishi, Y. 221 Inagaki, T. 212 Ino, A. 219 Inoue, H. 219, 237 Inoue, M. 77, 79 Ishiguro, M. 233 Ishii, Y. 233 Isomura, K. 80 Ito, Y 214, 219 Itoh, 1. 219 Iwamura, H. 237 Izard, D. 211, 212, 214, 225

Jacobs, FA. 217 Jacobs, M.F 77 Jacques, 1.F 211

Jacques, P. 219, 225, 227, 228 Jalal, M.A.E 219 James, A.T. 211 Jansen, S. 213 Janssen, B. 80 Jautelat, R. 75-77 Jeedigunta, S. 222 Jeffery, T. 40, 77 Jennings, M.P. 219 Jensen, C.E. 208 Jeomg, D.Y. 222 Jeong, J.U. 77, 80 Jin, Z. 78 Johnova, A. 219 Johnson, B.E. 78 Johnson, Z. 232 Johnstone, D.B. 153, 220

Johnstone, K. 226, 227 Johri, J.K. 220 Jolivet, S. 232 Jones, J.L. 213 Jones, L.R 217 Jones, RC.E 219 Jordan, E.O. 92, 220 Joubert, l 228 Joumet, M.P. 228 1iilich, M. 220 Jung, G. 214 Jurkevitch, E. 211,220

Kaleya, R. 75 Kallova, J. 220 Kamano, Y. 77, 79 Kamath, S. 205 Kameyama, A. 78 Kamigiri, K. 220 Kang, P.M. 226 Kao, C.Y. 209 Kapatral, Y. 205 Karle, I.L. 2 Jl, 220 Karle, J. 211, 220 Kas, A. 232 Kasal, A. 79 Kase, H. 221

Katayama, N. 220, 234 Katekaew, S. 230 Katzman, P.A. 217 Kaul, R 232 Kawaguchi, K. 219 Kawahara, K. 219

Author Index

Kawamura, Y. 221 Kawano, Y. 214 Kawata, M. 78 Kaye, El 78 Keating, T.A. 229 Keller, M. 80 Keller-Schierlein, W 220, 224 Kelley, MJ. 78 Kende, A.S. 228, 229 Kerley, E.L. 214 Kersters, K. 220 Kettner, M. 220 Khalil-Rizivi, S. 220 Khanna, P.L. 75 Khouri, H. 227 Khouw, C. 236 Kieffer, B. 206, 214, 235 Kiewitz, C. 227 Kilburn, L. 220 Kilz, S. 209, 220 Kim, C.H. 222, 226 Kim, D.S. 222 Kim, H.D. 222 Kim, H.M. 222 Kim, K.S. 222 Kim, S.D. 223 Kim, S.H. 77, 78 Kim, WS. 222 Kim, Y.P. 219 Kim, Y.S. 223 Kimura, M. 78 King, lY. 220 Kingsbury, C.A. 220 Kinzel, O. 221 Kisaalita, W.S. 236 Kitahara, T. 236 Kitamura, S. 221 Kitching, W. 77 Kleinkauf, H. 221 Kloepper, J.W. 96, 221 Knosp, O. 221 Knowles, C.J. 221 Ko, H. 214 Kobayashi, S. 221 Kodama, Y. 219 Koedam, N. 215,218,219,221,226 Koehl, P. 226 Kogo, H. 77, 80 Kohlbrenner, W.E. 212 Kohler, E 75

245

246 Author Index

Kojima, N. 212 Kojima, Y 212 Kolasa, T. 221,227 Kolonay, J. 227 Korth, H. 209,214,218,226,227,233,236 Korns, R. 208 Kosack, D. 227 Kosheleva, I.A. 207 Kosono, Y 228 Koster, M. 221, 222 Kourambas, S. 232 Kowalik, DJ. 232 Kozlovskii, A.G. 221 Krahnert, W.R. 80 Kramer, A. 77, 78, 80 Krebes, K. 229 Krishnapillai, V. 232 Kriiger, HJ. 221 Krupa, T.S. 79 Kubo, A. 12, 78 Kubodera, N. 78 Kumar, B.S.D. 208 Kumar, D. 221 Kunisawa, R. 228 Kunz, D.A. 210,222 Kuroda, M. 78 Kyslik, P. 207,217,219,227,230,231,

235, 236

LaCour, T.G. 76, 78, 80 Lagrou, M. 232 Lambert, P.A. 227, 231 Lamont, 1.1.. 207, 222, 235 Larbig, K. 232 Latifi, A. 236 Latour, X. 208 Lauber, 1. 227 Laurent, H. 78, 80 Lazdunski, A. 236 Leclerc, H. 211, 214 LeComte, J.R. 94, 153,210 Lee, e.H. 222 Lee, K. 227 Lee, K.A. 216 Lee, MJ. 222 Lee, P.e. 227 Lee, S.H. 219 Lee, W.C. 78 Leeman, M. 222 Lefevre, J.P. 206, 226, 233

Leimer, K.R. 222 Leisinger, T. 205 Lemanceau, P. 208, 225 Lenhoff, H. 94, 222 Lenz, e. 220, 222 Leonard, V. 224 Leong,1. 210,221,222,234,

237 Leoni, I.. 206, 235 L'Eplattenier, P. 206 Lepoivre, P. 219 Lesot, P. 206 Lessel Jr., E.P. 209 Levy, E. 210 Lewenza, S. 222 Lewis, CJ. 232 Lewis, T.A. 211, 222 Lex, J. 217, 226 Li, X.Z. 232 Liao, P.C. 223 Lim, H.S. 223 Lim, R. 232 Lin, YM. 230 Linget, e. 205, 213, 223, 224 Linget-Morice, e. 207, 227 Liotta, D. 78 Liu, p.v. 178, 223 Liu, W.e. 223 Livennore, D.M. 223 Llimis, M. 229 Lloyd, T. 217 Lluch, e. 223 Lluch, M.e. 223 Logan, R.T. 75 Longerich, I. 223 Lopez, M.M. 233 Lorenzo, e. 214 Lory, S. 232 Lotowski, Z. 78 Lotz, R. 214 Love, S.H. 223 Lu, Y 230 Lubin, I.. 229 Luckner, M. 230 Ludwig, V. 76 Ludwig, W. 220 Lugtenberg, B. 224 Luhowy, R. 223 Lupattelli, P. 75 Lysak, V.v. 223

Ma, S. 80 Mabbott, G.A. 236 Maccordick, HJ. 208 MacCordick, J. 223 MacDonald, J.e. 223 Machan, Z.A. 233 Machi, B. 217 MaCickova, T. 220 MacLeod, J.K. 213, 223 Madupu, R 227 Maekawa, R 78 Mahato, S.B. 76 Maheshwari, D.K. 216 Maksimova, N.P. 208, 223 Mancini, I. 212 Manley, K. 216 Mann, J. 77 Maraite, H. 210 Marchal, J.G. 224 Marek-Kozaczuk, M. 209, 224 Margaritis, A. 224 Margraff, R 205 Marinello, E. 229 Martin, L.W. 207 Martins dos Santos, V.A.P. 227 Marttinen, N. 226 Marugg, DJ. 236 Marugg, J.D. 207, 224, 234 Masaki, Y. 76 Masson, P.L. 211 Matagne, A. 224 Matsubara, 1. 231 Matsui, M. 236 Matsumoto, T. 233 Matsunaga, I. 78 Matsunaga, S. 76, 80 Matsunaga, Y. 212 Matthijs, S. 205 Mattiasson, B. 228 Matzanke, B.P. 208, 224 Maurer, B. 152, 224 Maurhofer, M. 224 Maurice, P.A. 206, 217 Mayer, 1. 232 McCaldin, DJ. 224 McCormick, M.L. 208 McCracken, A.R. 224 McDyer, D. 214 McEwen, A.G. 219 McFall, S. 211,224

