Toxicology in Vitro An international journal published in association with BIBRA

Author and Subject Indexes

to Volume 7 (1993)

Pergamon

TOXICOLOGY IN VITRO

An internat ional , journal publ i shed in associat ion with B I B R A

Editors

DANIEL ACOSTA Department t~ Pharmaeolog)' attd To.vicology,

College o f Pharmacy, Unirersit)" ~ Texas, Austin. TX 7871.- 9, USA

Associate Editor STUART E. JAGGI!RS

BIBRA btternational. Woodmansterne Road. Carshalton.

Surrey S M 5 4DS, UK

BAS J. BLAAUBOER Research Institute o f ToxicoloKv,

Utrecht Unh,ersity, Yalelaan Z PO Box 80.176, NL-3508

TD Utrecht, The Netherlands

Ret,iew l:Mitor PHILIP A. BOtHAM

Zeneca Celttra[ ToxieohJgy Laboratory, AMerhg' Park, Macch',s'6eld,

('heshire SKIO 4TJ. UK

Editor Emeritus IAIN F. II. PUR('HASE

Zt'neca Central "lbxicohJgy Laboratory, Alderh'y Park. Maccle,~ield, Cheshire SKIO 47".1, UK

Managing Editor Editorkd Assistant TtJAN A. H6 STEI,I.A HILL

J. C. Barrett NIEHS, Research Triangle Park NC. USA

E. Borenfreund Rockefeller University New York, NY, USA

3. Bradlaw FDA Washington, DC, USA

N. Brown St George's Hospital and Medical

School London. UK

B. Ekwall University of Uppsala Uppsala. Sweden

R. Fahrig Fraunhofer-lnstitut ffir Toxikologie

und AerosoI-Forschung Hannover, Germany

J. L. Farber Thomas Jefferson University Philadelphia, PA, USA

S. D. Gangolli MRC Toxicology Unit Leicester, UK

BIBRA International, Woodrnansterne Road, Carshalton. Surrey S M 5 4DS. UK

International Editorial Board

H. R. Glatt University of Mainz Mainz, Germany

T. J. B. (;ray Sterling--Winthrop Research Centre Alnwick, UK

A. Guilloazo H6pital de Pontchaillou INSERM. Rennes. France

G. C. Hard American Health Foundation Valhalla, NY, USA

C. A. McQueen University of Arizona Tucson, AZ, USA

P. Maier Swiss Federal Institute of Technology

and University of Zurich Schwerzenbach, Switzerland

M. Nagao National Cancer Center

Research Institute Tokyo, Japan

K. Onozaki Nagoya City University Nagoya. Japan

W. E. Parish Unilever Research Bedford. UK

J. A. Popp Sterling Winthrop Inc., Collegeville, PA, USA

N. Stacey National Institute of Occupational

Health and Safety Sydney, Australia

K. A. Stitzel The Procter & Gamble Company Cincinnati. OH, USA

I!. Tahtl University of Tamperc Tampcre. Finland

P. J. van Bladeren TNO--CIVO Institute Zeist. The Netherlands

E. Walum University of Stockholm Stockholm, Sweden

F. Zuceo Consiglio Nazionalc Delle Ricerchc Rome. Italy

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Abdallah M., 55 Abdulla E. M., 341 Abir R.. 817 Aerts L. A. G. J. M. van, 743, 769 Akrawi M., 477 Alvarez-Bujidos M. L., 669 Andersson M., 1, 205 Andrews J. E., 757 Arjun S., 111 Atterwill C. K., 69, 229, 569

Babich H., 105 Bai C. L., 197 Barber C. V., 695 Barile F. A., II1 Basketter D. A., 265, 269 Baur X., 531 Beamand J. A., 605 Bechter R., v, 247, 281, 685, 827 Beckman M., 321 Bcgue J.-M., 493 Beisker W., 447 Bellairs R., 701 Benford D. J., 293, 381, 385 Bergquist J., 205 Berry M., 461 Berthct P., 809 Bertram-Neis E., 505 Bianchi V., 511 Bieri F., 427 Bjcrregaard H. F., 411 Blaauboer B. J., 293 Bocchio F., I Bog~ G., 623 Bomhard E., 421 Borclla S., 511 Borcnfreund E., 105 Bos R. P., 769 Botham P. A., 155, 393 Bouis P., 427 Bouzard D., 499 Bowden H. C., 799 Brady A. M., 587 Braxatorisova E., 803 Bremer S., 551 Brissot P., 55 Broccia M. L., 777 Brook F. A., 679 Brown K. M., 285 Burin G. J., 285

