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Vitafoods 2013, May 14th F. Pousset Copyright
BEYOND PROBIOTIC AND PREBIOTIC
A SYNBIOTIC HEALTH SUPPLEMENT
SHS
FOR INTESTINAL HEALTH AND QUALITY OF LIFE
Florence Pousset
Vitafoods 2013, May 14th F. Pousset Copyright
Synbiotic: literature survey
Probiotics Prebiotics Synbiotics
Num
ber o
f pub
licat
ions
Years
1400
1200
1000
800
600
400
0
200
Vitafoods 2013, May 14th F. Pousset Copyright
Synbiotic: definition
If a synbiotic relationship is intended, then it should be verified scientifically
SYMBIOSIS
‘A mixture of probiotics and prebiotics that beneficially affect the host by improving the survival and the implantation of live bacteria in the gastrointestinal tract of the host’
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Vitafoods 2013, May 14th F. Pousset Copyright
Synbiotics efficacy : experimental studies
Rowland et al. 1998
azoxymethane A
bera
nt c
rypt
foci
/ co
lon
Control Inulin B. longum SynB β-gl
ucos
idas
e ac
tivity
Colorectal cancer
Synbiotics efficacy probiotics or prebiotics efficacy only in decreasing abnormal crypt foci and increasing β-glucosidase activity
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Control Inulin B. longum SynB
Vitafoods 2013, May 14th F. Pousset Copyright
Synbiotics efficacy : clinical studies
Fujimori et al., 2009 Treatment Total IBDQ score (Week 0 – Week 4)
Cross-over RCT B. longum (2e9) 162 - 169
Patients with ulcerative colitis (n = 120) Psyllium (8g/dose) 174 - 182
Synbiotic 168 – 176 (p<0.03)
Worthley et al., 2009 Treatment Abdominal bloating
Bowel movements
Gurgling
Cross-over RCT B. Lactis (e9) 78.9% 63.2% 89.5%
Healthy volunteers (n = 20)
High amylose maize starch (25g/dose)
77.8% 66.7% 83.3%
Synbiotic 61,1% 88.9% 94.4%
IBDQ: Inflammatory Bowel Disease Questionnaire
Synbiotic therapy could prove more effective than therapies based on prebiotics or probiotics
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Non severe digestive troubles
More than half of the population report at least one of these symptoms
External influences
• Diet • Stress • Drugs i.e. antibiotics • Travel • Illness • Psychological factors
Symptoms
• Abdominal pain 63% • Diarrhoea 55% • Bloating 53% • Flatulence 44% • Constipation 44% • Other 15%
Vitafoods 2013, May 14th F. Pousset Copyright
Synbiotics
Gallup for non severe clinical digestive troubles
Core Foundation study 2010
Vitafoods 2013, May 14th F. Pousset Copyright
Vitafoods 2013, May 14th F. Pousset Copyright
SHS synbiotic
Synbiotic: double effect
Prebiotic « Novel Fiber » Low calorie content 3.3 Kcal/g Low glycaemic index < 28 Low sodium content
4% B. longum 109 cfu/g
Corn Soluble fibers Carbohydrates
K+ Mg++ B6
Synbiotic Health Supplement
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Vitafoods 2013, May 14th F. Pousset Copyright
Preclinical study results: in vitro SHS synbiotic
Bifidobacterium longum is sensitive to all tested prebiotics SHS prebiotic novel fiber
Short chain fructooligosaccharides Inulin
Acacia gum Galactooligossacharides
SHS prebiotic induces the highest and earlier B. longum growth than commercially available competitors
Vitafoods 2013, May 14th F. Pousset Copyright
Preclinical study results: in vivo SHS synbiotic
SHS synbiotic induces a 13% increase of rat forelimb grip strength
Nutriose, SHS prebiotic novel fiber and B. longum administered independently have no effect
Muscle strength evaluation: Grip test
Vitafoods 2013, May 14th F. Pousset Copyright
Rat digestive parameters
P 1 4 16 64 SHS (g/day)
Jejunum crypt height
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Intestinal cellular permeability
p < 0.0011 Week 6
P 1 4 16 64 SHS (g/day)
Cry
pt v
illi h
eigh
t (µ
m)
(FD
4) 1
0-4 m
g/m
l pla
sma
Jejunum trophicity might favor nutrient absorption
Decreased cellular permeability might increase resistance to pathogens
SHS synbiotic