Author Index

McGuirk, P.R 212 McKay, G.A. 205 McKnight, S. 229 McMeekin, W. 75 Meader, P.D. 224 Mechoulam, R 24, 80 Meguro, Y. 237 Mehmet, S. 233 Meier, H. 80 Melchiorsen, J. 216 Meldrum, A. 231 Meneghini, F. 223 Menhart, N. 224 Mercado-Blanco, J. 224 Mergeay, M. 235 Merlet, D. 206 Merriman, RL. 79 Merritt, Jr. e. 215 Mertens, P. 220 Mertz, e. 213, 224 Metraux, J.P. 224 Meuwly, P. 224 Meyer, J.P. 225

247

Meyer, J.-M. 91,96, 140,205-207, 209-213, 215, 216, 218, 220, 223-226, 23{}-234, 236

Michalke, R 209, 225 MicMa, M. 226 Michels, J. 226 Mielczarek, E.V. 226 Miguel, J.A. 214 Mikami, Y. 11 Mikucki, J. 233 Milbank, J.BJ. 229 Milkova, T. 80 Miller, MJ. 221,227,230 Miller, S.I. 216 Milosovic, P. 220 Mimaki, Y. 77, 78, 80 Minocione, E. 75 MissaIe, M.C. 229 Miyadoh, S. 219 Miyagishima, T. 219 Miyairi, S. 233 Miyamoto, K. 78 Miyashita, E. 221 Mizoguchi, S.D. 232 Moazzez, A. 227 Mock, M. 225 Moenne-Loccoz 210

248

Moestl, D. 227 Moguilevsky, N. 211 Mohn, G. 226, 233 Mohr, N. 209 M6llmann, U. 217,236 Moon, S.S. 226 Moore, E.R.B. 229 Moore, M.L. 212 Moreau, N.J. 217 Mori, T. 78 Moriarty, R.M. 23, 78 Morioka, M. 220 Morris, M. 212 Morrison, S.M. 206 Mortishire-Smith, R.J. 226, 227 Morzycki, l.W. 13, 78 Moseley, ET. 234 Mosher, H.S. 209 Mossialos, D. 226 Moya, E. 231 Muir, R.D. 217 Muller, A. 224, 226 Muller-Fahrnow, A. 77 Munoz-Bellido, J.L. 226 Munro, M.H.G. 80 Munsch, P. 226, 234 Murabayashi, A. 219 Murakami, K. 219 Murata, M. 237 Murayama, E. 78 Muyldermans, S. 215 Myers, B. 237

Naegeli, H.U. 226 Nagappan, O. 222 Nagasawa, H.T. 227 Nakada, E 78 Nakagawa, K. 78 Nakai, H. 221 Nakata, M. 228 Namiranian, S. 227 Naoki, H. 237 Narano, Y. 228 Naudet, Y. 207 Nautiyal, e.S. 220 Nawasreh, M. 78 Neely, A. 225 Neidt, I. 235 Neilands, 1.B. 231 Neirinckx, L. 219

Author Index

Nelson, K.E. 227 Nelson, W. 227 Neshat, S. 220, 229 Neu, H.e. 227 Neuenhaus, W. 227 Newkirk, J.D. 227 Nguyen, H. 77 Niccolai, D. 227 Nicolas, l.L. 210, 212 Nielander, H.B. 224 Nielsen, P.H. 206 Nielsen, T.E 216 Nitoda, T. 219 Niven, M.L. 79 Noah, W.H. 214 Noble, D. 207 Noguchi, T. 231 Nogushi, K. 80 Nomoto, K. 234 Nomura, E. 212 Novak-Thompson, B. 227 Nowak, P. 78 Nozaki, Y. 220 Nutkins, J.e. 226, 227

Ocaktan, A. 205, 206, 227 Ochi, K. 78 Ochsner, U. 207, 222, 226, 227, 232, 235 Ockels, W. 209,217,227,236 Offord, R.E. 98, 227 Ogai, D.K. 237 O'Gara, E 216, 228 Ogawa, Y. 219 Ogena, M. 91 Oka, K. 78 Okonogi, K. 220 Okonya, J.E 227 Okuda, T. 214 Okujo, N. 236 Olivares, 1. 223 Olivier, J.M. 232 Olson, M.Y. 232 Olson, Y.M. 232 Olsson, P.E. 224 Ongena, M. 219, 227, 228 Ono, H. 220, 234 Oorthuizen, M. 224 Oota, S. 237 Orsi, N. 206, 235 Osawa, R. 78

Author Index 249

Osawa, S. 228 O'Sullivan, D.J. 228 Ovaa, W. 221 Ozaki, M. 221

Packman, L.e. 226, 227 Padikkala, J. 229 Page, W.J. 207,211,219,221,223,228 Paine, S.G. 228 Pajaro, M.e. 205 Palleroni, N.J. 85, 86, 225, 228, 232 Palnitkar, M. 209 Pan, G. 222 Pan, Y 79 Pannell, L.K. 230 Papa, A.J. 79 Parab, P. 222 Paris, J.M. 217 Park, K.S. 226 Park, W.W. 222 Park, YH. 222 Parrish, D.R. 77 Parsek, M.R. 231 Parsons, Y.N. 212 Paryzek, Z. 78 Passador, L. 228 Pasteur, L. 83, 194, 228 Paszczynski, A. 208, 211, 222 Patel, H.M. 229 Patel, H.N. 210 Pattery, T 212

Pattus, F. 205,214,231,237 Paull, K.D. 75 Paulsen, I.T 227, 232 Pearson, J.P. 228, 229 Pearson, N.M. 77 Pechere, J.e. 233 Perez-Ortin, J.E. 234 Perryman, D.D. 214 Persmark, M. 228 Pesci, E.e. 210, 229 Peters, E.M. 80 Peters, K. 80 Petersen, B.O. 206 Peterson, J. 227 Peterson, M.R. 236 Pettit, G.R. 1-4, 12, 15, 77, 79 Pfeffer, M. 220 Pham, X.Q. 232 Philson, S.B. 229

Piemont, Y 213, 223 Pierre, J.L. 215 Pietra, F. 212 Piper, TS. 229 Pirnay, J.P. 226 Plattner, A. 35, 76 Plumley, F.G. 206 Poe, e.F. 216 Polman, J. 79 Ponnaluri, P. 230 Ponticelli, F. 229 Poole, K. 205, 213, 217, 220, 225, 229,

231,232 Pop, M. 227 Poppe, K. 229 Pouteau-Thouvenot, M. 229 Pouzar, V. 75 Powell, e.L. 206 Poyner, D.R. 231 Preece, TF. 229, 236 Prelog, V. 220

Principe, P.A. 223 Prome, D. 231 Propst, e. 229 Pulverer, G. 209,214,218,226,227,229,