Cadet J. L , 595 Cain K., 117 Caldwell J., 141 Cambar J., 417 Campbell I. C., 341 Cano E., 785 Cao J., 447 Carda M. B., 695 Castell J. V., 481, 523 Catroux P., 465 Chapman D. E., 213 Charlton J. A., 129 Chesne C., 499 Ciabattoni G., 581 Coecke S., 487 Condevaux F., 317 Copp A. J., 679 Cottin M., 465 Coussement W., 471

Index of Authors

Cubria J. C., 669 Curro D., 581 Czuppon A. B., 531

Dauphin J.-F., 499 Davenport-Jones J., 569 Dazy A. C., 373 De Angclis I., 403 Debetto P., 511 Degwert J., 389 Deknudt Gh., 471 Delhaisc |:., 719 Desager J. P.. 809 Descotes J., 317 Despontin K., 809 Dickson F. M., 381 Dickson F. M., 385 Dierickx P. J., 527 Donato M. T., 481 Dossou K. G., 299, 465 Dunnage J. E., 69

Easty D. L., 461 Ebron-McCoy M., 757 Elcombe B. M., 587 Endo-Capron S., 7 Eskes T. K. A. B., 743 Eto K., 707

F'ahn S., 595 Falkcnberg F. W., 421 Fantcl A. G., 695 Fautz R., 305 Fijneman P. H. S.. 769 Finley R. B., 177 Fisher H. L., 221 Fissler B., 185 Forsby A., 1 Fortunati E., 511 Fouce R. B., 669 Fournex R., 453 Fujii K., 673 Furuya K., 61

Galli C. L., 559 Gerner I., 505 Ghosh A., 137 Giavini E., 777 Gibassier J., 87 Giladi N., 595 Girard J.-P., 205 Goffinct G., 433 Goftlot F., 719, 751 Gofflot G., 809 Goonetilleke S., 569 G6mez-Lech6n M. J., 481, 523 Gravierc C., 499 Gray T. J. B., 605 Greiner B., 685 Gueniche A., 15 Guennou C.. 373 Guery C., 453 Guillouzo A., 493, 499 Gurney J. A., 117 Gurwitz D., 345 Gfilden M., 25

Haakmat A S., 615 Hadnagy W., 365 Hagenaars A. M., 615

iii

Hagino S., 35 Hahn~ S. J. M., 769 Hall L. L., 221 Hansen D. K., 735 Happel A., 365 Haring R., 345 Harvey A. L., 275 Hasmall R. L., 587 Herrero E., 481 Herrmann K., 41 Heuer J., 551 Hewitt P., 141 lt i ldebrand H., 421 Hoet P. H. M., 359 Honegger P., 335, 785 Hopkinson D., I I l l toppe U., 389 Hotchkiss S. A. M., 141 Hubert N., 55 Hughes M. F., 221 Hur H. B., 817 Husoy T., 149

hagaki H., 35 Izumi J., 517

Jacobs M. C., 809 Jaffe P., 817 James C. A., 159 Janson X., 7 Jaurand M. C., 7 Jenssen J., 149 J6go P., 55 Johnston If. B., 229 Johnston H., 569 Jones C., 685 Jones FI. B., 69

Kalweit S., 505 Kato S., 35 Kavlock R. J., 757 Kawashima K., 259 Kefalas V., 235 Kenna J. G., 311 Kennedy S. W., 159 Kheuang L.. 7 Kiell A., 365 Kikuchi T., 61 Kimber I., 295, 393 Kishida K., 707 Klaasboer it. H., 743 van Kleef R. G. D. M., 327 Klug S., 727 Kniepen J., 541 Knight T. L., 311 Kobayashi T., 35 Koch P., 493 Ko&cr H. B. W. M., 81 Kondo T., 61 Krafft N., 827 Krauser K., 505 Kreiling R., 505 Kremers P., 433 Ku~era P., 785, 803

L'Azou B., 417 Lachapelle J. M., 809 Lake B. G., 605 Lang B., 427 Lauwerys R., 751

iv Index of Authors

Lawrence J. N., 381, 385 Le Tellier C., 87 Lecart C.. 809 Leclech G., 87 Leibold E., 447 Lenoir E., 809 Lenz D., 537 Leppens H., 547 Lescoat G., 55 Lewan L.. 1 Lewis D. F. V., 605 Lewis R. W., 155, 393 Lieb~h M., 505 I,ison D., 751 Lo B., 595 Lorenzen A., 159 Lorenzon G.. 453 Louver M., 433 Lovell W. W., 95

