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Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title:...

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Bioengineering (BIOE) 1 BIOENGINEERING (BIOE) BIOE 202 - CAREERS IN BIOENGINEERING Short Title: CAREERS IN BIOENGINEERING Department: Bioengineering Grade Mode: Satisfactory/Unsatisfactory Course Type: Seminar Credit Hour: 1 Restrictions: Enrollment is limited to Undergraduate, Undergraduate Professional or Visiting Undergraduate level students. Course Level: Undergraduate Lower-Level Description: This seminar is suitable for freshman, sophomores, and non- majors. A series of guest lectures will introduce students to a variety of career options in bioengineering. Students will participate in at least one field trip to an industry partner or hospital to learn more about careers in bioengineering. BIOE 238 - SPECIAL TOPICS Short Title: SPECIAL TOPICS Department: Bioengineering Grade Mode: Standard Letter Course Type: Internship/Practicum, Seminar, Lecture, Laboratory Credit Hours: 1-4 Restrictions: Enrollment is limited to Undergraduate, Undergraduate Professional or Visiting Undergraduate level students. Course Level: Undergraduate Lower-Level Description: Topics and credit hours vary each semester. Contact department for current semester's topic(s). Repeatable for Credit. BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course Type: Lecture Credit Hours: 4 Restrictions: Enrollment is limited to Undergraduate, Undergraduate Professional or Visiting Undergraduate level students. Course Level: Undergraduate Lower-Level Prerequisite(s): (MATH 101 or MATH 105) and (MATH 102 or MATH 106) and MATH 211 (may be taken concurrently) and (CHEM 112 or CHEM 122) and CAAM 210 and (PHYS 101 or PHYS 125 or PHYS 111) and (PHYS 102 or PHYS 126 or PHYS 112) Description: Introduction to material, energy, charge, and momentum balances in biological systems. Steady state and transient conservation equations for mass, energy, charge and momentum will be derived and applied using basic mathematical principles, physical laws, stoichiometry, and thermodynamic properties. Problem based learning groups will solve open-ended problems. Required for students intending to major in bioengineering. MATH 211 is a concurrent prerequisite and may be taken the same semester. BIOE 302 - SYSTEMS PHYSIOLOGY Short Title: SYSTEMS PHYSIOLOGY Department: Bioengineering Grade Mode: Standard Letter Course Type: Lecture Credit Hours: 3 Restrictions: Enrollment is limited to Undergraduate, Undergraduate Professional or Visiting Undergraduate level students. Course Level: Undergraduate Upper-Level Prerequisite(s): BIOC 201 and (PHYS 101 and PHYS 102) or (PHYS 125 and PHYS 126) Description: This course will teach the fundamentals of human physiology with a specific focus on the nervous, cardiovascular, respiratory, and urinary systems. Basic introductory engineering principles will be applied to the study of physiological systems. The course is aimed to be accessible to students with non-engineering backgrounds. Students may receive credit for only one of BIOE 302, BIOE 322, and BIOC 332. Cross-list: BIOC 332. Mutually Exclusive: Cannot register for BIOE 302 if student has credit for BIOE 322. BIOE 320 - SYSTEMS PHYSIOLOGY LAB MODULE Short Title: SYSTEMS PHYSIOLOGY LAB MODULE Department: Bioengineering Grade Mode: Standard Letter Course Type: Laboratory Credit Hour: 1 Restrictions: Enrollment is limited to Undergraduate, Undergraduate Professional or Visiting Undergraduate level students. Course Level: Undergraduate Upper-Level Prerequisite(s): BIOE 252 and (BIOS 332 or BIOE 322 (may be taken concurrently) or BIOC 332 (may be taken concurrently)) Description: Exploration of physiologic systems through measurement of biologic signals. EEG, ECG, EMG pulmonary function tests, etc. are performed and analyzed. Students will explore physiologic concepts through computer simulations, data collection, and analysis. Enrollment in or completion of BIOE 322/BIOC 332 is expected and maybe taken the same semester as BIOE 320. For students intending to major in Bioengineering. Instructor Permission Required. BIOE 321 - CELLULAR ENGINEERING Short Title: CELLULAR ENGINEERING Department: Bioengineering Grade Mode: Standard Letter Course Type: Lecture Credit Hours: 3 Restrictions: Enrollment is limited to Undergraduate, Undergraduate Professional or Visiting Undergraduate level students. Course Level: Undergraduate Upper-Level Prerequisite(s): BIOE 252 Description: Introduction to engineering principles and modeling regulation and circuitry at the cellular level. Topics include genetic metabolic networks and cell surface interactions.
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Page 1: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

Bioengineering (BIOE)           1

BIOENGINEERING (BIOE)BIOE 202 - CAREERS IN BIOENGINEERINGShort Title: CAREERS IN BIOENGINEERINGDepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: SeminarCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Lower-LevelDescription: This seminar is suitable for freshman, sophomores, and non-majors. A series of guest lectures will introduce students to a variety ofcareer options in bioengineering. Students will participate in at least onefield trip to an industry partner or hospital to learn more about careers inbioengineering.

BIOE 238 - SPECIAL TOPICSShort Title: SPECIAL TOPICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Internship/Practicum, Seminar, Lecture, LaboratoryCredit Hours: 1-4Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Lower-LevelDescription: Topics and credit hours vary each semester. Contactdepartment for current semester's topic(s). Repeatable for Credit.

BIOE 252 - BIOENGINEERING FUNDAMENTALSShort Title: BIOENGINEERING FUNDAMENTALSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 4Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Lower-LevelPrerequisite(s): (MATH 101 or MATH 105) and (MATH 102 or MATH 106)and MATH 211 (may be taken concurrently) and (CHEM 112 orCHEM 122) and CAAM 210 and (PHYS 101 or PHYS 125 or PHYS 111)and (PHYS 102 or PHYS 126 or PHYS 112)Description: Introduction to material, energy, charge, and momentumbalances in biological systems. Steady state and transient conservationequations for mass, energy, charge and momentum will be derived andapplied using basic mathematical principles, physical laws, stoichiometry,and thermodynamic properties. Problem based learning groups willsolve open-ended problems. Required for students intending to major inbioengineering. MATH 211 is a concurrent prerequisite and may be takenthe same semester.

BIOE 302 - SYSTEMS PHYSIOLOGYShort Title: SYSTEMS PHYSIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOC 201 and (PHYS 101 and PHYS 102) or (PHYS 125and PHYS 126)Description: This course will teach the fundamentals of humanphysiology with a specific focus on the nervous, cardiovascular,respiratory, and urinary systems. Basic introductory engineeringprinciples will be applied to the study of physiological systems. Thecourse is aimed to be accessible to students with non-engineeringbackgrounds. Students may receive credit for only one of BIOE 302,BIOE 322, and BIOC 332. Cross-list: BIOC 332. Mutually Exclusive: Cannotregister for BIOE 302 if student has credit for BIOE 322.

BIOE 320 - SYSTEMS PHYSIOLOGY LAB MODULEShort Title: SYSTEMS PHYSIOLOGY LAB MODULEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and (BIOS 332 or BIOE 322 (may be takenconcurrently) or BIOC 332 (may be taken concurrently))Description: Exploration of physiologic systems through measurementof biologic signals. EEG, ECG, EMG pulmonary function tests, etc. areperformed and analyzed. Students will explore physiologic conceptsthrough computer simulations, data collection, and analysis. Enrollmentin or completion of BIOE 322/BIOC 332 is expected and maybe takenthe same semester as BIOE 320. For students intending to major inBioengineering. Instructor Permission Required.

BIOE 321 - CELLULAR ENGINEERINGShort Title: CELLULAR ENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252Description: Introduction to engineering principles and modelingregulation and circuitry at the cellular level. Topics include geneticmetabolic networks and cell surface interactions.

Page 2: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

2        Bioengineering (BIOE)

BIOE 322 - FUNDAMENTALS OF SYSTEMS PHYSIOLOGYShort Title: FUND OF SYSTEMS PHYSIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureDistribution Group: Distribution Group IIICredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and MATH 211Description: This course will teach the fundamentals of humanphysiology from an engineering perspective, with specific focuson the nervous, cardiovascular, respiratory and urinary systems.Lectures, assignments and exams will be quantitative and will introduceengineering principles, such as conservation of mass and energy, controlsand system analysis, thermodynamics and mass transport, and applythem to the study of physiologic systems. This course is limited toundergraduates. Students may receive credit for only one of BIOE 302,BIOE 322, and BIOC 332 Mutually Exclusive: Cannot register for BIOE 322if student has credit for BIOC 332/BIOE 302.

BIOE 330 - BIOREACTION ENGINEERINGShort Title: BIOREACTION ENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and (BIOC 201 or BIOS 201)Description: Application of engineering principles to biological processes.Mathematical and experimental techniques for quantitative descriptionsof enzyme kinetics, metabolic and genetic networks, cell growth kinetics,bioreactor design and operation.

BIOE 332 - BIOENGINEERING THERMODYNAMICSShort Title: BIOENGINEERING THERMODYNAMICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and MATH 212Description: This course provides a mathematically rigorous andquantitative coverage of the fundamentals of thermodynamics withapplications drawn from contemporary bioengineering problems.Fundamental topics will include the Zeroth, First and Second Law,Entropy Inequality, Gibbs and Helmholtz Free Energies, The Third Law,Maxwell Relations, chemical potential, equilibrium, phase transitions,solution thermodynamics, protein-ligand binding and statisticalmechanics. Advanced topics will include transcription factor-DNAbinding, nucleic acid hybridization, translation initiation and geneticcircuits. The course will cover the role that thermodynamics plays inmolecular engineering and synthetic biology.

BIOE 333 - MOLECULAR BIOTECHNOLOGYShort Title: MOLECULAR BIOTECHNOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOC 201 and BIOE 252Description: This course will introduce the students to modernbiotechnology. The course will cover fundamental technologieswith emphasis on modern genome engineering, sequencing andbioinformatics, molecular diagnostics, design of therapeutics, andrecombinant microorganisms for industrial and environmentalapplications. The course includes discussion of bioethical issues,societal impact, and intellectual properties.