233,236 Purvine, S.O. 216 Putignani, L. 206

Quadri, L.E.N. 229

Riiber, M. 206 Rainey, P.B. 226, 227, 232

Rantiatmodjo, R.M. 220 Rao, K.S. 208 Rasmussen, G.T. 208,213 Ratefiarivelo, H. 225 Ratledge, e. 211 Ravel, J. 226, 229 Ravich, V. 230 Raymond, e.K. 232 Recourt, K. 224 Redpath, J. 75 Reeder, D.J. 217 Regenhardt, D. 229 Rehm, B.H.A. 229 Reiche, M. 209 Reimmann, e. 215,229,231 Reizer, J. 232 Relyea, J.D. 230

250

Ricca, C.S. 223 Rice, RH. 222 Richardson, A.R. 237 Richardson, DJ. 227 Riedel, K. 215 Rinehart, K.L. 206, 230 Rinehart Jr., K.L. 206, 212 Risse, D. 207, 230 Ritter, C. 230 Rivera, M. 210 Rizzo, M. 227 Roberts, C. 217 Robinson, G.H. 224 Rochel, N. 206 Roeder, T.L. 208 Roepstorff, P. 230 Romer, A. 227 Rosazza, J.P.N. 237 Rose, B. 80 Rosenberg, II J.M. 230 Roth, K.D.W. 230 Rot!, P. 215 Roy, RG. 75 Roy, S.c. 94, 210 Royse, D.J. 237 Royt, P.W. 217, 226, 230 Ruangviriyachai, C. 209, 216, 230 RUden, H. 208 Rudloff, V. 80 Ruiz, R. 230 Russel, D.A. 227

Sadagopan, N. 230 Saier, M.H. 232 Saito, N. 230 Sakakibara, T. 212 Sakakibara, Y. 236 Sakemi, S. 212 Sakurai, M. 80 Salah el Din, A.L.M. 206, 230 Salmond, G.P.c. 236 Samsom, R 215 Sanders-Loehr, 1. 219 Sanfilipo, V. 235 Sasaki, K. 215,230 Sasaki, T. 230 Sashida, Y. 11, 77, 78, 80 Sato, S. 215 Sauer, G. 76 Savage, D.S. 75

Author Index

Sawaya, T. 78 Scanlan, D. 227 Schafer, H. 230 Schafer, M. 207,215,218,222,226,228,

230, 231, 234 Schaffner, E.M. 209, 230, 233 Schalk, I. 227 Schalk, I.I. 214,231, 237 Schaller, U. 209 Scherlitz-Hofmann, I. 236 Schippers, B. 222, 236 Schlegel, K. 181, 231, 232 Schlemper, H. 80 Schmickler, H. 226, 232 Schmidt, 1.M. 79 Schmitt, D. 80 Schnabelrauch, M. 236 Schollmeyer, D. 80 Scholz, U. 76 Schroder, H. 209, 219, 231, 233 Schroth, M.N. 221 Schulz, G. 78 Schwarzenbach, G. 206 Schweng, 1. 80 Schwesinger, R 34, 80 Schwyn, B. 231 Screen, 1. 231 Sebat, J.L. 211 Seinsche, D. 219,231,233 Seipold, L. 233 Seki, N. 236 Sekiguchi, T. 219 Seleen, W.A. 231 Serino, L. 229, 231, 235 Setiawan, B. 220 Seto, H. 231 Sharma, A. 216 Shasby, D.M. 208 Shen,1. 231 Shibazaki, M. 220 Shida, Y. 231 Shiman, R 231 Shindo, K. 231 Shirahata, K. 221, 231 Shirota, EN. 227 Shivaji, S. 225 Shokrani, E 178, 223 Siddiqui, B.S. 232, 233 Siebeneicher, H. 76 Sigel, A. 205

Sigel, H, 205 Silva-Avalos, l 222 Silverman, GJ. 215 Simidu, U. 231 Sims, E.H. 232 Singer, E. 212 Singh, P.K. 231 Sirockin, F. 237 Siverio, F. 233 Skorupska, A. 209, 213, 224 Sleigh, T. 75

Smith, A.w. 215, 227, 231 Smith, B.S. 209 Smith, E.E. 232 Smith, K. 232 Smith, K.M. 231 Smith, P. 232 Smith, S.C. 17, 20, 77 Snider, B.B. 75 Sodeau, J.R. 22 7 Sokol, PA 222, 232 Soler-Rivas, C. 232 Somogyi, A. 213,232 Sondheimer, F. 24, 80 Song, K.l 219 Sowa, MA 207 Spanggaard, B. 216 Spence, J.T. 214 Spencer, D. 232 Spences, D.H. 232 Spiers, AJ. 232 Sposito, G. 217 Srikumar, R. 229, 232 Sriyosachati, S. 206 Staley, A.L. 206, 230 Stalick, W.M. 230 Standiford, T.J. 233 Stanier, R.Y. 232 Stark, C.N. 231 Steijl, H. 222 Stein, H. 80 Stephan, D. 230 Stephan, H. 214 Steward, G.S.A.B. 215,236 Stintzi, A. 205, 210, 225, 232 Stipanovic, R.D. 207, 212 Stjepandic, D. 227 Stoessl, A. 212 Stoiber, T. 217 Stojiljkovic, I. 237

Author Index

Stoll, A. 232 Stonehouse, M. 232 Stothers, J.B. 212 Stover, c.K. 232 Straetz, M. 227 Striimpl, C. 229 Stylianou, D.G. 223 Suga, H. 231 Sugita, K. 78 Sugizaki, H. 237 Sultana, R. 232, 233

Sun, W.Y. 221 Surange, S. 220 Sutta, L. 233 Sutton, S.c. 77 Suzuki, K. 220 Suzuki, T. 231 Suzuki, Y. 212 Swinburne, T.R. 205, 224 Sykes, R.B. 223 Szarapiriska-Kwaszewska, l 233 Szilagyi, L. 233

Takahashi, M. 236 Takahasi, S. 219 Takase, S. 234 Takashina, K. 228 Takeda, R. 221, 233 Takenaka, A. 231 Takimura, O. 219, 237 Tamura, K. 80 Tamura, T. 233 Tan, R. 79 Tanabe, T. 228 Tanaka, R. 80 Tang, XJ. 233 Tanigucki, H. 80 Tanzer, L.R. 79 Tappe, P. 221 Tappe, R. 225, 233

251

Taraz, K. 206-209, 214-220, 222, 223, 225, 229-236

Tari, L.w. 211 Tarsi, L. 227 Tateda, K. 233 Tatsuta, K. 233 Taylor, G.w. 233 Teintze, M. 96,221,234 Terano, H. 234 Testa, lR. 78

252 Author Index

Thamsen, J. 208 Thariath, A. 224 Thayer, S.A. 217 Thibault, P. 233 Thoma, M. 78 Thomas, R.I. 227 Thomas-Oates, lE. 224 Thonart,~ 219, 225,22~228 Throup, J.P. 2]5 Thumm, K. 92, 93, 234 Ticknor, L.a. 217 Tietze, L.F. 13, 80 Timmis. K.N. 227, 229 Toeplitz, B.K. 223 Tokunaga, T. 220 Tolaas, A.G. 165,234 Tolentino, E. 232 Tommassen, J. 207 Tomono, H. 228 Tong, Z. 78 Tordera, V. 234 Torres, L. 168, 234 Toth, S.I. 220 Toth-Allen, J. 226 Totter, J.R. 234 Toyokuni, T. 206 Tran, K. 227 Trejo, W.H. 223 Truong, Q.c. 217 Tsai, L. 223 Tsubotani, S. 234 Tucker, K.D. 228 Tummler, B. 213,215,227 Turfitt, G.E. 93, 94, 234 Turfreijer, A. 93, 94, 234