Madle S., 185 Marano F., 373 Marczynski B., 531 Marek W., 531 Marinovich M., 559 Martinez k. A., 523 Massart C., 87 Maurer G., 493 M~rtensson U., 241 McCall J. C., 155, 393 McGlynn H., 407 Menegola E., 777 Mertens K., 439 Michener S. R., 213 Mihalikov~i K., 803 Miltenburger ti. G., 305, 505 Miranda M. A., 523 Moirand R., 55 Monnet-Tschudi F.. 335 Montuschi P.. 581 Moody R. P., 167 Morel I., 55

Nadeau B., 167 N/issberger L., 241 Nemery B., 359 Neubert D., 727 Nicol M., 87 Niewold Th. A., 443 Ninomiya tl.. 707 Noordhoek J., 743, 769 Nordin M., 321 Nfisse M., 447 Nzeribe R., 177

Ocaktan A.. 55 Odland L , 321 Ohno Y., 707 ()no t1., 517 Oorlgiesen M.. 327 Oostendorp A. G. M., 769 Ordofiez D., 669 Ornoy A., 817 Ortiz AI., 669

Pape W. J. W., 389 Pape W., 505 Parker C. L., 177 Pasdeloup N., 55 Peereboom J. H. J. C., 743, 769 van Pelt F. N. A. M., 311

Perez M. J., 299 Pertijs J. C. L. M., 743, 769 Pesando D., 205 Phillips I. R., 477 Picard J. J., 719, 751. 809 Piersma A. H., 615, 763 Pillar A. M., 69 Pineau N., 299 Pinus H., 817 Plaetse F. V., 547 Pohl I., 551 Ponce M., 15 Postma N. S., 743 Powis G., 213 Prati M., 777 Preziosi P., 581 Prince A. K., 69 Przedborski S., 595 Purcell W., 569

Reinhardt C. A., 293 Renier A., 7 Rcpetto G., 353 Repctto M., 353 Rivcdal E., 631, 637 Roche H., 623 Roelandt L., 433 Rogers J. M., 757 Rogiers V., 439, 477, 487 Rohou S., 499 Romet-I laddad S., 373 Rosenbruch M.. 541 Roseng L E , 631, 637 Ross F. W., 799 Rougier A., 299, 465 Rutten A. A. J. J. L., 81 Ryan M. P., 407

Safran N., 345 Sakemi K., 259 van de Sandt J. J. M., 81 Sanner "1"., 637 San7 P., 353 Sasaki K., 517 Sato H.. 61 Sato N., 673 Sawyer T. W., 653 Schilter B.. 785 Schl~ter (,]., 421 Schmid B., 785 Schoeters G. E. R., 547 Schranner T.. 447 Schreiber G. H., 531 Schwarz L. R., 447 Schwengberg S., 421 Seelbach A.. 185 Scemayer N. H., 365 Segaert A., 487 Segner ti., 537 Shahar A., 345 Shainberg A.. 345 Sharma A., 137 Shephard E. A., 477 Shrivastava S. P., 221 Shum A. S. W., 679 de Silva O., 299 Simmons N. L., 129 Spielmann H., 51)5, 551 Stacey N. H., 197, 235 Stammati A., 403 Steckcl F.. 389

Steiling W., 505 Stepniewski J. P., 453 Stern A., 105 Sterner O., 1. 205 Stewart J., 177 Stouvenakers N., 433 Strandberg C., 205 Strohbusch A., [85 Sutton M., 595 Sysmans M., 471 Syversen T., 149

Tabata ll., 259 Takahashi S., 61 Takanaka A., 259 Talukder G., 137 Tanaka N., 517 Tedone R., 317 Terlouw G. D. C., 247, 281, 685.

827 Tesh J. M.. 799 Tcuns G., 471 Thcrasse P., 809 Thomas tt., 427 Thomas S. M.. 229, 569 Thomc J. P., 433 Tirmcnstein M. A., 645 Todaro A., 433 Toussaint M. J. M., 443 Tsurumi K., 707

Ujhfizy I-., 803 Usami M., 259

Van Cauteren H., 471 Van Den tleuvcl R., 547 Van Maele-Fabry G., 719, 751, 809 Vannier B., 453 Vanparys Ph., 471 Vercruysse A., 439, 477. 487 Verdict F., 317 Vijverberg II. P. M., 327 Vincentini O., 403 Virat M.. 317 Viviani B.. 559

W/ichter F., 685 Waechter F., 427 Wakuri S.. 517 Walum E., 321 Wfichter F., 685 Weishaupt (7., 54l Weiss M. T., 653 West M., 569 Whittle E., 265, 269 Williams S., 569 Wirnsberger T., 505 de Wit M. M. L.. 443 Wright B. (7., 177

Xie K., 275

Yamada M., 61 Yuge O., 673

Zhao J., 827 Zijlstra J. A., 785 Zucco F., 397, 403 Zurich M.-G.. 335 Zwart R., 327