BIOE 341 - CELL AND MOLECULAR BIOLOGY FOR ENGINEERSShort Title: CELL & MOL BIOL FOR ENGINEERSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and BIOC 201Description: Understanding the behaviors of cells and biomoleculesin health and disease is a prerequisite to appropriately applyingmodern bioengineering principles. In this course, students will learn thefundamentals of cell and molecular biology and how transformative newtechnologies permit measuring and engineering these alterations toimprove human health and uncover biological insights.

BIOE 342 - LABORATORY IN TISSUE CULTUREShort Title: LABORATORY IN TISSUE CULTUREDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 440 or STAT 440 or BIOC 311Description: Introduction to tissue culture techniques, including cellpassage, cell viability, and cell attachment and proliferation assays.Students complete quantitative analysis of their data. Engineering designand applications are featured in graded work. Sections 1 and 2 are taughtduring the first half of the semester. Sections 3 and 4 are taught duringthe second half of the semester. Students may be required to attendlab on a university holiday. Instructor Permission Required. Cross-list:BIOC 320.

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Bioengineering (BIOE)           3

BIOE 348 - MOLECULAR TECHNIQUES IN BIOENGINEERINGShort Title: MOLECULAR TECHNIQUES IN BIOEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOC 341 and (BIOE 342 (may be taken concurrently) orBIOC 320 (may be taken concurrently))Description: Introduction to the fundamental physical principles of lightinteraction with matter, separation (by charge, size, confirmation) anddetection techniques utilized in the field of bioengineering. These includeabsorbance and fluorescence spectroscopy, light and fluorescencemicroscopy, flow cytometry, electrophoresis, PCR, Blotting, and ELISA.BIOE 342/BIOC 320 may be taken concurrently with BIOE 348. Graduate/Undergraduate Equivalency: BIOE 648. Mutually Exclusive: Cannotregister for BIOE 348 if student has credit for BIOE 648.

BIOE 360 - APPROPRIATE DESIGN FOR GLOBAL HEALTHShort Title: APPRO DESIGN FOR GLOBAL HEALTHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: SeminarCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): GLHT 201Description: Seminar-style introductory design course coveringepidemiology, pathophysiology, health systems, health economics,medical ethics, humanitarian emergencies, scientific and engineeringdesign methods, and appropriate health technology case studies.To register, you must be enrolled in the GLHT minor and submit a250 statement to [email protected] by Monday ofpreregistration. The minor and course prerequisite is waived for studentsmajoring in Bioengineering. Instructor Permission Required. Cross-list:GLHT 360.

BIOE 361 - METABOLIC ENGINEERING FOR GLOBAL HEALTHENVIRONMENTSShort Title: METAB ENG GLOBAL HEALTH ENVMNTDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): (BIOE 362 or GLHT 362) and (PHYS 126 or PHYS 102 orPHYS 112 or PHYS 142) and (MATH 102 or MATH 106)Description: Importance of nutritional and pharmaceutical compounds,impact of cost of compounds on global health; Overview of biochemicalpathways; metabolite analysis; Genetic engineering and molecularbiology tools for ME; Pharmaceuticals and drug discovery approaches(antibiotics, antivirals; anti-parasite compounds); anti-diarrheatreatments; vaccines. Cross-list: BIOC 361, GLHT 361.Course URL: www.btb.rice.edu (http://www.btb.rice.edu)

BIOE 365 - SUSTAINABLE WATER PURIFICATION FOR THE DEVELOPINGWORLDShort Title: SUST WTR PURIF FOR DEV WORLDDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: This course is an overview of sustainable strategies for safewater supply in off-the-grid, low-income regions. Topics covered includewater quality and treatment, sustainability and WASH (water, sanitationand hygiene). A major element of the course is a project to solve a water-related issue in a real-world context. Cross-list: CEVE 314, GLHT 314.Repeatable for Credit.

BIOE 370 - BIOMATERIALSShort Title: BIOMATERIALSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and CHEM 211 and (MECH 211 (may be takenconcurrently) or CEVE 211 (may be taken concurrently))Description: This course will introduce both basic materials science andbiological concepts with an emphasis on application of basic quantitativeengineering principles to understanding the interactions betweenmaterials and biological systems. Topics covered include chemicalstructure of biomaterials, physical, mechanical, and surface propertiesof biomaterials, biomaterial degradation, and biomaterial processing.Additional topics include protein and cell interactions with biomaterials,biomaterial implantation, and acute inflammation, wound healingand the presence of biomaterials immune responses to biomaterials,biomaterials, immune responses to biomaterials, biomaterials andthrombosis, as well as infection, tumorigenesis, and calcification ofbiomaterials that can collectively apply to design of biomaterials formyriad applications. MECH 211 or CEVE 211 may be taken concurrentlywith BIOE 370.

BIOE 372 - BIOMECHANICSShort Title: BIOMECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and MATH 212 and (MECH 202 or MECH 211 orCEVE 211)Description: This course introduces the fundamental principles ofmechanics applied to the analysis and characterization of biologicalsystems. Topics covered include normal and shear stresses, normal andshear strains, mechanical properties of materials, load, deformation,elasticity and elastoplastic behavior. Quantitative analysis of staticallydeterminate and indeterminate structures subjected to tension,compression, torsion and bending will be covered. Additionally, aspectsof blood rheology, viscoelasticity, and musculoskeletal mechanics will beaddressed.

Page 4: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

4        Bioengineering (BIOE)

BIOE 380 - INTRODUCTION TO NEUROENGINEERING: MEASURING ANDMANIPULATING NEURAL ACTIVITYShort Title: INTRO TO NEUROENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): (PHYS 101 or PHYS 111 or PHYS 125 or PHYS 141) and(PHYS 102 or PHYS 112 or PHYS 126 or PHYS 142)Description: This course will serve as an introduction to quantitativemodeling of neural activity and the methods used to stimulate and recordbrain activity. Cross-list: ELEC 380, NEUR 383.

BIOE 381 - FUNDAMENTALS OF NERVE AND MUSCLEELECTROPHYSIOLOGYShort Title: FUND OF ELECTROPHYSIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: An introduction to cellular electrophysiology. Includesdevelopment of whole-cell models for neurons and muscle (cardiacand skeletal muscle) cells, based on ion channel currents obtainedfrom whole-cell voltage-clamp experiments. Material balance equationsare developed for various ions and chemical signaling agents (e.g.,second messengers). Numerical methods are introduced for solvingthe ordinary and partial differential equations associated with thesemodels. Several types of cell models are discussed ranging fromneurons and muscle cells to sensory cells of mechanoreceptors, auditoryhair cells and photoreceptor cells. Volume conductor boundary-valueproblems frequently encountered in electrophysiology are posed. Courseprovides a cellular basis for the interpretation of macroscopic bioelectricsignals such as the electrocardiogram (ECG), electromyogram (EMG),electroretinogram (ERG) and electroencephalogram. Cross-list: ELEC 381.

BIOE 383 - BIOMEDICAL ENGINEERING INSTRUMENTATIONShort Title: BIOMED ENGINEER INSTRUMENTTIONDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): MATH 211 and ELEC 243 and (BIOC 201 or BIOS 201) and(PHYS 102 or PHYS 126 or PHYS 112)Corequisite: BIOE 385Description: This is an introductory level course on fundamentals ofbiomedical engineering instrumentation and analysis. Topics includemeasurement principles; fundamental concepts in electronics includingcircuit analysis, data acquisition, amplifiers, filters and A/D converters;Fourier analysis; temperature, pressure, and flow measurements inbiological systems.

BIOE 385 - BIOMEDICAL INSTRUMENTATION LABShort Title: BIOMEDICAL INSTRUMENTATION LABDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelCorequisite: BIOE 383Description: Students will gain hands on experience with buildingbiomedical instrumentation circuits and systems. Students will learnthe basics of lab view programming and signal analysis. InstructorPermission Required.

BIOE 391 - NUMERICAL METHODSShort Title: NUMERICAL METHODSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 and CAAM 210 and MATH 211 and MATH 212(may be taken concurrently)Description: Introduction to numerical approximation techniques withbioengineering applications. Topics include error propagation, Taylor'sSeries expansions curre fitting, roots of equations, optimization numericaldifferentiation and integration, ordinary differential equations, and partialdifferential equations. Matlab and other software will be used for solvingequations. Math 212 may be taken concurrently with BIOE 391.

BIOE 392 - NEEDS FINDING AND DEVELOPMENT IN BIOENGINEERINGShort Title: NEEDS FINDING & DEV IN BIOEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: Students in this course will learn and develop theengineering skill of needs finding in the field of bioengineering focused ondesigning for disabilities. Students will work in groups with patients withdisabilities to identify daily needs and develop design criteria to meetthose needs including preliminary prototype development. InstructorPermission Required. Cross-list: GLHT 392.

BIOE 400 - ENGINEERING UNDERGRADUATE RESEARCHShort Title: ENGINEERING UG RESEARCHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: ResearchCredit Hours: 1-4Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: Independent investigation of a specific topic or problemin modern bioengineering research under the direction of a selectedfaculty member. Research project has a strong engineering component.Repeatable for Credit.

Page 5: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

Bioengineering (BIOE)           5

BIOE 401 - UNDERGRADUATE RESEARCHShort Title: UNDERGRADUATE RESEARCHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: ResearchCredit Hours: 1-4Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: Independent investigation of a specific topic or problem inmodern bioengineering research under the direction of a selected facultymember. Department Permission Required. Repeatable for Credit.

BIOE 403 - ADVANCES IN BIONANOTECHNOLOGYShort Title: ADVANCES IN BIONANOTECHNOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: SeminarCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 370 (may be taken concurrently)Description: This course covers nanotechnology applications inbioengineering. Students learn about cutting edge research thatuses the tools of nanotechnology to tackle medical problems. Topicsinclude bionanotechnology - related research for diagnosis, detection,and treatment of disease; cell targeting; drug design and delivery;gene therapy; prostheses and implants and tissue regeneration.(REGISTRATION NOTE: The prerequisite BIOE 370 can also be takenconcurrently with BIOE 403)

BIOE 408 - SYNTHETIC BIOLOGYShort Title: SYNTHETIC BIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 332Description: Design of biology at scales from molecules to multicellularorganisms will be covered by lecture, primary literature, and studentpresentations. Students will execute a team based design challenge.Graduate/Undergraduate Equivalency: BIOE 508. Mutually Exclusive:Cannot register for BIOE 408 if student has credit for BIOE 508.