Ullmann, U. 78,80 Umino, K. 214,219 Urban, S. 80 Uria Fernandez, D. 207, 209, 226, 228,

230, 234 Utterback, T. 227 Uyanik, C. 77

Vancanneyt, M. 220 Van Delden, C. 234 Van der Drift, K.M.G.M. 224 Van der Helm, D. 209, 219, 220, 234 Van der Hofstad, G.A.I.M. 173, 224, 234,

236

Vanderrnonde, A. 207 Van de Vossenberg, J. 221 Vande Woestyne, M. 235 Van Dorsselaer, A. 231 Van Loon, L.e. 224 Van Pelt, lA. 222 Van Vyncht, G. 228 Varma, R.K. 78 Vartivarian, S.E. 235 Vasil, A.I. 222, 227 Vasil, M.L. 222, 227, 232, 235 Venkatramani, L. 209 Venturi, V. 222 Verhille, S. 214 Verjans, G.M.G.M. 234 Verstraete, W. 235 Verzili, D. 235 Vidavsky, I. 220 Vincent, M. 214 Virtanen, A.I. 212 Visca, P. 206,231,235 Viscontini, M. 229 Visser, M.B. 222 Viswanatha, T. 224 Voeiter, W. 75 Vogel, H.I. 211 Vogler, B. 214 Vogt, W. 235 Von Diihren, H. 221 Von Schnering, H.G. 80 Von Tigerstrom, M. 221,228 Voss, J. 212, 225, 235 VoSen, W. 235 VoSwinkel, R. 235

Wada, T. 78 Wade, N.J. 217 Waffenschmidt, S. 234 Waikedre, J. 212 Wakabayashi, K. 237 Walker, F. 214 Walker, R.C. 235 Wallace, A. 215 Walser, A. 220

Walsh, C.T. 229 Walz, L. 80 Wang, S.Y. 217, 235 Warrener, P. 232 Wasielewski, E. 235 Wasserman, A.E. 235

Author Index

Wathelet, B. 210 Watson, I.T. 230 Weber, M. 235, 236 Wedler, H. 227 Weinel, c. 227 Weisbeek, P.J. 158,207,221,222,224,

234,236 Weisenborn, EL. 80 Wells,I.C. 195,217,236 Wells Ir., I.S. 223 Welsh, M.J. 231 Welte, W. 214 Welzel, P. 46,47, 50, 55, 57, 58, 80 Wendenbaum, S. 213, 236 Westbrock-Wadman, S. 232 Westervelt, P. 236 White, KB. 78 White, O. 227 White, V.E. 217 Whiting, A 212 Wibaut, J.P. 234 Wichers, H.J. 232 Widehem, P. 208 Wiechert, R. 38, 76, 78 Wight, H.G. 75 Wight, V.E. 235 Wilcox, M.H. 213 Wilderman, P.J. 227 Wilks, A 210 Willaredt, J. 80 Williams, D.H. 226, 227 Williams, I.A. 75 Williams, M.D. 79 Williams, P. 215,236 Wilson, M.I. 235 Wilson, R 233 Wilson, S.R. 230 Winkelmann, G. 205,214 Winkler, S. 217,236 Winkler, U.K. 229 Winson, M.K. 236 Winstanley, C. 212 Winterfeldt, E. 2, 13, 15, 32, 46, 47, 63, 64,

75-78,80 Wittmann, S. 217, 236 Wittouck, E. 221 Wolfe, M.S. 236 Wolff, RE. 223 Wolff, U. 226 Wong, G.KS. 232

Wong, W.C. 229, 236 Wong-Lun-Sang, S. 236 Woods, D.E. 232 Worobec, E.A. 216 Wratten, S.J. 236 Wright, AI. 235 Wright, I.M. 210 Wu, M. 216 Wu, Z. 232 Wuest, P.I. 237 Wurtz, B. 223 Wysocki, V.H. 213, 232

Xia, D. 209 Xiao, R. 236 Xu,I.-P. 79 Xu, W. 77

Yabuuchi, E. 228 Yakovlev, G.I. 221 Yalcin, T. 217, 236 Yamada, Y. 219,236 Yamaguchi, K 233 Yamamoto, S. 236 Yamaoka, Y. 219,237 Yamasaki, K 78 Yamauchi, Y. 212 Yamazaki, K 78 Yamazaki, T. 237 Yang, c.c. 237 Yang, W. 237 Yasumoto, T. 237 Yeo1e, RD. 237 Yi, E.C. 216 Yoshikawa, M. 237 Yotsu, M. 237 Young, L. 217, 229 Yu, H. 237 Yuan, Y. 232 Ynkawa, Y. 228

Zago,A 205 zahner, H. 214, 224, 226 Zamri, A 237 Zarkower, P.A 237 Zbiral, E. 33, 80 Zeng, Y. 210 Zbu, W. 237 Zunnundzhanov, A 237 Zyakun, AM. 221

253

Subject Index

Acetic acid 47, 64 Acetic anhydride 28 Acetone 29, 53, 54, 100 Acetonitrile 56, 58, 59 N5 -Acetyl/formyl-N5 -hydroxy­

ornithine 125 N5 -Acetyl-N5 -hydroxyornithine 116, 118,

130, 137, 156, 168, 177 Acidic methanol 66 Acinetobacter baumannii 184 Acinetobactin 184 Actinomycetes 186, 193 N-Acyl-homoserine lactone 196,200 N5 _Acyl_N5 -hydroxyornithine 95 Adriamycin 10, 16, 64, 67, 69 Aeromonas salmonicida 178 Aeromonas sp. 178 (+)-Aerugin 182 Aeruginoic acid 182, 183, 202 Aerugino1 182 Aeruginosin A 92 Aeruginosin B 92 Agaricus bisporus 86, 164 Alanine 96, 110, 118, 127, 131, 177 2-AlkyI-4-hydroxyquinolines 190, 195 Amberlyst® 15 40, 49, 53, 54 4-Amino-2-bromobutanoic acid 135 Aminochelin 175, 176, 197 2-Amino-4-dansylamino-butanoic acid

114 (1S)-5-Amino-2,3-dihydro-8,9-dihydroxy­

IH-pyrimido-[1 ,2-a ]quinoline­I-carboxylic acid 102

2-( 1-(R)-Amino-2-p-hydroxyphenylethyl)-1,4,5,6-tetrahydropyrimidine-4-(S)­carboxylic acid 108

3-Amino-I-hydroxy-piperidone-2 111, 137 Ampicillin 197 Ampicillin derivatives 134 Anguibactin 178, 184 Anthranilic acid 191 Anthrax 83,84, 194

Antibacterialactivity 177,194,196,197,198 Antibiotic activity 177, 185, 190, 191, 197,

