Be a part of Sirtris:World-class, headline science
At Sirtris, our phenomenal team ismaking headlines, from Forbes to Fortune,
because of one thing - our passion for creating therapies that allow people to live longer, healthier
lives. We’ve developed a culture that not only rewards creativity, but celebrates it - a community
dedicated to groundbreaking science, in which we learn from one another, inspire one another
and succeed together.
To learn more about life at Sirtris and opportunities to join our team, visit www.sirtrispharma.
com/careers.
Recent Sirtris papers
Nature. 2007 Nov 29;450(7170):712-6.
Cell. 2006 Dec 15;127(6):1109-22.
Nature. 2006 Nov 16;444(7117):337-42.
www.sirtrispharma.com/careers
Sirtris SaysIts Product
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The exclusive storyof the biotech startupsearching for anti-agingmiracle drugs— Fortune
Small molecule activators ofSIRT1 as therapeutics for thetreatment of Type 2 Diabetes
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Key: H Human M Mouse
TRANSCRIPTION FACTOR SPECIES CONTROL PRIMERS CATALOG #
β-Catenin H SUZ12 ECP1329
c-Myc H p21 ECP3696
CREB H Fos ECP2989
FoxP3 H IL-2 ECP3240
GATA-4 H MUC4 ECP2606
GATA-5 H MUC4 ECP2170
GATA-6 H MUC4 ECP1700
GLI-1 H Bcl-2 ECP3324
GLI-2 H Bcl-2 ECP3526
GLI-3 H GLI-1 ECP3690
HIF-1α H M Erythropoietin, VEGF ECP1935
KLF4 H M B2R ECP3640, ECP3158
Nanog H Nanog ECP1997
Oct-3/4 H Nanog ECP1759
p53 H p21 ECP1355
p300 H Fos ECP3789
Smad4 H p21 ECP2097
SOX2 H Nanog ECP2018
STAT3 H M c-Myc ECP1799
STAT5 H M Bcl-x ECP2168
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The FoxP3 ExactaChIP™ Chromatin IP Kit (Catalog # ECP3240) was used to detect FoxP3binding sites in human Jurkat leukemic T cells stimulated with PMA + ionomycin.Afterincubation with biotinylated anti-human FoxP3 or biotinylated anti-goat IgG poly-clonal antibodies, the IL-2 promoter was detected by standard PCR using primerstargeting the IL-2 promoter. M=DNA marker; Input = total DNA before IP.
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Speci�cTranscription Factor
Histones
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250 —
150 —
100 —
80 —
60 —
50 —
40 —
30 —
25 —
20 —
15 —
10 —
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