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Biochemistry

 ave

Dr. Soumya Kurup (MD)JR, Govt. Medical College, Calicut

Rank #55 in DNB-CET, November 2013 &Rank #165 in AIPGMEE 2014

THE COMPLETE NEET PATTERN BOOK FOR BIOCHEMISTRY

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Letterwave Books

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>  NUCLEOTIDES

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>  VITAMINS 2 g in a single dose may result in abdominal pain, diarrhea, and nausea n   Vitamin C may be metabolized to oxalate. So patients with a past history of

kidney stones not to take large doses of vitamin C.n   Chronic high doses could promote iron overload in patients taking supplemental iron.

Bullet points and Images for quicker learning

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>  NUCLEOTIDES

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>  NUCLEOTIDES

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>  TCA CYCLE

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>  MOLECULAR GENETICS, RECOMBINANT DNA & GENOMIC TECHNOLOGY 

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>  NUCLEOTIDES

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>  MINERALS 1.6 mmol (>100 mg) in symptom-

atic patients0.9 to >1.6 micromol

(60 to >100 microgram) in presymp-

tomatic patients

Liver Cu ++++ 0.3 - 0.8

mmol/g

(20 - 50 mg perg tissue)

>3.1 mmol (> 200 mg) (obstructive

liver disease can cause false-positive

results)

Haplotype

analysis

++++

(Siblings only)

0 Matches 2 Matches

Treatment

Recommended Anticopper Drugs for Wilson’s Disease

Disease Status First Choice Second Choice

Initial hepatic

Hepatitis or cirrhosis without

decompensation

Zinc Trientine

Hepatic decompensation

Mild

Moderate

Severe

Initial

Maintenance

Presymptomatic

Pediatric

Pregnant

 Trientine and zinc

 Trientine and zinc

Hepatic transplantation

 Tetrathiomolybdate and zinc

Zinc

Zinc

Zinc

Zinc

Penicillamine and zinc

Hepatic transplantation

 Trientine and zinc

Zinc

 Trientine

 Trientine

 Trientine

 Trientine

Some interesting points about Wilson disease:n   Te younger the patient, the more likely hepatic involvement will be thepredominant manifestation.n   Girls are 3 times more likely than boys to present with acute hepatic failure.n    After 20 years of age neurologic symptoms predominaten   Kayser Fleischer ring may be absent in young patients with liver disease but are

always present in patients with neurologic symptomsn   KF ring is not unique to Wilson disease but in Wilson, a complete KF ring is

seen

Nazer prognostic index is

used to establish disease

severity in Wilson’s diseasepresenting with hepatic

decompensation. The

laboratory parameters for

calculation are:

n  Serum bilirubinn  Serum aspartate

transferase (AST)

n  Prolongation ofprothrombin time

Related points from Medicine (Harrison) covered

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>  PROTEINS

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Letterwave Books

“Biochemistry is an important subject for NEET pattern.But we often tend to skip important topics or concepts

due to lack of time. Biochemistry Wave offers a solution to

this problem by breaking down the theory to points and

presenting in a manner that can be understood better, read

faster and more importantly can be revised towards the end.

It will be useful to all PG aspirants. Good luck!”

Dr. Nimitha P 

JR in Dermatology, AIIMS, New Delhi

Rank 33, AIPGMEE 2015

Rank 55, AIIMS November 2014

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