199,200 Antibiotic BN-227 186 Antibiotic YC 73 185 Antibiotics 83, 84, 164 Anticancer activity 10, 12, 23, 24, 26 Antileukemic activity 26 Anti-tumor activity 2 Anti-viral activity 195 f,8.14_Apocholic acid 52 Apocholic methylate 53 Apoptosis 202 Arginine 121, 128, 175, 197 Arthrobacter sp. 191 Asparagine 127 [U)4C]-Asparagine 163 Aspartic acid 95, 101, 112, 113, 127, 130,

153, 163, 170 Aurantioporis fissilis 49 Azirines 31, 32, 36 Azomonas macrocytogenes 91, 152, 155,

156, 175 Azomonas sp. 116, 153 Azotobacter agile 153, 155 Azotobacter macrocytogenes 155, 156 Azotobacter sp. 116, 153, 155 Azotobacter vinelandii 91,94,95, 155, 175 Azotobacter vinelandii ATCC 12837 153 Azotobacter vinelandii 0 163 Azotobactin 95 Azotobactin 87 89, 153 Azotobactin D 89, 153 Azotobactin DMS 87 154 Azotobactin 0 153 Azotobactin Ii 153 Azotobactins 105, 106, 111, 126, 127, 154,

155, 174, 175 Azotochelin 175, 176 Azoverdin 101, 108, 127, 149, 156, 157,

174, 175 Azurochelin 177

Subject Index 255

Bacillus anthracis 83, 84, 194 Bacillus fluorescens liquefaciens 92, 93 Bacillus fluorescens non-liquefaciens 92 Bacillus fluorescens putidus 92 Bacillus pyocyaneus 92, 195 Bacillus roseus fluorescens 86, 192 Bacterial fluorescin 93 Bacteriofluorescein 93 Barton remote oxidation 61 Benzene 30 Benzyl alcohol 100 5a-Bile acid 54 Bile acids 19, 48, 56 Biliverdin 193 Biological activity 1,3,5-12, 16,22,24,

28,31,36-38,42-45,54,55,61,67-69 Bisenolpivalate 22, 23 12,12'-;3-Bishydroxy pyrazine 22 Bissteroidal dienes 39 Bissteroidal pyrazines 3,13,15-17,20,27,

28,30-32,42,60,67,70 Borohydride 21-23 Boron trifluoride 51 N-Bromo succinimide 35 Bucherer reaction 160 Burkholderia cepacia 86, 177, 178, 186,

196 Burkholderia sp. 191 n-Butyllithium 36 Butynone 41

Camphor 94 N-Carbamylaspartic acid 163 Carboxylic acid 197 Carcinogenic activity 202 Casamino acid 100 Catecholate siderophores 155, 175 Cellvibrio gilvus 86, 95, 153 Cepabactin 186 Cephalodiscus gilchristi 2, 4 Cephalosporin 198 Cephalostatin 1 1-6,8-15,22,31,42-44,

60-62, 64, 67-74 12-0H-Cephalostatin I 44 12;30H-Cephalostatin I 43 14a-H-Cephalostatin 1 44 14' a-Cephalostatin 1 43,44, 73 Cephalostatin 2 6, 71 Cephalostatin 3 6, 71 Cephalostatin 4 6, 8, 9, 42, 43, 71, 72

Cephalostatin 5 6, 8, 9, 43, 66, 71, 72 Cephalostatin 6 6, 8, 9, 43, 66, 71, 72 Cephalostatin 7 3, 6, 13, 17, 22, 31, 43,

67,69 Cephalostatin 8 6 Cephalostatin 9 6 Cephalostatin 10 5, 6, 71 Cephalostatin 11 5, 6, 71 Cephalostatin 12 6, 9, 13, 17, 19, 73 Cephalostatin 13 6, 9, 73 Cephalostatin 14 6, 9, 43, 72 Cephalostatin 15 6, 9, 43, 72 Cephalostatin 16 3, 7 Cephalostatin 17 7 Cephalostatin 18 5, 7, 71 Cephalostatin 19 5, 7, 71 Cephalostatins 1-5, 9-13, 16, 20, 28,

30, 39, 43, 45, 48, 56, 60, 61, 64, 69--74

Cephalostatin analogues 1, 13, 17, 22, 27, 33,36,42,55,60,64-66,70,74

5;3-Cephalostatin analogues 54 Cesium carbonate 41 Charcoal 93 Chlorine 93 2;3-Chloro-3a-azide 34 Chloroform 53, 54, 100 Chloro titanium triisopropoxide 35 L~.2 -Cholestene 33 Cholic acid 36, 50, 52-54 5a-Cholic acid 55 Chorismic acid 177 Chrome Azurol Fe3+ complex 97 Chrome Azurol S 97 Chrome Azurol S procedure 96 Chromobacteria 186 Citric acid 158, 187, 193 Citrulline 95, 153 Claisen condensation 193 Collision activation 119, 123 Corrugatin 17 6 Corti sols 45 Cortisone synthesis 55 Cyanobacteria 189 Cyanohydrin 185 Cysteine 178,182-184,188 Cystic fibrosis 84, 164, 195, 196 Cytochrome c 94, 162 Cytostatic activity 9, 12, 61, 70, 73, 74 Cytotoxic activity 10, II, 182

256 Subject Index

Decandioic acid 197 Dehydro-alanine 133 7-Deoxy-14'a-ritterazine B 43,44,73 7-Deoxy-ritterazine G 42, 43 Depsipeptides 130 Desferral 98, 187 Desferriferribactin 152 Desferri-ferrioxamine B 187 Desferri-ferrioxamine E 186 Desferri-ferrithiocin 183, 184 5a-Desoxy bile acid 48 Desoxycholic acid 48, 49 2,4-Diaminobutanoic acid 104,111-113,

126, 136, 156, 158-160 L-2,4-Diaminobutanoic acid 101, 105, 108,

160 [4_ l5N]-2,4-Diaminobutanoic acid 163 (S)-2,4-Diaminobutanoic acid 103 1,2-Dibromoetbane 55 Dicarboxylic acid 118, 158, 162, 197 Dichlorodicyanoquinone 42 Diels-Alder cyc1oaddition 39 retro-Diels-Alder decomposition 121, 126 retro-Diels-Alder fragmentation 122 (+ )-(S)-4,5-Dihydroaeruginoic acid 182 5,6-Dihydro-azoverdin 152, 156 Dihydrocephalostatin 1 30 14' a-Dihydro-cephalostatin 1 30 5,6-Dihydro-isopyoverdin 108, 152 Dihydroisopyoverdins 160 Dihydro-omitbostatin OlIN 67--69 Dihydro-omitbozine OIGN 67--69 Dihydroorotate 162, 163 Dihydroorotic acid 161, 164 Dihydropyoverdins 107, 108, 126, 151,

167, 168, 194 5,6-Dihydropyoverdins 106, 108, 109, 151 Dihydropyoverdin-7-sulfonic acids 126 5,6-Dihydropyoverdin-7-sulfonic acids 108 2,3-Dihydroxybenzoic acid 87, 155, 175,

184, 187 3,4-Dihydroxybenzoic acid 175 N-(2,3-Dihydroxybenzoyl)-L-serine 187 (1S)-II, 12-Dihydroxy-4,7-dioxo-2,3,5,6,7 ,8-

hexahydro-lH-4H-13cH-3a,8, 13b-triaza­cyc1ooctalik]phenantren-l-carboxylic acid 106

