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BBMRI-ERIC and BBMRI.fiConnecting Biobanks at the European and National levelto proviede hiqh quality samples and associated data for health

29.05.2018

Anu Jalanko Terveystalo Biobank Finland

BBMRI- ERIC

• Biobanking and BioMolecular resources Research Infrastructure

• European Research Infrastructure Consortium

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ERIC

▪ ESFRI Roadmap & EU project application: 2006-2008

▪ Preparatory Phase: funded EU Project, 2008-2011

▪ Interim Phase: ERIC application, 2011-2013

▪ Establisment as an ERIC: 2013 –

▪ Host country: Austria

BBMRI-ERIC - largest infrastructure for health in Europe

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Members AustriaBelgiumBulgariaCzech RepublicEstoniaFinlandFranceGermanyGreeceItalyLatviaMaltaNetherlandsNorwayPolandSwedenUnited Kingdom

Observers CyprusSwitzerlandTurkeyIARC/WHO

GOVERNANCE STRUCTURE

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BBMRI-ERIC ServicesPriority Areas for Finland

Common ServicesIT

ELSI (Ethical and legal issues)

Central Service:Sample Quality

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Directory & NegotiatorAvailability requests

Direct negotiationbetween biobanksand researchers

2017:NegotiatorConnector DBDirectory v 4.0Central MDR

2018: Sample locatorMapping tool/s

IT Common Services

BBMRI-ERIC Directory

• A biobank registry (yellow pages), to provide a directory of relevant biobanks

• Directory 2.0 delivered at 2016

• Continuous development towardDirectory 3.0 until spring 2017

• switch to MOLGENIS framework

• Directory 3.1 integrated with theNegotiator (summer 2017)

31.5.2018

▶ 626 biobanks1363 collections

▶ estimated>100,000,000 samples

BBMRI-ERIC Quality Management Services

• International standards (ISO 9001, ISO 20387, ISO 15189, CEN Technical Specifications, etc.)

• Quality management in EU funded projects

• Quality management in national and international research projects

❖Webinars, counseling

• International biobanking standards

• General quality management systems

• Integrated management systems

• Interface management systems

❖ Inhouse training, Workshops

❖Summerschools, Master courses

FOR BASIC AND APPLIED RESEARCH

• BBMRI-ERIC Self-Assessment Survey for biobanks / researchers

• BBMRI-ERIC Audit

KNOWLEDGE HUB TRAINING & SUPPORT AUDITING

May 24, 2018 MC&AoM meeting, Bologna 8

BBMRI-ERIC / QM Network 109 PARTICIPANTS 05.2018

Finland 11

Poland 4

Estonia 2

Austria 15

Czech Republic 2

Italy 9

Greece

Turkey 5

Sweden 4

Norway 8

Germany 13

United Kingdom 7

Netherlands 1

Belgium 11

France 6

Switzerland 2

Malta 6

IARC 1

Cyprus

Latvia 2

May 24, 2018 MC&AoM meeting, Bologna 9

BBMRI.fi – Collaboration of Biobanks

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• Goal to function as a one-stop shop

• Joint projects beween biobanks

• Participation to BBMRI-ERIC

• BBMRI.fi is on the Finnish Infrastructure Roadmap

BBMRI.fi National Node:

Coordinating Institute 2014-2018: THL

National Coordinator: Anu Jalanko

Coordination funding from the Academy of Finland

Management Group

Chair: National Coordinator

Members: Biobank Directors

AuriaBiobank

THL Biobank

Helsinki Biobank

BBMRI.fi - BBMRI-ERIC 2018

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Steering Group

Ministry of Education and Culture

Ministry of Social Affairs and Health

Background organizations of biobanks

(THL, Universities, Hospital districts, FINBB, FRCBS)

Biobankof

Central Finland

Biobankof

Eastern Finland

BorealisBiobank

FHRBBiobank

Tampere Clinical Biobank

BBMRI-ERICManagement

CommitteeMember: Anu Jalanko

(Vice chair)