~ Pergamon

Index of Subjects

Abortions recurrent, immunoglobulin G exchange and 817

Adenosine triphosphate (ATP) assays, in cytotox- icity study of 32 MEIC chemicals 517 . . . leakage induction in ELD cells 1

Adrenaline cardiovascular effects on chick embryo 541

AIkoxyacids glycol ethers and, comparative embryotoxicity 777

Aluminium metabolic changes and 229 Aneugens detection by micronucleus assay 185 Anticholinergic drugs toxicity in human neuro-

blastoma cell lines 595 Antidepressants mitogen stimulation effects of

human lymphocytes 241 Antimuscarinic agents toxicity in human neuro-

blastoma cell lines 595 Antioxidant enzyme metal salt effects on, in fish

erythrocytes 623 Apoptosis after toluene diisocyanate exposure 531 Aroclor 1254 cyclophosphamide embryotoxicity

and mutagenicity effects 769 2-Arylpropionic acids photoperoxidation by 523 Auranofin plasminogen activator effects in post-

implantation embryos 751

Bacterial endotoxin effects on rat and hamster hepatocyte cultures 443

Balb/c mice monoclonal antibody development against rat papillary antigen 421 . . . proliferative response study 299

/]-N-methyI-L-amino-alanine (L-BMAA) neuro- filament concentration modulation and 341

Bile acid serum, elevated, uptake relationship 197 •. . transport, carbon tetrachloridc and chloroform effects in rat hepatocytes 197

Biochemical effects pentamidine in human liver cells 177

Biotoxins aquatic, diamine oxidase inhibition by 669

Biotransformation capacity maintenance by hu- man hepatocyte cultures 493

Bis(2-methoxyethyl) ether human/rat microsomal metabolism comparison 645

BMY 43748 comparative metabolism in cultured hepatocytes 499

Bone marrow cultures, 2-irradiation m t'itro/in t'it'o 547

Bovine corneal opacity-permeability assay evalua- tion as Draize test alternative 471

Brain development, metal compound toxicity and 335

Brain cell cultures aggregating embryonic, vali- dation with twelve coded compounds 785. . . dissociated, lasalocid-induced neurotoxicity 345 . . . reaggregate, ethylcholine mustard aziridinium effects 69

Caesium chloride clastogenic effects on human peripheral blood lymphocytes 137

Calcium cytosolic, changes in chemically induced cytotoxicity 511

Carbon tetrachloride bile acid transport effects in rat hepatocytes 197. . . lipid peroxidation inducing, in guinea pig liver microsomes 673 . . . trichloroethylcnc interactive toxicity 235

Carcinogens micronucleus induction in hepato- cytes by flow cytometric analysis 447

Cardiovascular effects adrenaline and nicotine on chick embryo 541

Cell communication, TPA inhibition in hamster embryo cells 631 . . . cultures, toxicity mechanism study in 559 . . . growth inhibition, in chemically induced cytotoxicity 511 . .. lines, human renal 129

Centrifugal elutriation proximal kidney cell iso- lation and purification 117

Cerebral cultures see Brain cell cultures Chemicals acute toxicity, prediction study I 1 l . . .

cell growth inhibition and cytosolic calcium changes causing 511 . . . eye irritancy using cho- rioallantoic membrane test 35 . . . MEIC test, cytotoxicity in primary neurone cultures 653 . . . screening, in whole chick and rat embryo cultures, aggregating brain cell cultures 785

Chemiluminescence phagocytosis assessment 317 Chick embryo cardiovascular effects of adrenaline

and nicotine 541 . . . development, endpoints 701 2-Chlorodibenzofuran developmental toxicity in

cultured rat embryos 259 Chloroform on bile acid transport effects in rat

hepatocytes 197 Chorioallantoic membrane (CAM) test quantita-

tive. using trypan blue in eye irritancy prediction 35 Chromatid exchanges genotoxicity assay in rat

pleural mesothelial cells 7 Cis-diamminedichloroplatinum II see Cisplatin Cisplatin toxicity modulation by dimethyl

sulphoxide in cultured thyrocytes 87 Clastogenicity caesium chloride on human

peripheral blood lymphocytes 137

Index of Subjects

Coal fly ash cytotoxicity in macrophagc culture 61

Cocaine microfilamcnt effects in chick embryo cultures 285

Colony formation in cytotoxicity study of 32 MEIC chemicals 517

Conceptal tissue rat, cy tochrome P-450 isozyrnes in 685

Conceptus cultured, cytochrome P-450-depen- dent metabol ism 247

Contact hypersensitivity epidermal cytokincs and 295

Corneal toxicity isolated human and rabbit eyes 461

Corrosivity test human skin, compar ison with in rico data 2 6 9 . . . h u m a n skin. method development 265

