Biotechnology in Biotechnology in the Islamic Republic the Islamic Republic

of Iranof Iran

2

Main Institutes involved in Main Institutes involved in BiotechnologyBiotechnology

National Institute for Genetic Engineering and National Institute for Genetic Engineering and Biotechnology Biotechnology Pasteur Institute of IranPasteur Institute of IranRaziRazi Institute for Vaccine developmentInstitute for Vaccine developmentSharifSharif UniversityUniversityPersian Golf Biotechnology Research centerPersian Golf Biotechnology Research centerTarbiateTarbiate ModarresModarres UniversityUniversityOther Universities (Tehran, Shiraz, Other Universities (Tehran, Shiraz, MashhadMashhad, , TabrizTabrizand and IsfahanIsfahan))Agriculture Biotechnology Research CenterAgriculture Biotechnology Research Center

3

Biotechnology in IRANBiotechnology in IRAN

5858Products in the MarketProducts in the Market55Policy Maker Committees Policy Maker Committees 44Scientific SocietiesScientific Societies1010Private Companies (Material)Private Companies (Material)1515Private Companies (Equipments)Private Companies (Equipments)4242UniversitiesUniversities3535Research InstitutesResearch Institutes

NumberNumberTitleTitle

4

NGOs Involved in BiotechnologyNGOs Involved in Biotechnology

Iranian Society for Biotechnology (ISB), Iranian Society for Biotechnology (ISB), established 1997, 600 members, four branches in established 1997, 600 members, four branches in different provincesdifferent provincesIranian Genetic Society (IGS), established 2001, Iranian Genetic Society (IGS), established 2001, 500 Members500 MembersIranian Iranian BiosafetyBiosafety Society (IBS), established 2003, Society (IBS), established 2003, 150 members150 membersEthics Society In Science and Technology (ESST), Ethics Society In Science and Technology (ESST), established 2004established 2004Biotechnology Private Companies, total No. 25Biotechnology Private Companies, total No. 25

5

Education in BiotechnologyEducation in Biotechnology

55Medical & Intellectual Medical & Intellectual Property RightProperty Right

99Industrial BiotechnologyIndustrial Biotechnology

1111Agriculture BiotechnologyAgriculture Biotechnology

88Molecular Biology and Molecular Biology and GeneticGenetic

Total 35Total 35(PhD 14 & (PhD 14 & MScMSc 19)19)

Educational Programs Educational Programs

NumberNumberTitleTitle

6

Biotechnology Human ResourcesBiotechnology Human Resources

TotalTotal

Universities Universities (42)(42)

Research Research Centers (35)Centers (35)

RaziRaziInstituteInstitute

Pasture Pasture InstituteInstitute

NIGEBNIGEB

InstituteInstitute

755755

300300

233233

4747

1291294646

PhD PhD ResearchersResearchers

572572

133133

241241

108108

59593131

MScMScResearchersResearchers

653653

480480

139139

1010

24242525

Capacity for Capacity for Training Training PhD/yearPhD/year

11031103

871871

9797

3030

30307575

Capacity for Capacity for Training Training MScMSc/year/year

7

Research Capacities in BiotechnologyResearch Capacities in Biotechnology

TotalTotal

Universities (42)Universities (42)

Research Research Centers (35)Centers (35)

RaziRazi InstituteInstitute

Pasture InstitutePasture Institute

NIGEBNIGEB

InstituteInstitute

12128080815815

221212478478

556363300300

111155

11112222

33331010

Gene or Cell Gene or Cell BankBank

Animal or Animal or Green HouseGreen House

LaboratoriesLaboratories

8

Research Projects in BiotechnologyResearch Projects in Biotechnology

2011201114511451560560TotalTotal

326326226226100100Basic ScienceBasic Science

572572432432140140Industry & Industry & EnvironmentEnvironment

470470360360110110MedicalMedical643643433433210210AgricultureAgriculture

TotalTotalFinalized Finalized Projects Projects

Projects in Projects in DemandDemand

SubjectSubject

9

International Value of Biological International Value of Biological Products (per year)Products (per year)