BBMRI-ERICAssembly of

MembersMembers: Riina Vuorento, Olli Carpen

Experts: Veli-Matti Kosma,Markus Perola, Sandra Liede

BBMRI-ERIC IT Common Service

BBMRI-ERIC ELSI Common Service

FRC Blood

Service Biobank

Academy of Finland

BBMRI-ERIC Finance Committee

Member: Sirpa Nuotio

The Finnish Biobank Act of 2013

• Registration of biobanks, wide consent and protectionof participants

• Transfer of existing sample and data collections to biobanks

• Possibility to recontact

• Possibility to collect samples and data from the health care

• Collaboration with industry

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Terveystalo

Biobank Finland

10 Biobanks

Finnish Biobanks 2018

• 10 registered biobanks

• Biobanks have samples and data of 2,6 millionstudy participants

• Collaboration of biobanks:

• Since 2011 BBMRI.fi coordinates collaboration of biobanks as a part of BBMRI-ERIC

• 9 biobanks as members, 1 observer

• FINBB Biobank Cooperative (legal entity) established in 2017

• 6 hospital biobanks as partners

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Veripalvelun Biopankki

▪ IT collaboration

• Sitra Isaacus pilot – all biobanks – tests integration of data

• Digital pathology – Academy of Finland infrastructure project- 3 biobanks and CSC

• SA-COHORT – Academy of Finland project - 2 biobanks and University of Oulu

▪ Public relations

• Regular meetings, www- and social media activities

▪ Formatting biobank consent and documents for children

▪ Development Group of National Biobanks – practical solutions

▪ Preparation, launch and implementation of FinnGen project

▪ FINBB – preparation of fresh tissue collection

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Collaboration of Finnish Biobanks 2017-2018

• Processing and logistics of human samples: FFPE, frozen tissues, blood, serum,

plasma, urine, DNA, RNA, cells

• Sample collection and storage

• Production of tissue microarrays (TMA), whole slide imaging and digital pathology

services

• Immunohistochemical staining

• Sample associated biological data, including genomic and metabolomics data

• Genomic data services and consultation of research use

• Real life data anlysis services of clinical data in EHR

• Evidence-based feasibility studies for clinical trials

• Consultation and training services

Research Services of Finnish Biobanks

Finnish biobanking activities are expanding

New biobank consents Biobank access projects

Studies with biobanked samples and data resulted in 90 publications in 2017 !

Industry driven studies are expanding

• Most current biobank projects are by the two first biobanks established in 2014

• Auria Biobank :

• 46 % Industry driven biobank studies

• 54 % Academic Research

• THL Biobank

• 17 % Industry driven biobank studies

• 83 % Academic Research

Biobank access projects

Coordinating partners:

Funding:

Funding partners:

Biobanks:FinnGen

FinnGen project has boosted collecting new blood samples for biobanks

38500

44900

49900

57400

63600

70700

35000

40000

45000

50000

55000

60000

65000

70000

Oct 2017 Nov 2017 Dec 2017 Jan 2018 Feb 2018 Mar 2018

Cumulative number of new biobank samples

Picture from:Anu Loukola, Helsinki Biobank

BBMRI.fi - Goals 2018 - 2019

Coordination:Integration of BBMRI and FINBB activities

Yearly training day

Increase in biobank key performance indicators

ICT infrastructure:National availability service in production use by

FINBB, intergrated with BBMRI-ERIC CS-IT

Tools for clinical text mining in use

Quality:Participation to implementation of ISO-276 standard

BBMRI-ERIC quality visits

BBMRI-ERIC quality requirements fulfilled

Ethical and Legal Issues (ELSI):Annual national seminar

Consultation service for biobanks

Implementation of GDPR requirements

▪ Efficient use of hospital data in research

• Harmonization and cleaning of clinical data

• ”Data lakes” to all university hospitals ?

▪ Genome data management

• Currently THL Biobanks large genome data resources are managed in

collaboration with UH/FIMM

• Biobanks will produce huge amounts of genome data in the near future

• Role of Genome Center ?

▪ Management of other Big data

• Imaging data

• Metabolomics, Proteomics, Transcriptomics etc.31/05/2018

Needs and Challenges

2019: BBMRI.fi activities will be integrated with FINBB Biobank Cooperative

All 10 Finnish biobanks collaborate under BBMRI.fi

6 biobanks have established a Cooperative FINBB (legal entity)

BBMRI services will be integrated with the FINBB services

FINBB will be the BBMRI.fi coordinating institute from 2019

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Terveystalo Biobank Finland

Contact Biobanks !www.bbmri.fi

finbb.fiwww.biopankki.fi