CrhCD (Charles River) rats glycol ethers and alkoxyacids, comparat ive embryotoxici ty 777

Culturing technique rat embryos, gestation days 14-15 695

Cutaneous toxicity (scc also Skin) . . . potential, corrosivity test development 265 . . . potential , m riro.,in ritro data compar ison 269

Cyclophosphamide embryotoxici ty and muta- genicity in rat hepatocytes 769

Cyclosporin vasoconstr ict ion and prevention in glomcruli 417

Cytochromc P-450 dependent conceptal metab- olism 247 . . . expression, phenobarbi ta l and val- proatc effects in co-cultured hepatocytcs 477 . . . isozymcs, in rat conceptal tissue 685

Cytokines contact hypersensitivity and 295 . . . effects on rat and hamster hcpatocytc cultures 443

Cytotoxicity biological/statistical significance of ht vitro testing I l l . . . chemically induced, cell growth inhibi t ion and cytosolic calcium changes in 511 . . . chemicals, topical appl icat ion 81 . . . coal fly ash in macrophagc culture 61 . . . compar ison of four tests 149 . . . electrophysiological measure- ments in toad renal epithelial cells (A6) 411 . . . cugenol to replicating cells 1 0 5 . . . M EIC chemicals by colony formulat ion and ATP assays 517 . . . MEIC test chemicals in pr imary neurone cultures 653 . . . ocular irri tancy test compar ison 155 . . . surfactant- induccd human kcratinocytes 381 . . . surfactants in skin cell cultures 15

Cytotoxicity a,~says tish cell line 537 . . . vali- dat ion as al ternative to Draize test 505

Dermal absorption procedure au tomated 167 Developmental toxicity 2-chlorodibenzofuran in

cultured rat embryos 259 . . . xenobiotic com- pounds 615

Dialdehydes unsaturated, s tructure activity re- lat ionship I, 205

Diamine oxidase inhibi t ion by aquatic biotoxins 669

N,N-Diethyl-m-toluamide (DEET) dermal ab- sorption test compar ison 167

Diethylstilboestrol m whole embryo cuhurc 799 Diffusion system stat ic/f low-through comparison,

percutaneous absorpt ion of p-subst i tu ted phenols 221

Dihydropyridines porphyr ia induction in rodent hepatocyte cultures 587

Dimethyl sulphoxide ( D M S O ) protective effects in cultured thyrocytes 87

2,4-Dinit rochlorobeuzene (DNCB) proliferative response study 299

2,6-1)initrotoluene (2,6-DNT) metabolism, hu- man..rat liver 213

DNA denatura t ion after toluene diisocyanate ex- posure 531 . . . synthesis, genotoxicity assay in rat pleural mesothelial cells 7

Draize eye irritation test bovine corneal opacity- permeabil i ty assay as al ternative 471 . . . chorio- allantoic membrane test as al ternative 35 . . . cytotoxicity assays validation as al ternative 5 0 5 . . . silicon microphysiometer for ocular testing com- parison 465

Drugs metabolism, b io t ransformat ion capacity maintenance by human hepatocyte cultures 493

Electrophysiological measurements cytotoxicity in toad renal epithelial cells (A6) 411

Embryo cultures chick, cocaine effects o n microli- laments 285 . . . developmental toxicity of xeno- biotic compounds 615 . . . pos t - implanta t ion see Post-implantation embryo culture . . . post- implan- tation, 2-chlorodibcnzofuran developmental tox- icity 259 . . . pre- implanta t ion see Pre-implantation embryo culture . . . rat see Rat embryo cultures

Embryonic stem cell cultures in embryotoxici ty test development 551

Embryotoxicity cyclophosphamide, sex difference and Aroclor 1254 t reatment effects 769 . . . glycol ethers and alkoxyacids 777 . . . i -homocyste ine in rodents 743 . . . isotretinoin in human serum 809 . . . testing, development using mouse embryonic stem cell cultures 551 . . . testing of twelve coded compot, nds 785 . . . valproate-induced, folate effects 735

Endotoxin eft'cots on rat and hamster hepatocytc cultures 443

Endpoints in chick embryo development 701 Epidermal cytokines contact hypersensitivity and

295 Epithelial cells (A6), cytotoxicity using electro-

physiological measurements 411 Epithelium permeabili ty to pol lutants in tracheal

cell cultures 373 Erythrocytes lysis test. compar ison with K562

cytotoxicity test 155 . . . sea bass, metal salt effects on ant ioxidant enzyme activities 623

