Behringhauser Str. 31

44575 Castrop-Rauxel

GERMANY

Tel. +49 – 23 05 – 9 73 22 12

Fax +49 – 23 05 – 9 73 22 99

BIOPHAN Europe GmbH -- locations

MR:comp GmbHGelsenkirchen

University of Applied SciencesGelsenkirchen

Prof. BückerAachen

Prof. Ladd, Dr. QuickEssen

BIOPHAN Europe GmbHCastrop-Rauxel

BIOPHAN Europe GmbH

Nicole BramselAssistant to the CEO

Peter LandsbergProject Manager

PhD - Students MSc - Students Scientific Staff

Andreas Melzer, MD, Prof.CTO

Gregor Schaefers, MScCEO - MR:comp GmbH

Arno Bücker, MD, Prof.Aachen

Harald Quick, PhD, PDEssen

Mark Ladd, PhD, Prof.Essen

CONSULTANTS

Michael Friebe, PhDPresident, CEO

Solingen•

Castrop-Rauxel

Solingen•

Castrop-Rauxel

Nordrhein-Westfalenone of 16 states in Germany20 Million people in 150 miles x 150 miles

WORLD-CLASS MRI +iMRI Research

- Aachen- Bochum- Cologne- Bonn- Münster- Essen- Düsseldorf- Gelsenkirchen- plus many more

Mission Statement:

• Develop MRI implants and interventional devices based on a huge dedicated patent portfolio.

• Introduce commercial products through development, via strategic joint ventures, and licensing agreements with major companies having marketing and development expertise.

• Provide marketing and technical support to various partners to assure commercial success.

• Position BIOPHAN as a development leader for MRI implants and interventional MRI devices and procedures.

Located in Castrop-Rauxel and Gelsenkirchen, Germany with an extensive R&D network, cooperations with some of the worlds leading MRI research groups, internal development laboratories and MRI systems.

• 0.3 Tesla unit and 1.0 Tesla unit

• Access to 1.5 Tesla units of all OEM

• Access to 3 Tesla in Münster in Aachen

• Access to 7 Tesla in Essen

• Government funded research

• Excellent network to many research institutions

• Consultant contracts with many of the worlds leading interventional MRI experts

• Ongoing research programs with the universities of Gelsenkirchen, Aachen, Essen

• Scientific presentations in most upcoming MRI meetings

BIOPHAN Europe GmbH -- Technology Portfolio

Aachen - Dr. Spuentrup Essen - Dr. Naber foreign institutionsnational institutionsSMS R&D, Erlangen

device manufacturers

aMRIs - TechnologieProf. Dr. A. Melzer- active implants

- tools and procedures

UCSF --Charles Higgens, MDGuys & St. Thomas --

Reza Razavi, MD

PMS R&D, HamburgPMS R&D, Best

Aachen ResonanceProf. Dr. A. Bücker- passive stents

- medical procedures

Other Prototypes

MRI Safe & CompatibleIMPLANTS

- MRI Intraoperative- MRI Interventional

aMRIs active MRI marker / guidewire

aMRIs Tantalum BX Stent

Plus :OccluderCatheterTools

aMRIs™ Technology -- Prof. Melzer

aMRIs Nitinol SX Stent (in cooperationwith ADMEDES and NDC)

aMRIs Nitinol Vena Cava Filter(in cooperation with ADMEDES and NDC)

aMRIs Polymer Stent

THROMBUS

aMRIs™ Technology --> Prof. Melzer

AACHEN RESONANCE™ Technology -- Prof. Bücker

UniversityClinic

Aachen

Animal Lab

Angio

Operating Room

1.5 T XMR Research Scanner

Cath Lab

Radiology

Research Partner