(1S)-8,9-Dihydroxy-4-oxo-2,3,4,5-tetrahy­dro-lH-l OcH-3a,5, 1 Ob-triazaacephenan­trylen-l-carboxylic acid 105

2,9-Dihydroxy-phenazine-l-carboxylic acid 143

Dihydroxyphenylalanine 158, 163 C4C-3]-Dihydroxyphenylalanine 163 3,4-Dihydroxyphenylalanine 134, 160 C4C-l]-3,4-Dihydroxyphenylalanine 163 Dimetbyl dioxirane 28, 33 Dimetbylforrnamide 48 Dinitrofluorobenzene 95 Dinoflagellates 200 4,5-Dioxoheptanoic acid 197 Ditbiodietbanol 121

Edman degradation 95, 112, 116, 173 Electrospray ionization 119, 123 Enol acetate 28 Enterobactin 186 Enterochelin 186 Enterococcus sp. 187 Enzyme inhibitors 11 20-Epi-cephalostatin 7 67, 69 25'-Epi-cephalostatin 7 67,69 Erwinia rhapontici 193 Escherichia coli 87, 146-148, 177, 187 Estrogens 11, 45 Ethanol 17, 23, 40 a-Etber 64 ,B-Etber 64 Etbyl acetate 56, 58, 59, 178 Ethylenediamine tetraacetic acid 139

Fast atom bombardment 119 Fast atom bombardment mass

spectrometry 121 Fatty acids 195 Fenton process 87, 182, 194, 196 Ferribactins 94, 108-110, 127, 151-153,

158, 161, 168, 170 Ferric citrate 104, 187 Ferric oxide hydrates 86 Ferric uptake regulator 87 Ferri-dihydropyoverdins 152 Ferri-enterobactin 187 Ferrioxamine B 187 Ferri-pyochelin 182 Ferri-pyoverdins 95, 121, 140, 144,

147-149, 167, 182 Ferri-siderophores 194 Ferri-transferrins 196 Ferro-chelatin 150, 194

Subject Index 257

Ferrocin A 177 Ferrocin B alanine 177 Ferrocin C 177 Ferrocin D 177 Ferrocins 177, 186 Ferrorosami ne 192 Ferrorosamine A 192, 193 F1uopsin 185 F1uopsin C 185 F1uopsin F 185 F1uopsin N 185 Fluorescein 94 F1uorescin 94, 153 F1uoroquinolones 195 5-F1uorouracil 10 e4C]-Forrnate 163 3-Forrnylamino-6, 7 -dihydroxycoumarine

161 ~-Forrnyl-~-hydroxyomithine III N5 -Forrnyl-N5-hydroxyomithine 116-118,

130, 137, 139, 152, 155, 168, 170, 177 4-Forrnyl-N-mercapto-quinolone-2 191

Gluconate 100 Glucose 98 Glutamic acid 95, 101, 108-110, 113, 118,

126-129, 151, 152, 156, 158, 170 Glutamine 113, 114, 125, 129 iso-Glutamine 114 L-Glutamine 164 L-Glutamic acid 101,108,160,168 Glutaminic acid 110 Glycerol 121 Glycine 95,110,118,153, 154, 163, 164,

167, 184 [U- '4CJ-Glycine 163 Glyoxylic acid 110, 193 Gutknecht-type pyrazine synthesis 16, 21

Hajos-Wiechert -ketone 38 Heck reaction 39, 40 Hecogenin 38, 39, 45, 48, 50, 57, 58, 62 ~14,15_Hecogenin 46

Hecogenin acetate 15, 19,25,47,64,65 Hecogenin acid 19 2-n-Heptyl-1,2-dihydro-1,2,4-

trihydroxyquinoline 191 2-Heptyl-3,4-dihydroxyquinoline 191 2-n-Heptyl-4-hydroxyquinoline 191 Hofmann degradation 114

Homoallylic alcohol 33, 46 Homoserine 95, 111, 113, 127, 153, 154,

156 Homoserine lactone 155, 196 Horse-liver alcohol dehydrogenase 20 Hospital infections 83, 84, 164, 195 Hydrogenbromide 48 Hydrogen chloride 34, 52, 54 14'-;3-Hydrogen ritterazine B 44,73 Hydroxamic acids 111,128,130,141,152,

169, 177, 185, 186 N5 -Hydroxy-N5 -acetyl-omithine 141 3-Hydroxyaspartic acid 141 ;3-Hydroxyaspartic acid 95, 153, 154, 167,

168 threo-;3-Hydroxy aspartic acid 111 2-Hydroxybenzonitril 183 N-Hydroxybenzoyl-L-cysteine 202 N5 -;3-Hydroxybutyrylomithine 137 a-Hydroxy-carboxylates 88 12-;3-Hydroxy-cephalostatin 1 43 Hydroxy-cyclo-omithine 141 N-Hydroxy-cyclo-omithine 101, 111 N-Hydroxy-l,5-diaminopentane 186 N5-Hydroxy-N5-forrnyl-omithine 141 a-Hydroxyglutaric acid 110 ;3-Hydroxyhistidine 111,118,176 threo-;3-Hydroxyhistidine 111 Hydroxyketone 64, 71 ;3-Hydroxyketone 60, 61, 70 3-Hydroxy-3-n-nonyl-1 ,2,3,4-

tetrahydroquinoline-2,4-dione 191 Hydroxyomithine 154 cyclo-Hydroxyomithine 95, 125, 131 cyclo-N-Hydroxyomithine 137 8-N-Hydroxyomithine III N5-Hydroxyomithine 96, 168 L_N5 -Hydroxyomithine 158 2-(2-0-Hydroxypheny J-2 -thiazolin-4-yl)-3-

methylthiazolidine-4-carboxylic acid 178

3-Hydroxypyridine-2-carboxylic acid 182, 184

4-Hydroxyquinoline 196 4-Hydroxyquinoline derivatives 190 8-Hydroxyquinoline 100

Imidazole 38 myo-Inositol hexakisphosphate 187 Iodobenzenediacetate 24

258 Subject Index

m-Iodosobenzene 40 Iron 86,87,96,99,100,155,156,175,178,

183, 187, 196 Isobaric amino acids 146 Isoe1ectrofocusing 97, 164 Isopyoverdin BTP1 149 Isopyoverdins 101, 104, 105, 108, 111,

126, 127, 149, 160, 162

Ketoglutaric acid 160 2-Ketoglutaric acid 126, 127 a-Ketoglutaric acid 98, 108-110, 124, 128,

149, 158

I'I-Lactamase activity 195 Lactic acid 121 Lactoferrin 195 Lactoflavin 94 Lactonic pyoverdins 116 Lates niloticus 177 Lead tetraacetate 61, 62, 11 ° Lemieux-Rudloff oxidation 40 Lethal hospital infections 195 Leukemia RPMI-8226 26 Leukopyocyanin 92, 193, 196 Lewis acid 46, 47, 50, 51, 87 Lipocyclodepsipeptides 177 Lithium diisopropyl amide 38 Lithium hexamethyldisilazane 39 Lung infections 182 Lysine 95, 112, 113, 116, 117, 121,

125, 127-132, 158, 168, 193

Malamide 109, 126-128, 158 MALDI mass spectrometry 146 Malic acid 109, 110 Mass fragmentography 115 McLafferty rearrangement 126, 133,