Vitafoods 2013, May 14th F. Pousset Copyright
Rat colonic transit time SHS
Cumulative faecal pellet output
Week 3 P
1 g/day
4 g/day
64 g/day
16 g/day
Num
ber o
f fae
ces
Time (min.) 15 30 45 60 75 90 105 120 135 150 165 180 195 210 225 240
SHS synbiotic regulates colonic transit time according to the dose
Vitafoods 2013, May 14th F. Pousset Copyright
Change of colon circular muscle contractility
Jejunum trophicity
Unchanged blood biological parameters
Total fecal anaerobes Facultative anaerobes
Functional digestive properties
SHS
Intestinal permeability
Transit time regulation
Forelimb grip strength improvement
SHS synbiotic
Vitafoods 2013, May 14th F. Pousset Copyright
IN NON SEVERE DIGESTIVE TROUBLES IN HUMAN
Vitafoods 2013, May 14th F. Pousset Copyright
Observational study 1
SHS (n = 30)
7 14 28 42 56 Days
Qg
QoL
0
Healthy volunteers 18 – 75 years
n = 60
- 14
Placebo (n = 30)
Escalating dose : 2, 4, 6, 8 g/day
Quality of life questionnaire (QoL): 11-item quality of life, to evaluate: physical sensations and psychological symptoms related to their digestive troubles. Score from 1 to 10, from "no symptom" to "extremely severe symptoms" intensity
General questionnaire (Qg): 16-item general questionnaire to evaluate non severe clinical digestive troubles (transit time and regularity, bloating, gas, stool consistency and frequency…)
SHS synbiotic
Vitafoods 2013, May 14th F. Pousset Copyright
Stool consistency Sc
ore
(%)
Day 7 Day 42
Placebo
Day 7 Day 42
SHS
Efficacy in gut function
SHS synbiotic increase moulded stool consistency And did not induce diarrhoea as common laxatives
Significant decrease of transit activity and regularity Significant decrease of stool number
SHS synbiotic
Vitafoods 2013, May 14th F. Pousset Copyright
SHS synbiotic
SHS synbiotic significant decrease Bloating Digestive comfort Heaviness Tends to decrease the frequence of flatulences
Efficacy in non severe clinical digestive troubles
Vitafoods 2013, May 14th F. Pousset Copyright
SHS synbiotic
SHS synbiotic induces a significant better general-well being a significant feeling of being more relaxed
Quality of life: mood changes
Transit improvement
Irritability Annoyed Stress Frightened
Scor
e (%
)
Day 7 Day 42
Day 7 Day 42
Placebo
SHS
Vitafoods 2013, May 14th F. Pousset Copyright
Observational study 2 SHS
SHS (n = 24)
14 28 42 56 Days
Dyn
Qg
0
Healthy volunteers 65 – 75 years
n = 48
- 14
Placebo (n = 24)
Standard dose: 4 g/day
Dynamometer (Dyn): evaluation of biceps muscle strength
General questionnaire (Qg): 15-item grouped into three dimensions, general well-being, muscle strength / vitality and non severe digestive troubles (transit time, bloating, gas…)
Vitafoods 2013, May 14th F. Pousset Copyright
Day 0 – Day 56
Synbiotic and muscular strength SHS
Day 0 - Day 28
SHS Placebo
- 6 - 4 - 2 0 2 4 6 Muscle strength (kg)
- 6 - 4 - 2 0 2 4 6 Muscle strength (kg)
SHS synbiotic: a long lasting energy supplier
< 0: 17% 0 < 46% < 2 > 2: 37%
< 0: 45% 0 < 46% < 2 > 2: 9%
< 0: 41% 0 < 50% < 2 > 2: 9%
< 0: 17% 0 < 33% < 2 > 2: 50%
Vitafoods 2013, May 14th F. Pousset Copyright
SHS functions
Beneficial bacteria
Low GI carbohydrates B6, K+, Mg++
Energy
Biomass
Faeces
Non severe digestive Troubles improvement
Metabolic activity
Mood changes
Quality of life improvement
Bowel
Systemic
Psychologic
Muscle strength
Energy / Vitality
Transit regulation
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SHS synbiotic
Vitafoods 2013, May 14th F. Pousset Copyright
Synbiotics efficacy prebiotics or probiotics used independently
SHS synbiotic activities Transit regulation Non severe digestive troubles improvement Well-being
Potential applications Sportmen Elders Convalescents Diabetics
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Take home messages SHS synbiotic
Vitafoods 2013, May 14th F. Pousset Copyright
Thank you
SHS
G.E.RM. INNOPHARM JOINT PHARMA RESEARCH ABC CONSEILS