794.1794.1248248TotalTotal

64642020PharmacutPharmacut. . CompaniesCompanies

Antibiotics (217 Antibiotics (217 tones/year)tones/year)

89.689.62828Pasture Inst.Pasture Inst.Vaccine, serum and Vaccine, serum and Cell CultureCell Culture

585585182.8182.8RaziRazi Inst.Inst.Vaccine & Serum Vaccine & Serum for Animalfor Animal

55.555.517.217.2RaziRazi Inst.Inst.Vaccine & Serum Vaccine & Serum for humanfor human

Private Market Private Market Price (million $)Price (million $)

UNICEF Price UNICEF Price (million $)(million $)

ProducerProducerProductProduct

10

Biotechnology Equipments Biotechnology Equipments

Cold and Hot roomCold and Hot roomPress FiltersPress FiltersFreezer (Freezer (--70oC)70oC)

CrystallizerCrystallizer

EvaporatorEvaporatorNitrogen TankNitrogen TankSpray DryerSpray Dryer

Trans LaminatorTrans LaminatorNameName

Private Co. Private Co. Kara Kara SanatSanat Co. Co. JallJall Co.Co.

Jihad Research Co.Jihad Research Co.

Jihad Research Co.Jihad Research Co.RahamRaham GazGaz Co. Co. Iran Iran KhoshkKhoshk Co.Co.

CadoosCadoos SepandSepand Co. Co. ProducerProducer

5000 $/Sq. meter5000 $/Sq. meter5,000 $5,000 $5,000 $5,000 $

20.000 $20.000 $

20,000 $20,000 $10,000 $10,000 $20,000 $20,000 $

500 $500 $Price Per UnitPrice Per Unit

11

Biotechnology Equipments Biotechnology Equipments

2000 $2000 $Pars Pars tebteb, , Laminar FellowLaminar Fellow

12000 $12000 $IROSTIROSTClean Steam Pro.Clean Steam Pro.

1000 $/ Sq. meter1000 $/ Sq. meterBesatBesat & Tehran & Tehran SakkooSakkoo Co.Co.

Clean RoomClean Room

>9000 $>9000 $IROST & Private IROST & Private Co.Co.

FermentorsFermentors (20 (20 10,000 liters)10,000 liters)

5000 $5000 $JallJall Co. Co. Shaker IncubatorShaker Incubator

500 $500 $PayaPaya pajooheshpajoohesh Co.Co.ElectrophoresisElectrophoresis

2000 $2000 $JaheshJahesh TebTeb Co.Co.Spectrophotometer Spectrophotometer (Visible)(Visible)

Price Per UnitPrice Per UnitProducerProducerNameName

12

Chemical and Food ProductsChemical and Food Products

--29,78029,780Citric acidCitric acid

525211,13711,137YeastYeast

0.90.9500500Vinegar form apple Vinegar form apple

--4,7004,700Protein for Feed Protein for Feed from molassesfrom molasses

40401,8901,890Ethanol from Ethanol from molassesmolasses

Value (million $)Value (million $)Capacity Capacity (tones/year)(tones/year)

ProductProduct

13

Biotechnology prioritiesBiotechnology prioritiesMolecular detection of infectious and genetic Molecular detection of infectious and genetic diseasesdiseasesProduction of Recombinant medicines and Production of Recombinant medicines and vvaccines accines BioremediationBioremediationBioinformaticsBioinformatics, , BisafetyBisafety and Bioethicsand BioethicsTransgenic plants Resistance to Biotic and Transgenic plants Resistance to Biotic and Abiotic StressAbiotic StressHuman Genome DiversityHuman Genome DiversityBioleaching of CooperBioleaching of CooperOil desulphurizationOil desulphurizationPrivatization of Biotechnology Industry Privatization of Biotechnology Industry