BIOE 419 - INNOVATION LAB FOR MOBILE HEALTHShort Title: INNOVATION LAB - MOBILE HEALTHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hours: 3Restrictions: Students with a class of Freshman may not enroll.Enrollment is limited to Undergraduate, Undergraduate Professional orVisiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: This course will be an innovation lab for mobile healthproducts. The students will organize themselves in groups withcomplementary skills and work on a single project for the wholesemester. The aim will be to develop a product prototype which can thenbe demonstrated to both medical practitioners and potential investors.For successful projects with an operational prototype, the next stepscould be applying for OWLspark (Rice accelerator program) or crowdsourcing (like Kickstarter) and/or work in Scalable Health Labs oversummer. ELEC Juniors can also continue the project outcomes as astarting point for their senior design. Cross-list: ELEC 419. Graduate/Undergraduate Equivalency: BIOE 534. Mutually Exclusive: Cannotregister for BIOE 419 if student has credit for BIOE 534. Repeatable forCredit.Course URL: www.ece.rice.edu/~ashu/ELEC419.html (http://www.ece.rice.edu/~ashu/ELEC419.html)

BIOE 420 - TRANSPORT PHENOMENA IN BIOENGINEERINGShort Title: TRANSPORT PHENOMENA IN BIOEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): MATH 211 and MATH 212 and (BIOE 332 or CHBE 411)and BIOE 391Description: BIOE/CHBE 420 covers transport phenomena as applied tobiological systems and biomedical devices. Conservation of momentumand mass equations are first derived and then used to analyze transportof momentum and mass in biology, physiology, and in biomedical devices.This course is designed for senior bioengineering students. Cross-list:CHBE 420.

Page 6: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

6        Bioengineering (BIOE)

BIOE 421 - MICROCONTROLLER APPLICATONSShort Title: MICROCONTROLLER APPLICATIONSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 385Description: This class covers the usage of microcontrollers in alaboratory setting. We will start with basic electronics and, in the labcomponent, design, program, and build systems utilizing widely-availablemicrocontrollers (e.g. Arduino, Raspberry Pi). Units in motion control,sensors (light, temperature, humidity, UV/Vis absorbance), and actuation(pneumatics, gears, and motors) will provide students with functionalknowledge to design and prototype their own experimental systems forlaboratory-scale automation. Instructor Permission Required. Graduate/Undergraduate Equivalency: BIOE 521. Mutually Exclusive: Cannotregister for BIOE 421 if student has credit for BIOE 521.

BIOE 422 - GENE THERAPYShort Title: GENE THERAPYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment limited to students with a class of Senior.Enrollment is limited to Undergraduate, Undergraduate Professional orVisiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): CHEM 211 and (BIOS 201 or BIOC 201)Description: This course will examine the gene therapy field, with topicsranging from gene delivery to vectors to ethics of gene therapy. Thedesign principles for engineering improved gene delivery vectors, bothviral and nonviral, will be discussed. The course will culminate in a designproject focused on engineering a gene delivery device for a specifictherapeutic application. Graduate/Undergraduate Equivalency: BIOE 522.Mutually Exclusive: Cannot register for BIOE 422 if student has credit forBIOE 522.

BIOE 431 - BIOMATERIALS APPLICATIONSShort Title: BIOMATERIALS APPLICATIONSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): (CHEM 211 or CHEM 251) and BIOE 370Description: Emphasis will be placed on issues regarding thedesign, synthesis, evaluation, regulation and clinical translation ofbiomaterials for specific applications. An overview of significantbiomaterials engineering applications will be given, including topicssuch as ophthalmologic, orthopedic, cardiovascular and drug deliveryapplications, with attention to specific case studies. Regulatory issuesconcerning biomaterial will also be addressed. Assignments for this classwill include frequent readings of the scientific literature with occasionalhomework questions, one midterm and cumulative final, a group project,a seminar report and individual presentations. Graduate/UndergraduateEquivalency: BIOE 631. Mutually Exclusive: Cannot register for BIOE 431 ifstudent has credit for BIOE 631.

BIOE 439 - APPLIED STATISTICS FOR BIOENGINEERING ANDBIOTECHNOLOGYShort Title: APPLIED STAT FOR BIOE BIOTECHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 (may be taken concurrently)Description: Course will cover fundamentals of probability and statisticswith emphasis on application t biomedical problems and experimentaldesign. Recommended for students pursuing careers in medicine orbiotechnology. BIOE 439 and BIOE 440/STAT 440 cannot both be takenfor credit. Prerequisite BIOE 252 may be taken concurrently. Graduate/Undergraduate Equivalency: BIOE 539. Mutually Exclusive: Cannotregister for BIOE 439 if student has credit for BIOE 440/BIOE 539/STAT 440.

BIOE 440 - STATISTICS FOR BIOENGINEERINGShort Title: STATISTICS FOR BIOENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 252 (may be taken concurrently)Description: Course covers application of statistics to bioengineering.Topics include descriptive statistics, estimation, hypothesis testing,ANOVA, and regression. Offered first five weeks of the semester. BIOE 252may be taken concurrently with BIOE 440. BIOE 440/STAT 440 andBIOE 439 cannot both be taken for credit. Cross-list: STAT 440. MutuallyExclusive: Cannot register for BIOE 440 if student has credit for BIOE 439.

BIOE 442 - TISSUE ENGINEERING LAB MODULEShort Title: TISSUE ENGINEERING LAB MODULEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): (BIOE 342 or BIOC 320 or BIOS 320) and (BIOE 440 orSTAT 440)Description: Students design and conduct a series of tests to synthesizePLLA, characterize PLLA and PLGA, monitor PLLA and PLGA degradation,and assess the viability, attachment, and proliferation of HDF cellson PLLA films. The experiments include many of the basic types ofexperiments that would be required to do a preliminary investigation ofa tissue engineered product. Sections 1 and 2 will be taught during thefirst half of the semester and sections 3 and 4 will be taught during thesecond half of the semester. In addition sections 1 and 3 will need tocome into lab on 2-3 Fridays and sections 2 and 4 will need to come intolab on 2-3 Saturdays. Section sign-up is required by the instructor in Keck108 during preregistration week.

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Bioengineering (BIOE)           7

BIOE 443 - BIOPROCESSING LAB MODULEShort Title: BIOPROCESSING LAB MODULEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): (BIOE 342 or BIOC 320 or BIOS 320) and (BIOE 440 orSTAT 440)Description: Students design and conduct a series of experimentsto observe the growth of E. coli under different conditions, includingagar plates, shake flasks, and a small-scale bioreactor. The E. coli hasbeen transformed with a plasmid that produces beta-galactosidase.Engineering applications are emphasized. Some work ’off hours’ (earlyevening) is required. Sections 1 and 2 are taught in the first half of thesemester and Sections 3 and 4 are taught in the second half of thesemester. Section sign-up is required by the instructor in Keck 108 duringpreregistration week.

BIOE 444 - MECHANICAL TESTING LAB MODULEShort Title: MECHANICAL TESTING LAB MODULEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 372 (may be taken concurrently) and (BIOE 440 orSTAT 440)Description: Students design and conduct a series of tests to elucidatethe mechanical and material properties of animal tissue using theInstron. BIOE 372 may be taken concurrently with BIOE 444.

BIOE 445 - ADVANCED INSTRUMENTATION LAB MODULEShort Title: ADVNCED INSTRMENTN LAB MODULEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 383 and BIOE 385 and (BIOE 440 or STAT 440)Description: Students design and build a biomedical instrumentationdevice. Sign up is required in Keck 108 during preregistration week.

BIOE 446 - COMPUTATIONAL MODELING LABShort Title: COMPUTATIONAL MODELING LABDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 391Description: This course offers a hands-on application to systemsbiology modeling. Students will learn a range of modeling methods,and apply them directly in class to current bioengineering problems.Weekly tutorials will be offered, and a laptop is required (or can beloaned). Topics covered include in silico drug delivery and designstudies, integrating multiscale models with high-resolution imaging,experimental design vial computer modeling, and patient-specificsimulations. Modeling methods include protein-protein interactionnetworks, biocircuits, stochastic differential equations, agent-basedmodeling, computational fluid dynamics, and finite element modeling.

BIOE 447 - DIGITAL DESIGN & VISUALIZATIONShort Title: DIG DES & VISDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: Students will acquire basic to intermediate-level digitaldesign proficiency for bioengineering-related applications. Programs forthe design of patient-specific therapies including image reconstruction,computer aided design, and parameter modeling will be used to createmodels. Section sign up is required during pre-registration week.

BIOE 449 - TROUBLESHOOTING WORKSHOP FOR CLINICALLY-RELEVANTBIOMEDICAL EQUIPMENTShort Title: MED BIOENGINEERING WORKSHOPDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hour: 1Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): ELEC 243Description: Bioengineering course in the troubleshooting, repair, andmaintenance of standard biomedical equipment used in hospitals in thedeveloped and developing worlds. Cross-list: GLHT 449. Repeatable forCredit.

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8        Bioengineering (BIOE)

BIOE 451 - BIOENGINEERING DESIGN IShort Title: BIOENGINEERING DESIGN IDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 383 and BIOE 385 and (BIOE 332 or BIOE 372)Description: Senior Bioengineering students will design devices inbiotechnology or biomedicine. This project-based course coverssystematic design processes, engineering economics, FDA requirements,safety, engineering ethics, design failures, research design, intellectualproperty rights, environmental impact, business planning and marketing.Students will be expected to compile documentation and present orallyprogress of their teams. BIOE 451 and 452 must be taken the sameacademic year. Instructor Permission Required.

BIOE 452 - BIOENGINEERING DESIGN IIShort Title: BIOENGINEERING DESIGN IIDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 451Description: Senior Bioengineering students will design devices inbiotechnology or biomedicine. This project-based course coverssystematic design processes, engineering economics, FDA requirements,safety, engineering ethics, design failures, research design, intellectualproperty rights, environmental impact, business planning and marketing.Students will be expected to compile documentation and present orallyprogress of their teams. BIOE 451 and 452 must be taken the sameacademic year. Instructor Permission Required.