136 Metallophores 189 Methanol 20, 22,23, 53, 54, 109, 180, 181 Methionine 188 8-Methoxy-4-hydroxy-monothioquinaldic

acid 190, 191 Methyl anthranilate 191 2-Methyl-cysteine 184 N-Methyl-L-cysteine 180, 183 Methy1ether 23 Methyl glutamate 113 Methyl hydroxylamine hydrochloride 28

Methylomonas methanica 86 N-Methyl-N-phenylacetyJhydroxylamine 186 Methyl propiolate 41 Micacocidin 183, 184 Mild alkaline hydrolysis 133 Mitsunobu reaction 33 Mono-12-acetylated-ritterazine B 43 Monoenolpivolate 23 Monopivalate 22 Monothiocarboxylic acid 188 Mucoviscidosis 84, 195 Murine Iymphozytic leukemia P388 2 Mycobacteria 189 Mycoplasma sp. 184

Nafion-H 30 Nano-electrospray mass spectrometry 146 Neopyochelin I 180 Neopyochelin II 180 Nicotinamide-adenine-dinucleotide

(NAD /NADH) oxido-reductase activity 150

Nitrilotriacetic acid 187 Nocardamine 186 Nocardia sp. 193 2-n-Nonyl-4-hydroxyquinoline 191 Norvaline 115 Nuclear Overhauser effect 180

n-Octanoic acid 177 N-Octanoyl-homoserinelactone 196 Ornithine 95, 96, 111, 113, 116, 139, 153,

158 D-Ornithine 158 L-Ornithine 158 Ornithogalum saundersiae 11 Orotic acid 162 Osmium tetroxide 56 OSW-1 3, 11, 12, 67-69, 74 OSW-l aglycon 67--69 Overhauser effect 27 Oxalic acid 100, 186 Oxocarbenium ions 11, 12 N-(3-0xododecanoyl)-homoserine

lactone 155, 196 2-0xo-etanoic acid 193

Pasteur's paradoxon 83 Paterno-Biichi addition 46 Peptide mass fingerprinting 146

Subject Index 259

Peptide synthetases 158 Perchloric acid 28, 35 Phenazines 166 Phenol 100 Phenylalanine 160, 163 Phenyl iodosyl diacetate 23 Phenylisothiocyanate 95 N-Phenyl triftimid 39 Phosphate 100 Phytic acid 187 Phytopathogens 185, 200 Phytotoxins 200 Picric acid 121 Pivalic acid chloride 22 cis-Platin 10, 64 Polyvinylpyridine 30 Potassium carbonate 41 Potassium hydroxide 22 Pro-ferrorosamine A 192-194 Pro-ferrorosamine B 192, 193 Progesteron derivatives 57 Propargylic aldehyde 41 Protochelin 175, 176 Pseudan VII 191 Pseudan IX 191 Pseudans 191 Pseudobactin 94, 96, 99, 136 Pseudobactin 7SRI 171, 172 Pseudobactin A214 172 Pseudobactin A225 171, 172 Pseudobactin ATCC 39167 172 Pseudobactin WCS 358 172, 173 Pseudomonadaceae sensu stricto 185 Pseudomonas aeruginosa 83-85, 87-93,

96,99, 118, 146, 155-157, 160, 161, 163-166,177,178, 182, 186, 187, 190, 191, 193-196, 198

Pseudomonas aeruginosa 15152 164 Pseudomonas aeruginosa ATCC 9027 90 Pseudomonas aeruginosa ATCC 15692 84,

98, 150, 165, 171, 197 Pseudomonas aeruginosa ATCC 27853 150,

165, 197 Pseudomonas aeruginosa ATCC PAOI 197 Pseudomonas aeruginosa PAOI 144--147,

158, 164, 165, 171,202 Pseudomonas aeruginosa R 150, 165 Pseudomonas alcaligenes 85, 186 Pseudomonas aptata 86, 88, 90, 168 Pseudomonas asplenii 86, 90, 167

Pseudomonas aureofaciens 85, 88, 91, 166 Pseudomonas calciprecipitans 86, 94 Pseudomonas cepacia 86, 177, 186 Pseudomonas chlororaphis 83, 85, 89, 90,

96, 201 Pseudomonas chlororaphis ATCC 9446 90 Pseudomonas chlororaphis CNRI5 90 Pseudomonas cichoriae 89, 167 Pseudomonas cichorii 85, 166 Pseudomonas corrugata 176, 177 Pseudomonas costantinii 85, 86, 88, 91,

166 Pseudomonas fluorescens 85, 86, 88-93,

95, 96, 99, 116, 118, 147, 148, 160, 164--167,177,178,185,190,191

Pseudomonas fluorescens 1,3 98, 150 Pseudomonas fluorescens 9AW 150 Pseudomonas fluorescens 12 150 Pseudomonas fluorescens 18.1 150 Pseudomonas fluorescens 33 109 Pseudomonas fluorescens 51 W 150 Pseudomonas fluorescens AH2 177 Pseudomonas fluorescens ATCC 13525

84, 150, 152, 197 Pseudomonasfluorescens ATCC 17400 150 Pseudomonas fluorescens BTP 7 174 Pseudomonas fluorescens CCM 2798 150 Pseudomonas fluorescens CFBP 2392 150,

174 Pseudomonas fluorescens CHAO 90, 150 Pseudomonas fluorescens G173 108, 116,

118, 146, 147, 168-170 Pseudomonas fluorescens ii 98, 150 Pseudomonas fluorescens pfOI 146 Pseudomonas fluorescens SB83 90, ISO Pseudomonas fluorescens WCS 374 178 Pseudomonas fluorescens Y. 143 Pseudomonas fluorescens YK-31O 177 Pseudomonas fragi 86, 187 Pseudomonas fuscovaginae 86, 167 Pseudomonas liquefaciens 85 Pseudomonas marginalis 86, 90 Pseudomonas mendocina 85, 194 Pseudomonas methanica 86, 191 Pseudomonas mildenbergii 85,86,90,91,

95, 153, 186 Pseudomonas monteilii 85 Pseudomonas monteilii CFML 90-54 150 Pseudomonas mosselii 85 Pseudomonas mosselii CFML 90-77 ISO

260 Subject Index

PseudomolUls non-liquefaciens 85 PseudomolUls palleroniana 85, 89 Pseudomonas pseudoalcaligenes 85 Pseudomonas putida 83, 85, 86, 88-92, 96,

98,99, 101, 112, 119, 127, 157, 160, 162, 164, 167, 177, 187, 195, 201

PseudomolUls putida 9AW 90 Pseudomonas putida 9BW 91 PseudomolUls putida ATCC 12633 98, 150 Pseudomonas putida CFBP 2461 150 PseudomolUls putida CFML 90-51 150 Pseudomonas putida KT2440 90, 146 PseudomolUls putida M 163 Pseudomonas putida WCS 358 146, 172,

173 Pseudomonas reactans 86, 166 PseudomolUls reactans NCPPB 387 166 Pseudomonas reptilivora 86 PseudomolUls rhodesiae 85, 90 Pseudomonas rhodesiae CFML 92-104 98,

150 Pseudomonas roseus fiuorescens 86, 192,

193 Pseudomonas salomonii 85 Pseudomonas sensu stricto 83,85, 153, 192 Pseudomonas solanacearum 83 Pseudomonas sp, 83-85,94, 104, 116, 142,