14

Biotechnology PolicyBiotechnology Policy

National Biotechnology Committee at National Biotechnology Committee at Ministry of Science, Research and Ministry of Science, Research and Technology Technology National Strategic plan of BiotechnologyNational Strategic plan of BiotechnologyBiotechnology Committees at Ministry of Biotechnology Committees at Ministry of Industry and Mine, Ministry of Health, Industry and Mine, Ministry of Health, Ministry of Agricultural jihad, Ministry of Agricultural jihad, Department of Environment protectionDepartment of Environment protection

15Tehran, Islamic Republic of Iran

National Institute for Genetic Engineering and Biotechnology

Established at 1989

Under the Supervision of The

Ministry of Science, Research and Technology

Scope:Plant, Animal, Medical and Marine, Industrial and Environmental Biotechnology

16

National Institute for Genetic Engineering National Institute for Genetic Engineering and Biotechnology (NIGEB)and Biotechnology (NIGEB)

Aims:Aims:Research activities in the field of advanced Research activities in the field of advanced

molecular biology & biotechnologymolecular biology & biotechnologyPromoting applied and basic research in Promoting applied and basic research in

science and technologyscience and technologyTechnology production in different field of Technology production in different field of

biotechnologybiotechnology

17

PatentsPatentsGenes Submitted at Gene Bank Genes Submitted at Gene Bank

16162727

Article Presented at National & Article Presented at National & Int. SeminarsInt. Seminars

612 612

Full Research PapersFull Research PapersBooksBooks

115 115 2424

Total No. of TechnologiesTotal No. of TechnologiesNo. Transferred to IndustryNo. Transferred to Industry

393955

National & International National & International CongressesCongresses

55

WorkshopsWorkshopsNo. of Trained ParticipantsNo. of Trained Participants

4747847847

NIGEB ResultsNIGEB Results

18

RaziRazi is one of the oldest and most important is one of the oldest and most important applied R&D organization in Iran.applied R&D organization in Iran.RaziRazi produces over 2.5 billion doses of 55 different produces over 2.5 billion doses of 55 different biological products, including human and biological products, including human and veterinary vaccines and also diagnostic antigens, at veterinary vaccines and also diagnostic antigens, at an annual value of about $105m.an annual value of about $105m.RaziRazi has 28 different departments and employs has 28 different departments and employs 1250 staff, including 133 scientists.1250 staff, including 133 scientists.The institute uses locally produced fermenters for The institute uses locally produced fermenters for vaccine production.vaccine production.RaziRazi has links to the WHO and is part of the UN has links to the WHO and is part of the UN health care infrastructure. health care infrastructure.

RaziRazi Vaccine & Serum Research Vaccine & Serum Research Institute Institute (1925)(1925)

19

List of products of List of products of RaziRazi InstituteInstitute

Vaccines for medical use Vaccines for medical use Sera for Therapeutic medical useSera for Therapeutic medical useVaccines for Veterinary use Vaccines for Veterinary use Veterinary Veterinary antiparasiticantiparasitic drugs drugs Antigens and other biological productsAntigens and other biological productsLaboratory animals Laboratory animals Herbal medicinal products Herbal medicinal products Other biotechnological productsOther biotechnological products

20

Medical VaccinesMedical VaccinesTetanus vaccine Tetanus vaccine Combined Diphtheria and Tetanus vaccine for children Combined Diphtheria and Tetanus vaccine for children Combined Diphtheria and Tetanus vaccine for adults Combined Diphtheria and Tetanus vaccine for adults Combined Diphtheria, Tetanus and Combined Diphtheria, Tetanus and PertusisPertusis vaccine vaccine (DTP)(DTP)Measles vaccineMeasles vaccineRubella vaccine Rubella vaccine Mumps vaccine Mumps vaccine Combined Measles, Rubella and Mumps vaccine Combined Measles, Rubella and Mumps vaccine (MMR)(MMR)Poliomyelitis vaccinePoliomyelitis vaccine

21

Molecular MedicineMolecular MedicinePrenatal Diagnostic for the following genetic Disorders:Prenatal Diagnostic for the following genetic Disorders:

Beta Beta ThelassemiaThelassemiaHemophiliaHemophiliaMuscular DystrophyMuscular Dystrophy