BIOE 454 - COMPUTATIONAL FLUID MECHANICSShort Title: COMPUTATIONAL FLUID MECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): MECH 371 (may be taken concurrently) or CEVE 363(may be taken concurrently) or CHBE 401 (may be taken concurrently)or BIOE 420 (may be taken concurrently) or CHBE 420 (may be takenconcurrently)Description: Fundamental concepts of finite element methods in fluidmechanics, including spatial discretization and numerical integrationin multidimensions, time-integration, and solution of nonlinear ordinarydifferential equation systems. Advanced numerical stabilizationtechniques designed for fluid mechanics problems. Strategies forsolution of complex, real-world problems. Topics in large-scalecomputing, parallel processing, and visualization. Prerequisites maybe taken concurrently. Cross-list: CEVE 454, MECH 454. Graduate/Undergraduate Equivalency: BIOE 554. Mutually Exclusive: Cannotregister for BIOE 454 if student has credit for BIOE 554.

BIOE 464 - EXTRACELLULAR MATRIXShort Title: EXTRACELLULAR MATRIXDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOS 341 or BIOC 341Description: This course will address the biology, organization,mechanics, and turnover of extracellular matrix. There will be anemphasis on cells and cell-matrix interactions, matrix distribution withinand design of connective tissues and organs techniques for quantitativeanalysis of matrix, techniques for measurement and modeling ofconnective tissue biomechanics, changes with growth and aging andtissue/matrix degradation. Cross-list: BIOC 464. Graduate/UndergraduateEquivalency: BIOE 524. Recommended Prerequisite(s): BIOE 372, BIOC/BIOE 341. Mutually Exclusive: Cannot register for BIOE 464 if student hascredit for BIOE 524.

BIOE 477 - SPECIAL TOPICSShort Title: SPECIAL TOPICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Internship/Practicum, Seminar, Lecture, LaboratoryCredit Hours: 1-4Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: Topics and credit hours vary each semester. Contactdepartment for current semester's topic(s). Repeatable for Credit.

BIOE 481 - COMPUTATIONAL NEUROSCIENCE AND NEURALENGINEERINGShort Title: COMP/NEUROSCIENCE/NEURAL ENGNRDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: An introduction to the anatomy and physiology of thebrain. Includes basic electrophysiology of nerve and muscle. Developsmathematical models of neurons, synaptic transmission and naturalneural networks. Leads to a discussion of neuromorphic circuitswhich can represent neuron and neural network behavior in silicon.Recommendation: Knowledge of electrical circuits, operational amplifiercircuits and ordinary differential equations. Involves programmingMatlab. Cross-list: ELEC 481, NEUR 481. Graduate/UndergraduateEquivalency: BIOE 583. Recommended Prerequisite(s): Knowledge ofbasic electrical and operational amplifier circuits; and ordinary differentialequations. Mutually Exclusive: Cannot register for BIOE 481 if student hascredit for BIOE 583.

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BIOE 482 - PHYSIOLOGICAL CONTROL SYSTEMSShort Title: PHYSIOLOGICAL CONTROL SYSTEMSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: A study of the somatic and autonomic nervous systemcontrol of biological systems. Simulation methods, as well as, techniquescommon to linear and nonlinear control theory are used. Also includedis an introduction to sensors and instrumentation techniques. Examplesare taken from the cardiovascular, respiratory, and visual systems.Cross-list: ELEC 482. Graduate/Undergraduate Equivalency: BIOE 582.Recommended Prerequisite(s): Knowledge of basic electrical andoperational amplifier circuits: and ordinary differential equations.Mutually Exclusive: Cannot register for BIOE 482 if student has credit forBIOE 582.

BIOE 484 - BIOPHOTONICS INSTRUMENTATION AND APPLICATIONSShort Title: BIOPHOTONICS INSTRUMENTATIONDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 383Description: This course is an introduction to the fundamentals ofBiophotonics instrumentation related to coherent light generation,transmission by optical components such as lenses and fibers, andmodulation and detection. Interference and polarization conceptsand light theories including ray and wave optics will be covered. Abroad variety of optical imaging and detection techniques includingnumerous microscopy techniques, spectral imaging, polarimetry, OCTand others will be covered. The course will guide through the principlesand concepts used in a variety of optical instruments and point to specialrequirements for Biomedical applications with emphasis on principlesand concepts used in a variety of optical instruments and point to specialrequirements for Biomedical applications with emphasis on principlesand concepts used in a variety of optical instruments and point outspecial requirements for bio-medical applications in optical sensing,diagnosis, and biomedical applications. Graduate/UndergraduateEquivalency: BIOE 512. Mutually Exclusive: Cannot register for BIOE 484 ifstudent has credit for BIOE 512.

BIOE 485 - FUNDAMENTALS OF MEDICAL IMAGING IShort Title: FUND MEDICAL IMAGING IDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: This course will introduce basic principles of imageacquisition, formation and processing of several medical imagingmodalities such as X-Ray, CT, MRI, and US that are used to evaluate thehuman anatomy. The course also includes visits to a clinical site togain experience with the various imaging modalities covered in class.Cross-list: COMP 485, ELEC 485. Graduate/Undergraduate Equivalency:BIOE 591. Recommended Prerequisite(s): MATH 211 and MATH 212.Mutually Exclusive: Cannot register for BIOE 485 if student has credit forBIOE 591.

BIOE 486 - FUNDAMENTALS OF MEDICAL IMAGING IIShort Title: FUND MEDICAL IMAGING IIDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): ELEC 485 or BIOE 485 or COMP 485Description: This course focuses on functional imaging modalities usedspecifically in nuclear medicine such as Gamma cameras, SPECT, andPET imaging. The course will introduce the basic principles of imageacquisition, formation, processing and the clinical applications of theseimaging modalities and lays the foundations for understanding theprinciples of radiotracer kinetic modeling. A trip to a clinical site in alsoplanned to gain experience with nuclear medicine imaging. Cross-list:COMP 486, ELEC 486. Graduate/Undergraduate Equivalency: BIOE 596.Mutually Exclusive: Cannot register for BIOE 486 if student has credit forBIOE 596.

BIOE 490 - INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING &DESIGN PRINCIPLES OF BIOCHEM NETWORKSShort Title: INTRO SYSTEMS BIOLOGY MODELINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): (MATH 212 or MATH 213) and (BIOE 252 or CHBE 310)and BIOC 341 and CAAM 210Description: The course summarizes techniques for quantitativeanalysis and simulations of basic circuits in genetic regulation, signaltransduction and metabolism. We discuss engineering approachesadapted to computational systems biology and aim to formulateevolutionary design principles explaining organization of networks interms of their physiological demands. We discuss biochemical simulationmethodology and software as well as recent advances in the field.Topics include end-product inhibition in biosynthesis, optimality androbustness of the signaling networks and kinetic proofreading. Graduate/Undergraduate Equivalency: BIOE 552. Mutually Exclusive: Cannotregister for BIOE 490 if student has credit for BIOE 552.

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10        Bioengineering (BIOE)

BIOE 492 - SENSORY NEUROENGINEERINGShort Title: SENSORY NEUROENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: SeminarCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelPrerequisite(s): BIOE 332Description: This course will explore how bioengineering techniques andprinciples are applied to understand and model sensory systems, witha focus on the auditory, vestibular, and visual systems. The interactionbetween the electrical, mechanical and optical aspects of these systems,and ways to modulate these interactions, will be explored. The coursewill also cover the design of current auditory, visual and somato-sensoryneuroprosthetics (i.e. cochlear implants, retinal implants and brain-machine interfaces), as well as emerging technologies for neuralstimulation. Graduate/Undergraduate Equivalency: BIOE 592. MutuallyExclusive: Cannot register for BIOE 492 if student has credit for BIOE 592.

BIOE 493 - BUILDING LIFE SCIENCES, BIOMEDICAL ANDBIOTECHNOLOGY STARTUPSShort Title: BIOTECH STARTUPDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Undergraduate, UndergraduateProfessional or Visiting Undergraduate level students.Course Level: Undergraduate Upper-LevelDescription: This semester-long course aims to provide entrepreneurialstudents with a hands-on experience in building a high-tech companybased on novel biomedical technologies being developed at RiceUniversity and in the Texas Medical Center. Students will form teams of2-4, and identify a promising biomedical technology, perform intellectualproperty landscape analysis, identify a minimum viable product, builda business plan, construct 1 year and 5 year financial projections,conduct voice of customer interviews, and present a fundraising“pitch.” Students are expected to spend 8-10 hours per week outsidethe classroom to complete tasks assigned during lectures, and willsummarize their findings every 2 weeks in a 7-minute presentation.Graduate/Undergraduate Equivalency: BIOE 593. Mutually Exclusive:Cannot register for BIOE 493 if student has credit for BIOE 593.

BIOE 500 - GRADUATE RESEARCHShort Title: GRADUATE RESEARCHDepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: ResearchCredit Hours: 1-15Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Repeatable for Credit.

BIOE 502 - PHYSICAL BIOLOGYShort Title: PHYSICAL BIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Basic introduction to a biophysical view of living systems,from the subcellular to the multicellular scales. Topics include:biomolecular dynamics, cellular biomechanics, cell motility and celldivision, calcium signaling, action potential propagation, and tissueorganization. Cross-list: BIOC 501, SSPB 501.

BIOE 504 - FIRST YEAR GRADUATE STUDENT LAB ROTATIONShort Title: GRADUATE LAB ROTATIONDepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course provides students the opportunity to experiencedifferent research projects and assists first-year students in choosingan advisor and a lab for conduction thesis research. Students mustsuccessfully complete rotations in three labs to receive a satisfactorygrade. All new BIOE PhD students must take this course during their firstsemester.

BIOE 505 - MACROMOLECULAR ASSEMBLIESShort Title: MACROMOLECULAR ASSEMBLIESDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Course Level: GraduateDescription: There is increasing attention on the biological phenomenaand engineering opportunities at the mesoscopic scale, which isbetween the size of a single protein and that of the large organelles. Thiscourse will cover a range of these phenomena, such as viral particles,ribosomes, bacterial microcompartments, amyloid fibrils, gas vesicles,and membraneless condensates. Additionally, the course will aim toformulate physical principles behind these phenomena, describe theexperimental and computational approaches to study them, and discusshow to engineer these assemblies.