143, 155, 163, 164, 166, 168, 170, 175, 176, 182, 184, 187, 191, 192, 199,200

Pseudomonas sp, 7SRI 150 Pseudomonas sp. 267 150 Pseudomonas sp. 2908 ISO Pseudomonas sp. A214 150 PseudomolUls sp. ATCC 15915 150 Pseudomonas sp. CFBP 4396 150 Pseudomonas sp. CFML 90-40 150 Pseudomonas sp. CFML 90-42 150 Pseudomonas sp. CFML 95-275 174 Pseudomonas sp. CFML 96-188 150 Pseudomonas sp. E8 150 Pseudomonas sp. 57-250 (FERM P-14235)

183 Pseudomonas sp. FML 96-188 150 PseudomolUls sp. GH 192 Pseudomonas sp. Ps3a 150 Pseudomonas sp. UV3 95 Pseudomonas stutzeri 85,175,188,189,202 Pseudomonas stutzeri ATCC 17588 186 Pseudomonas syringae 83, 85, 86, 89,

90, 100, 137, 152, 166--168,200

Pseudomonas syringae ATCC 19310 150 Pseudomonas syringae DC3000 146 Pseudomonas tolaasii 83, 86, 88, 164, 166 Pseudomonas tolaasii NCPPB 1116 166 Pseudomonas tolaasii NCPPB 2192 91,

150 Pseudomonas veronii 85 Pseudomonas veronii CFML 92-124 150 Pseudomonas viridiflava 85, 166, 167 Pseudomonine 177, 178 Pseudonocardia sp. 191 Pseudoverdin 160 Pterins 192 Pyochelin 178,179, 181-185, 196,202 Pyochelin I 179-182 Pyochelin II 179-181 Pyochelins A 178 Pyochelins B 178 Pyo compounds 191, 195 Pyocyanase 194, 195 Pyocyanin 92, 94, 164 Pyorubrin 92, 94 Pyoverdin I 181 Pyoverdin II 181 Pyoverdin avi 12837 II 154 Pyoverdin BTP7 174 Pyoverdin CFBP 2392 174 Pyoverdin CFBP 2461 172, 173 Pyoverdin PAOI 171 Pyoverdin R 196 Pyoverdine 94 Pyoverdins 85-92,94,95,97-106,

108, 110--113, 115-121, 123, 124, 126--129, 131-133, 137, 139-141, 144, 147, 149, 151-153, 155, 156, 158, 161, 164-168, 170, 171, 176, 178, 182, 185-187, 193, 194, 196--198, 200

Pyoverdin-fiuoroquino1one 198 Pyrazine coupling 19 Pyrazine formation 16, 18 Pyridine 29, 47, 188 Pyridine-2,6-di(monothiocarboxy1ic)

acid 185, 187, 189,201,202 Pyridine-2,6-di -(monothio )-dicarboxy lic

acid 194 Pyridinium bromide perbromide 38 Pyridinium p-to1uene sulfonate 36 (S)5-(2-Pyridyl)-2-amino-5-oxopentanoic

acid 192

Subject Index 261

2-(2-Pyridyl)-I-pyroline-(5S)-carboxylic acid 192

Pyrimine 192

Quinolobactin 190, 191

Ralstonia solanacearum 83 Rast method 94 Reichstein S acetate 55, 56 Renal cancer RXF-393 26 Rhizobacteria 96, 178, 185 Riboflavin 94 Riboflavin-5'-phosphate 150 Ribosomal ribonucleic acid 85 Ritterazine A 7, 9, 61, 73 Ritterazine B 3, 4, 7, 9, 10, 42--44, 61,

66-68, 72, 73 Ritterazine C 7 Ritterazine D 7 Ritterazine E 7 Ritterazine F 7 Ritterazine G 7, 9, 42--44, 68, 69,

73 Ritterazine H 7, 9, 43, 72 Ritterazine I 7 Ritterazine J 3,7-9,42,71,73 Ritterazine K 3, 4, 7-9, 13, 17, 42, 61,

71,73 Ritterazine L 3, 7, 9, 61, 73 Ritterazine M 3, 7, 9, 73 Ritterazine N 8, 9, 73 Ritterazine 0 8, 9, 73 Ritterazine P 8 Ritterazine Q 8 Ritterazine R 8, 9, 73 Ritterazine S 8, 9, 73 Ritterazine T 8, 9, 61, 73 Ritterazine U 8 Ritterazine V 8 Ritterazine W 8 Ritterazine X 8 Ritterazine Y 8, 9, 61, 73 Ritterazine Z 8 Ritterazines 2-5, 9, 10, 12, 16, 28, 39, 43,

45, 60, 70-74 Ritterazine analogues 71 Ritterella tokioka 3 Ritterostatin GN 1 N 31 Ritterostatin GN Is 31 Ritterostatins 30, 31

ROESY experiments 26, 27 Ruthenium tetroxide 57 Ruthenium trichloride 57, 60

Salicylic acid 87, 177, 178, 182 Sanger's reagent 95 Saxitoxins 200 Selectride 23 Serine 95,113,117,127,130,131,153,

154, 168, 184, 188 Siderochelin 192, 193 Siderophores 85, 87, 88, 94, 96, 97, 102,

137, 150, 153, 164, 196 Siderophore transport proteins 146 Silica gel 58 Sodium hydroxide 20 Sodium periodate 60 Staudinger reduction 28 Streptomyces antibioticus 184 Streptomyces sp. 187 Succinamide 109, 122-124, 126, 127, 151,

156, 158, 160 Succinate 100 Succinic acid 98, 106, 109, 110, 113, 124,

126--128, 156, 160, 170, 197 Succinimide 109 Succinopyoverdins 106, 126, 127 Su1fenic acid 188 Sulfur 94

Taricha torosa 199 Taxo1 2, 4, 10 Testosterone 68 Tetradecacyc1ic ethers 62, 63 Tetrahydropyrimidine 126 Tetrahydropyrimidine derivatives 136 Tetramethyl ethylene diamine 36 Tetramethylguanidinium azide 35 Tetrodotoxin 83, 199 Thiazostatin A 180 Thioacids 188 Thiocarboxylic acids 190 Thioformin 185 Thioglycerol 121 Threonine 95, 113, 168, 171 Titaniumtetrach10ride 51 Tolaasin 166 Toluene 18,20,29,38,40,46 Tosylhydrazone 35 N-Tosyl-valine 64

262 Subject Index

Toxic activity 202 Transferrins 87, 182 Transstilbene 32 Trifluoroacetic acid 33 2,3,9-Trihydroxy-phenazine-I-carboxylic

acid 143 Triisopropylbenzene sulfonyl azide 36 Triphenylphosphonium chloride 33 Trisdecacyclic pyrazines 62, 64 Tumor cell growth inhibiting activity 3, 12,

16,22,60,64,69-74 Tumor inhibiting activity 10 Tyrosine 110, 158, 159, 161 D-Tyrosine 101, 108, 160

Valine 110 Vibr;o anguillarum 178, 184 Vinyl azides 32, 33, 35, 36,

54

Watasemycin A 180 Wittig olefination 25 Wittig reaction 24

Yersiniabactin 184 Yers;n;a enterolyt;ca 184

Zinc 93 Zinc chloride 54

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