Date post: | 02-Jun-2018 |
Category: |
Documents |
Upload: | martina-rizki |
View: | 220 times |
Download: | 0 times |
of 12
8/10/2019 Benign Mixed Tumor
1/12
Benign Mixed Tumor(Pleomorphic Adenoma)
8/10/2019 Benign Mixed Tumor
2/12
Clinical Features
Pleomorphic adenoma is benign tumor that isderived from a mixture of ductal epithelial cellsand myoepithelial cells --- show both epithelial andmesenchymal differentiation.
The most common neoplasm of salivary glands. Location: 60% of tumors in the parotid, less
common in the submandibular glands, & relativelyrare in the minor salivary glands. In parotid gland,
most tumor arise within the superficial lobe. Sex & Age: frequent in women in the 4thdecade of
life. But it can be occurred in children & in elderlypersons of either sex.
8/10/2019 Benign Mixed Tumor
3/12
Symptoms: painless, slow growing, mobilediscrete mass within the parotid orsubmadibular areas or in the buccal cavity.
Treatment: parotidectomy.
Recurrence: 4% (parotidectomy) 25%(enucleation).
8/10/2019 Benign Mixed Tumor
4/12
Macroscopic
Rounded and well demarcated mass.
Encapsulated (but sometimes the capsule isnot fully developed producing a tongue-likeprotrusions into the surrounding gland)
Cut Section: solid, gray white in color,consistency depends on the relative amountof epithelial cells and stroma.
8/10/2019 Benign Mixed Tumor
5/12
8/10/2019 Benign Mixed Tumor
6/12
Microscopic
Tumor composed of two components(biphasic appearance): Epithelial component
Forming duct structures / acini / irregular tubules /sheets of cells.
Foci of squamous metaplasia are common.
Mesenchymal component
Loose myxoid tissue (contained stellate cells)Cartilagenous or osseus differentiation are usually
found
8/10/2019 Benign Mixed Tumor
7/12
8/10/2019 Benign Mixed Tumor
8/12
8/10/2019 Benign Mixed Tumor
9/12
8/10/2019 Benign Mixed Tumor
10/12
8/10/2019 Benign Mixed Tumor
11/12
8/10/2019 Benign Mixed Tumor
12/12