BIOE 506 - GRADUATE INDEPENDENT STUDYShort Title: GRADUATE INDEPENDENT STUDYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Independent StudyCredit Hours: 1-6Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Independent investigation of a specific topic in modernbioengineering research under the direction of a faculty member.Department Permission Required. Repeatable for Credit.

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BIOE 508 - SYNTHETIC BIOLOGYShort Title: SYNTHETIC BIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Design of biology at scales from molecules to multicellularorganisms will be covered by lecture, primary literature, and studentpresentations. Students will write a research proposal at the end of thecourse. Cross-list: SSPB 503. Graduate/Undergraduate Equivalency:BIOE 408. Mutually Exclusive: Cannot register for BIOE 508 if student hascredit for BIOE 408.

BIOE 509 - POINT-OF-CARE DIAGNOSTICSShort Title: POINT-OF-CARE DIAGNOSTICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course provides an overview of diagnostic technologiesthat can be used at the point-of-care, including lateral flow assays, 2- and3-D paper-based assays, and imaging based assays. Topics include theprinciples of assay design, validation and commercial development, witha focus on diagnostics for low-resource settings. The course includesa lecture and laboratory component, along with a team-based designproject. Only graduate students may register for this course.

BIOE 510 - SEMINAR IN TROPICAL MEDICINEShort Title: SEMINAR IN TROPICAL MEDICINEDepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: SeminarCredit Hour: 1Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: 8 week lecture series on topics in global health. The themefor this offering is one health; integrating efforts to obtain optimal healthfor humans, animals, and the environment. Offered in conjunction withthe new National School of Tropical Medicine, the course will featurelectures by various experts on the public health issues most pressing inpoor populations in the world today. Course open to all undergraduatesand graduate students. Cross-list: GLHT 510. Repeatable for Credit.

BIOE 512 - BIOPHOTONICS INSTRUMENTATION AND APPLICATIONSShort Title: BIOPHOTONICS INSTRUMENTATIONDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course is an introduction to the fundamentals ofBiophotonics instrumentation related to coherent light generation,transmission by optical components such as lenses and fibers, andmodulation and detection. Interference and polarization conceptsand light theories including ray and wave optics will be covered. Abroad variety of optical imaging and detection techniques includingnumerous microscopy techniques, spectral imaging, polarimetry, OCTand others will be covered. The course will guide through the principlesand concepts used in a variety of optical instruments and point to specialrequirements for Biomedical applications with emphasis on principlesand concepts used in a variety of optical instruments and point to specialrequirements for Biomedical applications with emphasis on principlesand concepts used in a variety of optical instruments and point outspecial requirements for bio-medical applications in optical sensing,diagnosis, and biomedical applications. In addition to the undergraduaterequirements in BIOE 484, graduate students will be required to completemore complex problems on both homework and tests. Graduate studentswill also be required to submit a research paper with oral presentations.Graduate/Undergraduate Equivalency: BIOE 484. Mutually Exclusive:Cannot register for BIOE 512 if student has credit for BIOE 484.

BIOE 513 - STRATEGIC CAREER PREPAREDNESS FOR INDUSTRY JOBSShort Title: CAREER PREP FOR INDUSTRYDepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: LectureCredit Hours: 1.5Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course is designed for MBE candidates and PhDstudents planning to graduate within the year who are interested inindustry careers. The course will help students design a resume, coverletter, and other career development tools to strategically identify andmarket their skills to bioengineering industry partners.

BIOE 514 - INTRODUCTION TO BIOSTATISTICSShort Title: INTRODUCTION TO BIOSTATISTICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to students with a major inBioengineering. Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Presents basic and advanced methods of statistics asapplied to problems in bioengineering. Demonstrates techniques for dataorganization, exploration, and presentation. Foundations of statisticalestimation, inference, and testing are reviewed. Optimal planningof experiments is explored. Advanced techniques include multipleregression, variable selection, logistic regression, analysis of variance,survival analysis, multiple measurements and measurements over time.Additional topics, such as Bayesian methods, will be discussed as timeallows. Labs will use the statistical software JMP and/or R. Cross-list:STAT 514.

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12        Bioengineering (BIOE)

BIOE 515 - ENGINEERING DRUG DELIVERY SYSTEMSShort Title: ENGINEERING DRUG DELIVERY SYS.Department: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will focus on the application of innovativeengineering approaches to enhance drug efficacy and/or reducetoxicity. Topics of emphasis include, but are not limited to, routesof administration, bioavailability, biodistribution, pharmacokinetics,pharmacodynamics, therapeutic drug windows, patient compliance,immunogenicity, the foreign body reaction, and solubility enhancement.A wide array of device types will be discussed, such as biodegradablemicrospheres, self-assembled lipid nanoparticles, microneedles, andosmotic pumps. Students will be expected to quantitatively evaluatedrug release from complex devices and determine drug distribution andclearance using multi-compartment models. An additional project will berequired of graduate level students.

BIOE 516 - MECHANICS, TRANSPORT, AND CELLULAR SIGNALINGShort Title: MECHANICS/TRANSPORT/SIGNALINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will cover the fundamental principles ofmechanics, thermodynamics, and transport in the context of classicaland contemporary bioengineering problems. An overall goal will be toexpose students to the integrated approaches that are necessary tosolve complex research problems. Topics covered will include membranetransport, cell signaling, and mechanotransduction. This course isintended for first year BIOE PhD students only.

BIOE 517 - INSTRUMENTATION AND MOLECULAR ANALYSISShort Title: INSTRUMENT/MOLECULAR ANALYSISDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will cover the basic principles of optics, opticalinstrumentation, microscopy and molecular detection technologies.Emphasis will be placed on the application of advance microscopytechniques to imaging problems in biology and medicine. This course isintended for first year BIOE PhD students only.

BIOE 518 - INTRODUCTION TO COMPUTATIONAL BIOLOGYShort Title: INTRO TO COMPUTATION BIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Provides students with the ability to use computationalmethods to understand and analyze biological data. This course willintroduce students to advances in computational cell biology from anengineering perspective, and equip them with a suite of tools emergingfrom systems biology. Topics covered include computational cellengineering, high-throughput analysis, modeling of signaling pathways,network analysis, imaging coupled to modeling, and multi scale modeling.This course is intended for first year BIOE PhD students only.

BIOE 519 - BIOMATERIALS SYNTHESISShort Title: BIOMATERIALS SYNTHESISDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Biomaterials covers the design and synthesis of materialswhich interact with biologic phenomena such as cell-free, microbial,and mammalian systems. Topics covered include: surfaces and surfacefractionalization, biomedical implants and them immune response,three dimensional cell culture systems, and regulatory hurdles (e.g.,FDA clearance). The class will be rooted in a historical perspective, witha particular emphasis on the latest techniques in synthetic chemistryrelating to biomaterials. This course is intended for first year BIOE PhDstudents only. Instructor Permission Required.

BIOE 521 - MICROCONTROLLER APPLICATIONSShort Title: MICROCONTROLLER APPLICATIONSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): BIOE 385Description: This class covers the usage of microcontrollers in alaboratory setting. We will start with basic electronics and, in the labcomponent, design, program, and build systems utilizing widely-availablemicrocontrollers (e.g. Arduino, Raspberry Pi). Units in motion control,sensors (light, temperature, humidity, UV/Vis absorbance), and actuation(pneumatics, gears, and motors) will provide students with functionalknowledge to design and prototype their own experimental systemsfor laboratory-scale automation. BIOE 521 students will be expectedto complete a final research paper. Instructor Permission Required.Graduate/Undergraduate Equivalency: BIOE 421. Mutually Exclusive:Cannot register for BIOE 521 if student has credit for BIOE 421.

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BIOE 522 - GENE THERAPYShort Title: GENE THERAPYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Gene therapy suffered from major clinical setbacks in thelate 1990’s, putting the entire field of genetic medicine at a standstill.However, through perseverance and strategic re-thinking of how virusesand cells could be used as therapeutics, the field is currently experiencinga biotechnological revolution. In December of 2017, a virus-based genetherapy drug was approved by the FDA, making it the first of its kind forthe treatment of an inherited disease. This landmark achievement is justthe beginning of a new era of human therapeutics. This class will discussthe gene therapy field – where it was and where it is now. Clinicallyimportant vectors currently under human testing, and opportunities forthe next generation of improved gene delivery vectors will be presented.The biological and physiological barriers to efficient gene delivery will beinvestigated in order to spur new ideas for improving vector efficiencyand specificity. Graduate/Undergraduate Equivalency: BIOE 422. MutuallyExclusive: Cannot register for BIOE 522 if student has credit for BIOE 422.

BIOE 523 - BIOENGINEERING SYSTEMS AND CONTROLShort Title: BIOENG SYSTEMS & CONTROLSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Introduction to basic principles of control theory andapplications of these methods and tools to analyze the dynamics ofbiological systems with examples from metabolic pathway control,synthetic biology and physiological systems. Cross-list: CHBE 523.

BIOE 524 - EXTRACELLULAR MATRIXShort Title: EXTRACELLULAR MATRIXDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will address the biology, organization,mechanics, and turnover of extracellular matrix. There will be anemphasis on cells and cell-matrix interactions, matrix distributionwithin and design of connective tissues and organs techniques forquantitative analysis of matrix, techniques for measurement andmodeling of connective tissue biomechanics, changes with growth andaging and tissue/matrix degradation. Additional projects will be requiredof graduate level students. Cross-list: BIOC 523. Graduate/UndergraduateEquivalency: BIOE 464. Recommended Prerequisite(s): BIOE 372, BIOC/BIOE 341. Mutually Exclusive: Cannot register for BIOE 524 if student hascredit for BIOE 464.

BIOE 525 - NANOBIOENGINEERING AND NANOMEDICINEShort Title: NANOBIOENG AND NANOMEDICINEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Covers broad range of topics in nanobioengineering andnanomedicine, including synthesis characterization and fractionalizationof nanomaterials and nanostructures, nanoparticle-based molecularimaging probes, nanocarriers, for drug/gene delivery, and nanomachinesfor gene editing and regulation. Examples will be given to illustrate theapplications of nanobioengineering and nanomedicine.