Molecular Diagnostic tests includingMolecular Diagnostic tests includingTBTBHCVHCVHBVHBVH.pyloriH.pyloriCMVCMVLeishmaniasisLeishmaniasisToxoplasmosisToxoplasmosis

22

Recombinant ProductsRecombinant ProductsHepatitis B VaccineHepatitis B VaccineStreptokinaseStreptokinaseInterferon AlphaInterferon AlphaInterferon GammaInterferon GammaGG--CSF & GMCSF & GM--CSFCSFHIV diagnostic KitsHIV diagnostic KitsHCV diagnostic KitsHCV diagnostic KitsHBS diagnostic kitsHBS diagnostic kitsHTLVHTLV--I, III, IIHuman Growth HormoneHuman Growth HormoneBlood group typing (Blood group typing (mAbmAb))Molecular Diagnostic kits for Infectious DiseasesMolecular Diagnostic kits for Infectious Diseases

23

Medical Therapeutic SeraMedical Therapeutic Sera

AntitetanicAntitetanic Serum Serum AntidiphthericAntidiphtheric Serum Serum Polyvalent Scorpion Polyvalent Scorpion AntivenumAntivenumPolyvalent Snake Polyvalent Snake AntivenumAntivenum

24

Biological ProductsBiological Products

Rabbit SerumRabbit SerumRabbit Plasma Rabbit Plasma Rabbit Complement Rabbit Complement Haemolyzin Haemolyzin Guinea Pig Serum Guinea Pig Serum Guinea Pig ComplementGuinea Pig ComplementMouse SerumMouse SerumRat SerumRat Serum

25

Herbal Medicinal ProductsHerbal Medicinal Products

Herb ExtractsHerb ExtractsEssential OilsEssential OilsActive Constituent of Eucalyptus i.e. 1.8Active Constituent of Eucalyptus i.e. 1.8CineoleCineole ((EucalyptotEucalyptot))

26

Other Biotechnology ProductsOther Biotechnology Products

BilirubinBilirubin Standard Standard F ANA Glass Slides F ANA Glass Slides Lectin Lectin Cholesterol KitCholesterol KitGlucose Kit Glucose Kit PeroxidasePeroxidase EnzymeEnzymeAnti Human Anti Human Polyvalent and Polyvalent and MonovalentMonovalent AntiseraAntisera for Salmonella for Salmonella Groups A, B, C and Groups A, B, C and TxphiTxphiAnimal Animal AntiseraAntisera and and ImmunoglobulinsImmunoglobulinsAnti Malaria Biological product Anti Malaria Biological product

27

PasteurPasteur Institute of Iran Institute of Iran (1920)(1920)

–– A primary center for research on infectious diseasesA primary center for research on infectious diseases–– A center for production of biological products, vaccines, and A center for production of biological products, vaccines, and

serums.serums.

Biotechnology DepartmentBiotechnology Department (1993)(1993)

–– The goal is conducting biotechnologyThe goal is conducting biotechnology-- related researchrelated research

Research Activities:Research Activities:

–– Molecular diagnostics:Molecular diagnostics: include molecular detection of include molecular detection of prevalent genetic disorders and various infectious diseases.prevalent genetic disorders and various infectious diseases.

–– Recombinant DNA technology: includes developmentRecombinant DNA technology: includes development of of recombinant vaccines and pharmaceutics. recombinant vaccines and pharmaceutics.

28

Iranian Research Organization for Science Iranian Research Organization for Science &Technology (IROST)&Technology (IROST) (1979)(1979)

IROST is affiliated with the Ministry of Science, IROST is affiliated with the Ministry of Science, Research and Technology.Research and Technology.Biotechnology Department:Biotechnology Department:

Persian Type Culture Collection (PTCC)Persian Type Culture Collection (PTCC)Bioprocess Engineering Projects:Bioprocess Engineering Projects:

–– BiopesticidesBiopesticides ProductionProduction–– Feed Production from Agricultural wasteFeed Production from Agricultural waste–– SCP ProductionSCP Production–– Production of Production of BiofertilizersBiofertilizers