BerryPEPProduct Technical Report

INCI name: Panax Ginseng Berry Extract, Lactobacillus/Ginseng Root Ferment Filtrate

BerryPEP

Introduction of Our Peptide Products.

BerryPEPINCI Name : Panax Ginseng Berry Extract, Lactobacillus/Ginseng Root Ferment Filtrate

Scientific name Panax ginseng C. A. Meyer

Kingdom Plantae

Division Anthophyta

Class Dicotyledoneae

Order Umbelliferae

Distribution area Korea, China, Russia

Habitat/Home

It is native to an area ranging from 30° to 48° Nort

h latitude, and native to three areas; Korea (33.7° t

o 43.21°), Manchuria (43° to 47°) in China, and the

Siberian Maritime Territory (40° to 48°).

Size Height 60cm

Classification of domesti

c varieties and overseas

varieties

Korean ginseng is called Goryeo (Korean) ginseng

and written in ‘蔘’.

Foreign ginseng is written into ‘參’. For example, A

merican ginseng (Panax quinquefolium,花旗參), Jap

anese ginseng (Panax japonicum, 東洋參), Chinese

ginseng (Panax notoginseng, 關東參)

Content 100% pH 5.5 ~ 7.5

Appearance Clear yellowsh Liquid Specific Gravity 0.98 - 1.20

Odor Characteristic Preservative Free

Introduction of Our Peptide Product

BerryPEP

A product made by separating and fermenting peptide, a

functional ingredient, from Ginseng Berry

Ginseng Berry, which is borne only once every four years, is

rich in essential nutrients such as saponin and peptides.

Ginseng contains about two to three times more active

ingredients in its fruits than the roots.

Developed as a low-irritating material specialized in various

cosmetic formulations by multiplying the efficacy by fermenting

highly functional lactic acid bacteria.

A product that is especially effective in anti-wrinkle and anti-

aging and that can be applied to any formulation

Application : Anti-Oxidant, Anti-aging

Ginseng Berry

Keywords “Fruit of the youngest time”, “only once”, “rarity”, “ginsenoside”, “modern elixir plant”

Introduction of Our Peptide Product

BerryPEP : Cell regeneration

Results: BerryPPEP is artificially scared and rapidly recovered (reduced free space) depending on concentration when

processing skin cells (HACAT, Keratinocyte)

0 hr

12 hr

24 hr

control 5% 10% 20%

100%

83%

61.8%

100%

79.3%

55.5%

100%

65.3%

47.5%

100%

51.3%

32.5%

Introduction of Our Peptide Product

BerryPEP : Reference

Fig. 3. Ginseng components have antioxidative activities. Ginseng root, ginseng berry, and syringaresinol have DPPH radical-scavenging activity (A) and H2O2 scavenging activity(B). Data are presented are the mean SD. * p < 0.05 by two-tailed Student t test.(해설) Fig. 3. 인삼성분은산화방지기능이있다. 인삼뿌리, 인삼열매 그리고시린가레시놀은 DPPH radical-scavenging activity, H2O2 scavenging activity 가있음을확인하였다.

GR: Ginseng RootGB: Ginseng BerrySYR:Syringaresinol

Effects of Korean ginseng berry on skin antipigmentation and

antiaging via FoxO3a activationJ Ginseng Res 2017;41:277e283

GR: Ginseng RootGB: Ginseng BerrySYR: Syringaresinol

Fig. 5. Ginseng components have potent Anti-aging activity(A, B). induce a life span extension in the Caenorhabditis elegans wild type N2 strain. The survival curves (A) and the mean life span (B)(C, D). Ginseng components decrease lipofuscin accumulation in passaged human dermal fibroblasts(해설) Fig. 35 인삼성분은 안티에이징효과가있으며 C.elegans의수명연장효과와사람의피부세포 (fibroblast)에서 lipofuscin accumulation 을억제하여 Anti-aging 효과를보인다.

Introduction of Our Peptide Product

BerryPEP : ReferenceEffects of Korean ginseng berry on skin antipigmentation and

antiaging via FoxO3a activationJ Ginseng Res 2017;41:277e283

Introduction of Our Peptide Product

BerryPEP: Efficacy Test

BerryPEP has a concentration-dependent antioxidant effect,which is beneficial to the skin.

0%

20%

40%

60%

80%

100%

DP

PH

RA

DIC

AL

SCA

VEN

GIN

G(%

)

DPPH radical scavenging assay(BerryPEP)

-28.2% -45.3% -72.5%-53.2%

1.0% 2.0% 4.0% 8.0%control

Tested by A&PEP Laboratory

Introduction of Our Peptide Product

BerryPPEP has concentration-dependent ellastase activity-suppressing effects It is effective for wrinkle improvement and anti-aging.

0%

20%

40%

60%

80%

100%

ELA

STA

SE IN

HIB

ITIO

N (

%)

Elastase inhibition assay(BerryPEP)

1.0% 2.0% 4.0% 8.0%Control

-27.6% -38.3% -62.1%-53.8%

Introduction of Our Peptide Product

BerryPEP: Efficacy Test

BerryPEP has concentration-dependent collagenase activity-suppressing effects and is effective for wrinkle improvement and anti-aging

0%

20%

40%

60%

80%

100%

CO

LLA

GEN

ASE

INH

IBIT

ION

(%)

Collagenase inhibition assay(BerryPEP)

1.0% 2.0% 4.0% 8.0%Control

-29% -35% -45% -59%

Introduction of Our Peptide Product

BerryPEP: Efficacy Test

BerryPEP is effective for wrinkle improvement and anti-aging, which are concentration-dependently effective for MMP-1 activity suppression.

0%

20%

40%

60%

80%

100%

MM

P1

EX

PR

ESSI

ON

(%

)

MMP-1 inhibition assay(BerryPEP)

7%29% 41% 51%

1.0% 2.0% 4.0% 8.0%Control 0%

Introduction of Our Peptide Product

BerryPEP the simplified human body application test

• Ages : 40s – 50s

• Subjects : improving wrinkles around the eyes

• Periods : 8 weeks (checking in duplicate)

• Concentration:

- Test group “applying BerryPEP 10% cream”

- Control group “non-applying BerryPEP cream”

• Methods

1) 8 weeks of clinical trial, using the product at least 5

times a week

2) Using 7 times a week depending on skin age and

wrinkles

0

65

75

0

20

40

60

80

0W 4W 8W

Wrinkle improvement rate of subjects after 4W : 65.0%

Introduction of Our Peptide Product

As a result of the simplified human body application test0W 4W 8W

Test grou

p

Contro

l gro

up

4W8W

4W

8W

0W

0W

it is confirmed that BerryPEP improved the length and depth of wrinkles in the test group compared to the control group.