BIOE 526 - ADVANCES IN GENOME EDITING AND ENGINEERINGShort Title: ADVANCES IN GENOME EDITINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This is a course for graduate students who are interestedin learning the emerging field of precision genome editing and itsapplications in biology and medicine. This is a lecture course consistingof classes that meet weekly for 3 hours; instruction is delivered both in alecture setting and through projects.

BIOE 527 - HEALTHCARE INNOVATION AND ENTREPRENEURSHIPShort Title: HEALTHCARE INNOV & ENTREPRENDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course is designed for healthcare entrepreneurswho want to build innovative medical technologies. During the course,students will learn how to identify customers, key stakeholders, and themarket opportunity for a clinical need; apply design thinking, includinglow-fidelity prototyping, to quickly test and iterate on a concept; assessregulatory, reimbursement, and clinical trial requirements; identify keyassumptions and develop a business model; create a financial modelbased on business model assumptions; determine capital requirementsand funding sources for their venture; understand and evaluate termsheets; create a pitch presentation for investors.

BIOE 528 - MEDICAL ENGINEERING AND DESIGN LABShort Title: MED ENGINEERING & DESIGN LABDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: In this studio-based lab, students apply technicalengineering and prototyping skills to medical design projects.Participants are taught and apply a range of topics including engineeringdesign processes, medical materials, biocompatibility, design formanufacturing, rapid prototyping, medical equipment, sterility,manufacturing techniques, and quality system implementation.

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BIOE 529 - HEALTHCARE INNOVATION AND ENTREPRENEURSHIP LABShort Title: INNOV & ENTREPRENEURSHIP LABDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: In this follow-on experiential Lab course, students work onrefining and completing the plan for the venture they created in HealthInnovation and Entrepreneurship. Teams receive guidance and Mentoringfrom faculty and mentors to develop the next steps of their business. TheLab takes place in the Liu Idea Lab for Innovation and Entrepreneurship, apurpose built state-of-the-art incubator and co-working space on the Ricecampus.

BIOE 530 - MEDICAL ENGINEERING & DESIGN LAB 2Short Title: MED ENGIN & DESIGN LAB 2Department: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to students with a major inBioengineering. Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): BIOE 528Description: In this studio-based lab, students apply technicalengineering and prototyping skills to medical design projects.Participants are taught and apply a range of topics including engineeringdesign processes, medical materials, biocompatibility, design formanufacturing, rapid prototyping, medical equipment, sterility,manufacturing techniques, and quality system implementation. Thiscourse is intended for only those students in Bioengineering.

BIOE 534 - INNOVATION LAB FOR MOBILE HEALTHShort Title: INNOVATION LAB - MOBILE HEALTHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will be an innovation lab for mobile healthproducts. The students will organize themselves in groups withcomplementary skills and work on a single project for the wholesemester. The aim will be to develop a product prototype which canthen be demonstrated to both medical practitioners and potentialinvestors. For successful projects with an operational prototype, thenext steps could be applying for OWLspark (Rice accelerator program)or crowd sourcing (like Kickstarter) and/or work in Scalable Health Labsover summer. ELEC Juniors can also continue the project outcomesas a starting point for their senior design. Additional course workrequired beyond the undergraduate course requirements. Cross-list:ELEC 559. Graduate/Undergraduate Equivalency: BIOE 419. MutuallyExclusive: Cannot register for BIOE 534 if student has credit for BIOE 419.Repeatable for Credit.Course URL: www.ece.rice.edu/~ashu/ELEC419.html (http://www.ece.rice.edu/~ashu/ELEC419.html)

BIOE 535 - ENGINEERING CELL-BASED THERAPEUTICS FOR THETREATMENT OF DISEASEShort Title: CELL-BASED THERAPEUTICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Course Level: GraduateDescription: Once the stuff of science fiction, there is increasing attentionon using engineered living cells as therapeutic agents. We will discusshow application of synthetic biology, genetic engineering, and systemsbiology can endow cells with the ability to detect and treat disease,identifying breakthroughs, challenges, and long-term possibilities for thisexciting new field. Recommended Prerequisite(s): BIOE 321.

BIOE 536 - FRONTIERS IN IMMUNOENGINEERINGShort Title: IMMUNOENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Course Level: GraduateDescription: This course will introduce immunology concepts from anengineering perspective and covers various immune responses includingto pathogens, self, allergens, cancer, and biomaterials. Using principlesof engineering we will perform an in-depth analysis of these responsesand the latest advances on the development of novel therapeutics. Topicsinclude systems immunology, nanotechnology, hydrogels, biomaterials,vaccines, cancer immunotherapy, autoimmunity, tissue engineering, stemcells, viruses, and the microbiome.

BIOE 537 - GENETIC AND EPIGENETIC CONTROLShort Title: GENETIC AND EPIGENETIC CONTROLDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: All human diseases are driven by alterations in geneticsequences, cellular transcription, and/or chromatin structure. In thiscourse, students will learn how transformative new technologies permitmeasuring and manipulating these alterations, and how bioengineers canleverage these innovative tools to combat human diseases and catalyzeadvances in biotechnology.

BIOE 539 - APPLIED STATISTICS FOR BIOENGINEERING ANDBIOTECHNOLOGYShort Title: APPLIED STAT FOR BIOE BIOTECHDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Course will cover fundamentals of probability and statisticswith emphasis on application to biomedical problems and experimentaldesign. Recommended for students pursuing careers in medicineor biotechnology. Graduate/Undergraduate Equivalency: BIOE 439.Recommended Prerequisite(s): BIOE 252 Mutually Exclusive: Cannotregister for BIOE 539 if student has credit for BIOE 439.

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BIOE 543 - DNA BIOTECHNOLOGY, BIOPHYSICS, AND MODELINGShort Title: DNA BIOTECHNOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Semester-long course on fundamental properties of DNA,and their role in DNA biotechnology. Students will develop, analyze, andsimulate simple biophysical models of DNA reactions, as well as learnand model methods of modern DNA biotechnology. Proficiency withMATLAB required.

BIOE 548 - MACHINE LEARNING AND SIGNAL PROCESSING FOR NEUROENGINEERINGShort Title: NEURAL SIGNAL PROCESSINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: The activity of a complex network of billions ofinterconnected neurons underlies our ability to sense, represent andstore the details of experienced life, and enables us to interact with ourenvironment and other organisms. Modern neuroscience techniquesenable us to access this activity, and thus to begin to understand theprocesses whereby individual neurons enable complex behaviors. Inorder to increase this understanding and to design biomedical systemswhich might therapeutically interact with neural circuits, advancedstatistical signal processing and machine learning approaches arerequired. This class will cover a range of techniques and their applicationto basic neuroscience and neural interfaces. Topics include latentvariable models, point processes, Bayesian inference, dimensionalityreduction, dynamical systems, and spectral analysis. Neuroscienceapplications include modeling neural firing rates, spike sorting, decoding,characterization of neural systems, and field potential analysis. Cross-list:ELEC 548.

BIOE 552 - INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING &DESIGN PRINCIPLES OF BIOCHEM NETWORKSShort Title: INTRO SYSTEMS BIOLOGY MODELINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: The course summarizes techniques for quantitativeanalysis and simulations of basic circuits in genetic regulation, signaltransduction and metabolism. We discuss engineering approachesadapted to computational systems biology and aim to formulateevolutionary design principles explaining organization of networks interms of their physiological demands. We discuss biochemical simulationmethodology and software as well as recent advances in the field. Topicsinclude end-product inhibition in biosynthesis, optimality and robustnessof the signaling networks and kinetic proofreading. Same as 490 butwith more emphasis on recent advances in the field - paper readingand presentations. Cross-list: SSPB 502. Graduate/UndergraduateEquivalency: BIOE 490. Recommended Prerequisite(s): Basic knowledgeof biochemistry, cell biology, linear algebra, and ordinary differentialequations is expected. Mutually Exclusive: Cannot register for BIOE 552 ifstudent has credit for BIOE 490.

BIOE 553 - SYSTEMS BIOLOGY AND NEUROENGINEERINGShort Title: SYS BIOLOGY & NEUROENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will introduce students to advances incomputational biology relevant to neuroengineering, and equip them witha suite of tools emerging from systems biology to student neurologicalprocesses. Example class topics include: decoding multineuron activity,models for optogenetic control, and optimization of neuro-generativetherapies.

BIOE 554 - COMPUTATIONAL FLUID MECHANICSShort Title: COMPUTATIONAL FLUID MECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): MECH 371 (may be taken concurrently) or CEVE 363(may be taken concurrently) or CHBE 401 (may be taken concurrently)or BIOE 420 (may be taken concurrently) or CHBE 420 (may be takenconcurrently)Description: Fundamental concepts of finite element methods in fluidmechanics, including spatial discretization and numerical integrationin multidimensions, time-integration, and solution of nonlinear ordinarydifferential equation systems. Advanced numerical stabilizationtechniques designed for fluid mechanics problems. Strategies forsolution of complex, real-world problems. Topics in large-scalecomputing, parallel processing, and visualization. Prerequisites maybe taken concurrently. Additional work required. Cross-list: CEVE 554,MECH 554. Graduate/Undergraduate Equivalency: BIOE 454. MutuallyExclusive: Cannot register for BIOE 554 if student has credit for BIOE 454.

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BIOE 560 - CANCER BIOLOGYShort Title: CANCER BIOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Provides an integrated lecture series summarizing currentknowledge in cancer biology and integrating current literature withbasic concepts. Topics include: statistics of incidence/survival, typesof cancer, pathology, the process of carcinogenesis and sources ofcarcinogens, genetic and epigenetic mechanisms and consequences,cancer progression, metastasis and current treatment options. Studentswill learn to use online databases to develop independent strategiesfor analyzing datasets. There will be several writing assignments andin class oral presentations of research articles. This course requiresinstructor permission to enroll. Please fill out the special registration formfrom https://registrar.rice.edu/student/special_registration. All requestswill be reviewed and you will be notified of an enrollment decision.Instructor Permission Required. Cross-list: BIOC 560.