Ethoxyresorufin-O-deethylase (EROD) induc- tion UV irradiat ion effects in hepatocytes 159

Index of Subjects vii

Ethylcholine mustard aziridinium (ECMA) effects in rat brain reaggregatc cultures 69

17~-Ethynyloestradiol in whole embryo culture 799

Eugenol (4-hydroxy-3-methoxy-allybenzene) cyto- toxicity to replicating cells 105

Eye irritancy (see also Draize eye irritation test) . . . bovine corneal opacity-permeability assay, evaluation as Draize test alternative 471 . . . cho- rioallantoic membrane test evaluation 35 . . . sur- factants, predictive ability of tests comparison 155

Eyes isolated human and rabbit, corneal toxicity models 461 . . . toxicity testing using silicon microphysiometer 465

FAC Scan analysis proliferative response specifi- city 299

Fatty acid changes carbon tctrachloride-induced lipid peroxidation and 673

Female sex hormones in whole embryo culture 799

Fertilization sesquiterpenoids and, sea urchin gametes 205

Fischer 344 rats percutancous absorption of 4,4"- mcthylene-his(2-chloroaniline) and 4,4'-mcthyl- enedianiline 141 . . . percutaneous absorption of p-substituted phenols 221

Fish cultured fathcad minnow cells, protein con- tent and fish lethality data correlation 527 . . . sea bass, metal salt effects on antioxidant enzyme activities in erythrocytes 623

Fish cell l ine cytotoxicity assays 537 Flavin-containing monooxygenase expression in

rat hepatocytc culture 487 Flow cytometry micronucleus induction in hep-

atocytes 447 Folate derivatives valproate-induced ncural tube

defects and 735 Formate embryonic sensitivity and pH in whole

embryo culture 757 Furazolidone toxic effects on intestinal cells, food

contamination studies 403

Halothane hepatocyte exposure to, TFA-prote ins and 31 I

Hen's egg tcst-chorioallantoic membrane ( H E T - C A M ) validation as alternative to Draize test 505

Hepatic microsomes bis(2-methoxyethyl) ether metabolism in human/rat 645

Hepatocyte cultures bacterial endotoxin and hy- drocortisone effects in rat and hamster 443 . . . biotransformation capacity maintenance 493 . . . flavin-containing monooxygenase expression in 487 . . . malondialdehyde measurement in 439 . . . PCB effects 4 3 3 . . . porphyria induction by griseo- fulvin and dihydropyridines 5 8 7 . . . propaquizafop effects on laurie acid hydroxylation and pcroxiso- real /I-oxidation 427 . . . pyoverdin Pa A, iron toxicity inhibition 55 . . . quinolone metabolism in 499 . . . rat carbon tetrachloride:'trichloroethylene interactive toxicity study 235 . . . rat long-term, on porous membranes 453 . . . sequential, cyclophos- phamidc embryotoxicity and mutagenicity 769 . . . structure activity relationships for peroxisomal enzyme induction 605

Hepatocytes carbon tetrachloridc and chloro- form effects on b i l e . . , acid transport 197 . . . chick embryo, UV irradiation effects 159 . . . co-cultured, phenobarbital and valproate effects on cytochrome P-450 expression 477 . . . halothanc exposure and TFA-protein generation 311 . . . human liver cells, pentamidine effects 177 . . . micronucleus induc- tion, flow cytometric analyses 447 . . . monooxy- gcnase inhibition by intcrferons 481

~.-Homocysteine stereospecific cmbryotoxicity in rodents 743

Hormones female sex, in whole embryo culture 799

Hydrocortisone effects on rat and hamster hep- atocyte cultures 443

N-Hydroxy-N-methyl-7-propoxy-2-naphthalenethan- amine (QA 208-199, QAB) see QA 208-199, QAB

Gap junctional intercellular communication (GJIC) protein kinase C inhibitor effects 637

Genotoxicity talc in mesothelial cells 7 . . . toluene diisocyanate 531

Gentamicin nephrotoxicity mechanisms and models 407

Gestation days 14-15, culturing technique for rat embryos 695

Glomerulus rat, prevention of cyclosporin- induccd vasoconstriction in 417

Glycol ethers alkoxyacids and, comparative em- bryotoxicity 777

Griseofulvin porphyria induction in rodent hep- atocyte cultures 587

Immunoeompetent cells in cells irritation screen- ing 389

Immunofluoresccnce cocaine effects on microfila- ments in chick embryos 285

lmmunoglobulin G exchange and recurrent abor- tions 817

Immunotoxicity ,screening multiple endpoint test battery 305

Inflammatory mediators release in keratinocytes following irritation 385

Insect repellent DEET, dermal absorption test comparison 167

Interactive toxicity carbon tetrachloride and trichloroethylene in rat hepatocyte cultures 235

lnterferons monooxygenase inhibition in human hepatocytes 481

viii Index of Subjects

Intestinal cells furazolidone effects 403. . . in toxi- cological studies 397

INVITOX 92 Seventh International Workshop on in vitro Toxicology 293

Iron metabolic changes and 229 . . . toxicity inhi- bition in hepatocytcs by pyoverdin Pa A 55

~-lrradiation bone marrow cultures, in vitro~in vivo 547

Isotretinoin embryotoxicity in human serum 809

Japanese White rabbit nique 707

embryos, culturing tech-

K562 cytotoxicity test, comparison with red blood cell lysis tcst 155

Kainate neurofilament concentration modulation and 341

Keratinocyte cultures inflammatory mediator re- lease following irritation 385 . . . surfactant-in- duced cytotoxicity in 381

Kidney cells proximal, isolation and purification 117

Lasalneid induced neurotoxicity in dissociated cerebral cultures 345

Laurie acid hydroxylation propaquizafop effects in hepatocytes, comparison with benzafibratc 427

Lethality data fish, protein content in cultured fathead minnow cells correlation 527

Liver human S-9 fraction and whole embryo cul- ture in teratogenic prediction 827

l,iver cells see Hepatocytes Liver slice tissue culture human.'rat, 2,6-dinitro-

toluene metabolism 213 I,ocal lymph node assay (LLNA) contact allergens

screening procedure 299 Lung cells isolated, in pulmonary toxicology 359 I,ung toxicity testing see Pulmonary toxicity test-

ing I,ympbocytes cacsium chloride clastogenic effects

137 . . . mitogcn stimulation, antidepressant effects 241

Macrophage ah'eolar, coal fly fish cytotoxicity 61 . . . human cultures, in pulmonary toxicity testing 365

Malondialdehyde measurement in rat hepatocytc cultures 439

MEIC sce Multicentre Evaluation of in vitro Cytotoxicity (MEIC)

Membrane toxicity sesquiterpenoids 1 Mercuric chloride neurotoxicity in neuroblas-

toma cells 353 . . . plasminogen activator effects in post-implantation embryos 751

Mesothelial cells talc genotoxicity assays 7

Metabolic changes aluminium/iron induccd in neuroblastoma cells and primary neural cultures 229

Metal compounds toxicity during brain develop- ment 335

Metal salts antioxidant enzyme effects on fish erythrocytes 623

Methoctramine toxicity in human neuroblastoma cell lines 595

2-Methoxyethanol microsomal formation 645 4,4"-Methylene-bis(2-chloroafffline) (MbOCA) per-

cutaneous absorption 141 4,4'- Melhylenedianiline (MDA) percutaneous

absorption 141 Methylmercury chloride neurotoxicity in neuro-

blastoma ceils 353 Methylmercury chloride neurotoxicity in neuro-

blastoma cclls 353 B-N-MethyI-L-amino-alanine (L-BMAA) neuro-

filament concentration modulation and 341 Microfilament cocaine effects in chick embryo

cultures 285 Micronucleus assay aneugcnic effect detection 185 Micronucleus induction in hepatocytes, flow cyto-

metric analysis 447 Microsomes guinea pig liver, lipid peroxidation in

673 Mitochondrial poisons

tures 25 Mitogen stimulation Monoclonal antibody

papillary antigen 421

effects on muscle cell cul-

antidepressant effects 241 development against rat

Monooxygenase flavin-containing, expression in rat hepatocyte cultures 487 . . . inhibition by inter- ferons in human hepatocytes 481

Mouse embryo post-implantation, developmental table 719

MTT assay comparison with other cytotoxicity tests 149

Multicentre Evaluation of in vitro Cytotoxicity (MEIC) 32 chemicals by colony tbrmulation and ATP assays 517 . . . cell growth inhibition and cytosolic calcium changes, chemically induced 511 •.. chemical assay in primary neurone cultures 653

Muscle cell cultures toxicity screening 25 Mutagenicity cyclophosphamide, sex difference

and Aroclor 1254 treatment effects 769 Mutants mouse, neural tube defects analysis in

whole embryo culture 670

Nephrotoxicity gentamicin, mechanisms and models 407

Nerve cell toxicity see Neurotoxicity Neural cell cultures primary, aluminium/iron in-

duced metabolic changes 229 Neural tube defects analysis in mouse mutant.

using whole embryo culture 679 . . . valproate- induced in rat and mouse embryos, tblate effects 735