BIOE 564 - BIOINFORMATICS: NETWORK ANALYSISShort Title: BIOINFORMATICS: NETWORKSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course covers computational aspects of biologicalnetwork analysis, a major theme in the area of systems biology. Thecourse discusses protein-protein interaction, signaling, metabolic,and functional networks, and covers issues related to constructing,analyzing various types of networks, as well as how they can be used fordownstream applications. Cross-list: BIOC 572, COMP 572.

BIOE 574 - CONTINUUM BIOMECHANICSShort Title: CONTINUUM BIOMECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): BIOE 372Description: This course deals with elements of continuum mechanicsrelevant to bioengineering. The course covers important concepts intensor calculus, kinematics, stress and strain, and constitutive theoriesof continua. Selected topics in bone, articular cartilage, blood andcirculation, and cell biomechanics will be discussed to illustrate theapplication of continuum mechanism to bioengineering problems.

BIOE 578 - BIOTECHNOLOGY PRACTICUMShort Title: BIOTECHNOLOGY PRACTICUMDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Internship/PracticumCredit Hour: 1Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course is part of the NIH Biotechnology TrainingProgram and is limited to program participants. Students will receiveexposure and training in cutting edge concepts and technologies. Cross-list: BIOC 578.

BIOE 580 - PROTEIN ENGINEERINGShort Title: PROTEIN ENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Manipulation of gene expression in prokaryotic andeukaryotic cells. Rational design and directed evolution for cell andprotein engineering. Selection and screening technologies and processoptimization. Synthetic Biology: engineering and application of genecircuits. Molecular biotechnology applications: Diagnosis, Therapeuticsand Vaccines. Cross-list: BIOC 580, CHBE 580. RecommendedPrerequisite(s): CHBE 310/510 or equivalent is highly recommended.

BIOE 581 - CARDIOVASCULAR AND RESPIRATORY SYSTEM DYNAMICSShort Title: CARDIO - RESP SYSTEM DYNAMICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Autonomic nervous system control of the cardiovascularand respiratory systems. Development of models of neuron and cardiaccell activity; models of ventricular and vascular system mechanics;models of pulmonary mechanics and gas transport. Includes a studyof instrumentation and techniques used in the cardiac catherizationlaboratory. Discussions of different types of ventricular assist devicesis also included. The course serves as an introduction to engineeringin cardiovascular and respiratory system diagnosis and criticalcare medicine. Cross-list: ELEC 581. Recommended Prerequisite(s):Knowledge of ordinary differential equations; electricity and magnetism,and solid mechanics form elementary physics; linear control theory andelementary physiology of the cardiovascular and respiratory systems.Repeatable for Credit.

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BIOE 582 - PHYSIOLOGICAL CONTROL SYSTEMSShort Title: PHYSIOLOGICAL CONTROL SYSTEMSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Lecture/LaboratoryCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: A study of the somatic and autonomic nervous systemcontrol of biological systems. Simulation methods, as well as, techniquescommon to linear and nonlinear control theory are used. Also included isan introduction to sensors and instrumentation techniques. Examples aretaken from the cardiovascular, respiratory, and visual systems. Additionalcoursework required beyond the undergraduate course requirements.Cross-list: ELEC 582. Graduate/Undergraduate Equivalency: BIOE 482.Mutually Exclusive: Cannot register for BIOE 582 if student has credit forBIOE 482.

BIOE 583 - COMPUTATIONAL NEUROSCIENCE AND NEURALENGINEERINGShort Title: COMP/NEUROSCIENCE/NEURAL ENGNRDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: An introduction to the anatomy and physiology of thebrain. Includes basic electrophysiology of nerve and muscle. Developsmathematical models of neurons, synaptic transmission and naturalneural networks. Leads to a discussion of neuromorphic circuitswhich can represent neuron and neural network behavior in silicon.Recommendation: Knowledge of electrical circuits, operational amplifiercircuits and ordinary differential equations. Involves programmingMatlab. Cross-list: ELEC 583, NEUR 583. Graduate/UndergraduateEquivalency: BIOE 481. Recommended Prerequisite(s): Knowledge ofbasic electrical and operational amplifier circuits; and ordinary differentialequations. Mutually Exclusive: Cannot register for BIOE 583 if student hascredit for BIOE 481.

BIOE 586 - RESPIRATORY SYSTEM MECHANICSShort Title: RESPIRIATORY SYSTEM MECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Mechanics of ventilation, respiratory muscle mechanics, ribcage mechanics, mechanical coupling between the respiratory musclesand the rib cage, and inferences on mechanics from respiratory muscleanatomy. The class will meet in the Pulmonary Division at Baylor Collegeof Medicine in the Texas Medical Center. Cross-list: MECH 586.

BIOE 587 - OPTICAL IMAGING AND NANOBIOPHOTONICSShort Title: OPTIC IMAGING/NANOBIOPHOTONICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course focuses on diagnostic and therapeuticapplications of photonics-based technologies with particular emphasison nanotechnology enabled optical approaches. This course emphasizesbiomedical applications of optics and complements BIOE 484 whichintroduces fundamental principles of optics to bioengineers.

BIOE 589 - COMPUTATIONAL MOLECULAR BIOENGINEERING/BIOPHYSICSShort Title: COMP MOLECULAR BIOENG/BIOPHYSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This is a course designed for students in computationally-oriented biomedical and bioengineering majors to introduce theprinciples and methods used for the simulations and modeling ofmacromolecules of biological interest. Protein conformation anddynamics are emphasized. Empirical energy function and moleculardynamics calculations are described. Specific biological problems arediscussed to illustrate the methodology. Classic examples such as thecooperative mechanism of hemoglobin and more frontier topics suchas the motional properties of molecular motors and ion channels aswell as results derived from the current literature are covered. Cross-list: BIOC 589. Recommended Prerequisite(s): MATH 212, (BIOS 301 orBIOC 301), BIOE 332.

BIOE 591 - FUNDAMENTALS OF MEDICAL IMAGING IShort Title: FUND MEDICAL IMAGING IDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will introduce basic principles of imageacquisition, formation and processing of several medical imagingmodalities such as X-Ray, CT, MRI, and US that are used to evaluate thehuman anatomy. The course also includes visits to a clinical site togain experience with the various imaging modalities covered in class.Additional coursework required beyond the undergraduate courserequirements. Cross-list: ELEC 585. Graduate/Undergraduate Equivalency:BIOE 485. Mutually Exclusive: Cannot register for BIOE 591 if student hascredit for BIOE 485.

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BIOE 592 - SENSORY NEUROENGINEERINGShort Title: SENSORY NEUROENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: SeminarCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): BIOE 332 and BIOE 384Description: This course will explore how bioengineering techniques andprinciples are applied to understand and model sensory systems, witha focus on the auditory, vestibular, and visual systems. The interactionbetween the electrical, mechanical and optical aspects of these systems,and ways to modulate these interactions, will be explored. The coursewill also cover the design of current auditory, visual and somato-sensoryneuroprosthetics (i.e. cochlear- implants, retinal implants and brain-machine interfaces), as well as emerging technologies for neuralstimulation. Graduate/Undergraduate Equivalency: BIOE 492. MutuallyExclusive: Cannot register for BIOE 592 if student has credit for BIOE 492.

BIOE 593 - BUILDING LIFE SCIENCES, BIOMEDICAL, ANDBIOTECHNOLOGY STARTUPSShort Title: BIOTECH STARTUPDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This semester-long course aims to provide entrepreneurialstudents with a hands-on experience in building a high-tech companybased on novel biomedical technologies being developed at RiceUniversity and in the Texas Medical Center. Students will form teams of2-4, and identify a promising biomedical technology, perform intellectualproperty landscape analysis, identify a minimum viable product, builda business plan, construct 1 year and 5 year financial projections,conduct voice of customer interviews, and present a fundraising“pitch.” Students are expected to spend 8-10 hours per week outsidethe classroom to complete tasks assigned during lectures, and willsummarize their findings every 2 weeks in a 7-minute presentation.Graduate/Undergraduate Equivalency: BIOE 493. Mutually Exclusive:Cannot register for BIOE 593 if student has credit for BIOE 493.

BIOE 595 - MODELING TISSUE MECHANICSShort Title: MODELING TISSUE MECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Independent StudyCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Independent study and seminar course which focuseson modeling the mechanical properties of biological tissues. Datafrom experiments will be used to refine the predictions of nonlinearmathematical computer models. Aimed at juniors, seniors, and graduatestudents. Laboratory work performed at Baylor College of Medicine,computer work at Rice University. Cross-list: MECH 595.

BIOE 596 - FUNDAMENTALS OF MEDICAL IMAGING IIShort Title: FUND MEDICAL IMAGING IIDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course focuses on functional imaging modalities usedspecifically in nuclear medicine such as Gamma cameras, SPECT, andPET imaging. The course will introduce the basic principles of imageacquisition, formation, processing and the clinical applications of theseimaging modalities and lays the foundations for understanding theprinciples of radiotracer kinetic modeling. A trip to a clinical site in alsoplanned to gain experience with nuclear medicine imaging. Additionalcoursework required beyond the undergraduate course requirements.Cross-list: ELEC 586. Graduate/Undergraduate Equivalency: BIOE 486.Mutually Exclusive: Cannot register for BIOE 596 if student has credit forBIOE 486.

BIOE 600 - GRADUATE BIOENGINEERING INDUSTRY INTERNSHIPShort Title: GRAD BIOE INDUSTRY INTERNSHIPDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Internship/PracticumCredit Hours: 6Restrictions: Enrollment limited to students in the MBE-GMI program.Enrollment is limited to Graduate level students. Enrollment limited tostudents in a or Master of Bioengineering degrees.Course Level: GraduateDescription: Students will participate in an industry internship or industry-sponsored project under the direction of Bioengineering faculty. Thiscourse is taken in the summer for six credits. Enrollment is limited tostudents in the Global Medical Innovation track of the MBE degree.Instructor permission is required. Instructor Permission Required.

BIOE 610 - METHODS OF MOLECULAR SIMULATIONShort Title: METHODS OF MOLECULAR SIMULDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): CHBE 611 or BIOC 589 or BIOE 589 or BIOS 589 orCHEM 520 or PHYS 526Description: Modern simulation techniques for classical atomisticsystems. Review of statistical mechanical systems. Monte Carlo andmolecular dynamics simulation techniques. Extensions of the basicmethods to various ensembles. Applications to simulations of largemolecules such as proteins. Advanced techniques for simulation ofcomplex systems, including constraint satisfaction, cluster moves, biasedsampling, and random energy models. Cross-list: PHYS 610.

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BIOE 615 - BIOENGINEERING AND CARDIAC SURGERYShort Title: BIOENGINEERING/CARDIAC SURGERYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will address biomaterials and medical devicesrelevant to cardiac and vascular surgery and interventional cardiologyin adult and pediatric patients. Mechanical and design considerations,notable successes and failures, and ethical issues will also be discussed,as will differences in cardiac disease and care due to health disparities.

BIOE 620 - TISSUE ENGINEERINGShort Title: TISSUE ENGINEERINGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Study of cell-cell interactions and the role of the extracellularmatrix in the structure and function of normal and pathological tissues.Includes strategies to regenerate metabolic organs and repair structuraltissues, as well as cell-based therapies to deliver proteins and othertherapeutic drugs, with emphasis on issues related to cell and tissuetransplantation such as substrate properties, angiogenesis, growthstimulation, cell differentiation, and immunoprotection. Cross-list:CHBE 620.

BIOE 621 - BIOVENTURESShort Title: BIOVENTURESDepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: SeminarCredit Hours: 2Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): MGMT 633 or BIOE 633Description: A hands-on immersion into life science entrepreneurshipthrough practical lessons that are applied to students' group projectsthroughout the course. This practical course will provide the skills andresources to facilitate scientist-driven entrepreneurship in conceivingnew life science ventures and translating research ideas into commercialventures. This course will be taught in conjunction w/UTMB faculty onthe Rice campus (BRC) and will meet from Feb 26 - April 30, 2015. Toapply for the course, Rice students should fill out the online applicationlocated on the URL site listed above. Instructor Permission Required.Repeatable for Credit.Course URL: goo.gl/forms/pJ0UMeJItO (http://goo.gl/forms/pJ0UMeJItO/)

BIOE 627 - MEDICAL INNOVATION INDUSTRY SEMINARShort Title: MED. INNOVATION INDUSTRY SEM.Department: BioengineeringGrade Mode: Standard LetterCourse Type: SeminarCredit Hours: 1.5Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course exposes participants to the wide variety ofcareer paths in the medical technology industry including large to midsized companies, consulting, biotech, pharma, diagnostics, hospitaladministration and more through guest lectures, case studies, andinformational interviews. Additional topics include: Resume and LinkedInrefinement, Job Application Process, Interview Skills, Delivering OralPresentations

BIOE 628 - MEDICAL TECHNOLOGY DESIGN SEMINAR 2Short Title: MED TECH DESIGN SEMINAR 2Department: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 1.5Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Students will learn to address unmet clinical needsthru methodical design. Concept generation principles & proof-of-concept prototyping will be discussed. Screening techniques will betaught that not only weigh technical merit of a concept, but regulatory,reimbursement, IP & business strategies. Students will participate inindustry case studies & guest lectures from industry professionals.

BIOE 631 - BIOMATERIALS APPLICATIONSShort Title: BIOMATERIALS APPLICATIONSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Emphasis will be placed on issues regarding thedesign, synthesis, evaluation, regulation and clinical translation ofbiomaterials for specific applications. An overview of significantbiomaterials engineering applications will be given, including topicssuch as ophthalmologic, orthopedic, cardiovascular and drug deliveryapplications, with attention to specific case studies. Regulatory issuesconcerning biomaterial will also be addressed. Assignments for thisclass will include frequent readings of the scientific literature withoccasional homework questions, one midterm and cumulative final, agroup project, a seminar report and individual presentations. In addition,graduate students in BIOE 631 will have additional exam problems andan additional research paper. Graduate/Undergraduate Equivalency:BIOE 431. Mutually Exclusive: Cannot register for BIOE 631 if student hascredit for BIOE 431.

Page 20: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

20        Bioengineering (BIOE)

BIOE 633 - ROLES OF PHYSICIANS, SCIENTISTS, ENGINEERS ANDMBA’S IN HIGH-TECH STARTUPSShort Title: LIFE SCIENCE ENTREPRENEURSHIPDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 1.5Restrictions: Enrollment limited to students in the following programs:EMBA MBA PMBA WMBA XMBA Enrollment is limited to Graduate levelstudents.Course Level: GraduateDescription: This pragmatic course combines core lectures onentrepreneurship with special guest presentations by notable life scienceentrepreneurs. It explores the roles that physicians, scientists, engineers,and MBA's play in biotech, medical device, and healthcare companies, aswell as major trends in Angel and Venture Capital Financings of Startups.Lectures on entrepreneurial team building, leadership and career planningare included. Cross-list: MGMT 633.

BIOE 643 - CELL MECHANICS, MECHANOTRANSDUCTION AND THE CELLMICROENVIRONMENTShort Title: MECHANOTRANSDUCTIONDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Mechanotransduction is a fundamental process essentialfor living systems and plays a fundamental role in cell signaling, cancermetastasis and stem cell differentiation. Additionally, fundamentalbiological processes such as endocytosis cell fusion and cell migrationare driven by a coordinated interplay of molecular interactions thatdrive membrane deformation. This course will survey the currentunderstanding of mechanotransduction and the mechanical properties ofcells and their microenvironment, including membrane and cytoskeletalmechanics. Experimental approaches for measuring and manipulatingthe material properties of cells and their environment; includingoptical, electrical and magnetic techniques will be covered. A varietyof application will be covered, including manipulation in engineering ofmechanotransduction pathways to drive cell migration and stem celldifferentiation. Instructor Permission Required. Cross-list: BIOC 643,PHYS 643.

BIOE 648 - MOLECULAR TECHNIQUES IN BIOENGINEERINGShort Title: MOLECULAR TECHNIQUES IN BIOENGDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Introduction to the fundamental physical principles of lightinteraction with matter, separation (by charge, size, confirmation) anddetection techniques utilized in the field of bioengineering. These includeabsorbance and fluorescence spectroscopy, light and fluorescencemicroscopy, flow cytometry, electrophoresis, PCR, Blotting, and ELISA. Aresearch paper on new advancements on a technique/technology of theirchoice based on the ones covered. Graduate/Undergraduate Equivalency:BIOE 348. Mutually Exclusive: Cannot register for BIOE 648 if student hascredit for BIOE 348.

BIOE 654 - ADVANCED COMPUTATIONAL MECHANICSShort Title: ADV COMPUTATIONAL MECHANICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): BIOE 554 or CEVE 554 or MECH 554 or BIOE 454 orCEVE 454 or MECH 454Description: Advanced topics in computational mechanics with emphasison finite element methods and fluid mechanics. Stabilized formulations.Fluid-particle and fluid-structure interactions and free-surface and two-fluid flows. Interface tracking and interface-capturing techniques, space-time formulations, and mesh update methods. Enhanced discretizationand solution techniques. Iterative solution methods, matrix-freecomputations, and advanced preconditioning techniques. Cross-list:CEVE 654, MECH 654.

BIOE 677 - SPECIAL TOPICSShort Title: SPECIAL TOPICSDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: Laboratory, Lecture, Seminar, Internship/PracticumCredit Hours: 1-4Restrictions: Enrollment is limited to Graduate or Visiting Graduate levelstudents.Course Level: GraduateDescription: Topics and credit hours vary each semester. Contactdepartment for current semester's topic(s). Repeatable for Credit.

BIOE 680 - NANO-NEUROTECHNOLOGYShort Title: NANO-NEUROTECHNOLOGYDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: SeminarCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: This course will review current nanofabricated technologiesfor measuring, manipulating, and controlling neural activity. The coursewill be based on reviewing current academic literature and topics willinclude nano-electronic, -photonic, -mechanical, and -fluidic neuraldevices. Cross-list: ELEC 680.

BIOE 682 - SYSTEMS BIOLOGY OF HUMAN DISEASESShort Title: SYS BIO OF HUMAN DISEASESDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Introduction to concepts necessary for application ofsystems - Biology Approaches to Human Diseases. Topics includetranscriptional and metabolic design principles, introduction to variousregulatory network motifs in diseases and potential treatments usingembryonic stem cells. Analysis of complex diseases using engineeringconcepts such as optimality, nonequilibrium thermodynamics, multiscaleanalysis and spatiotemporal transport. Cross-list: CHBE 682.

Page 21: Bioengineering (BIOE) - Rice University · BIOE 252 - BIOENGINEERING FUNDAMENTALS Short Title: BIOENGINEERING FUNDAMENTALS Department: Bioengineering Grade Mode: Standard Letter Course

Bioengineering (BIOE)           21

BIOE 690 - PROFESSIONAL DEVELOPMENT FOR BIOENGINEERSShort Title: PROF DEVELOPMENT FOR BIOEDepartment: BioengineeringGrade Mode: Standard LetterCourse Type: LectureCredit Hours: 3Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduatePrerequisite(s): BIOE 517Description: Professional development topics relevant to academiccareers including applying for faculty positions, interviewing , negotiatingoffers, building a lab, obtaining funding and balancing professionalobligations. Designed for graduate students planning academic careersin research-intensive bioengineering departments.

BIOE 698 - BIOENGINEERING COLLOQUIAShort Title: BIOENGINEERING COLLOQUIADepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: SeminarCredit Hour: 1Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Recent research in bioengineering will be presented in thiscolloquium series. These colloquia provide an opportunity to learn aboutthe research at other institutions, oftentimes in an area outside students'specific dissertation specialty, and are an important part of graduateeducation. Graduate students in BIOE are expected to attend all regularBioengineering colloquia. Repeatable for Credit.

BIOE 699 - BIOENGINEERING COLLOQUIAShort Title: BIOENGINEERING COLLOQUIADepartment: BioengineeringGrade Mode: Satisfactory/UnsatisfactoryCourse Type: SeminarCredit Hour: 1Restrictions: Enrollment is limited to Graduate level students.Course Level: GraduateDescription: Recent research in bioengineering will be presented in thiscolloquium series. These colloquia provide an opportunity to learn aboutthe research at other institutions, oftentimes in an area outside students'specific dissertation specialty, and are an important part of graduateeducation. Graduate students in BIOE are expected to attend all regularBioengineering colloquia. Repeatable for Credit.


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