Index of Subjects ix

Neurite outgrowth /3-N-methyI-L-amino-alanine and kainate effects 341

Neuroblastoma cells aluminium/iron induced metabolic changes 229 . . . antimuscarinic agcnts and anticholincrgic drug toxicity 595 . . . mercuric chloride and methylmercury chloride effects 353

Neuroepithelium microfilamcnt integrity disrup- tion, cocaine causing, in chick embryos 285

Neurofilaments /3-N-methyl-L-amino-alanine and kainate effects 341

Neurone cultures MEIC test chemicals cytotox- icity 653

Neurotoxicity assessment, new models and "tiered-test' model validation 569 . . . cthylcholine mustard aziridinium in rat brain cultures 69 . . . evaluation, elect rophysiological/biochemical methods 275 . . . in t'itro test implications 341 . . . lasalocid-induced in dissociated cerebral cultures 345 . . . mercuric chloride and methylmercury chloride 353 . . . risk estimation 321

Neurotoxins effect on nicotinic acetylcholine receptors in cell cultures 327 . . . identification, cellular methods 321

Neutral red assay, comparison with other cyto- toxicity tests 149 . . . assay, eugenol cytotoxicity 105 . . . uptake in skin toxicity testing 81

Nicotine cardiovascular effects on chick embryo 541

Nicotinic acetylcholine receptors neurotoxicants in cell cultures 327

Ocular irritancy Ocular toxicity

iometer 465 i 7/3-Oestradiol

see Eye irritancy testing using silicon microphys-

in whole embryo culturc 799

Papillary antigen monoclonal antibody develop- ment against 421

Partial least square (PLS) method struc- ture-activity correlation, unsaturated dialdchydes I

Pentamidine biochemical effects in human liver cells 177

Pentane formation carbon tetrachloride-induced lipid peroxidation and 673

Percutaneous absorption 4,4"-methy lene-b is (2- chloroaniline) and 4,4'-methylenedianiline 141 . . . p-substituted phenols, static/flow-through diffu- sion system comparison 221

Peroxisomal/~-oxidation propaquizafop effects in hepatocytcs, comparison with benzafibrate 427

Peroxisomal enzyme induction, structure-activity relationships and, in rat hepatocytes 605

pH formate sensitivity effects in whole embryo culture 757

Phagocytosis chemiluninescence assessment 317 Phenobarbital cytochromc P-450 expression

effects in co-cultured hepatocytes 477

Phenols p-substituted, percutancous absorption, comparative study 221

Photoallergens in ri tro screening 95 Photoperoxidation 2-arylpropionic acids, as pho-

totoxicity indicator 523 Phototoxicity photoperoxidation by 2-arylpropi-

onic acid 523 Plasminogen activator activity retinoic acid, aura-

nofin and mercuric chloride effects in cultured mouse embryos 751

Pollutants epithelium permeability in tracheal cell cultures 373 . . . inhaled, pulmonary toxicity investigation using human macrophagcs 365

Polychlorinated biphenyls (PCBs) effects on hep- atocyte cultures as alternative to in r iro systems 433

Porous membranes rat hepatocytes, long-term culture on 453

Porpbyria induction by griseofulvin and dihy- dropyridines in rodent hepatocyte cultures 587

Porphyrin accumulation TCB-mediated. UV ir- radiation effects in hepatocytes 159

Post-implantation embryo culture mouse, devel- opmental table 719 . . . mouse, plasminogen activa- tor activity in 751 . . . rodent, L-homocysteine embryotoxicity 743

Progesterone in whole embryo culture 799 Proliferative response sodium lauryl sulphate/2,4-

dinitrochlorobenzene 299 Propaquizafop effects, benzafibrate comparison

427 . . . laurie acid hydroxylation and peroxisomal /3-oxidation effects in hepatocyte cultures 427

Protein kinase C inhibitors, effect on cell com- munication and transformation 637

Protein content in cultured fish cells, lethality data correlation 527 . . . measurement, comparison with other cytotoxicity test 149

Pseudomonas aeruginosa peptidic fluorescent siderophore 55

Pulmonary toxicity testing 581 . .. human macro- phage cultures in 365

Pulmonary toxicology isolated lung cells in 359 Pyoverdin Pa A iron toxicity inhibition in rat

hepatocyte cultures 55

QA 208-199, QAB cytochrome P-450-dependcnt biotransformation in cultured rat conceptuses 247

Quinolones comparative metabolism in culture hepatocytcs 499

Rabbit embryo culture trypan blue effects 707 Rat embryo cultures culturing technique for ges-

tation days 14-15 695 . . . strain differences and 281 . . . trypan blue effects 707

Red blood cells see Erythrocytes Renal cell lines human, for toxicological model

systems 129 Retinoic acid plasminogen activator effects in

post-implantation embryos 751